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PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 11, p. e1003773
... with the mitochondrial adaptor protein MAVS (also known as IPS-1, CARDIF and VISA) and initiates a signalling cascade that culminates in the activation of the transcriptional... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Neuron, ISSN 0896-6273, 02/2013, Volume 77, Issue 3, pp. 472 - 484
Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and... 
MUTANT MICE | CORTICAL AXONS | THALAMOCORTICAL AXONS | GROWTH | SEMAPHORIN 3E | CENTRAL-NERVOUS-SYSTEM | GUIDANCE | CHICK HINDLIMB | CAJAL-RETZIUS CELLS | NEUROSCIENCES | CEREBRAL-CORTEX | Thyroid Nuclear Factor 1 | Age Factors | Embryo, Mammalian | Leukocyte L1 Antigen Complex - metabolism | Gene Expression Regulation, Developmental - genetics | Axons - physiology | Cerebral Cortex - cytology | Neural Pathways - physiology | DNA-Binding Proteins - metabolism | POU Domain Factors - genetics | tau Proteins - genetics | Thalamus - physiology | Contactin 2 - metabolism | Repressor Proteins - metabolism | Glycoproteins - genetics | Tumor Suppressor Proteins - metabolism | Wnt3A Protein - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | S100 Calcium Binding Protein G - metabolism | Transcription Factors - metabolism | Animals | Calbindin 2 | Thalamus - cytology | Cerebral Cortex - physiology | Luminescent Proteins - genetics | Mice | Body Patterning - genetics | Luminescent Proteins - metabolism | Developmental biology | Neurons | Studies | Laboratories | Experiments | Repressor Proteins | Cerebral Cortex | Cellular Biology | Neural Pathways | tau Proteins | Life Sciences | Contactin 2 | Gene Expression Regulation, Developmental | Body Patterning | Thalamus | Membrane Glycoproteins | Luminescent Proteins | DNA-Binding Proteins | POU Domain Factors | Calcium-Binding Protein, Vitamin D-Dependent | Glycoproteins | Nerve Tissue Proteins | Nuclear Proteins | Membrane Proteins | Axons | Homeodomain Proteins | Leukocyte L1 Antigen Complex | Transcription Factors | Wnt3A Protein | Tumor Suppressor Proteins | reciprocal connections | handshake | waiting period | PlexinD1 | axon guidance | Sema3E | thalamocortical | corticothalamic
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2011, Volume 18, Issue 8, pp. 941 - 946
.... Recent studies indicate that the same SNARE-binding protein, complexin (CPX), can act either as a facilitator or as an inhibitor of membrane fusion, constituting a controversial dilemma... 
BIOPHYSICS | FORCE | NEUROTRANSMITTER RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT DOMAINS | SWITCH | BINDING | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Humans | Vesicle-Associated Membrane Protein 2 - physiology | Syntaxin 1 - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Nerve Tissue Proteins - chemistry | SNARE Proteins - chemistry | Vesicle-Associated Membrane Protein 2 - chemistry | Adaptor Proteins, Vesicular Transport - chemistry | Syntaxin 1 - chemistry | Binding Sites | Protein Structure, Tertiary | Nerve Tissue Proteins - physiology | Adaptor Proteins, Vesicular Transport - physiology | SNARE Proteins - physiology | Models, Molecular | Rats | Synaptosomal-Associated Protein 25 - chemistry | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing - physiology | Animals | Synaptosomal-Associated Protein 25 - physiology | Mice | Synaptosomal-Associated Protein 25 - metabolism | Lipid Bilayers - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Membrane Fusion - physiology | Vesicle-Associated Membrane Protein 2 - metabolism | SNARE Proteins - metabolism | Syntaxin 1 - physiology | Cell hybridization | Physiological aspects | Research | Exocytosis | Membrane proteins | Proteins | Neurotransmitters | Membranes | Molecular biology | Vesicle-Associated Membrane Protein 2 | Membrane Fusion | Biochemistry, Molecular Biology | Nerve Tissue Proteins | Biophysics | Cellular Biology | Adaptor Proteins, Vesicular Transport | Life Sciences | Adaptor Proteins, Signal Transducing | Lipid Bilayers | Syntaxin 1 | Synaptosomal-Associated Protein 25 | SNARE Proteins
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 4, p. e94380
Nesprin-1-giant and nesprin-2-giant regulate nuclear positioning by the interaction of their C-terminal KASH domains with nuclear membrane SUN proteins and their N- terminal calponin-homology domains... 
REAL-TIME PCR | SKELETAL-MUSCLE | CELLS | ROLES | SUN PROTEINS | MULTIDISCIPLINARY SCIENCES | ENVELOPE | DREIFUSS MUSCULAR-DYSTROPHY | LAMIN A/C | ACTIN CYTOSKELETON | NUCLEAR-MEMBRANE PROTEIN | Embryonic Stem Cells - metabolism | Conserved Sequence - genetics | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Muscle, Skeletal - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Organ Specificity - genetics | Nerve Tissue Proteins - chemistry | Protein Isoforms - metabolism | Proteolysis | Myocardium - metabolism | Microfilament Proteins - metabolism | Nuclear Proteins - genetics | Microfilament Proteins - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Microfilament Proteins - chemistry | Muscular Dystrophy, Emery-Dreifuss - genetics | Alternative Splicing - genetics | RNA, Messenger - genetics | Exons - genetics | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Spleen - metabolism | Protein Isoforms - genetics | Analysis | Monoclonal antibodies | Muscles | Physiological aspects | Smooth muscle | Muscle proteins | Health aspects | Heart | Alternative splicing | Cardiomyopathy | Genes | Emery-Dreifuss muscular dystrophy | Homology | Kinases | Tissues | Muscular dystrophy | Western blotting | Proteins | Calponin | Cell growth | Actin | Bioinformatics | Heart diseases | Neuromuscular diseases | Immunoglobulins | Degradation products | Splicing | Gene expression | Skeletal muscle | Polymerase chain reaction | Dilated cardiomyopathy | Cell lines | Isoforms | Stem cells | Cytoskeleton | Mutation | Dystrophy
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 543, Issue 7645, pp. 438 - 442
...). Multiple protein complexes regulate the Rag GTPases in response to amino acids, including GATOR1, a GTPase activating protein for RAGA, and GATOR2, a positive regulator of unknown molecular function... 
ENCEPHALOPATHY | COMPLEX | SZT2 | RAG GTPASES | GENE | SIGNALING PATHWAY | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | MUTATIONS | FOCAL EPILEPSIES | Lysosomes | Physiological aspects | Protein research | Research | Biological control systems | Protein-protein interactions | Proteins | Amino acids | Phosphorylation | Mutation | Glucose | Molecular weight
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 7, p. e0177962
.... Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC... 
PROGENITOR CELLS | MESENCHYMAL STROMAL CELLS | STEM-CELLS | TRUNK | MULTIDISCIPLINARY SCIENCES | PERIODONTAL-LIGAMENT | ONTOGENY | GENERATION | SKIN-DERIVED PRECURSORS | DIFFERENTIATION | MELANOCYTES | RNA-Binding Proteins - genetics | Humans | Adipose Tissue - cytology | Melanocytes - metabolism | Neurons - cytology | Receptors, Nerve Growth Factor - metabolism | Neural Stem Cells - cytology | Schwann Cells - cytology | Neural Crest - metabolism | Adipose Tissue - metabolism | Mesenchymal Stromal Cells - cytology | Snail Family Transcription Factors - genetics | Melanocytes - cytology | Nestin - genetics | Adult | Female | Cell Differentiation | Neurons - metabolism | Dermis - cytology | Nuclear Proteins - genetics | Biomarkers - metabolism | SOX9 Transcription Factor - metabolism | Gene Expression | Neural Crest - cytology | Dermis - metabolism | Snail Family Transcription Factors - metabolism | Microinjections | Bone Marrow Cells - cytology | Neural Crest - growth & development | Mesenchymal Stromal Cells - metabolism | Nuclear Proteins - metabolism | Schwann Cells - metabolism | Transcription Factor Brn-3A - metabolism | Chick Embryo | Nerve Tissue Proteins - genetics | Receptors, Nerve Growth Factor - genetics | Nerve Tissue Proteins - metabolism | Nestin - metabolism | Animals | Transcription Factor Brn-3A - genetics | Twist-Related Protein 1 - genetics | Twist-Related Protein 1 - metabolism | Neural Stem Cells - metabolism | SOX9 Transcription Factor - genetics | Bone Marrow Cells - metabolism | Mesenchymal Stem Cell Transplantation | RNA-Binding Proteins - metabolism | Adipose tissues | Comparative analysis | Skin | Neurosciences | Nestin | Adipose tissue | Leukocyte migration | Laboratories | Sox9 protein | Dermis | Melanocytes | Nervous system | Human tissues | Regeneration (physiology) | Cell adhesion & migration | Msi1 protein | Plasticity (neural) | Ethics | Immunology | Pathways | Surgery | Bone marrow | Hair | Hematology | Neurons | Tissue engineering | Schwann cells | Brn-3 protein | Gene expression | Embryos | Neural crest | Medicine | Regeneration | Human performance | Stromal cells | Stem cells | Cell migration | Dental pulp
Journal Article
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2013, Volume 79, Issue 6, pp. 1169 - 1182
.... CYFIP1 plays a dual role in two apparently unrelated processes, inhibiting local protein synthesis and favoring actin remodeling... 
MAMMALIAN TARGET | LOCAL PROTEIN-SYNTHESIS | AUTISM | FMRP | MOUSE MODEL | FRAGILE-X-SYNDROME | MECHANISMS | RAC1 | SYNAPTIC PLASTICITY | NEUROSCIENCES | CRITICAL REGION | Humans | Male | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Mental Disorders - genetics | Brain-Derived Neurotrophic Factor - pharmacology | Neurons - ultrastructure | Time Factors | Chromatography, Liquid | Nerve Tissue Proteins - ultrastructure | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Pyrimidines - pharmacology | Synaptosomes - ultrastructure | Analysis of Variance | Indole Alkaloids - pharmacology | Protein Biosynthesis - drug effects | Mice | Carbazoles - pharmacology | Adaptor Proteins, Signal Transducing - chemistry | Synaptosomes - drug effects | Meta-Analysis as Topic | Immunoprecipitation | Age Factors | Synaptosomes - metabolism | Cerebral Cortex - cytology | Microscopy, Immunoelectron | DNA-Binding Proteins - metabolism | Tandem Mass Spectrometry | Nerve Tissue Proteins - chemistry | Transfection | Dendritic Spines - drug effects | Protein Biosynthesis - genetics | Neurons - drug effects | Aminoquinolines - pharmacology | Green Fluorescent Proteins - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Fragile X Mental Retardation Protein - ultrastructure | Dendritic Spines - genetics | Fragile X Mental Retardation Protein - genetics | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Dendritic Spines - ultrastructure | Luminescent Proteins - metabolism | Nervous system diseases | Neurosciences | Neurons | Oncology, Experimental | Genes | Polymerization | Schizophrenia | Protein biosynthesis | Research | Genetic translation | Messenger RNA | Actin | Cancer | Proteins | Brain-derived neurotrophic factor | Protein synthesis | Crystal structure
Journal Article