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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 01/2014, Volume 21, Issue 1, pp. 79 - 91
The immunogenic demise of cancer cells can be induced by various chemotherapeutics, such as anthracyclines and oxaliplatin, and provokes an immune response... 
quinacrine | apoptosis | U2OS cells | caspases | endoplasmic reticulum stress | Beclin 1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | AUTOPHAGY | CLEAVAGE | CHEMOTHERAPY | CELL BIOLOGY | CALRETICULIN EXPOSURE | PANNEXIN 1 | ASSAYS | FIND-ME SIGNAL | Connexins - antagonists & inhibitors | RNA-Binding Proteins - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cell Death - immunology | rho-Associated Kinases - antagonists & inhibitors | Antineoplastic Agents - toxicity | DNA-Binding Proteins - metabolism | Lysosomes - metabolism | Lysosomal-Associated Membrane Protein 1 - genetics | Myosin Type II - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Adenosine Triphosphate - metabolism | HMGB1 Protein - metabolism | Cell Membrane - metabolism | Cell Death - drug effects | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Connexins - genetics | rho-Associated Kinases - genetics | Lysosomal-Associated Membrane Protein 1 - antagonists & inhibitors | Microtubule-Associated Proteins - antagonists & inhibitors | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Animals | Autophagy-Related Protein 5 | Cell Line, Tumor | Lysosomal-Associated Membrane Protein 1 - metabolism | Mice | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Index Medicus | Original Paper
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2015, Volume 18, Issue 5, pp. 690 - 697
The developing mammalian brain is destined for a female phenotype unless exposed to gonadal hormones during a perinatal sensitive period. It has been assumed... 
SPINE PLASTICITY | SEXUAL-DIFFERENTIATION | BEHAVIOR | MAST-CELLS | ESTRADIOL | ESTROGEN | RAT-BRAIN | EXPRESSION | NEUROSCIENCES | PROSTAGLANDIN-E2 | FEMALE | DNA (Cytosine-5-)-Methyltransferases - physiology | Nerve Tissue Proteins - deficiency | Nerve Tissue Proteins - analysis | Testosterone - physiology | Cytidine - pharmacology | Male | Copulation - drug effects | Brain - growth & development | Cytidine - analogs & derivatives | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Preoptic Area - physiopathology | Testosterone - pharmacology | Phthalimides - pharmacology | DNA Methylation | Gene Expression Regulation, Developmental | Tryptophan - analogs & derivatives | Nerve Tissue Proteins - biosynthesis | Female | Disorders of Sex Development - physiopathology | Estradiol - physiology | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - physiology | DNA (Cytosine-5-)-Methyltransferases - deficiency | Microfilament Proteins - analysis | Rats | Sex Characteristics | DNA, Intergenic - genetics | Disorders of Sex Development - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | DNA (Cytosine-5-)-Methyltransferases - genetics | Sex Differentiation - physiology | Copulation - physiology | Animals | Protein Isoforms - biosynthesis | CpG Islands | Mice | Tryptophan - pharmacology | Preoptic Area - enzymology | Protein Isoforms - genetics | Enzymes | Hormones, Sex | Regulation | Gene expression | Properties | Health aspects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7542, pp. 237 - 241
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 06/2012, Volume 74, Issue 6, pp. 1031 - 1044
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2007, Volume 13, Issue 10, pp. 1228 - 1233
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8708 - 8713
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we... 
Phosphorylation | Messenger RNA | Glucocorticoids | Antidepressants | Genetic variation | Rodents | Neurogenesis | Progenitor cells | Hippocampus | Depressive disorders | Neuroplasticity | Hypothalamus-pituitary-adrenal axis | Stem cells | PROGENITOR CELLS | hypothalamus-pituitary-adrenal axis | stem cells | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | antidepressants | CELL-PROLIFERATION | MODEL | RECEPTOR ANTAGONIST | RESPONSES | DENTATE GYRUS | MODULATION | neuroplasticity | AXIS | Receptors, Glucocorticoid - antagonists & inhibitors | Depression - pathology | Humans | Middle Aged | Stress, Physiological | Hedgehog Proteins - metabolism | Hydrocortisone - metabolism | Male | Receptors, Glucocorticoid - metabolism | RNA, Messenger - metabolism | Immediate-Early Proteins - metabolism | Cell Nucleus - metabolism | Cell Nucleus - pathology | Glucocorticoids - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adult | Female | Hippocampus - enzymology | Protein-Serine-Threonine Kinases - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Rats | Hippocampus - pathology | Rats, Sprague-Dawley | Depression - enzymology | Nerve Tissue Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Signal Transduction - drug effects | Active Transport, Cell Nucleus - drug effects | Benzoates - pharmacology | Mifepristone - pharmacology | Cell Line, Transformed | Immediate-Early Proteins - antagonists & inhibitors | Physiological aspects | Corticosteroids | Hippocampus (Brain) | Phosphotransferases | Depression, Mental | Brain | Molecules | Hormones | Mental depression | Gene expression | Stress | Index Medicus | Biological Sciences | hypothalamus–pituitary–adrenal axis
Journal Article
Leukemia, ISSN 0887-6924, 03/2009, Volume 23, Issue 3, pp. 477 - 485
The detailed molecular mechanism of action of second-generation BCR-ABL tyrosine kinase inhibitors, including perturbed targets and pathways, should contribute... 
BCR-ABL INHIBITORS | SRC | TYROSINE KINASE | MECHANISMS | NILOTINIB | BREAST-CANCER CELLS | dasatinib | ONCOLOGY | IMATINIB | kinase profiling | RESISTANCE | chronic myeloid leukemia | chemical proteomics | SKI-606 | HEMATOLOGY | bosutinib | Nitriles - pharmacology | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Substrate Specificity | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | K562 Cells - drug effects | Quinolines - pharmacology | Drug Delivery Systems | Leukemia, Myeloid, Accelerated Phase - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Dasatinib | Nerve Tissue Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Leukocytes, Mononuclear - drug effects | Quinolines - chemistry | src-Family Kinases - antagonists & inhibitors | Pyrimidines - pharmacology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors | K562 Cells - enzymology | Leukemia, Myeloid, Accelerated Phase - enzymology | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Leukocytes, Mononuclear - enzymology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors | Enzyme inhibitors | Physiological aspects | Chronic myeloid leukemia | Research | Drug therapy | Health aspects | Protein kinases | Index Medicus
Journal Article