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The New England Journal of Medicine, ISSN 0028-4793, 10/2009, Volume 361, Issue 18, pp. 1760 - 1767
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2015, Volume 18, Issue 5, pp. 690 - 697
The developing mammalian brain is destined for a female phenotype unless exposed to gonadal hormones during a perinatal sensitive period. It has been assumed... 
SPINE PLASTICITY | SEXUAL-DIFFERENTIATION | BEHAVIOR | MAST-CELLS | ESTRADIOL | ESTROGEN | RAT-BRAIN | EXPRESSION | NEUROSCIENCES | PROSTAGLANDIN-E2 | FEMALE | DNA (Cytosine-5-)-Methyltransferases - physiology | Nerve Tissue Proteins - deficiency | Nerve Tissue Proteins - analysis | Testosterone - physiology | Cytidine - pharmacology | Male | Copulation - drug effects | Brain - growth & development | Cytidine - analogs & derivatives | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Preoptic Area - physiopathology | Testosterone - pharmacology | Phthalimides - pharmacology | DNA Methylation | Gene Expression Regulation, Developmental | Tryptophan - analogs & derivatives | Nerve Tissue Proteins - biosynthesis | Female | Disorders of Sex Development - physiopathology | Estradiol - physiology | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - physiology | DNA (Cytosine-5-)-Methyltransferases - deficiency | Microfilament Proteins - analysis | Rats | Sex Characteristics | DNA, Intergenic - genetics | Disorders of Sex Development - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | DNA (Cytosine-5-)-Methyltransferases - genetics | Sex Differentiation - physiology | Copulation - physiology | Animals | Protein Isoforms - biosynthesis | CpG Islands | Mice | Tryptophan - pharmacology | Preoptic Area - enzymology | Protein Isoforms - genetics | Enzymes | Hormones, Sex | Regulation | Gene expression | Properties | Health aspects | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7344, pp. 471 - 475
Journal Article
Neuron, ISSN 0896-6273, 2009, Volume 64, Issue 2, pp. 173 - 187
Nuclear movement is critical during neurogenesis and neuronal migration, which are fundamental for mammalian brain development. Although dynein, Lis1, and... 
CELLBIO | DEVBIO | SKELETAL-MUSCLE | DYNEIN | MEMBRANE PROTEIN | ENVELOPE | DREIFUSS MUSCULAR-DYSTROPHY | LIS1 | CELL POLARIZATION | CENTRAL-NERVOUS-SYSTEM | ACTIN CYTOSKELETON | NEUROMUSCULAR-JUNCTION | NEUROSCIENCES | Cell Proliferation | Microtubule-Associated Proteins - metabolism | Nerve Tissue Proteins - deficiency | Neurons - cytology | Protein Transport - physiology | Cell Movement - genetics | Cell Movement - physiology | Neurogenesis - genetics | Exploratory Behavior - physiology | Membrane Proteins - deficiency | Cell Nucleus - metabolism | Neurons - ultrastructure | Nuclear Proteins - deficiency | Female | Membrane Proteins - metabolism | Bromodeoxyuridine - metabolism | Microtubule-Associated Proteins - deficiency | Telomere-Binding Proteins - metabolism | Dyneins - metabolism | Brain - cytology | Mice, Inbred C57BL | Cells, Cultured | Behavior, Animal - physiology | Mice, Transgenic | Nuclear Proteins - metabolism | Protein Structure, Tertiary - genetics | Telomere-Binding Proteins - deficiency | Electroporation - methods | Centrosome - metabolism | Nerve Tissue Proteins - metabolism | Pregnancy | Protein Interaction Mapping - methods | Animals | Neurogenesis - physiology | Mice | Proteins | Neurosciences | Neurons | Developmental biology | Dynein | Neurogenesis | Colleges & universities | Cell adhesion & migration | Index Medicus | Brain | nuclear envelope | UNC-84 | interkinetic nuclear movement | learning and memory | KASH domain | nucleokinesis
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5389 - 5400
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVOUS-SYSTEM | CYCLOOXYGENASE-2 | RHYTHMS | IN-VIVO | ADAPTATION | GENE-EXPRESSION | COMPONENTS | BMAL1 | BRAIN | NPAS2 | Neurons - pathology | Oxidative Stress | Neuroglia - pathology | Nerve Tissue Proteins - deficiency | Cerebral Cortex - pathology | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | Period Circadian Proteins - deficiency | CLOCK Proteins - deficiency | Mice, Neurologic Mutants | Gliosis - pathology | ARNTL Transcription Factors - deficiency | RNA Interference | Neurons - metabolism | Corpus Striatum - pathology | Basic Helix-Loop-Helix Transcription Factors - deficiency | Period Circadian Proteins - physiology | Basic Helix-Loop-Helix Transcription Factors - physiology | CLOCK Proteins - physiology | Gliosis - genetics | Nerve Tissue Proteins - physiology | Oxidation-Reduction | Brain - physiopathology | Mice, Inbred C57BL | Circadian Rhythm - genetics | Gene Expression Regulation - physiology | Circadian Rhythm - physiology | Hippocampus - pathology | Mice, Knockout | Animals | Aging - physiology | Homeostasis - physiology | Brain - pathology | Sleep Disorders, Circadian Rhythm - physiopathology | Neuroglia - metabolism | Locomotion - physiology | ARNTL Transcription Factors - physiology | Homeostasis - genetics | Circadian rhythms | Physiological aspects | Homeostasis | Nervous system | Degeneration | Research | Brain | Oxidative stress | Neurodegeneration | Rodents | Circadian rhythm | Behavior | Kinases | Gene expression | Age | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 438 - 442
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated... 
ENCEPHALOPATHY | COMPLEX | SZT2 | RAG GTPASES | GENE | SIGNALING PATHWAY | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | MUTATIONS | FOCAL EPILEPSIES | Lysosomes | Physiological aspects | Protein research | Research | Biological control systems | Protein-protein interactions | Proteins | Amino acids | Phosphorylation | Mutation | Glucose | Molecular weight | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2010, Volume 466, Issue 7302, pp. 133 - 137
The question of whether tumorigenic cancer stem cells exist in human melanomas has arisen in the last few years. Here we show that in melanomas, tumour stem... 
PROGENITORS | PROSPECTIVE IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | CANCER STEM-CELLS | Bone and Bones - pathology | Neoplasm Transplantation | Neoplastic Stem Cells - cytology | Humans | Nerve Tissue Proteins - deficiency | Neural Crest - pathology | Receptors, Nerve Growth Factor - metabolism | Neoplasm Proteins - metabolism | DNA-Binding Proteins - deficiency | Neural Crest - metabolism | Neoplasm Metastasis | Lung Neoplasms - secondary | Neoplastic Stem Cells - metabolism | Antigens, Neoplasm - metabolism | Neoplastic Stem Cells - pathology | Skin Transplantation | Antigens, Neoplasm - analysis | Skin - pathology | Melanoma - metabolism | Melanoma-Specific Antigens | Neural Crest - cytology | Melanoma - pathology | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Neoplastic Stem Cells - transplantation | Receptors, Nerve Growth Factor - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Bone Transplantation | Neoplasm Proteins - analysis | Transplantation, Heterologous - pathology | Mice | Receptors, Nerve Growth Factor - deficiency | Care and treatment | Melanoma | Stem cells | Physiological aspects | Development and progression | Nerve growth factor | Genetic aspects | Growth factor receptors | Research | Risk factors | Transplants & implants | Skin & tissue grafts | Cancer | Tumors | Human | Enrichment | Antigens | Tumours | Bones | Transplantation | Index Medicus
Journal Article