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Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, pp. e1003773 - e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Index Medicus | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 438 - 442
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated... 
ENCEPHALOPATHY | COMPLEX | SZT2 | RAG GTPASES | GENE | SIGNALING PATHWAY | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | MUTATIONS | FOCAL EPILEPSIES | Lysosomes | Physiological aspects | Protein research | Research | Biological control systems | Protein-protein interactions | Proteins | Amino acids | Phosphorylation | Mutation | Glucose | Molecular weight | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7340, pp. 637 - 641
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 01/2014, Volume 21, Issue 1, pp. 79 - 91
The immunogenic demise of cancer cells can be induced by various chemotherapeutics, such as anthracyclines and oxaliplatin, and provokes an immune response... 
quinacrine | apoptosis | U2OS cells | caspases | endoplasmic reticulum stress | Beclin 1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | AUTOPHAGY | CLEAVAGE | CHEMOTHERAPY | CELL BIOLOGY | CALRETICULIN EXPOSURE | PANNEXIN 1 | ASSAYS | FIND-ME SIGNAL | Connexins - antagonists & inhibitors | RNA-Binding Proteins - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cell Death - immunology | rho-Associated Kinases - antagonists & inhibitors | Antineoplastic Agents - toxicity | DNA-Binding Proteins - metabolism | Lysosomes - metabolism | Lysosomal-Associated Membrane Protein 1 - genetics | Myosin Type II - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Adenosine Triphosphate - metabolism | HMGB1 Protein - metabolism | Cell Membrane - metabolism | Cell Death - drug effects | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Connexins - genetics | rho-Associated Kinases - genetics | Lysosomal-Associated Membrane Protein 1 - antagonists & inhibitors | Microtubule-Associated Proteins - antagonists & inhibitors | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Animals | Autophagy-Related Protein 5 | Cell Line, Tumor | Lysosomal-Associated Membrane Protein 1 - metabolism | Mice | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Index Medicus | Original Paper
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7340, pp. 591 - 596
Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in immunity and inflammation. Recently linear ubiquitin chains... 
RHEUMATOID-ARTHRITIS | KAPPA-B ACTIVATION | CHRONIC PROLIFERATIVE DERMATITIS | K11-LINKED POLYUBIQUITINATION | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | MICE | CHAINS | TNF | NEMO | MEDIATED REGULATION | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Inflammation - pathology | Skin - cytology | Skin - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Ubiquitin - metabolism | NF-kappa B - metabolism | Tumor Necrosis Factor-alpha - deficiency | Multiprotein Complexes - metabolism | Inflammation - metabolism | Nerve Tissue Proteins - chemistry | Ubiquitination | CD40 Ligand - metabolism | I-kappa B Kinase - metabolism | Interleukin-1beta - metabolism | Carrier Proteins - chemistry | Receptors, Tumor Necrosis Factor - deficiency | Skin - pathology | Receptors, Tumor Necrosis Factor - genetics | Skin - immunology | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Signal Transduction | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Immunity - immunology | Ubiquitin-Protein Ligases - chemistry | Nerve Tissue Proteins - genetics | Ubiquitin-Protein Ligase Complexes - chemistry | Nerve Tissue Proteins - metabolism | Multiprotein Complexes - chemistry | Phenotype | Animals | Carrier Proteins - metabolism | Ubiquitin-Protein Ligase Complexes - metabolism | Inflammation - prevention & control | Mice | Transcription Factors | Prevention | Tumor necrosis factor | Genes | Physiological aspects | Inflammation | Genetic aspects | Cellular signal transduction | Research | Ubiquitin-proteasome system | Proteins | Mutation | Disease | Apoptosis | Recruitment | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists