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Neuron (Cambridge, Mass.), ISSN 0896-6273, 2013, Volume 79, Issue 6, pp. 1169 - 1182
.... CYFIP1 plays a dual role in two apparently unrelated processes, inhibiting local protein synthesis and favoring actin remodeling... 
MAMMALIAN TARGET | LOCAL PROTEIN-SYNTHESIS | AUTISM | FMRP | MOUSE MODEL | FRAGILE-X-SYNDROME | MECHANISMS | RAC1 | SYNAPTIC PLASTICITY | NEUROSCIENCES | CRITICAL REGION | Humans | Male | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Mental Disorders - genetics | Brain-Derived Neurotrophic Factor - pharmacology | Neurons - ultrastructure | Time Factors | Chromatography, Liquid | Nerve Tissue Proteins - ultrastructure | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Pyrimidines - pharmacology | Synaptosomes - ultrastructure | Analysis of Variance | Indole Alkaloids - pharmacology | Protein Biosynthesis - drug effects | Mice | Carbazoles - pharmacology | Adaptor Proteins, Signal Transducing - chemistry | Synaptosomes - drug effects | Meta-Analysis as Topic | Immunoprecipitation | Age Factors | Synaptosomes - metabolism | Cerebral Cortex - cytology | Microscopy, Immunoelectron | DNA-Binding Proteins - metabolism | Tandem Mass Spectrometry | Nerve Tissue Proteins - chemistry | Transfection | Dendritic Spines - drug effects | Protein Biosynthesis - genetics | Neurons - drug effects | Aminoquinolines - pharmacology | Green Fluorescent Proteins - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Fragile X Mental Retardation Protein - ultrastructure | Dendritic Spines - genetics | Fragile X Mental Retardation Protein - genetics | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Dendritic Spines - ultrastructure | Luminescent Proteins - metabolism | Nervous system diseases | Neurosciences | Neurons | Oncology, Experimental | Genes | Polymerization | Schizophrenia | Protein biosynthesis | Research | Genetic translation | Messenger RNA | Actin | Cancer | Proteins | Brain-derived neurotrophic factor | Protein synthesis | Crystal structure
Journal Article
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 2010, Volume 128, Issue 3, pp. 549 - 558
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 470, Issue 7332, pp. 105 - 109
...) that have therapeutic efficacy in animal models of liver disease(7,8) and diabetes(9), respectively. However, the generation of complex three-dimensional organ tissues in vitro remains a major challenge for translational studies... 
NEUROGENIN-3 | MULTIDISCIPLINARY SCIENCES | LIVER | ENDODERM | GENERATION | SPECIFICATION | FATE | CULTURE | EFFICIENT DIFFERENTIATION | ENDOCRINE-CELLS | Body Patterning - drug effects | Intestines - drug effects | Wnt Proteins - pharmacology | Embryonic Stem Cells - cytology | Humans | Endoderm - embryology | Intestines - embryology | Organogenesis - drug effects | Intestines - anatomy & histology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Endoderm - cytology | Fibroblast Growth Factor 4 - pharmacology | Cell Culture Techniques | Culture Media - chemistry | Induced Pluripotent Stem Cells - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Induced Pluripotent Stem Cells - drug effects | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Microvilli - drug effects | Activins - pharmacology | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Endoderm - drug effects | Culture Media - pharmacology | Morphogenesis - drug effects | Wnt3 Protein | Wnt3A Protein | Intestines - cytology | Physiological aspects | Intestines | Genetic aspects | Health aspects | Endoderm | Stem cells | Proteins | Studies | posterior endoderm | intestine | FGF | transplantation | colon | drug transport | Wnt | progenitor cell
Journal Article
Nature neuroscience, ISSN 1546-1726, 2015, Volume 18, Issue 5, pp. 690 - 697
The developing mammalian brain is destined for a female phenotype unless exposed to gonadal hormones during a perinatal sensitive period. It has been assumed... 
SPINE PLASTICITY | SEXUAL-DIFFERENTIATION | BEHAVIOR | MAST-CELLS | ESTRADIOL | ESTROGEN | RAT-BRAIN | EXPRESSION | NEUROSCIENCES | PROSTAGLANDIN-E2 | FEMALE | DNA (Cytosine-5-)-Methyltransferases - physiology | Nerve Tissue Proteins - deficiency | Nerve Tissue Proteins - analysis | Testosterone - physiology | Cytidine - pharmacology | Male | Copulation - drug effects | Brain - growth & development | Cytidine - analogs & derivatives | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Preoptic Area - physiopathology | Testosterone - pharmacology | Phthalimides - pharmacology | DNA Methylation | Gene Expression Regulation, Developmental | Tryptophan - analogs & derivatives | Nerve Tissue Proteins - biosynthesis | Female | Disorders of Sex Development - physiopathology | Estradiol - physiology | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - physiology | DNA (Cytosine-5-)-Methyltransferases - deficiency | Microfilament Proteins - analysis | Rats | Sex Characteristics | DNA, Intergenic - genetics | Disorders of Sex Development - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | DNA (Cytosine-5-)-Methyltransferases - genetics | Sex Differentiation - physiology | Copulation - physiology | Animals | Protein Isoforms - biosynthesis | CpG Islands | Mice | Tryptophan - pharmacology | Preoptic Area - enzymology | Protein Isoforms - genetics | Enzymes | Hormones, Sex | Regulation | Gene expression | Properties | Health aspects
Journal Article
Blood, ISSN 0006-4971, 01/2015, Volume 125, Issue 4, pp. 710 - 719
The precise mechanism for reduced thrombosis in prekallikrein null mice (Klkb1(-/-)) is unknown. Klkb1(-/-) mice have delayed carotid artery occlusion times on... 
KALLIKREIN | PLASMA PREKALLIKREIN | MOLECULAR-WEIGHT KININOGEN | ENDOTHELIAL-CELLS | NITRIC-OXIDE | FACTOR EXPRESSION | VASCULAR-PERMEABILITY | CONTACT ACTIVATION | HEMATOLOGY | FACTOR-XII | BRADYKININ | Epoprostenol - genetics | Receptor, Bradykinin B2 - genetics | Receptors, G-Protein-Coupled - metabolism | Epoprostenol - biosynthesis | Peptide Fragments - pharmacology | Carotid Artery Thrombosis - metabolism | Pyrones - pharmacology | Sirtuin 1 - genetics | Thromboplastin - antagonists & inhibitors | Nerve Tissue Proteins - biosynthesis | Synaptotagmins - biosynthesis | Carotid Artery Thrombosis - chemically induced | Prekallikrein | Thromboplastin - biosynthesis | Proto-Oncogene Proteins - metabolism | Kruppel-Like Transcription Factors - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Angiotensin II - pharmacology | Receptor, Bradykinin B2 - biosynthesis | Sirtuin 1 - biosynthesis | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Angiotensin II - analogs & derivatives | Sulfonamides - pharmacology | Nerve Tissue Proteins - genetics | Sirtuin 1 - antagonists & inhibitors | Mice, Knockout | Naphthalenes - pharmacology | Animals | Partial Thromboplastin Time | Thromboplastin - genetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice | Receptors, G-Protein-Coupled - genetics | Synaptotagmins - genetics | Carotid Artery Thrombosis - genetics | Carotid Artery Thrombosis - pathology | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | RNA, Messenger | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2010, Volume 40, Issue 1, pp. 75 - 86
... (a protein rich in glutamate, leucine, lysine, and serine). K63-linked polyubiquitination of ELKS, dependent on the ubiquitin ligase XIAP and the conjugating enzyme UBC13, allows ELKS association with TAK1 via its ubiquitin-binding subunits TAB2/3... 
PROTEIN | POLYUBIQUITIN | ISOFORMS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NF-KAPPA-B | BINDING | CELL BIOLOGY | Protein-Serine-Threonine Kinases - deficiency | Humans | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | RNA Interference | Time Factors | Tumor Suppressor Proteins - deficiency | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | MAP Kinase Kinase Kinases - genetics | Cell Cycle Proteins - metabolism | Etoposide - pharmacology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Mice | DNA Damage | Enzyme Activation | Mutation | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Pyrones - pharmacology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Transfection | I-kappa B Kinase - metabolism | MAP Kinase Kinase Kinases - deficiency | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | I-kappa B Kinase - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Camptothecin - pharmacology | Ubiquitin | Ligases | Lysine | Oncology, Experimental | Automated teller machines | Research | Glutamate | Cancer
Journal Article
Nature (London), ISSN 1476-4687, 2006, Volume 443, Issue 7112, pp. 709 - 712
.... Here we show that nesfatin, corresponding to NEFA/nucleobindin2 (NUCB2), a secreted protein of unknown function, is expressed in the appetite-control hypothalamic nuclei in rats... 
SYSTEM | OBESITY | NUCLEOBINDIN | PATHWAY | CLONING | FOOD-INTAKE | NEFA | MULTIDISCIPLINARY SCIENCES | LEPTIN RECEPTOR | BINDING PROTEIN | MELANOCORTIN-4 RECEPTOR | Rats, Wistar | Leptin - metabolism | Injections, Intraventricular | Body Weight - drug effects | Male | Gene Expression Profiling | alpha-MSH - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Satiety Response - physiology | Receptors, Melanocortin - metabolism | Nerve Tissue Proteins - pharmacology | DNA-Binding Proteins - administration & dosage | Leptin - pharmacology | Nerve Tissue Proteins - administration & dosage | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Receptors, Leptin | Satiety Response - drug effects | DNA-Binding Proteins - pharmacology | Nerve Tissue Proteins - cerebrospinal fluid | Appetite Regulation - drug effects | Rats | Receptors, Cell Surface - metabolism | Anorexia - metabolism | DNA-Binding Proteins - chemistry | Feeding Behavior - physiology | Calcium-Binding Proteins - administration & dosage | Feeding Behavior - drug effects | Obesity - metabolism | Nerve Tissue Proteins - metabolism | Rats, Zucker | Animals | Hypothalamus - metabolism | Signal Transduction - drug effects | Anorexia - prevention & control | Anorexia - chemically induced | Mice | Appetite Regulation - physiology | Calcium-Binding Proteins - pharmacology | Receptors, Cell Surface - genetics | Proteins | Brain | Signal transduction | Hormones | Gene expression | Rodents
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2005, Volume 168, Issue 3, pp. 441 - 452
Invadopodia are actin-rich membrane protrusions with a matrix degradation activity formed by invasive cancer cells. We have studied the molecular mechanisms of... 
Receptors | Microfilaments | Actin depolymerizing factors | Small interfering RNA | Actins | Antibodies | Polymerization | Cultured cells | Cell membranes | Cells | CARCINOMA-CELLS | GROWTH-FACTOR RECEPTOR | MAMMARY ADENOCARCINOMA | ACTIN POLYMERIZATION | LAMELLIPOD EXTENSION | N-WASP | EXTRACELLULAR-MATRIX | SPECIALIZED SURFACE PROTRUSIONS | ALDRICH-SYNDROME PROTEIN | INVASIVE CELLS | CELL BIOLOGY | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Epidermal Growth Factor - physiology | Cytoskeletal Proteins - genetics | Actins - metabolism | Microfilament Proteins - physiology | Extracellular Matrix - metabolism | cdc42 GTP-Binding Protein - metabolism | Quinazolines | Oncogene Proteins - physiology | Cell Movement - physiology | Transfection | Cytoskeletal Proteins - metabolism | Microfilament Proteins - metabolism | Cytoskeletal Proteins - physiology | Wiskott-Aldrich Syndrome Protein Family | Microfilament Proteins - genetics | Carrier Proteins - physiology | Nerve Tissue Proteins - physiology | Wiskott-Aldrich Syndrome Protein, Neuronal | ErbB Receptors - antagonists & inhibitors | Cell Surface Extensions - metabolism | Neoplasm Invasiveness | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Oncogene Proteins - metabolism | Rats | Tyrphostins - pharmacology | Actin Depolymerizing Factors | cdc42 GTP-Binding Protein - physiology | Nerve Tissue Proteins - genetics | Fibronectins - metabolism | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing - physiology | Animals | Carrier Proteins - metabolism | GRB2 Adaptor Protein | Models, Biological | cdc42 GTP-Binding Protein - genetics | Cell Surface Extensions - drug effects | Adaptor Proteins, Signal Transducing - genetics | Actin-Related Protein 2 | Cell Line, Tumor | Actin-Related Protein 3 | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | Cell Surface Extensions - physiology | Epidermal growth factor | Metastasis | Cancer invasiveness | Cancer cells
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2011, Volume 31, Issue 7, pp. 2352 - 2360
The extracellular matrix molecule Reelin is known to control neuronal migration during development. Recent evidence suggests that it also plays a role in the... 
APOE RECEPTOR 2 | PRESYNAPTIC CALCIUM | CORTICAL-NEURONS | SIGNALING PATHWAY | BRAIN-DEVELOPMENT | RADIAL NEURONAL MIGRATION | GRANULE CELL DISPERSION | CAJAL-RETZIUS CELLS | SYNAPTIC PLASTICITY | NEUROSCIENCES | RAT HIPPOCAMPAL-FORMATION | Action Potentials - genetics | CA1 Region, Hippocampal - cytology | Humans | Nerve Tissue Proteins - deficiency | Green Fluorescent Proteins - genetics | Presynaptic Terminals - ultrastructure | LDL-Receptor Related Proteins - genetics | Serine Endopeptidases - immunology | Excitatory Postsynaptic Potentials - genetics | Animals, Newborn | Synapses - drug effects | Serine Endopeptidases - deficiency | Electron Microscope Tomography - methods | Enzyme Inhibitors - pharmacology | Neurotransmitter Agents - metabolism | Mice, Transgenic | Synapses - ultrastructure | Mutation - genetics | Clathrin - metabolism | Patch-Clamp Techniques | Cell Adhesion Molecules, Neuronal - pharmacology | Mice | Synaptic Vesicles - metabolism | Extracellular Matrix Proteins - deficiency | R-SNARE Proteins - metabolism | Serine Endopeptidases - physiology | Serine Endopeptidases - pharmacology | Culture Media, Conditioned - pharmacology | Cell Adhesion Molecules, Neuronal - physiology | Excitatory Postsynaptic Potentials - drug effects | Cell Adhesion Molecules, Neuronal - deficiency | Synapses - metabolism | Transfection - methods | Nerve Tissue Proteins - pharmacology | Action Potentials - drug effects | Receptors, LDL - genetics | Nerve Tissue Proteins - physiology | Nerve Tissue Proteins - immunology | Synaptic Vesicles - ultrastructure | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Extracellular Matrix Proteins - pharmacology | Extracellular Matrix Proteins - physiology | Nerve Tissue Proteins - genetics | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Integrin beta1 - metabolism | Nerve Tissue Proteins - metabolism | Animals | Extracellular Matrix Proteins - immunology | Presynaptic Terminals - metabolism | Synaptosomal-Associated Protein 25 - metabolism | In Vitro Techniques | Cell Adhesion Molecules, Neuronal - immunology | Cell Line, Transformed
Journal Article
PLoS genetics, ISSN 1553-7404, 2017, Volume 13, Issue 1, p. e1006536
Journal Article