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Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2166
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and... 
METHYLATION | 5-METHYLCYTOSINE | DNA | GLIOMA | MULTIDISCIPLINARY SCIENCES | MECHANISMS | RETINOIC ACID RECEPTORS | MUTATIONS | Neoplasms - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Cholangiocarcinoma - metabolism | Bone Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Bone Neoplasms - metabolism | Glioma - metabolism | DNA-Binding Proteins - metabolism | Glioma - genetics | DNA Methylation | Neoplasms - genetics | Glioma - pathology | Trans-Activators - genetics | Chondrosarcoma - genetics | Chondrosarcoma - pathology | Bone Neoplasms - genetics | Bile Duct Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Central Nervous System Neoplasms - metabolism | Bile Duct Neoplasms - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Central Nervous System Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | Receptors, Retinoic Acid - metabolism | DNA-Binding Proteins - genetics | Central Nervous System Neoplasms - pathology | Cholangiocarcinoma - pathology | Chondrosarcoma - metabolism | Cholangiocarcinoma - genetics | Isocitrate Dehydrogenase - metabolism | Trans-Activators - metabolism | Glutarates - metabolism | Bile Duct Neoplasms - pathology | Mutation | Neoplasms - pathology | Leukemia, Myeloid, Acute - genetics
Journal Article
Blood, ISSN 0006-4971, 2016, Volume 127, Issue 7, pp. 869 - 881
Journal Article
Critical Reviews in Oncology and Hematology, ISSN 1040-8428, 2007, Volume 63, Issue 1, pp. 81 - 89
Abstract Ependymomas are rare tumours of neuroectodermal origin classified as myxopapillary ependymoma and subependymoma (grade I), ependymoma (grade II) and... 
Hematology, Oncology and Palliative Medicine | Ependymomas | Treatment | Prognosis | treatment | MOLECULAR-GENETIC ANALYSIS | PROGNOSTIC-FACTORS | POSTERIOR-FOSSA EPENDYMOMAS | SPINAL-CORD EPENDYMOMAS | MALIGNANT BRAIN-TUMORS | CHOROID-PLEXUS TUMORS | prognosis | ependymomas | RADIATION-THERAPY | ONCOLOGY | NERVOUS-SYSTEM TUMORS | CHILDRENS CANCER GROUP | HEMATOLOGY | INTRACRANIAL EPENDYMOMA | Ependymoma - etiology | Age Distribution | Brain Neoplasms - etiology | Humans | Brain Neoplasms - pathology | Male | Spinal Cord Neoplasms - metabolism | Glial Fibrillary Acidic Protein - metabolism | Brain Neoplasms - metabolism | Brain Neoplasms - surgery | Incidence | Infratentorial Neoplasms - metabolism | Ependymoma - diagnosis | Infratentorial Neoplasms - epidemiology | Infratentorial Neoplasms - etiology | Spinal Cord Neoplasms - surgery | Ependymoma - pathology | Female | Spinal Cord Neoplasms - radiotherapy | Brain Neoplasms - radiotherapy | Ependymoma - epidemiology | Infratentorial Neoplasms - radiotherapy | Brain Neoplasms - diagnosis | Risk Factors | Neoplasm Recurrence, Local | Spinal Cord Neoplasms - etiology | Infratentorial Neoplasms - pathology | Ependymoma - metabolism | Ependymoma - surgery | Sex Factors | Spinal Cord Neoplasms - diagnosis | Survival Analysis | Infratentorial Neoplasms - surgery | Spinal Cord Neoplasms - pathology | Neoplasm Staging | Ependymoma - radiotherapy | Infratentorial Neoplasms - diagnosis | Brain Neoplasms - epidemiology | Spinal Cord Neoplasms - epidemiology | Chemotherapy | Cancer | Tumors
Journal Article
The Journal of Pathology, ISSN 0022-3417, 01/2014, Volume 232, Issue 1, pp. 23 - 31
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 9/2018, Volume 35, Issue 9, pp. 1 - 20
The treatment of metastatic lesions in the brain represents a serious unmet medical need in the field of neuro-oncology. Even though many effective compounds... 
Biochemistry, general | Biomedical Engineering | blood-brain barrier | Biomedicine | metastasize | Pharmacy | brain metastases | Medical Law | efflux transporters | molecularly-targeted anti-cancer agents | drug delivery | Pharmacology/Toxicology | PROPHYLACTIC CRANIAL IRRADIATION | RESISTANCE PROTEIN ABCG2 | MULTICENTER PHASE-II | EML4-ALK FUSION GENE | CHEMISTRY, MULTIDISCIPLINARY | P-GLYCOPROTEIN ABCB1 | NEGATIVE BREAST-CANCER | CELL LUNG-CANCER | MOLECULARLY TARGETED THERAPIES | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | CEREBROSPINAL-FLUID CONCENTRATION | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Brain Neoplasms - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Kidney Neoplasms - metabolism | Antineoplastic Agents - administration & dosage | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Brain - metabolism | Brain Neoplasms - secondary | Female | Antineoplastic Agents - pharmacokinetics | Carcinoma, Renal Cell - drug therapy | Molecular Targeted Therapy - methods | Melanoma - metabolism | Carcinoma, Renal Cell - pathology | Melanoma - pathology | Brain Neoplasms - drug therapy | Blood-Brain Barrier - drug effects | Breast Neoplasms - drug therapy | Blood-Brain Barrier - metabolism | Brain - drug effects | Blood-Brain Barrier - pathology | Carcinoma, Renal Cell - metabolism | Animals | Breast Neoplasms - pathology | Melanoma - drug therapy | Brain - pathology | Kidney Neoplasms - pathology | Kidney Neoplasms - drug therapy | Drug Delivery Systems - methods | Precision Medicine - methods | Drugs | Care and treatment | Drug delivery systems | Therapeutics | Brain damage | Metastasis | Permeability | Homeopathy | Materia medica and therapeutics | Vehicles | Efflux | Brain | Toxicity | Brain tumors | Central nervous system | Membrane permeability | Oncology | Success | Metastases | Medicine | Blood-brain barrier | Precision medicine | Lesions | Tumors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2017, Volume 127, Issue 12, pp. 4498 - 4515
Conventional therapies for breast cancer brain metastases (BCBMs) have been largely ineffective because of chemoresistance and impermeability of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PATHWAY | STAT3 | GROWTH | GENES | THERAPEUTIC TARGETS | BONE METASTASIS | CENTRAL-NERVOUS-SYSTEM | JAK2 | MOLECULAR-BASIS | Human Umbilical Vein Endothelial Cells | NIH 3T3 Cells | Humans | Brain Neoplasms - pathology | Neoplasm Proteins - metabolism | RNA, Neoplasm - metabolism | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | Neoplasm Metastasis | Tumor Microenvironment - genetics | MCF-7 Cells | U937 Cells | Janus Kinase 2 - metabolism | HEK293 Cells | Female | Neoplasm Proteins - genetics | Janus Kinase 2 - genetics | Brain Neoplasms - genetics | RNA, Long Noncoding - genetics | Signal Transduction - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | RNA, Neoplasm - genetics | Mice | RNA, Long Noncoding - metabolism | Care and treatment | RNA | Analysis | Development and progression | Breast cancer | Diagnosis | Metastasis | Brain | Phosphorylation | Animal models | Intercellular adhesion molecule 1 | Stat3 protein | Chemoresistance | Oncostatin M | Kinases | Macrophages | Gene expression | Ribonucleic acid--RNA | Metastases | Cell adhesion & migration | Nanoparticles | Interleukin 6 | Proteins | Blood-brain barrier | Janus kinase 2 | Monocyte chemoattractant protein 1 | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Cancer, ISSN 0008-543X, 08/2006, Volume 107, Issue 4, pp. 696 - 704
Journal Article
Brain Pathology, ISSN 1015-6305, 09/2018, Volume 28, Issue 5, pp. 710 - 720
Central nervous system high‐grade neuroepithelial tumors with BCOR alteration (CNS HGNET‐BCOR) are a recently reported rare entity, identified as a small... 
BCOR ITD | clear cell sarcoma of the kidney | high‐grade neuroepithelial tumor | high-grade neuroepithelial tumor | GLIOMAS | CLEAR-CELL-SARCOMA | PATHOLOGY | CHILDHOOD | NEUROSCIENCES | IMMUNOHISTOCHEMICAL MARKER | CLINICAL NEUROLOGY | SIOP | ENTITY | CENTRAL-NERVOUS-SYSTEM | FUSIONS | INFANCY | Brain - diagnostic imaging | Kidney - pathology | Exons | Humans | Child, Preschool | Infant | Male | Segmental Duplications, Genomic | Kidney Neoplasms - metabolism | Neoplasms, Neuroepithelial - pathology | Young Adult | Kidney - metabolism | Oligodendrocyte Transcription Factor 2 - metabolism | Neoplasms, Neuroepithelial - genetics | Female | Child | Central Nervous System Neoplasms - metabolism | Central Nervous System Neoplasms - genetics | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Sarcoma - pathology | Neoplasms, Neuroepithelial - metabolism | Sarcoma - metabolism | Central Nervous System Neoplasms - pathology | Central Nervous System Neoplasms - diagnostic imaging | Neoplasms, Neuroepithelial - diagnostic imaging | Kidney Neoplasms - pathology | Chromatin | Sarcoma | Gliomas | Analysis | Nerve proteins | Stem cells | Synaptophysin | Nervous system diseases | Kidneys | Mesenchyme | Brain tumors | Glial fibrillary acidic protein | Cytology | Central nervous system | Olig2 protein | Staining | Necrosis | Proteins | Glioma | Reproduction (copying) | Morphology | Nuclei (cytology) | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 50, pp. 20528 - 20543
Lymphangioleiomyomatosis (LAM) is a fatal lung disease associated with germline or somatic inactivating mutations in tuberous sclerosis complex genes (TSC1 or... 
MAMMALIAN TARGET | TOR complex (TORC) | BIOCHEMISTRY & MOLECULAR BIOLOGY | mammalian target of rapamycin (mTOR) | FIBROBLAST-GROWTH-FACTOR | urokinase receptor | MUTATIONAL ANALYSIS | lung | plasminogen | MATRIX METALLOPROTEINASES | PULMONARY LYMPHANGIOLEIOMYOMATOSIS LAM | INSULIN-RESISTANCE | tuberous sclerosis complex (TSC) | SQUAMOUS-CELL CARCINOMA | SERUM RESPONSE FACTOR | EXTRACELLULAR-MATRIX | tumor cell biology | TRANSCRIPTION FACTOR | mTOR complex (mTORC) | Lung Neoplasms - drug therapy | Neoplasm Transplantation | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Kidney Neoplasms - genetics | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Neoplasm Invasiveness - prevention & control | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Kidney Neoplasms - metabolism | Angiomyolipoma - drug therapy | Lymphangioleiomyomatosis - pathology | Neoplasm Proteins - metabolism | RNA Interference | Neoplasm Invasiveness - pathology | Tumor Suppressor Proteins - genetics | Antineoplastic Agents - pharmacology | Lung - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Lung Neoplasms - genetics | Lung - pathology | Tumor Suppressor Proteins - metabolism | Lymphangioleiomyomatosis - metabolism | Mice, Inbred C57BL | Angiomyolipoma - pathology | Lymphangioleiomyomatosis - drug therapy | Urokinase-Type Plasminogen Activator - genetics | Angiomyolipoma - genetics | Mice, Knockout | Animals | Tuberous Sclerosis Complex 2 Protein | Tumor Burden - drug effects | Urokinase-Type Plasminogen Activator - metabolism | Lung - drug effects | Cell Line, Tumor | Kidney Neoplasms - pathology | Tuberous Sclerosis Complex 1 Protein | Mutation | Angiomyolipoma - metabolism | Kidney Neoplasms - drug therapy | Lymphangioleiomyomatosis - genetics | Index Medicus | Molecular Bases of Disease
Journal Article