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European journal of clinical pharmacology, ISSN 0031-6970
Journal
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 2004
Journal
Alimentary pharmacology & therapeutics, ISSN 1365-2036, 1987
Journal
Naunyn-Schmiedeberg's archives of pharmacology, ISSN 0028-1298, 1972
Journal
Nature Biotechnology, ISSN 1087-0156, 10/2007, Volume 25, Issue 10, pp. 1110 - 1111
  The common analogy of drug action is that of a lock and key, with a drug acting as a selective key that fits into the lock of a specific drug target. Over... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOLOGY | DRUGS | Models, Biological | Computer Simulation | Genomics | Humans | Gene Expression Regulation | Pharmacology | Metabolic Networks and Pathways - drug effects | Systems Biology | Biotechnology | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2005, Volume 8, Issue 3, pp. 354 - 364
Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the... 
CALCIUM-CHANNELS | NMDA RECEPTORS | MEMBRANE-POTENTIALS | GABA RELEASE | MITRAL CELLS | DENDRODENDRITIC INHIBITION | GRANULE CELLS | PERIGLOMERULAR CELLS | NEUROSCIENCES | CA1 PYRAMIDAL NEURONS | SYNAPTIC ORGANIZATION | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Membrane Potentials - radiation effects | Drug Interactions | Time Factors | Synaptic Transmission - drug effects | Neural Conduction - drug effects | Tetrodotoxin - pharmacology | Nickel - pharmacology | Olfactory Bulb - cytology | Animals, Newborn | Membrane Potentials - drug effects | Dendrites - drug effects | Calcium - pharmacology | Cadmium - pharmacology | Rats | Neural Conduction - physiology | Bicuculline - pharmacology | Chelating Agents - pharmacology | Pyrimidines - pharmacology | Potassium - pharmacology | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Signal Transduction - drug effects | Calcium Signaling - drug effects | Phosphinic Acids - pharmacology | Dihydropyridines - pharmacology | Neurons - radiation effects | Neural Conduction - radiation effects | Synaptic Transmission - physiology | Calcium Signaling - physiology | Neurons - cytology | Nimodipine - pharmacology | Patch-Clamp Techniques - methods | Diagnostic Imaging - methods | Dose-Response Relationship, Drug | Neural Inhibition - physiology | Neurons - physiology | Neurons - drug effects | Electric Stimulation - methods | Neural Networks (Computer) | Dendrites - metabolism | Synapses - physiology | Calcium Signaling - radiation effects | Valine - analogs & derivatives | 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology | Calcium Channel Blockers - pharmacology | Membrane Potentials - physiology | Dendrites - radiation effects | Animals | Egtazic Acid - pharmacology | Synaptic Transmission - radiation effects | Calcium Channel Agonists - pharmacology | Signal Transduction - physiology | Valine - pharmacology | In Vitro Techniques | Propanolamines - pharmacology | Neural Inhibition - drug effects | Physiological aspects | Olfactory bulb | Cellular signal transduction | Neural circuitry | Research | Index Medicus
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 7/2011, Volume 384, Issue 1, pp. 47 - 57
In epilepsy, allegedly, a neurotransmitter imbalance between the inhibitory GABA and the excitatory glutamate prevails. Therefore, some antiepileptic drugs... 
Neurosciences | Veratridine | Biomedicine | Epilepsy | GABA | Neocortical synaptosomes | Pharmacology/Toxicology | Antiepileptic drugs | Potassium | ACTION-POTENTIALS | VOLTAGE-DEPENDENT LIMITATION | TEMPORAL-LOBE EPILEPSY | NEUROTRANSMITTER RELEASE | VALPROIC ACID | TRANSPORTER GAT-1 | MOUSE CENTRAL NEURONS | IN-VITRO | SODIUM VALPROATE | PHARMACOLOGY & PHARMACY | CALCIUM-CHANNEL | Synaptosomes - drug effects | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Humans | Middle Aged | Child, Preschool | Infant | Male | Pregabalin | Synaptosomes - metabolism | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Calcium - deficiency | Young Adult | Calcium - antagonists & inhibitors | Neocortex - metabolism | Neocortex - drug effects | Piracetam - pharmacology | Adult | Female | Phenytoin - pharmacology | Tetrodotoxin - pharmacology | Nipecotic Acids - pharmacology | Child | Carbamazepine - pharmacology | Triazines - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Tetanus Toxin - pharmacology | Potassium - pharmacology | Veratridine - pharmacology | GABA Antagonists - pharmacology | Animals | Cyclohexanecarboxylic Acids - pharmacology | Piracetam - analogs & derivatives | Adolescent | Oximes - pharmacology | Aged | gamma-Aminobutyric Acid - analogs & derivatives | Amines - pharmacology | Phenytoin - pharmacokinetics | Drugs | Brain | Anticonvulsants | Marine toxins | Neurons | Tetanus | Glutamate | Sodium channels | gamma -Aminobutyric acid | Calcium | lamotrigine | Cortex | veratridine | tetanus toxin | Antiepileptic agents | Exocytosis | Valproic acid | Etiracetam | Carbamazepine | Depolarization | Neurotransmitters | Neural networks | gabapentin | Synaptosomes | Phenytoin | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 33, pp. 14621 - 14626
A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off-target effects. Previous... 
Community structure | Datasets | Communities | Genes | Cell lines | Antineoplastics | Signatures | Dosage | Gene expression | Mode of action | Drug repurposing | Chemotherapy | Systems biology | Computational drug discovery | systems biology | TARGET | NETWORK | computational drug discovery | MULTIDISCIPLINARY SCIENCES | CONNECTIVITY MAP | EXPRESSION PROFILES | KAPPA-B | AUTOPHAGY | chemotherapy | CANCER | CELL-DEATH | drug repurposing | CAMPTOTHECIN | DISEASE | Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Drug Discovery - methods | Gene Expression Profiling | RNA Polymerase II - metabolism | Autophagy - drug effects | Neoplasms - genetics | Piperidines - pharmacology | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Antineoplastic Agents - classification | Fuzzy Logic | Camptothecin - analogs & derivatives | Pyrazoles - pharmacology | Drug Screening Assays, Antitumor - methods | Blotting, Western | Pyrroles - pharmacology | Algorithms | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cell Line, Tumor | HeLa Cells | Neoplasms - pathology | Camptothecin - pharmacology | Doxorubicin - pharmacology | Dose-response relationship (Biochemistry) | Physiological aspects | Research | Observations | Methods | Cancer | Pharmacology | Biochemistry | Kinases | Research & development--R&D | Index Medicus | Cyclin-dependent kinase 2 | Drugs | Enhancers | Neurodegenerative diseases | Transcription | Drug discovery | Nodes | Phagocytosis | Rho-associated kinase | Biological Sciences
Journal Article
Neuron, ISSN 0896-6273, 2008, Volume 58, Issue 5, pp. 775 - 788
Journal Article
Molecular Informatics, ISSN 1868-1743, 07/2019, Volume 38, Issue 7, pp. 1900032 - n/a
With the advent of increasing computational power and large‐scale data acquisition, network analysis has become an attractive tool to study the organisation of... 
systems biology | computational toxicology | drug discovery | polypharmacology | DRUG | CHEMISTRY, MEDICINAL | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | DATABASE | MATHEMATICAL & COMPUTATIONAL BIOLOGY | IDENTIFICATION | Domains | Data acquisition | Apexes | Network analysis | Computer applications | Projection | Pharmacology | Complex systems | Lossless
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 12/2016, Volume 16, Issue 30, pp. 3646 - 3656
Low drug productivity has been a significant problem of the pharmaceutical industry for several decades even though numerous novel technologies were introduced... 
Pathway analysis | Drug repositioning | Network pharmacology | CHEMISTRY, MEDICINAL | INFORMATION | KNOWLEDGE | GENOME | MOLECULES | BIOMARKERS | DATABASE | DISEASE | BIOLOGY | TARGET INTERACTION PREDICTION | WEB SERVER
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 06/2019, Volume 59, Issue 6, pp. 3006 - 3017
Multitarget pharmacology of small-molecule cancer drugs significantly contributes to their mechanism of action, side effects, and emergence of drug resistance... 
TARGET | CHEMISTRY, MEDICINAL | COMPUTER SCIENCE, INFORMATION SYSTEMS | GENE ONTOLOGY | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | ENCYCLOPEDIA | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | NETWORK PHARMACOLOGY | DATABASE | LIGANDS | SITES | INHIBITOR | Drugs | Side effects | Chemotherapy | Pharmacology | Maps | Cancer
Journal Article
Journal Article