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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | MULTIDISCIPLINARY SCIENCES | INVOLVEMENT | CLASSIFICATION | NEURODEGENERATION | machine learning | CANCER | organoid | IN-VITRO | MICROGLIA | GENE-EXPRESSION | SYSTEMS | BRAIN | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Neurotoxicity | Stem cells | Gene expression | Biological assays | Bioinformatics | Artificial intelligence | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7308, pp. 829 - 834
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial... 
PROGENITOR CELLS | OSTEOBLAST | OSTEOPONTIN | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | RECEPTOR | DIFFERENTIATION | NEURAL CREST | COOPERATION | EXPRESSION | Chondrocytes - cytology | Nestin | Multipotent Stem Cells - metabolism | Parathyroid Hormone - pharmacology | Cell Lineage - drug effects | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Multipotent Stem Cells - drug effects | Sympathetic Nervous System - physiology | Cell Division | Stromal Cells - drug effects | Osteoblasts - cytology | Hematopoietic Stem Cells - drug effects | Mesenchymal Stromal Cells - drug effects | Gene Expression Regulation - genetics | Osteoblasts - drug effects | Stromal Cells - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Stem Cell Niche - cytology | Nerve Tissue Proteins - metabolism | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Chemokine CXCL12 - metabolism | Cell Differentiation - drug effects | Multipotent Stem Cells - cytology | Hematopoietic Stem Cells - cytology | Stem Cell Niche - metabolism | Mice | Stem Cell Niche - drug effects | Osteoblasts - metabolism | Intermediate Filament Proteins - metabolism | Mesenchymal Stem Cell Transplantation | Stromal Cells - cytology | Cell Movement | Physiological aspects | Genetic aspects | Research | Bone marrow cells | Gene expression | Osteoblasts | Hematopoietic stem cells | Studies | Proteins | Bone marrow | Rodents | Stem cells | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 06/2012, Volume 1, Issue 6, pp. 703 - 714
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors... 
HUMAN ES | IN-VITRO | VENTRAL MESENCEPHALON | FLOOR PLATE | MIDBRAIN DOPAMINE NEURONS | SUBSTANTIA-NIGRA | RAT MODEL | LINES | PARKINSONS-DISEASE | IPS CELLS | CELL BIOLOGY | Body Patterning - drug effects | Organ Specificity - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Cell Survival - genetics | Motor Activity - drug effects | Neurons - cytology | Neural Stem Cells - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Neural Tube - drug effects | Cell Differentiation - genetics | Organ Specificity - genetics | Dopamine - secretion | Dopaminergic Neurons - metabolism | Telencephalon - drug effects | Dopaminergic Neurons - drug effects | Neural Stem Cells - transplantation | Neurons - metabolism | Neurons - drug effects | Cell Lineage - genetics | Cell Survival - drug effects | Telencephalon - metabolism | Telencephalon - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Glycogen Synthase Kinase 3 - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Embryonic Stem Cells - drug effects | Wnt Signaling Pathway - genetics | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Neural Tube - embryology | Body Patterning - genetics | Neural Stem Cells - metabolism | Electrophysiological Phenomena - drug effects | Index Medicus | Biological Sciences | Biologi | Naturvetenskap | Cellbiologi | Natural Sciences | Cell Biology
Journal Article
Science, ISSN 0036-8075, 06/2016, Volume 352, Issue 6292, pp. 1436 - 1443
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 8, pp. 2005 - 2016
Abstract Brain injury is almost irreparable due to the poor regenerative capability of neural tissue. Nowadays, new therapeutic strategies have been focused on... 
Advanced Basic Science | Dentistry | Self-assembly | Hydrogel | Functionalized | Neural stem cell | Brain tissue engineering | MIGRATION | MATERIALS SCIENCE, BIOMATERIALS | PROTEIN | ENGINEERING, BIOMEDICAL | LAMININ | INJURY | TRANSPLANTATION | CHAIN | NEUROGENESIS | EXTRACELLULAR-MATRIX | DIFFERENTIATION | SCAFFOLDS | Immunohistochemistry | Molecular Sequence Data | Neural Stem Cells - cytology | Brain - physiology | Neural Stem Cells - transplantation | Cells, Immobilized - transplantation | Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology | Circular Dichroism | Amino Acid Sequence | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Cell Adhesion - genetics | Tissue Engineering - methods | Peptides - chemistry | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Cell Adhesion - drug effects | Cells, Immobilized - cytology | Rats, Sprague-Dawley | Peptides - pharmacology | Brain - drug effects | Gene Expression Regulation - drug effects | Regeneration - drug effects | Animals | Cell Differentiation - drug effects | Staining and Labeling | Brain - surgery | Cell Proliferation - drug effects | Hydrogen-Ion Concentration | Brain | Biological products | Peptides | Tissue engineering | Neurons | Analysis | Stem cells | Brain damage | Injuries | Index Medicus | Encapsulation | Regenerative | Hydrogels | Differentiation | Three dimensional
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2016, Volume 22, Issue 10, pp. 1101 - 1107
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2011, Volume 469, Issue 7328, pp. 102 - 107
Journal Article