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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
.... Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
PloS one, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e56289
Journal Article
Cell death & disease, ISSN 2041-4889, 2018, Volume 9, Issue 5, pp. 492 - 14
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging... 
REGULATORY SUBUNIT | PHOSPHORYLATION | PATHWAY | ER STRESS | MITOTIC CATASTROPHE | DEPHOSPHORYLATION | PROTEIN PHOSPHATASE 2A | MEDIATED APOPTOSIS | HUMAN BREAST-CANCER | IONIZING-RADIATION | CELL BIOLOGY | Neural Stem Cells - radiation effects | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | Hematopoietic Stem Cells - pathology | Male | Mouse Embryonic Stem Cells - drug effects | Stem Cells - enzymology | Time Factors | Mouse Embryonic Stem Cells - enzymology | Mouse Embryonic Stem Cells - pathology | Proto-Oncogene Proteins c-akt - metabolism | Hematopoietic Stem Cells - radiation effects | Mouse Embryonic Stem Cells - radiation effects | Hematopoietic Stem Cells - drug effects | Protein Phosphatase 2 - antagonists & inhibitors | Signal Transduction | Tissue Culture Techniques | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Neural Stem Cells - drug effects | Stem Cells - radiation effects | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Radiation Tolerance - drug effects | Animals | DNA Repair | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Stem Cells - drug effects | Stem Cells - pathology | Mice | Oxazoles - pharmacology | Hematopoietic Stem Cells - enzymology | Apoptosis | Radiosensitivity | Cell survival | Phosphoprotein phosphatase | DNA damage | Stem cell transplantation | Radiation therapy | Embryos | DNA repair | Radioprotection | Hematopoietic stem cells | Hemopoiesis | Ionizing radiation | Allografts | Intestine | Cell death | Stem cells | Aging | Cancer | Phosphoprotein phosphatase 2A
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2012, Volume 30, Issue 12, pp. 2672 - 2682
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 549, Issue 7672, pp. 389 - 393
...) in the haematopoietic stem cell lineage causes leukaemic and tumoural... 
DENDRITIC CELLS | PATTERN | LANGERHANS CELL HISTIOCYTOSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | MODEL | ERDHEIM-CHESTER-DISEASE | EXPRESSION | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, p. e77053
.... GBMs contain cells with molecular and cellular characteristics of neural stem cells that drive tumour growth... 
CANCER-CELLS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | HUMAN GLIOMAS | IMAGE-BASED SCREENS | CENTRAL-NERVOUS-SYSTEM | BRAIN-BARRIER MODEL | ADHERENT CULTURE | PHASE-I | TUMOR-INITIATING CELLS | Small Molecule Libraries - pharmacology | Glioblastoma - enzymology | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Glioblastoma - genetics | Swine | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Neoplastic Stem Cells - pathology | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Drug Screening Assays, Antitumor - methods | Cell Cycle Proteins - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Protein-Serine-Threonine Kinases - genetics | Brain Neoplasms - genetics | Thiophenes - pharmacology | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Tumor Suppressor Protein p53 - deficiency | Blood-Brain Barrier - drug effects | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Blotting, Western | Blood-Brain Barrier - metabolism | Mice, Knockout | Animals | Cell Cycle Checkpoints - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Neoplastic Stem Cells - enzymology | Indans - pharmacology | Viral antibodies | Polo | Brain tumors | Stem cells | Antibodies | Tumor proteins | Glioblastoma multiforme | Neuroimaging | Image processing | Polo-like kinase 1 | Laboratories | p53 Protein | Brain cancer | Glioblastoma | Childrens health | Membrane permeability | Stem cell transplantation | Kinases | Cancer therapies | Defects | Allografts | Blood-brain barrier | Clonal deletion | DNA methylation | Polo-like kinase | Cyclin-dependent kinase inhibitors | Pharmaceutical industry | Bioinformatics | Pharmaceutical sciences | Medical research | Antibody microarrays | INK4 protein | Permeability | Gene expression | Medical screening | Endothelial cells | Image analysis | Sensitivity | Brain research | Inhibitors | Neural stem cells | Adults | Mutation | Molecular biology | Human behavior | Tumors | Cancer
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 3/2018, Volume 41, Issue 2, pp. 221 - 229
.... Human induced pluripotent stem cells (iPSC) represent an alternative system that complements the available MPSII murine model... 
Human Genetics | Biochemistry, general | Pediatrics | Internal Medicine | Medicine & Public Health | Metabolic Diseases | MEDICINE, RESEARCH & EXPERIMENTAL | HUNTER-SYNDROME | DEFECTS | PROTEIN | DISEASE | GROWTH | ENDOCRINOLOGY & METABOLISM | GENETICS & HEREDITY | NEURONS | ENZYME REPLACEMENT THERAPY | Neurons - pathology | Iduronate Sulfatase - metabolism | Oligodendrocyte Precursor Cells - enzymology | Neuroglia - pathology | Humans | Astrocytes - pathology | Lysosomes - enzymology | Male | Astrocytes - enzymology | Neurogenesis | Mucopolysaccharidosis II - pathology | Mucopolysaccharidosis II - genetics | Female | Lysosomes - pathology | Induced Pluripotent Stem Cells - pathology | Induced Pluripotent Stem Cells - enzymology | Mucopolysaccharidosis II - enzymology | Glycosaminoglycans - metabolism | Neuroglia - enzymology | Cells, Cultured | Oligodendrocyte Precursor Cells - pathology | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Oligodendroglia - pathology | Cell Lineage | Phenotype | Neurons - enzymology | Iduronate Sulfatase - genetics | Oligodendroglia - enzymology | Medical research | Enzymes | Genetic vectors | Neurons | Analysis | Stem cells | Medicine, Experimental | Mucopolysaccharidosis | Sulfates | Tubulins | Cell culture | Animal models | Glycosaminoglycans | Central nervous system | Stem cell transplantation | Leukocytes | Neuronal-glial interactions | Respiratory tract | Airway management | Tubulin | Allografts | Gag protein | Oligodendrocytes | Rheumatic heart disease | Heart diseases | Astrocytes | Blood cells | Glial fibrillary acidic protein | Coronary artery disease | Hearing loss | Neurological complications | Culture media | Pluripotency
Journal Article
International journal of cancer, ISSN 0020-7136, 10/2016, Volume 139, Issue 8, pp. 1776 - 1787
In a previous study, Protein Kinase C iota (PRKCI) emerged as an important candidate gene for glioblastoma (GBM) stem‐like cell (GSC) survival... 
atypical protein kinase C iota | glioblastoma | notch signaling | glioblastoma stem‐like cells | Glioblastoma stem-like cells | Atypical protein kinase C iota | Notch signaling | Glioblastoma | glioblastoma stem-like cells | SURVIVAL | LAMBDA/IOTA | ACTIVATION | LUNG-CANCER CELLS | IDENTIFICATION | TUMORS | SMALL-MOLECULE INHIBITOR | ONCOLOGY | TRANSFORMED GROWTH | PKC-IOTA | EXPRESSION | Protein Kinase C - genetics | Glioblastoma - enzymology | Neoplastic Stem Cells - drug effects | Receptors, Notch - metabolism | Humans | Brain Neoplasms - pathology | Apoptosis - genetics | Gene Expression Profiling | Molecular Targeted Therapy | Glioblastoma - genetics | Isoenzymes - metabolism | Protein Kinase C - metabolism | HEK293 Cells | Neoplastic Stem Cells - pathology | Brain Neoplasms - enzymology | Isoenzymes - genetics | Gene Silencing | Neural Stem Cells - drug effects | Brain Neoplasms - genetics | Protein Kinase C - antagonists & inhibitors | Brain Neoplasms - drug therapy | Mice, SCID | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Animals | Glioblastoma - pathology | Protein Kinase C - biosynthesis | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Glioblastoma - drug therapy | Isoenzymes - biosynthesis | Neoplastic Stem Cells - enzymology | Isoenzymes - antagonists & inhibitors | Analysis | Stem cells | Automated teller machines | Lung cancer, Non-small cell | Gene expression | Glioblastoma multiforme | Protein kinases | Proteins | Kinases | Rodents | Brain cancer
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2004, Volume 101, Issue 47, pp. 16659 - 16664
It has become apparent that chromatin modification plays a critical role in the regulation of cell-type-specific gene expression... 
Biological Sciences | Chromatin | Histone deacetylase inhibitors | Astrocytes | Neurons | Histones | Oligodendroglia | Neural stem cells | Cultured cells | Acetylation | Progenitor cells | Valproic acid | Neural stem cell | Ce