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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
.... Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 466, Issue 7308, pp. 829 - 834
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells... 
PROGENITOR CELLS | OSTEOBLAST | OSTEOPONTIN | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | RECEPTOR | DIFFERENTIATION | NEURAL CREST | COOPERATION | EXPRESSION | Chondrocytes - cytology | Nestin | Multipotent Stem Cells - metabolism | Parathyroid Hormone - pharmacology | Cell Lineage - drug effects | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Multipotent Stem Cells - drug effects | Sympathetic Nervous System - physiology | Cell Division | Stromal Cells - drug effects | Osteoblasts - cytology | Hematopoietic Stem Cells - drug effects | Mesenchymal Stromal Cells - drug effects | Gene Expression Regulation - genetics | Osteoblasts - drug effects | Stromal Cells - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Stem Cell Niche - cytology | Nerve Tissue Proteins - metabolism | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Chemokine CXCL12 - metabolism | Cell Differentiation - drug effects | Multipotent Stem Cells - cytology | Hematopoietic Stem Cells - cytology | Stem Cell Niche - metabolism | Mice | Stem Cell Niche - drug effects | Osteoblasts - metabolism | Intermediate Filament Proteins - metabolism | Mesenchymal Stem Cell Transplantation | Stromal Cells - cytology | Cell Movement | Physiological aspects | Genetic aspects | Research | Bone marrow cells | Gene expression | Osteoblasts | Hematopoietic stem cells | Studies | Proteins | Bone marrow | Rodents | Stem cells
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 7, p. e0177962
Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine... 
PROGENITOR CELLS | MESENCHYMAL STROMAL CELLS | STEM-CELLS | TRUNK | MULTIDISCIPLINARY SCIENCES | PERIODONTAL-LIGAMENT | ONTOGENY | GENERATION | SKIN-DERIVED PRECURSORS | DIFFERENTIATION | MELANOCYTES | RNA-Binding Proteins - genetics | Humans | Adipose Tissue - cytology | Melanocytes - metabolism | Neurons - cytology | Receptors, Nerve Growth Factor - metabolism | Neural Stem Cells - cytology | Schwann Cells - cytology | Neural Crest - metabolism | Adipose Tissue - metabolism | Mesenchymal Stromal Cells - cytology | Snail Family Transcription Factors - genetics | Melanocytes - cytology | Nestin - genetics | Adult | Female | Cell Differentiation | Neurons - metabolism | Dermis - cytology | Nuclear Proteins - genetics | Biomarkers - metabolism | SOX9 Transcription Factor - metabolism | Gene Expression | Neural Crest - cytology | Dermis - metabolism | Snail Family Transcription Factors - metabolism | Microinjections | Bone Marrow Cells - cytology | Neural Crest - growth & development | Mesenchymal Stromal Cells - metabolism | Nuclear Proteins - metabolism | Schwann Cells - metabolism | Transcription Factor Brn-3A - metabolism | Chick Embryo | Nerve Tissue Proteins - genetics | Receptors, Nerve Growth Factor - genetics | Nerve Tissue Proteins - metabolism | Nestin - metabolism | Animals | Transcription Factor Brn-3A - genetics | Twist-Related Protein 1 - genetics | Twist-Related Protein 1 - metabolism | Neural Stem Cells - metabolism | SOX9 Transcription Factor - genetics | Bone Marrow Cells - metabolism | Mesenchymal Stem Cell Transplantation | RNA-Binding Proteins - metabolism | Adipose tissues | Comparative analysis | Skin | Neurosciences | Nestin | Adipose tissue | Leukocyte migration | Laboratories | Sox9 protein | Dermis | Melanocytes | Nervous system | Human tissues | Regeneration (physiology) | Cell adhesion & migration | Msi1 protein | Plasticity (neural) | Ethics | Immunology | Pathways | Surgery | Bone marrow | Hair | Hematology | Neurons | Tissue engineering | Schwann cells | Brn-3 protein | Gene expression | Embryos | Neural crest | Medicine | Regeneration | Human performance | Stromal cells | Stem cells | Cell migration | Dental pulp
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 1, p. e29597
Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) provide new prospects for studying human neurodevelopment and modeling neurological disease... 
HUMAN ES | INHIBITION | FGF | MULTIDISCIPLINARY SCIENCES | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION CAPACITY | PRECURSORS | Oligonucleotide Array Sequence Analysis | Humans | Fibroblast Growth Factor 2 - pharmacology | Neurons - cytology | Gene Expression Profiling | Neural Stem Cells - cytology | Neuroepithelial Cells - cytology | Neuroglia - cytology | Neurons - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Pluripotent Stem Cells - cytology | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Neuroglia - metabolism | Cell Proliferation - drug effects | Neuroepithelial Cells - metabolism | Epidermal Growth Factor - pharmacology | Neural Stem Cells - metabolism | Cluster Analysis | Medical research | Nervous system diseases | Epidermal growth factor | Neurons | Medicine, Experimental | Fibroblast growth factors | Comparative analysis | Embryonic stem cells | Neurophysiology | Neurosciences | Laboratories | Neurobiology | Embryo cells | Radial glial cells | Nervous system | Biochemistry | Neurodevelopmental disorders | Neuronal-glial interactions | Genotype & phenotype | Fibroblasts | Physiology | Growth factors | Fibroblast growth factor 2 | Fetuses | Embryos | Brain research | Stem cells | Comparative studies | Hindbrain | Bayesian analysis | Pluripotency
Journal Article
Experimental cell research, ISSN 0014-4827, 2012, Volume 318, Issue 13, pp. 1528 - 1541
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and offer a cost-effective approach... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | HUMAN NEOCORTEX | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | HUMAN BRAIN | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | FATTY-ACIDS | machine learning | CANCER | organoid | IN-VITRO | HUMAN CEREBRAL-CORTEX | MICROGLIA | GENE-EXPRESSION | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 23, pp. 8518 - 8523
Progress in retinal-cell therapy derived from human pluripotent stem cells currently faces technical challenges that require the development of easy and standardized protocols... 
Epithelial cells | Induced pluripotent stem cells | Stem cells | Cell lines | Photoreceptors | Neural stem cells | Cultured cells | Pluripotent stem cells | Embryonic stem cells | Cellular differentiation | Cones | Retinal ganglion cells | Rods | DIRECTED DIFFERENTIATION | VESICLE-LIKE STRUCTURES | MULTIDISCIPLINARY SCIENCES | MOUSE | INDUCTION | FATE | PLURIPOTENT STEM-CELLS | cones | GROWTH | rods | retinal ganglion cells | GENERATION | EXPRESSION | REVEALS | Immunohistochemistry | Retinal Pigment Epithelium - metabolism | Homeodomain Proteins - metabolism | Humans | Multipotent Stem Cells - metabolism | Retinal Neurons - cytology | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Transfection | SOXB1 Transcription Factors - genetics | Adult | Cell Differentiation | Cell Culture Techniques | Dermis - cytology | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Cell Line | Gene Expression | Nanog Homeobox Protein | Photoreceptor Cells - cytology | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Retinal Neurons - metabolism | Multipotent Stem Cells - cytology | Octamer Transcription Factor-3 - metabolism | Photoreceptor Cells - metabolism | Fibroblasts - cytology | Microscopy, Fluorescence | Retinal Pigment Epithelium - cytology | Physiological aspects | Retina | Biological Sciences
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2018, Volume 76, Issue 2, pp. 231 - 244
Stem cells drive embryonic and fetal development. In several adult tissues, they retain the ability to self-renew and differentiate into a variety... 
Life Sciences | Biomedicine, general | Biochemistry, general | Fetal alcohol spectrum disorders | Life Sciences, general | Alcoholic beverages | Mesenchymal stromal cells | Alcohol dehydrogenase | Alcohol-related disorders | Cell Biology | Acetaldehyde | PROGENITOR CELLS | OXIDATIVE STRESS | ALDEHYDE DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | CANCER | CELL BIOLOGY | EXTRACELLULAR VESICLES | LIVER | ENDOGENOUS ALDEHYDES | HIPPOCAMPAL NEUROGENESIS | EXPOSURE | Neoplastic Stem Cells - cytology | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Neoplastic Stem Cells - drug effects | Humans | Neural Stem Cells - drug effects | Aldehyde Dehydrogenase, Mitochondrial - metabolism | MicroRNAs - metabolism | Stem Cells - cytology | Neural Stem Cells - cytology | Stem Cells - metabolism | Ethanol - pharmacology | Neoplastic Stem Cells - metabolism | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Neural Stem Cells - metabolism | Osteoprogenitor cells | Ethanol | Drinking behavior | Fetuses | Embryo cells | Health risks | Homeostasis | Alcohol | Tissues | Hematopoietic stem cells | Hemopoiesis | Embryogenesis | Intestine | Stem cells | Cells (biology) | Bone marrow | Neural stem cells | Dental pulp | Review
Journal Article