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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
.... Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 466, Issue 7308, pp. 829 - 834
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells... 
PROGENITOR CELLS | OSTEOBLAST | OSTEOPONTIN | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | RECEPTOR | DIFFERENTIATION | NEURAL CREST | COOPERATION | EXPRESSION | Chondrocytes - cytology | Nestin | Multipotent Stem Cells - metabolism | Parathyroid Hormone - pharmacology | Cell Lineage - drug effects | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Multipotent Stem Cells - drug effects | Sympathetic Nervous System - physiology | Cell Division | Stromal Cells - drug effects | Osteoblasts - cytology | Hematopoietic Stem Cells - drug effects | Mesenchymal Stromal Cells - drug effects | Gene Expression Regulation - genetics | Osteoblasts - drug effects | Stromal Cells - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Stem Cell Niche - cytology | Nerve Tissue Proteins - metabolism | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Chemokine CXCL12 - metabolism | Cell Differentiation - drug effects | Multipotent Stem Cells - cytology | Hematopoietic Stem Cells - cytology | Stem Cell Niche - metabolism | Mice | Stem Cell Niche - drug effects | Osteoblasts - metabolism | Intermediate Filament Proteins - metabolism | Mesenchymal Stem Cell Transplantation | Stromal Cells - cytology | Cell Movement | Physiological aspects | Genetic aspects | Research | Bone marrow cells | Gene expression | Osteoblasts | Hematopoietic stem cells | Studies | Proteins | Bone marrow | Rodents | Stem cells
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 1, p. e29597
Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) provide new prospects for studying human neurodevelopment and modeling neurological disease... 
HUMAN ES | INHIBITION | FGF | MULTIDISCIPLINARY SCIENCES | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION CAPACITY | PRECURSORS | Oligonucleotide Array Sequence Analysis | Humans | Fibroblast Growth Factor 2 - pharmacology | Neurons - cytology | Gene Expression Profiling | Neural Stem Cells - cytology | Neuroepithelial Cells - cytology | Neuroglia - cytology | Neurons - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Pluripotent Stem Cells - cytology | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Neuroglia - metabolism | Cell Proliferation - drug effects | Neuroepithelial Cells - metabolism | Epidermal Growth Factor - pharmacology | Neural Stem Cells - metabolism | Cluster Analysis | Medical research | Nervous system diseases | Epidermal growth factor | Neurons | Medicine, Experimental | Fibroblast growth factors | Comparative analysis | Embryonic stem cells | Neurophysiology | Neurosciences | Laboratories | Neurobiology | Embryo cells | Radial glial cells | Nervous system | Biochemistry | Neurodevelopmental disorders | Neuronal-glial interactions | Genotype & phenotype | Fibroblasts | Physiology | Growth factors | Fibroblast growth factor 2 | Fetuses | Embryos | Brain research | Stem cells | Comparative studies | Hindbrain | Bayesian analysis | Pluripotency
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 12, p. e52787
Murine and human iPSC-NS/PCs (induced pluripotent stem cell-derived neural stem/progenitor cells... 
FIBERS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | EXPRESSION PROFILE | GENE-EXPRESSION | FETAL-BRAIN | STEM/PROGENITOR CELLS | PLURIPOTENCY | GENERATION | GROWTH-FACTOR | TRANSPLANTATION | Humans | Induced Pluripotent Stem Cells - secretion | Motor Neurons - pathology | Recovery of Function | Spinal Cord Injuries - pathology | Microglia - physiology | Spinal Cord - pathology | Neural Stem Cells - transplantation | Female | Cell Differentiation | Calcitonin Gene-Related Peptide - metabolism | Spinal Cord Injuries - therapy | Hand Strength | Induced Pluripotent Stem Cells - physiology | Nerve Growth Factors - secretion | Callithrix | Cell Survival | Induced Pluripotent Stem Cells - transplantation | Cells, Cultured | Neural Stem Cells - physiology | Nerve Regeneration | Spinal Cord - blood supply | Demyelinating Diseases - prevention & control | Motor Neurons - metabolism | Locomotion | Animals | Neural Stem Cells - secretion | Cicatrix - pathology | Spinal Cord - physiopathology | Cell Transformation, Neoplastic - pathology | Neovascularization, Physiologic | Stem Cell Transplantation - adverse effects | Transplantation | Spinal cord injuries | RNA | Stem cells | Cell culture | Spinal cord | Recovery of function | Stem cell transplantation | Spinal cord injury | Bone surgery | Recovery | Proteins | Angiogenesis | Allografts | Demyelination | Rodents | Fibroblasts | Primates | Physiology | Injuries | Injury analysis | Cloning | Regrowth | Tumorigenicity | Neurotrophic factors | Gene expression | Polymerase chain reaction | Medicine | Orthopedics | Cells (biology) | Neural stem cells | Skin | Laboratory animals | Human behavior | Pluripotency
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 548, Issue 7665, pp. 52 - 57
.... Here we develop several mouse models in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1 are ablated, as we observed that ageing in mice started with a substantial loss of these hypothalamic cells... 
OBESITY | MICRORNA REGULATION | ADULT HIPPOCAMPUS | MULTIDISCIPLINARY SCIENCES | EXTENDS LIFE-SPAN | IKK-BETA | NEUROGENESIS | MICE | SUBVENTRICULAR ZONE | DIFFERENTIATION | BETA/NF-KAPPA-B | Exosomes - metabolism | SOXB1 Transcription Factors - deficiency | Exosomes - genetics | Male | MicroRNAs - metabolism | Aging - cerebrospinal fluid | I-kappa B Proteins - metabolism | Neural Stem Cells - cytology | I-kappa B Proteins - genetics | Polycomb Repressive Complex 1 - deficiency | Aging - genetics | Time Factors | Neural Stem Cells - transplantation | MicroRNAs - cerebrospinal fluid | Hypothalamus - physiology | Mice, Inbred C57BL | Cellular Microenvironment | Neural Stem Cells - physiology | Hypothalamus - pathology | Inflammation | Longevity - genetics | Proto-Oncogene Proteins - deficiency | Aging - pathology | Animals | Aging - physiology | Hypothalamus - cytology | Mice | MicroRNAs - genetics | Longevity - physiology | Neural Stem Cells - metabolism | Aging | Physiological aspects | Control | MicroRNA | Hypothalamus | Stem cells | Animal models | Stem cell transplantation | Cerebrospinal fluid | Exosomes | Ablation | Neurogenesis | Studies | Allografts | Life span | MicroRNAs | Cells (biology) | miRNA | Physiology | Genetic engineering | neural stem cell | exosome | hypothalamus
Journal Article