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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
.... Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 02/2017, Volume 18, Issue 9, pp. 2113 - 2123
Journal Article
Journal Article
Journal Article
Experimental cell research, ISSN 0014-4827, 2007, Volume 313, Issue 9, pp. 1820 - 1829
Human mesenchymal stem cells (hMSCs) have been shown to trans-differentiate into neuronal-like cells by culture in neuronal induction media, although the mechanism is not well understood... 
Nanotopography | Neuronal differentiation | Nanoimprinting | Human mesenchymal stem cells | Cytoskeleton rearrangement | nanoimprinting | nanotopography | neuronal differentiation | CELL BIOLOGY | NEURAL CELLS | ONCOLOGY | human mesenchymal stem cells | cytoskeleton rearrangement | SURFACE | IN-VITRO DIFFERENTIATION | EXPRESSION | MARROW STROMAL CELLS | MORPHOLOGY | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Neurons - cytology | Gene Expression Profiling | Cell Culture Techniques - methods | Cell Lineage - drug effects | Cell Nucleus - physiology | Mesenchymal Stromal Cells - cytology | Extracellular Matrix - physiology | Neurons - physiology | Neurons - drug effects | Cell Differentiation - physiology | Mesenchymal Stromal Cells - physiology | Tretinoin - pharmacology | Biomarkers - metabolism | Cell Line | Nanotechnology - methods | Nanostructures - standards | Cytoskeleton - ultrastructure | Cell Nucleus - ultrastructure | Cell Lineage - physiology | Mesenchymal Stem Cell Transplantation - methods | Extracellular Matrix - ultrastructure | Cell Differentiation - drug effects | Cell Polarity - physiology | Cytoskeleton - physiology | Neurons | Nanotechnology | Stem cells | Cell culture | Cartography | Biomedical research | Cellular biology | Genetics | RETINOIC ACID | MICROTUBULES | TOPOGRAPHY | NANOSTRUCTURES | STEM CELLS | GENE REGULATION | IN VIVO | PROTEINS | 60 APPLIED LIFE SCIENCES | nano-imprinting
Journal Article
Small, ISSN 1613-6810, 02/2016, Volume 12, Issue 5, pp. 631 - 646
This study explores the use of human embryonic stem cells (hESCs) for assessing nanotoxicology, specifically, the effect of gold nanoparticles (AuNPs... 
gold | toxicology | assays | nanoparticles | human embryonic stem cells | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | ZEBRAFISH | QUANTILE NORMALIZATION | ALZHEIMERS-DISEASE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | DENDRIMERS | CHEMISTRY, MULTIDISCIPLINARY | DNA METHYLATION MICROARRAY | PARTICLE-SIZE | DIFFERENTIATION | CYTOTOXICITY | EXPRESSION | EXPOSURE | Human Embryonic Stem Cells - ultrastructure | Human Embryonic Stem Cells - cytology | Humans | Neural Stem Cells - cytology | Fibroblasts - ultrastructure | Embryoid Bodies - cytology | Human Embryonic Stem Cells - drug effects | Epigenesis, Genetic - drug effects | Gold - toxicity | Metal Nanoparticles - ultrastructure | Gold - chemistry | Cell Survival - drug effects | Pluripotent Stem Cells - cytology | Endocytosis - drug effects | Metal Nanoparticles - chemistry | Neural Stem Cells - drug effects | Particle Size | Metal Nanoparticles - toxicity | Animals | Cell Differentiation - drug effects | Fibroblasts - drug effects | Dendrimers - chemistry | Fibroblasts - cytology | Mice | DNA Methylation - drug effects | Nanoparticles | Methylation | Embryonic stem cells | Gold | Cohesion | Capping | Toxicity | Exposure | Derivatives | Embryos | Detachment | Cell death | Cells (biology) | Stem cells | DNA methylation | Differentiation | Viability | Deoxyribonucleic acid--DNA | human embryonic stem cell
Journal Article
Molecular brain, ISSN 1756-6606, 2012, Volume 5, Issue 1, pp. 17 - 17
...) in the Huntingtin gene that results in an expanded polyglutamine tract. Multiple mechanisms have been proposed to explain the preferential striatal and cortical degeneration that occurs with HD, including non-cell-autonomous contribution from astrocytes... 
Huntingtons disease | Disease modeling | Neural differentiation | Astrocytes | Induced pluripotent stem cells | MOTOR-NEURONS | MUTANT HUNTINGTIN | ALS | DOPAMINERGIC-NEURONS | Huntington's disease | NEUROSCIENCES | NEURONAL INTRANUCLEAR INCLUSIONS | MODELS | INTEGRATION | FAMILIAL ALZHEIMERS-DISEASE | NEUROGENESIS | EXPRESSION | Neurons - pathology | Vacuoles - ultrastructure | Humans | Huntington Disease - pathology | Astrocytes - pathology | Male | Vacuoles - drug effects | Stem Cell Transplantation | Chloroquine - pharmacology | Adult | Female | Neurons - drug effects | Induced Pluripotent Stem Cells - pathology | Astrocytes - drug effects | Cell Line | Cell Survival - drug effects | Induced Pluripotent Stem Cells - drug effects | Neural Stem Cells - drug effects | Induced Pluripotent Stem Cells - ultrastructure | Neural Stem Cells - pathology | Astrocytes - ultrastructure | Animals | Cell Differentiation - drug effects | Vacuoles - metabolism | Mice | Medical research | Nervous system diseases | Neurons | Analysis | Stem cells | Medicine, Experimental | Genetic aspects | High-definition television | Cognition disorders | Proteins | Disease | Cell culture | Animal models | Polyglutamine | Huntingtin | Neurodegenerative diseases | Cognitive ability | Trinucleotide repeats | Hereditary diseases | Neurological diseases | trinucleotide repeat diseases | Lymphocytes | Neostriatum | Peripheral blood | Vacuoles | Inhibitory postsynaptic potentials | Huntington’s disease
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 362, Issue 6416, pp. eaau1810 - 793
Harnessing the potential of human stem cells for modeling the physiology and diseases of cortical circuitry requires monitoring cellular dynamics in vivo... 
PLURIPOTENT STEM-CELLS | STRUCTURAL PLASTICITY | CONNECTIVITY | ALZHEIMERS-DISEASE | INTEGRATE | MULTIDISCIPLINARY SCIENCES | AXONAL BOUTON DYNAMICS | DIFFERENTIATION | TRISOMY-21 | CEREBRAL-CORTEX | BRAIN | Neuroimaging | Neurons - pathology | Cerebral Cortex - blood supply | Humans | Axons - physiology | Neural Stem Cells - cytology | Neurogenesis | Cerebral Cortex - ultrastructure | Neuroglia - cytology | Neurons - ultrastructure | Axons - ultrastructure | Neurons - physiology | Induced Pluripotent Stem Cells - cytology | Microscopy, Fluorescence, Multiphoton | Single-Cell Analysis | Down Syndrome - pathology | Induced Pluripotent Stem Cells - physiology | Synapses - physiology | Induced Pluripotent Stem Cells - transplantation | Neural Stem Cells - physiology | Mice, SCID | Down Syndrome - embryology | Animals | Cerebral Cortex - embryology | Models, Biological | Neuronal Plasticity | Mice | Brain | Synaptogenesis | Spine | Pathogenesis | Grafting | Neuronal-glial interactions | Mimicry | Autopsy | Neurodegeneration | Animal tissues | Fibroblasts | Physiology | Fetuses | Cortex | Brain mapping | Blood vessels | Stem cells | Chromosome 21 | Neural stem cells | Synapses | Surgical implants | Transplants & implants | Circuits | Oscillations | Transplantation | Dendritic spines | Down's syndrome | Dynamics | Pruning | Modelling | Degeneration | Immune system | Phenotypes | Brain architecture | Medical imaging | Neurons | Transplants | Down syndrome | Grafts | Microscopy | Biopsy | Neural networks | Skin & tissue grafts | Cell size | Gene mapping | Inhibitory postsynaptic potentials
Journal Article