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1. Full Text Human neural tube defects: Genetic causes and prevention
by De Marco, Patrizia and Merello, Elisa and Cama, Armando and Kibar, Zoha and Capra, Valeria
BioFactors, ISSN 0951-6433, 07/2011, Volume 37, Issue 4, pp. 261 - 268
Neural tube defects (NTDs) are severe congenital malformations affecting 1–2 in 1,000 live births, whose etiology is multifactorial, involving environmental... 
inositol | folate | neural tube defects | planar cell polarity | prevention | Prevention | Planar cell polarity | Inositol | Neural tube defects | Folate | CANCER RISK | BIOCHEMISTRY & MOLECULAR BIOLOGY | FETAL SURGERY | D-CHIRO-INOSITOL | METHIONINE SYNTHASE | BIRTH-DEFECTS | FOLIC-ACID | METHYLENETETRAHYDROFOLATE REDUCTASE | RISK-FACTOR | ENDOCRINOLOGY & METABOLISM | FOLATE INTAKE | Carrier Proteins - genetics | Cell Polarity - genetics | Animals | Membrane Proteins - genetics | Humans | Neural Tube Defects - genetics | Neural Tube Defects - epidemiology | Neural Tube Defects - etiology | Neural Tube Defects - prevention & control | Signal Transduction - physiology | Signal Transduction - genetics | Intracellular Signaling Peptides and Proteins - genetics
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2. Full Text Neural tube defects
by Greene, Nicholas D.E and Copp, Andrew J
Annual Review of Neuroscience, ISSN 0147-006X, 2014, Volume 37, Issue 1, pp. 221 - 242
Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth defects of the central nervous system that originate during embryonic... 
Anencephaly | Spina bifida | Genetics | Folic acid | FOLIC-ACID FORTIFICATION | EMBRYONIC-DEVELOPMENT | INDUCED BIRTH-DEFECTS | SONIC HEDGEHOG | spina bifida | CONVERGENT EXTENSION | anencephaly | MOUSE SPINAL NEURULATION | NEUROSCIENCES | MICE LACKING | PERICONCEPTIONAL VITAMIN SUPPLEMENTATION | genetics | PLANAR-CELL-POLARITY | folic acid | ONE-CARBON METABOLISM | Genetic Predisposition to Disease - genetics | Neural Tube Defects - diagnosis | Animals | Folic Acid - therapeutic use | Neural Tube Defects - physiopathology | Humans | Risk Factors | Neural Tube Defects - genetics | Neural Tube Defects - etiology | Neural Tube Defects - prevention & control | Neural Tube Defects - drug therapy | Neurulation - physiology | Neural tube | Abnormalities | Genetic research | Genetic aspects | Research | Gene expression | Neurological research
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3. Full Text Genetics of human neural tube defects
by Greene, Nicholas D.E and Stanier, Philip and Copp, Andrew J
Human Molecular Genetics, ISSN 0964-6906, 10/2009, Volume 18, Issue 2, pp. R113 - R129
Neural tube defects (NTDs) are common, severe congenital malformations whose causation involves multiple genes and environmental factors. Although more than... 
METHYLENETETRAHYDROFOLATE REDUCTASE | SPINA-BIFIDA RISK | METHIONINE SYNTHASE REDUCTASE | FOLATE-RELATED GENES | LOOP-TAIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | LOW DIETARY-FOLATE | IRISH POPULATION | CONGENITAL HEART-DEFECTS | PLANAR CELL-POLARITY | PROMOTER HAPLOTYPE COMBINATIONS | Folic Acid - metabolism | Mice | Animals | Models, Biological | Humans | Neural Tube Defects - genetics | Reviews
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4. Full Text Genetics and development of neural tube defects
by Copp, Andrew J and Greene, Nicholas DE
The Journal of Pathology, ISSN 0022-3417, 01/2010, Volume 220, Issue 2, pp. 217 - 230
Congenital defects of neural tube closure (neural tube defects; NTDs) are among the commonest and most severe disorders of the fetus and newborn. Disturbance... 
neural tube defect | development | genetics | inositol | folic acid | retinoid | non‐canonical Wnt | Inositol | Retinoid | Development | Genetics | Noncanonical Wnt | Folic acid | Neural tube defect | PROTEIN-KINASE-A | EARLY EMBRYONIC LETHALITY | PATHOLOGY | TRANSCRIPTION FACTOR AP-2 | MOUSE SPINAL NEURULATION | PLANAR CELL-POLARITY | ONCOLOGY | GCN5 HISTONE ACETYLTRANSFERASE | ABNORMAL BRAIN-DEVELOPMENT | non-canonical Wnt | NF-KAPPA-B | HEDGEHOG SIGNALING PATHWAY | SONIC-HEDGEHOG | Animals | Folic Acid - therapeutic use | Humans | Neural Tube Defects - embryology | Neural Tube Defects - genetics | Neural Tube Defects - prevention & control | Mice | Signal Transduction - genetics | Neurulation - genetics | Causality | Neural Tube - embryology | Disease Models, Animal | Anencephaly | Chromatin | Transcription | Wnt protein | Congenital defects | Fetuses | Neural tube defects | Retinoids | Embryos | Signal transduction | Spina bifida | Hedgehog protein | Cell cycle | Cytoskeleton | Polarity | Mutation | Supplementation
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5. Full Text Neural tube defects: recent advances, unsolved questions, and controversies
by Copp, Andrew J, Prof and Stanier, Philip, PhD and Greene, Nicholas DE, PhD
Lancet Neurology, The, ISSN 1474-4422, 2013, Volume 12, Issue 8, pp. 799 - 810
Summary Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come... 
Neurology | CONGENITAL-MALFORMATIONS | FOLATE-DEFICIENCY | PLASMA FOLATE | FLOOR PLATE | PLANAR-CELL-POLARITY | MOUSE EMBRYOS | CURLY TAIL | CONVERGENT EXTENSION | CLOSURE | FOLIC-ACID SUPPLEMENTATION | CLINICAL NEUROLOGY | Genetic Predisposition to Disease | Folic Acid - therapeutic use | Humans | Databases, Factual - statistics & numerical data | Neural Tube Defects - genetics | Neural Tube Defects - epidemiology | Neural Tube Defects - etiology | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Mutation - genetics | Animals | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Folic Acid - metabolism | Neural Tube Defects - therapy | Disease Models, Animal | Spina bifida | Birth defects | Analysis | Folic acid
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6. Full Text The continuing challenge of understanding, preventing, and treating neural tube defects
by Wallingford, John B and Niswander, Lee A and Shaw, Gary M and Finnell, Richard H
Science, ISSN 0036-8075, 03/2013, Volume 339, Issue 6123, pp. 1222022.7 - 1011
Human birth defects are a major public health burden: The Center for Disease Control estimates that 1 of every 33 United States newborns presents with a birth... 
SPINA-BIFIDA | DIABETES-MELLITUS | FOLIC-ACID FORTIFICATION | PLANAR-CELL-POLARITY | MULTIDISCIPLINARY SCIENCES | CONVERGENT EXTENSION | VALPROIC ACID | APICAL CONSTRICTION | HISTONE DEACETYLASE | BIRTH PREVALENCE | SONIC-HEDGEHOG | Primary Prevention | Humans | Neural Tube Defects - genetics | Neural Tube Defects - prevention & control | Folic Acid - administration & dosage | Embryo, Nonmammalian - abnormalities | Animals | Folic Acid Deficiency - complications | Folic Acid - metabolism | Amphibians - abnormalities | Neural Tube Defects - therapy | Mutation | Folic Acid Deficiency - genetics | Disease Models, Animal
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7. Full Text Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis
by Robinson, Alexis and Escuin, Sarah and Doudney, Kit and Vekemans, Michel and Stevenson, Roger E and Greene, Nicholas D.E and Copp, Andrew J and Stanier, Philip
Human Mutation, ISSN 1059-7794, 02/2012, Volume 33, Issue 2, pp. 440 - 447
Craniorachischisis (CRN) is a severe neural tube defect (NTD) resulting from failure to initiate closure, leaving the hindbrain and spinal neural tube entirely... 
neural tube defects | SCRIB | craniorachischisis | planar cell polarity | CELSR1 | Craniorachischisis | Planar cell polarity | Scrib | Neural tube defects | Celsr1 | CIRCLETAIL | LOOP-TAIL | CLOSURE | PREVALENCE | IDENTIFICATION | MOUSE MUTANT | VANGL2 | DISRUPTION | GENETICS | GENETICS & HEREDITY | NEURULATION | Cell Line | Genetic Predisposition to Disease | Tumor Suppressor Proteins - metabolism | Immunoprecipitation | Cadherins - metabolism | Membrane Proteins - genetics | Humans | Neural Tube Defects - genetics | Neural Tube Defects - metabolism | Mutation, Missense | Protein Transport - genetics | Animals | Tumor Suppressor Proteins - genetics | Dogs | Fetus | Membrane Proteins - metabolism | Mutation | Cadherins - genetics | Gene Order | Genetic research | Genetic aspects | Analysis | Protein-protein interactions
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