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Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2011, Volume 19, Issue 16, pp. 4796 - 4802
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 34, pp. 10611 - 10616
Antibodies have been developed as therapeutic agents for the treatment of cancer, infection, and inflammation. In addition to binding activity toward the... 
Fc glycosylation | Endoglycosidase | Glycoengineered antibodies | Sugar oxazoline | Homogeneous antibodies | RHEUMATOID-ARTHRITIS | N-ACETYLGLUCOSAMINE | ANTIINFLAMMATORY ACTIVITY | FC-GAMMA-RIII | MULTIDISCIPLINARY SCIENCES | GLYCOFORMS | ANTIBODY | FUCOSE | DEPENDENT CELLULAR CYTOTOXICITY | STAUDINGER LIGATION | glycoengineered antibodies | endoglycosidase | sugar oxazoline | CHEMICAL LIGATION | homogeneous antibodies | Orthomyxoviridae Infections - prevention & control | Acetylglucosamine - immunology | Humans | Structure-Activity Relationship | Sialic Acids - chemistry | Immunoglobulin Fc Fragments - immunology | Immunoglobulin G - immunology | HEK293 Cells | Protein Engineering | Polysaccharides - chemistry | Female | Rituximab - chemistry | Sialic Acids - immunology | Trastuzumab - chemistry | Antibodies, Viral - therapeutic use | Antibody-Dependent Cell Cytotoxicity | alpha-L-Fucosidase - metabolism | Immunoglobulin G - chemistry | Neuraminidase - metabolism | Immunoglobulin Fc Fragments - chemistry | Bacteroides fragilis - enzymology | Receptors, IgG - immunology | Acetylglucosamine - chemistry | Animals | Streptococcus pyogenes - enzymology | Antibodies, Viral - chemistry | Lymphoma, B-Cell - pathology | Cell Line, Tumor | Antibodies, Viral - immunology | Bacterial Proteins - metabolism | Mice | Mice, Inbred BALB C | Rituximab - immunology | Trastuzumab - immunology | Viral antibodies | Medical research | Tissue engineering | Immunoglobulin G | Antibodies | Medicine, Experimental | Genetic aspects | Research | Properties | Immune system | Cytotoxicity | T cell receptors | Glycosylation | Cells | Binding sites | Cancer | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0137113 - e0137113
Objectives Three strong interactions between amino acid side chains (salt bridge, cation-p, and amide bridge) are studied that are stronger than (or comparable... 
CATION-PI INTERACTIONS | COUPLED-CLUSTER SINGLES | CHANNEL | MULTIDISCIPLINARY SCIENCES | INTERACTION ENERGIES | VIRUS P7 | MODEL | INHIBITORS | DENSITY-FUNCTIONAL THEORY | HEPATITIS-C | BINDING | Influenza A virus - chemistry | Viral Proteins - chemistry | Viral Proteins - antagonists & inhibitors | Hepacivirus - chemistry | Thermodynamics | Quantum Theory | Hydrogen Bonding | Viral Matrix Proteins - chemistry | Antiviral Agents - chemistry | Viral Matrix Proteins - antagonists & inhibitors | Drug Design | Neuraminidase - chemistry | Amides - chemistry | Protein Binding | Ligands | Neuraminidase - antagonists & inhibitors | Cations | Molecular Docking Simulation | Protein Interaction Domains and Motifs | Hydrogen-Ion Concentration | Physiological aspects | Usage | Research | Quantum chemistry | Protein-protein interactions | Salts | Laboratories | Hydrogen | Amino acids | Chains | Viruses | Biochemistry | Biomass | Drug development | pH effects | Proteins | Hepatitis | Energy | Aqueous solutions | Hydrogen bonds | Mathematical analysis | Exo-a-sialidase | pH | Ion channels | Life sciences | Hydrogen ion concentration | Deoxyribonucleic acid--DNA | Food | Crystal structure | Enzymes | Chemistry | Solvation | Engineering research | Influenza | Protein interaction | Binding sites | Methods | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2018, Volume 13, Issue 2, pp. e0193623 - e0193623
The rise of drug-resistant influenza A virus strains motivates the development of new antiviral drugs, with different structural motifs and substitution.... 
IN-VITRO | POTENT | CYCLIC ENONES | VIRUS | ACID | ZANAMIVIR | RECEPTOR AGONISTS | MULTIDISCIPLINARY SCIENCES | DRUG DESIGN | RESISTANCE | OSELTAMIVIR | Influenza A Virus, H5N1 Subtype - enzymology | Catalytic Domain | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | Viral Proteins - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Influenza A Virus, H9N2 Subtype - drug effects | Enzyme Inhibitors - pharmacology | Neuraminidase - metabolism | Viral Proteins - antagonists & inhibitors | Influenza A Virus, H5N1 Subtype - drug effects | Enzyme Inhibitors - chemical synthesis | Viral Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Enzyme Inhibitors - chemistry | Drug Design | Neuraminidase - chemistry | Neuraminidase - antagonists & inhibitors | Molecular Docking Simulation | Bridged Bicyclo Compounds, Heterocyclic - metabolism | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Influenza A Virus, H9N2 Subtype - enzymology | Influenza viruses | Enzymes | Research | Sialic acids | Drug resistance | Analysis | Drugs | Ammonium | Chains | Viruses | Event-related potentials | Critical point | Drug development | Exo-a-sialidase | Catalysis | Chemical synthesis | Pharmaceutical sciences | Crystal structure | Antiviral agents | Glycerol | Cyclohexene | Organic chemistry | Oseltamivir | Molecular modelling | Acids | Influenza | Ligands | Mutation | Functional groups | Conformation | Index Medicus
Journal Article