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1. Full Text Predicting Displaceable Water Sites Using Mixed-Solvent Molecular Dynamics
by Graham, Sarah E and Smith, Richard D and Carlson, Heather A
Journal of Chemical Information and Modeling, ISSN 1549-9596, 02/2018, Volume 58, Issue 2, pp. 305 - 314
Water molecules are an important factor in protein-ligand binding. Upon binding of a ligand with a protein's surface, waters can either be displaced by the... 
HSP90 | PROTEIN-LIGAND BINDING | CHEMISTRY, MEDICINAL | RECOGNITION | SOLVATION THERMODYNAMICS | CRYSTAL-STRUCTURE | STRUCTURAL-ANALYSIS | COMPUTER SCIENCE, INFORMATION SYSTEMS | TEM-1 BETA-LACTAMASE | ATP BINDING | CHEMISTRY, MULTIDISCIPLINARY | INHOMOGENEOUS FLUID APPROACH | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | INHIBITORS | Reproducibility of Results | Transcription Factors - chemistry | Tetrahydrofolate Dehydrogenase - chemistry | Solvents - chemistry | Humans | Nuclear Proteins - chemistry | Amyloid Precursor Protein Secretases - chemistry | Molecular Dynamics Simulation | Pepsin A - chemistry | beta-Lactamases - chemistry | Thrombin - chemistry | Allosteric Site | Neuraminidase - chemistry | Water - chemistry | HSP90 Heat-Shock Proteins - chemistry | Protein Binding | Ligands | Proteins - chemistry | Proteins | Binding | Molecules | Solvents | Water chemistry | Molecular dynamics | Affinity | Molecular chemistry | Displacement | Functional groups | Index Medicus
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2. Full Text Sandwich-type biosensor for the detection of α2,3-sialylated glycans based on fullerene-palladium-platinum alloy and 4-mercaptophenylboronic acid nanoparticle hybrids coupled with Au-methylene blue-MAL signal amplification
by Yuan, Qiqi and He, Junlin and Niu, Yazhen and Chen, Jun and Zhao, Yilin and Zhang, Yuchan and Yu, Chao
Biosensors and Bioelectronics, ISSN 0956-5663, 04/2018, Volume 102, pp. 321 - 327
α2,3-sialylated glycans (α2,3-sial-Gs) are one of the significant tumour biomarkers for the early diagnosis of cancer. In this work, a neoteric sandwich-type... 
Sandwich-type sensor | α2,3-sialylated glycans | 4-mercaptophenylboronic acid | Maackia amurensis lectin | Methylene blue | Gold - chemistry | Limit of Detection | Nanoparticles - chemistry | Humans | Boronic Acids - chemistry | Platinum - chemistry | Polysaccharides - isolation & purification | Biosensing Techniques | Neuraminidase - chemistry | Polysaccharides - chemistry | Sulfhydryl Compounds - chemistry | Fullerenes - chemistry | Graphite - chemistry | Glycoproteins - chemistry | Methylene Blue - chemistry | Palladium - chemistry | Index Medicus
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3. Full Text Glycan structure of Gc Protein-derived Macrophage Activating Factor as revealed by mass spectrometry
by Borges, Chad R and Rehder, Douglas S
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 09/2016, Volume 606, pp. 167 - 179
Disagreement exists regarding the O-glycan structure attached to human vitamin D binding protein (DBP). Previously reported evidence indicated that the... 
GcMAF | Vitamin D binding protein | ESI-MS | Linear trisaccharide | Disaccharide | Linkage analysis | PRECURSOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | GLOBULIN | GROUP-SPECIFIC COMPONENT | MAF | BIOPHYSICS | IMMUNOSUPPRESSION | BETA-GALACTOSIDASE | DEGLYCOSYLATION | VITAMIN-D-BINDING | ALPHA-N-ACETYLGALACTOSAMINIDASE | Escherichia coli - enzymology | Vitamin D-Binding Protein - chemistry | Humans | Glycosylation | alpha-N-Acetylgalactosaminidase - chemistry | Disaccharides - chemistry | Macrophage Activation | Spectrometry, Mass, Electrospray Ionization | Trifluoroacetic Acid - chemistry | Trisaccharides - chemistry | Alleles | Neuraminidase - chemistry | Glycoside Hydrolases - chemistry | Polysaccharides - chemistry | Macrophage-Activating Factors - chemistry | beta-Galactosidase - chemistry | Glycosides - chemistry | Mannose - chemistry | Enzymes | Vitamin D | Analysis | Calcifediol | Macrophage colony stimulating factor | Alfacalcidol | Galactose | Macrophages | Mass spectrometry | Fructose | Protein binding | Index Medicus
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4. Full Text Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase
by Campo, Vanessa L and Sesti-Costa, Renata and Carneiro, Zumira A and Silva, João S and Schenkman, Sergio and Carvalho, Ivone
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2012, Volume 20, Issue 1, pp. 145 - 156
Synthesis of 1,2,3-triazole-linked sialic acid glycoside by Cu(I)-assisted 1,3-dipolar azide–alkyne cycloaddition (CuAAC) reaction. This work describes the... 
Triazole | Click chemistry | trans-Sialidase | Sialylmimetics | Trypanosoma cruzi | PHASE SYNTHESIS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | C-GLYCOSIDES | DEPROTECTION | SIALYL-LEWIS | AMINO-ACID | O-METHYL | BIOLOGICAL EVALUATION | INHIBITORS | DERIVATIVES | Glycoconjugates - chemistry | Click Chemistry | Triazoles - chemistry | Enzyme Inhibitors - pharmacology | Glycoconjugates - pharmacology | Glycoproteins - antagonists & inhibitors | Glycoproteins - metabolism | Neuraminidase - metabolism | Alkynes - chemistry | Enzyme Inhibitors - chemical synthesis | Azides - chemistry | Glycoconjugates - chemical synthesis | Sialic Acids - chemistry | Trypanosoma cruzi - enzymology | Antiparasitic Agents - chemical synthesis | Copper - chemistry | Enzyme Inhibitors - chemistry | Antiparasitic Agents - pharmacology | Drug Design | Trypanosoma cruzi - drug effects | Neuraminidase - antagonists & inhibitors | Catalysis | Antiparasitic Agents - chemistry | Triazoles | Index Medicus
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5. Full Text Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir
by Liu, Kung-Cheng and Lee, Pei-Shan and Wang, Shi-Yun and Cheng, Yih-Shyun E and Fang, Jim-Min and Wong, Chi-Huey
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2011, Volume 19, Issue 16, pp. 4796 - 4802
A new class of 1-hydroxy-2-napthoic acid modified prodrugs of zanamivir and guanidino-oseltamivir is designed as an intramolecular ion-pair with improved... 
Intramolecular ion-pair | Prodrug | Neuraminidase inhibitor | Influenza | ESTER | VIRUS NEURAMINIDASE INHIBITOR | DESIGN | CHEMISTRY, MEDICINAL | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | POTENT ANTIINFLUENZA ACTIVITY | PHARMACOKINETICS | DRUGS | MICE | INFLUENZA-VIRUS | GS 4071 | Carbon Dioxide - chemistry | Guanidine - chemistry | Humans | Influenza, Human - enzymology | Naphthols - chemistry | Prodrugs - chemistry | Enzyme Inhibitors - chemical synthesis | Oseltamivir - chemistry | Zanamivir - chemistry | Antiviral Agents - chemistry | Esters - chemistry | Enzyme Inhibitors - chemistry | Neuraminidase - chemistry | Molecular Structure | Influenza, Human - drug therapy | Drug Evaluation, Preclinical | Oseltamivir - pharmacology | Cell Line | Antiviral Agents - pharmacology | Ions - chemistry | Administration, Oral | Antiviral Agents - therapeutic use | Guanidine - pharmacology | Enzyme Inhibitors - pharmacology | Zanamivir - pharmacology | Influenza, Human - epidemiology | Enzyme Inhibitors - therapeutic use | Zanamivir - therapeutic use | Antiviral Agents - chemical synthesis | Hydrophobic and Hydrophilic Interactions | Neuraminidase - antagonists & inhibitors | Influenza A virus - drug effects | Prodrugs - pharmacology | Index Medicus
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6. Full Text A common glycan structure on immunoglobulin G for enhancement of effector functions
by Chin-Wei Lin and Ming-Hung Tsai and Shiou-Ting Li and Tsung-I Tsai and Kuo-Ching Chu and Ying-Chih Liu and Meng-Yu Lai and Chia-Yu Wu and Yung-Chieh Tseng and Sachin S. Shivatare and Chia-Hung Wang and Ping Chao and Shi-Yun Wang and Hao-Wei Shih and Yi-Fang Zeng and Tsai-Hong You and Jung-Yu Liao and Yu-Chen Tu and Yih-Shyan Lin and Hong-Yang Chuang and Chia-Lin Chen and Charng-Sheng Tsai and Chiu-Chen Huang and Nan-Horng Lin and Che Ma and Chung-Yi Wu and Chi-Huey Wong
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 34, pp. 10611 - 10616
Antibodies have been developed as therapeutic agents for the treatment of cancer, infection, and inflammation. In addition to binding activity toward the... 
Fc glycosylation | Endoglycosidase | Glycoengineered antibodies | Sugar oxazoline | Homogeneous antibodies | RHEUMATOID-ARTHRITIS | N-ACETYLGLUCOSAMINE | ANTIINFLAMMATORY ACTIVITY | FC-GAMMA-RIII | MULTIDISCIPLINARY SCIENCES | GLYCOFORMS | ANTIBODY | FUCOSE | DEPENDENT CELLULAR CYTOTOXICITY | STAUDINGER LIGATION | glycoengineered antibodies | endoglycosidase | sugar oxazoline | CHEMICAL LIGATION | homogeneous antibodies | Orthomyxoviridae Infections - prevention & control | Acetylglucosamine - immunology | Humans | Structure-Activity Relationship | Sialic Acids - chemistry | Immunoglobulin Fc Fragments - immunology | Immunoglobulin G - immunology | HEK293 Cells | Protein Engineering | Polysaccharides - chemistry | Female | Rituximab - chemistry | Sialic Acids - immunology | Trastuzumab - chemistry | Antibodies, Viral - therapeutic use | Antibody-Dependent Cell Cytotoxicity | alpha-L-Fucosidase - metabolism | Immunoglobulin G - chemistry | Neuraminidase - metabolism | Immunoglobulin Fc Fragments - chemistry | Bacteroides fragilis - enzymology | Receptors, IgG - immunology | Acetylglucosamine - chemistry | Animals | Streptococcus pyogenes - enzymology | Antibodies, Viral - chemistry | Lymphoma, B-Cell - pathology | Cell Line, Tumor | Antibodies, Viral - immunology | Bacterial Proteins - metabolism | Mice | Mice, Inbred BALB C | Rituximab - immunology | Trastuzumab - immunology | Viral antibodies | Medical research | Tissue engineering | Immunoglobulin G | Antibodies | Medicine, Experimental | Genetic aspects | Research | Properties | Immune system | Cytotoxicity | T cell receptors | Glycosylation | Cells | Binding sites | Cancer | Index Medicus | Biological Sciences | Physical Sciences
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7. Full Text Surface modifications of influenza proteins upon virus inactivation by β‐propiolactone
by She, Yi‐Min and Cheng, Keding and Farnsworth, Aaron and Li, Xuguang and Cyr, Terry D
PROTEOMICS, ISSN 1615-9853, 12/2013, Volume 13, Issue 23-24, pp. 3537 - 3547
Inactivation of intact influenza viruses using formaldehyde or β‐propiolactone (BPL) is essential for vaccine production and safety. The extent of chemical... 
PTM | Biomedicine | β‐Propiolactone | Influenza vaccine | Virus inactivation | β-Propiolactone | DISULFIDE BONDS | HEMAGGLUTININ | PANDEMIC INFLUENZA | BIOCHEMISTRY & MOLECULAR BIOLOGY | VACCINE | BIOCHEMICAL RESEARCH METHODS | Propiolactone | SITE-SPECIFIC ATTACHMENT | H1N1 | MASS-SPECTROMETRY | SULFENIC ACIDS | NEURAMINIDASE INHIBITOR RESISTANCE | FORMALDEHYDE-INDUCED MODIFICATIONS | Amino Acid Sequence | Viral Core Proteins - chemistry | Viral Proteins - chemistry | RNA-Binding Proteins - chemistry | Antigens, Viral - chemistry | Propiolactone - chemistry | Cysteine - chemistry | Tandem Mass Spectrometry | Hemagglutinins - chemistry | Influenza Vaccines - chemistry | Neuraminidase - chemistry | Polysaccharides - chemistry | Virus Inactivation | Index Medicus
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8. Full Text Prediction of the water content in protein binding sites
by Michel, Julien and Tirado-Rives, Julian and Jorgensen, William L
Journal of Physical Chemistry B, ISSN 1520-6106, 10/2009, Volume 113, Issue 40, pp. 13337 - 13346
An efficient molecular simulation methodology has been developed to determine the positioning of water molecules in the binding site of a protein or... 
INHOMOGENEOUS FLUID APPROACH | NONNUCLEOSIDE INHIBITORS | LIGAND-BINDING | SOLVATION THERMODYNAMICS | BIOMOLECULAR SYSTEMS | ACTIVE-SITE | CHEMISTRY, PHYSICAL | ENERGY PERTURBATION CALCULATIONS | HIV-1 REVERSE-TRANSCRIPTASE | MONTE-CARLO SIMULATIONS | MOLECULAR-DYNAMICS SIMULATIONS | Solvents | Cyclooxygenase 2 - chemistry | Models, Molecular | Thermodynamics | Animals | Cattle | Computer Simulation | Neuraminidase - chemistry | Water - chemistry | Protein Binding | Hydro-Lyases - chemistry | Proteins - chemistry | Binding Sites | Lactoglobulins - chemistry | Thermal properties | Water | Evaluation | Analysis | Chemical properties | Structure | Gibbs' free energy | Globulin | Protein binding | Index Medicus | protein-ligand interactions | protein hydration | free energy simulations | water in proteins
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9. Full Text Antioxidant, anti-inflammatory and anti-influenza properties of components from chaenomeles speciosa
by Zhang, Li and Cheng, Yong-Xian and Liu, Ai-Lin and Wang, Hai-Di and Wang, Ya-Ling and Du, Guan-Hua
Molecules, ISSN 1420-3049, 11/2010, Volume 15, Issue 11, pp. 8507 - 8517
The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present... 
Antioxidants | Chaenomeles speciosa | NA inhibition | Anti-inflammatory | CELLS | VIRUS | antioxidants | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUCOSIDES | anti-inflammatory | ARTHRITIS | EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | Tumor Necrosis Factor-alpha - metabolism | Plant Extracts - chemistry | Antioxidants - chemistry | Plant Extracts - pharmacology | Hydroxybenzoates - pharmacology | Antiviral Agents - chemistry | Picrates - chemistry | Hydroxybenzoates - chemistry | Biphenyl Compounds - chemistry | Interleukin-6 - metabolism | Cell Line | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Fruit - chemistry | Neuraminidase - metabolism | Antioxidants - pharmacology | Enzyme Activation - drug effects | Influenza A Virus, H1N1 Subtype - drug effects | Nitrous Oxide - metabolism | Rosaceae - chemistry | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Macrophages - drug effects | Mice | Index Medicus
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10. Full Text Exploring strong interactions in proteins with quantum chemistry and examples of their applications in drug design
by Xie, Neng-Zhong and Du, Qi-Shi and Li, Jian-Xiu and Huang, Ri-Bo
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0137113 - e0137113
Objectives Three strong interactions between amino acid side chains (salt bridge, cation-p, and amide bridge) are studied that are stronger than (or comparable... 
CATION-PI INTERACTIONS | COUPLED-CLUSTER SINGLES | CHANNEL | MULTIDISCIPLINARY SCIENCES | INTERACTION ENERGIES | VIRUS P7 | MODEL | INHIBITORS | DENSITY-FUNCTIONAL THEORY | HEPATITIS-C | BINDING | Influenza A virus - chemistry | Viral Proteins - chemistry | Viral Proteins - antagonists & inhibitors | Hepacivirus - chemistry | Thermodynamics | Quantum Theory | Hydrogen Bonding | Viral Matrix Proteins - chemistry | Antiviral Agents - chemistry | Viral Matrix Proteins - antagonists & inhibitors | Drug Design | Neuraminidase - chemistry | Amides - chemistry | Protein Binding | Ligands | Neuraminidase - antagonists & inhibitors | Cations | Molecular Docking Simulation | Protein Interaction Domains and Motifs | Hydrogen-Ion Concentration | Physiological aspects | Usage | Research | Quantum chemistry | Protein-protein interactions | Salts | Laboratories | Hydrogen | Amino acids | Chains | Viruses | Biochemistry | Biomass | Drug development | pH effects | Proteins | Hepatitis | Energy | Aqueous solutions | Hydrogen bonds | Mathematical analysis | Exo-a-sialidase | pH | Ion channels | Life sciences | Hydrogen ion concentration | Deoxyribonucleic acid--DNA | Food | Crystal structure | Enzymes | Chemistry | Solvation | Engineering research | Influenza | Protein interaction | Binding sites | Methods | Index Medicus | Deoxyribonucleic acid | DNA
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11. Full Text Effectiveness of Prenyl Group on Flavonoids from Epimedium koreanum Nakai on Bacterial Neuraminidase Inhibition
by Choi, Hong Min and Kim, Jeong Yoon and Li, Zuo Peng and Jenis, Janar and Jun Ban, Yeong and Baiseitova, Aizhamal and Park, Ki Hun
Molecules, ISSN 1420-3049, 01/2019, Volume 24, Issue 2, p. 317
In this study, the inhibitory potential of bacterial neuraminidase (NA) was observed on the leaves of Epimedium koreanum Nakai, which is a popular ingredient... 
Koreanoside G | Koreanoside F | Bacterial neuraminidase | Epimedium koreanum Nakai | Binding affinity | binding affinity | FLUORESCENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIALIDASE | koreanoside F | koreanoside G | CELL | CHEMISTRY, MULTIDISCIPLINARY | bacterial neuraminidase | Plant Leaves - chemistry | Bacterial Proteins - antagonists & inhibitors | Plant Extracts - chemistry | Epimedium - chemistry | Plant Extracts - pharmacology | Enzyme Inhibitors - pharmacology | Neoprene - chemistry | Enzyme Inhibitors - chemistry | Inhibitory Concentration 50 | Neuraminidase - antagonists & inhibitors | Flavonoids - pharmacology | Molecular Structure | Flavonoids - chemistry | Index Medicus
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12. Full Text Sialidase Unmasks Mucin Domain Epitopes of Lubricin
by Solka, Kathryn A and Miller, Ira J and Schmid, Thomas M
Journal of Histochemistry & Cytochemistry, ISSN 0022-1554, 11/2016, Volume 64, Issue 11, pp. 647 - 668
Lubricin is a secreted, mucin-like glycoprotein and proteoglycan abundant in synovial fluid that provides boundary lubrication and prevents cell adhesion in... 
sialidase | epitopes | lubricin | eyelid | pericardium | liver | spleen | neuraminidase | synovial fluid | PROTEIN | ACID | MOLECULAR-STRUCTURE | ASIALOGLYCOPROTEIN RECEPTOR | GLYCOPROTEINS | BOUNDARY LUBRICANT | CELL-SURFACE | LUBRICATING FRACTION | CARTILAGE | CELL BIOLOGY | BOVINE SYNOVIAL-FLUID | Humans | Eyelids - chemistry | Mucins - immunology | Mucins - chemistry | Epitopes | Organ Specificity | Synovial Fluid - chemistry | Esophagus - chemistry | Spleen - chemistry | N-Acetylneuraminic Acid - chemistry | Glycoproteins - immunology | Neuraminidase - chemistry | Protein Domains | Glycoproteins - chemistry | Pericardium - chemistry | Antibodies, Monoclonal - chemistry | Index Medicus
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13. Full Text Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome
by Kim, Young Ho and Kim, Jang Hoon and Ryu, Young Bae and Lee, Woo Song
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2014, Volume 22, Issue 21, pp. 6047 - 6052
is a Gram-positive spore-forming bacterium that causes food poisoning. The neuraminidase (NA) protein of plays a pivotal role in bacterial proliferation and is... 
Fumariaceae | Bacterial neuraminidase | Non-competitive inhibition | Isoquinoline alkaloids | Corydalis turtschaninovii | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ROOTS | Clostridium perfringens - enzymology | Alkaloids - pharmacology | Humans | Alkaloids - isolation & purification | Enzyme Inhibitors - pharmacology | Neuraminidase - metabolism | Anti-Bacterial Agents - isolation & purification | Enzyme Inhibitors - isolation & purification | Corydalis - chemistry | Isoquinolines - chemistry | Clostridium perfringens - drug effects | Isoquinolines - pharmacology | Rhizome - chemistry | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Clostridium Infections - drug therapy | Neuraminidase - antagonists & inhibitors | Anti-Bacterial Agents - pharmacology | Molecular Docking Simulation | Alkaloids - chemistry | Isoquinolines - isolation & purification | Index Medicus
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14. Full Text Scaffold hopping through virtual screening using 2D and 3D similarity descriptors: Ranking, voting, and consensus scoring
by Zhang, Qiang and Muegge, Ingo
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2006, Volume 49, Issue 5, pp. 1536 - 1548
The ability to find novel bioactive scaffolds in compound similarity-based virtual screening experiments has been studied comparing Tanimoto-based,... 
BIOACTIVE REFERENCE STRUCTURES | CHEMISTRY, MEDICINAL | LIBRARY DESIGN | ANTIESTROGENS | ESTROGEN-RECEPTOR MODULATORS | INFORMATION | VALIDATION | MOLECULAR SIMILARITY | INHIBITORS | MULTIFUNCTIONAL MEDICINES | QUANTITATIVE STRUCTURE | Receptors, Estrogen - chemistry | Thrombin - chemistry | Cyclooxygenase 2 - chemistry | Neuraminidase - chemistry | Models, Molecular | Protein Binding | Ligands | Cyclin-Dependent Kinase 2 - chemistry | HIV Protease - chemistry | Proteins - chemistry | p38 Mitogen-Activated Protein Kinases - chemistry | Quantitative Structure-Activity Relationship | Index Medicus
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15. Full Text Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase
by Colombo, Cinzia and Podlipnik, Črtomir and Presti, Leonardo Lo and Niikura, Masahiro and Bennet, Andrew J and Bernardi, Anna
PLoS ONE, ISSN 1932-6203, 02/2018, Volume 13, Issue 2, pp. e0193623 - e0193623
The rise of drug-resistant influenza A virus strains motivates the development of new antiviral drugs, with different structural motifs and substitution.... 
IN-VITRO | POTENT | CYCLIC ENONES | VIRUS | ACID | ZANAMIVIR | RECEPTOR AGONISTS | MULTIDISCIPLINARY SCIENCES | DRUG DESIGN | RESISTANCE | OSELTAMIVIR | Influenza A Virus, H5N1 Subtype - enzymology | Catalytic Domain | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | Viral Proteins - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Influenza A Virus, H9N2 Subtype - drug effects | Enzyme Inhibitors - pharmacology | Neuraminidase - metabolism | Viral Proteins - antagonists & inhibitors | Influenza A Virus, H5N1 Subtype - drug effects | Enzyme Inhibitors - chemical synthesis | Viral Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Enzyme Inhibitors - chemistry | Drug Design | Neuraminidase - chemistry | Neuraminidase - antagonists & inhibitors | Molecular Docking Simulation | Bridged Bicyclo Compounds, Heterocyclic - metabolism | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Influenza A Virus, H9N2 Subtype - enzymology | Influenza viruses | Enzymes | Research | Sialic acids | Drug resistance | Analysis | Drugs | Ammonium | Chains | Viruses | Event-related potentials | Critical point | Drug development | Exo-a-sialidase | Catalysis | Chemical synthesis | Pharmaceutical sciences | Crystal structure | Antiviral agents | Glycerol | Cyclohexene | Organic chemistry | Oseltamivir | Molecular modelling | Acids | Influenza | Ligands | Mutation | Functional groups | Conformation | Index Medicus
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