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Journal Article
Trends in Neurosciences, ISSN 0166-2236, 2009, Volume 32, Issue 11, pp. 591 - 601
Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histones and other proteins and in regulating fundamental cellular... 
Neurology | SPINAL MUSCULAR-ATROPHY | DISEASE TRANSGENIC MICE | SUBEROYLANILIDE HYDROXAMIC ACID | PROTECTS DOPAMINERGIC-NEURONS | INCREASES SMN EXPRESSION | VALPROIC ACID | AMYOTROPHIC-LATERAL-SCLEROSIS | HISTONE DEACETYLASE INHIBITORS | BDNF GENE-TRANSCRIPTION | NEUROSCIENCES | HEAT-SHOCK-PROTEIN | Neuroprotective Agents - therapeutic use | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Muscular Atrophy, Spinal - enzymology | Parkinson Disease - drug therapy | Neurodegenerative Diseases - drug therapy | Stroke - physiopathology | Amyotrophic Lateral Sclerosis - drug therapy | Amyotrophic Lateral Sclerosis - enzymology | Acetylation | Huntington Disease - drug therapy | Huntington Disease - enzymology | Muscular Atrophy, Spinal - physiopathology | Huntington Disease - physiopathology | Disease Models, Animal | Alzheimer Disease - physiopathology | Neurodegenerative Diseases - pathology | Alzheimer Disease - drug therapy | Rats | Histone Deacetylases - metabolism | Stroke - drug therapy | Alzheimer Disease - enzymology | Parkinson Disease - physiopathology | Stroke - enzymology | Animals | Neurodegenerative Diseases - physiopathology | Neuroprotective Agents - classification | Parkinson Disease - enzymology | Muscular Atrophy, Spinal - drug therapy | Histone Deacetylase Inhibitors - therapeutic use | Histones - metabolism | Neurodegenerative Diseases - enzymology | Histones | Nervous system diseases | Analysis
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7672, pp. 389 - 393
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by... 
DENDRITIC CELLS | PATTERN | LANGERHANS CELL HISTIOCYTOSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | MODEL | ERDHEIM-CHESTER-DISEASE | EXPRESSION | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells
Journal Article
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 2012, Volume 35, Issue 11, pp. 700 - 709
Caspase-3 has been identified as a key mediator of neuronal programmed cell death. This protease plays a central role in the developing nervous system and its... 
Neurology | synaptic plasticity | synaptic loss | Alzheimer's disease | long-term depression | neuronal differentiation | long-term potentiation | Neuronal differentiation | Synaptic loss | Long-term depression | Long-term potentiation | Synaptic plasticity | ALZHEIMERS-DISEASE | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | PROGRAMMED CELL-DEATH | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | PRECURSOR PROTEIN | HUNTINGTONS-DISEASE | PARKINSONS-DISEASE | Nerve Net - embryology | Mitochondria - enzymology | Caspase Inhibitors - pharmacology | Humans | Huntington Disease - pathology | Neurons - cytology | Nerve Net - enzymology | Molecular Targeted Therapy | Alzheimer Disease - pathology | Caspase 3 - physiology | Nervous System - growth & development | Nervous System - embryology | Huntington Disease - enzymology | Disease Models, Animal | Nerve Net - growth & development | Long-Term Synaptic Depression - physiology | Nerve Tissue Proteins - physiology | Nervous System - enzymology | Parkinson Disease - pathology | Embryonic Development - physiology | Neural Tube - physiology | Alzheimer Disease - enzymology | Receptors, N-Methyl-D-Aspartate - physiology | Mice, Knockout | Animals | Caspase Inhibitors - therapeutic use | Neurons - enzymology | Parkinson Disease - enzymology | Apoptosis Regulatory Proteins - physiology | Mice | Apoptosis - physiology | Enzyme Activation | Nervous system diseases | Neurosciences | Neural networks | Proteases | Neurons | Depression, Mental | Apoptosis | Neurodegenerative diseases | Proteinase | Central nervous system | Caspase-3 | Neurological diseases | Axons | Mitochondria | Neural tube | Plasticity (synaptic) | Reviews | Differentiation
Journal Article
SCIENCE, ISSN 0036-8075, 09/2017, Volume 357, Issue 6357, pp. 1255 - 1255
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson's disease (PD), but how these... 
GLUCOCEREBROSIDASE | PACEMAKING | DJ-1 | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | MULTIDISCIPLINARY SCIENCES | Mitochondria - enzymology | Mesencephalon - metabolism | Humans | Protein Deglycase DJ-1 - genetics | Substantia Nigra - metabolism | Melanins - metabolism | Glucosylceramidase - deficiency | Lysosomes - metabolism | Dopaminergic Neurons - metabolism | Tacrolimus - pharmacology | Parkinson Disease - metabolism | Dopamine - metabolism | Disease Models, Animal | Substantia Nigra - enzymology | Cell Line | Calcineurin Inhibitors - pharmacology | Oxidation-Reduction | Mesencephalon - enzymology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Parkinson Disease - genetics | Mice, Knockout | Animals | Parkinson Disease - enzymology | Mice | Oxidative Stress - drug effects | alpha-Synuclein - metabolism | Oxidation-reduction reaction | Development and progression | Mitochondria | Dopamine | Parkinson's disease | Health aspects | Brain | Energy metabolism | Animal models | Target recognition | Mesencephalon | Pathogenesis | Substantia nigra | Parkinsons disease | Lysosomes | Synuclein | Accumulation | Pathways | Enzymatic activity | Neurodegeneration | Rodents | Oxidation | Degeneration | Species | Movement disorders | Dopamine receptors | Neurodegenerative diseases | Neurons | Medical treatment | Metabolism | Patients | Glucosylceramidase | Index Medicus
Journal Article
Archives of Toxicology, ISSN 0340-5761, 6/2015, Volume 89, Issue 6, pp. 867 - 882
Journal Article