X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (30855) 30855
Book Review (9375) 9375
Publication (3764) 3764
Book Chapter (464) 464
Conference Proceeding (252) 252
Book / eBook (110) 110
Web Resource (30) 30
Dissertation (18) 18
Magazine Article (15) 15
Data Set (13) 13
Streaming Video (12) 12
Reference (9) 9
Trade Publication Article (5) 5
Newspaper Article (4) 4
Government Document (2) 2
Journal / eJournal (1) 1
Paper (1) 1
Poster (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (26453) 26453
humans (18837) 18837
neurodegenerative diseases (17877) 17877
animals (17366) 17366
neurosciences (11013) 11013
alzheimer's disease (8029) 8029
alzheimers-disease (7164) 7164
mice (6912) 6912
brain (6666) 6666
male (6624) 6624
oxidative stress (6394) 6394
biochemistry & molecular biology (6133) 6133
neurodegeneration (5770) 5770
proteins (5699) 5699
neurodegenerative diseases - metabolism (5545) 5545
parkinson's disease (5164) 5164
neurology (4968) 4968
female (4613) 4613
neurons (4528) 4528
cell biology (4410) 4410
nervous system diseases (4335) 4335
parkinsons-disease (4199) 4199
rats (4059) 4059
brain - metabolism (3547) 3547
multidisciplinary sciences (3535) 3535
nervous system (3483) 3483
disease models, animal (3478) 3478
apoptosis (3476) 3476
analysis (3468) 3468
medicine (3445) 3445
neurons - metabolism (3443) 3443
movement disorders (3328) 3328
research article (3328) 3328
alzheimers disease (3267) 3267
neurodegenerative diseases - pathology (3230) 3230
rodents (3183) 3183
science (2964) 2964
mutation (2922) 2922
clinical neurology (2718) 2718
article (2707) 2707
neurodegenerative disease (2680) 2680
dementia (2677) 2677
gene expression (2660) 2660
research (2554) 2554
aged (2547) 2547
biology (2518) 2518
pathology (2514) 2514
pharmacology & pharmacy (2502) 2502
physiological aspects (2480) 2480
metabolism (2463) 2463
inflammation (2458) 2458
mitochondria (2336) 2336
neuroprotection (2320) 2320
aging (2317) 2317
alzheimer disease - metabolism (2314) 2314
alpha-synuclein (2278) 2278
disease (2274) 2274
neurodegenerative diseases - genetics (2262) 2262
brain - pathology (2257) 2257
neurodegenerative disorders (2228) 2228
neuroscience (2196) 2196
amyotrophic-lateral-sclerosis (2148) 2148
middle aged (2144) 2144
signal transduction (2081) 2081
animal models (2077) 2077
cells, cultured (2073) 2073
phosphorylation (2067) 2067
cognitive ability (2058) 2058
degeneration (1975) 1975
neurological diseases (1972) 1972
mice, transgenic (1937) 1937
neurodegenerative diseases - physiopathology (1924) 1924
dopamine (1853) 1853
neurodegenerative diseases - drug therapy (1832) 1832
transgenic mice (1823) 1823
biochemistry (1792) 1792
mouse model (1776) 1776
pathogenesis (1757) 1757
central-nervous-system (1747) 1747
neurons - pathology (1746) 1746
mice, inbred c57bl (1740) 1740
expression (1731) 1731
cell death (1692) 1692
health aspects (1667) 1667
genetic aspects (1638) 1638
neurons - drug effects (1637) 1637
enzymes (1617) 1617
in-vivo (1613) 1613
neurotoxicity (1609) 1609
amyloid precursor protein (1595) 1595
biomedicine (1582) 1582
alzheimer disease - pathology (1549) 1549
in-vitro (1541) 1541
antioxidants (1501) 1501
studies (1492) 1492
amyloid beta-peptides - metabolism (1486) 1486
hippocampus (1485) 1485
kinases (1485) 1485
protein (1478) 1478
mitochondria - metabolism (1471) 1471
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (45) 45
Online Resources - Online (35) 35
Collection Dvlpm't (Acquisitions) - Vendor file (12) 12
Collection Dvlpm't (Acquisitions) - Closed Orders (7) 7
UofT at Mississauga - Stacks (5) 5
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (4) 4
Providence Healthcare - Stacks (3) 3
UofT at Scarborough - Stacks (3) 3
Baycrest Hospital - Stacks (2) 2
Gerstein Science - Circulation Desk (1) 1
Providence Healthcare - Reference (1) 1
St. Michael's Hospital - Stacks (1) 1
Trillium Health Centre - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (30737) 30737
Japanese (155) 155
French (60) 60
Spanish (60) 60
Polish (55) 55
Russian (47) 47
German (35) 35
Chinese (32) 32
Hungarian (9) 9
Portuguese (8) 8
Czech (4) 4
Danish (4) 4
Korean (3) 3
Turkish (3) 3
Icelandic (2) 2
Catalan (1) 1
Corsican (1) 1
Croatian (1) 1
Dutch (1) 1
Finnish (1) 1
Italian (1) 1
Norwegian (1) 1
Romanian (1) 1
Serbian (1) 1
Swedish (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Disease | Transcription | Genes | Homeostasis | Sclerosis | Proteins | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | Plaques | Myeloid cells | Neurodegenerative diseases | Microglia | Neurological diseases | Molecular modelling | β-Amyloid | Phagocytosis | Apoptosis | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 08/2017, Volume 170, Issue 4, pp. 649 - 663.e13
Journal Article
SCIENCE, ISSN 0036-8075, 09/2017, Volume 357, Issue 6357, pp. 1255 - 1255
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson's disease (PD), but how these... 
GLUCOCEREBROSIDASE | PACEMAKING | DJ-1 | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | MULTIDISCIPLINARY SCIENCES | Mitochondria - enzymology | Mesencephalon - metabolism | Humans | Protein Deglycase DJ-1 - genetics | Substantia Nigra - metabolism | Melanins - metabolism | Glucosylceramidase - deficiency | Lysosomes - metabolism | Dopaminergic Neurons - metabolism | Tacrolimus - pharmacology | Parkinson Disease - metabolism | Dopamine - metabolism | Disease Models, Animal | Substantia Nigra - enzymology | Cell Line | Calcineurin Inhibitors - pharmacology | Oxidation-Reduction | Mesencephalon - enzymology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Parkinson Disease - genetics | Mice, Knockout | Animals | Parkinson Disease - enzymology | Mice | Oxidative Stress - drug effects | alpha-Synuclein - metabolism | Oxidation-reduction reaction | Development and progression | Mitochondria | Dopamine | Parkinson's disease | Health aspects | Brain | Energy metabolism | Animal models | Target recognition | Mesencephalon | Pathogenesis | Substantia nigra | Parkinsons disease | Lysosomes | Synuclein | Accumulation | Pathways | Enzymatic activity | Neurodegeneration | Rodents | Oxidation | Degeneration | Species | Movement disorders | Dopamine receptors | Neurodegenerative diseases | Neurons | Medical treatment | Metabolism | Patients | Glucosylceramidase | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2010, Volume 30, Issue 9, pp. 3184 - 3198
Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and... 
BACKBONE DYNAMICS | MULTIPLE SYSTEM ATROPHY | INCLUSION FORMATION | BETA-SHEET | ALZHEIMERS-DISEASE | SERINE 129 | TAU-PHOSPHORYLATION | NEUROSCIENCES | LEWY BODIES | RAT MODEL | PARKINSONS-DISEASE | Phosphorylation | Rats, Wistar | Humans | Male | Brain - metabolism | Lewy Bodies - genetics | Lewy Body Disease - genetics | Protein Isoforms - metabolism | Multiple System Atrophy - metabolism | Cell Membrane - metabolism | Neurons - metabolism | Parkinson Disease - metabolism | Lewy Bodies - metabolism | Lewy Bodies - pathology | Disease Models, Animal | Alzheimer Disease - physiopathology | Rats | Mice, Transgenic | Neurodegenerative Diseases - genetics | Amino Acid Sequence - physiology | Multiple System Atrophy - genetics | Neurodegenerative Diseases - metabolism | Parkinson Disease - genetics | Parkinson Disease - physiopathology | Serine - metabolism | alpha-Synuclein - chemistry | Creatine Kinase - genetics | Lewy Body Disease - metabolism | Animals | Neurodegenerative Diseases - physiopathology | Alzheimer Disease - metabolism | Brain - pathology | Creatine Kinase - metabolism | Mice | Multiple System Atrophy - physiopathology | Alzheimer Disease - genetics | alpha-Synuclein - metabolism | Polymers - metabolism | Lewy Body Disease - physiopathology | Protein Isoforms - genetics | Index Medicus | serine 87 | phosphorylation | synucleinopathies | phosphomimics | Parkinson’s disease | α-synuclein
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2012, Volume 32, Issue 39, pp. 13454 - 13469
Abnormal deposition and intercellular propagation of alpha-synuclein plays a central role in the pathogenesis of disorders such as Parkinson's Disease (PD) and... 
IMMUNIZATION | PROTEIN | PLASMA | BIOMARKER | ALZHEIMERS-DISEASE | MOUSE MODEL | PATHOLOGY | FC-GAMMA-RIIA | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | PARKINSONS-DISEASE | Synaptic Transmission - physiology | Antibodies - metabolism | Lewy Body Disease - immunology | Humans | alpha-Synuclein - immunology | Extracellular Space - drug effects | Nerve Degeneration - genetics | Cell Communication - physiology | Culture Media, Conditioned - pharmacology | Phosphopyruvate Hydratase - metabolism | Amyloid - ultrastructure | Antigens, CD - metabolism | Neuroglia - drug effects | Brain - metabolism | Lewy Body Disease - genetics | Extracellular Space - metabolism | Amyloid - metabolism | Microfilament Proteins - metabolism | alpha-Synuclein - genetics | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Cell Line | Microscopy, Electron, Transmission | Cytokines - metabolism | Mice, Transgenic | Nerve Degeneration - immunology | Cathepsin D - metabolism | Extracellular Space - immunology | Antibodies - pharmacology | Caveolin 1 - metabolism | Lewy Body Disease - metabolism | Platelet-Derived Growth Factor - metabolism | Animals | Analysis of Variance | Brain - pathology | Immunization, Passive | Neuroglia - metabolism | Mice | Chromatography, Gel | alpha-Synuclein - metabolism | Nerve Degeneration - drug therapy | Astrocytes - metabolism | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2009, Volume 11, Issue 2, pp. 219 - 225
Sequence-specific nucleated protein aggregation is closely linked to the pathogenesis of most neurodegenerative diseases and constitutes the molecular basis of... 
IN-VITRO | PROTEIN MISFOLDING DISEASES | PEPTIDES | FIBRILS | MECHANISM | TOXICITY | HUNTINGTIN | PROPAGATION | YEAST PRION | CELL BIOLOGY | Prion Diseases - physiopathology | Humans | Cell Communication - physiology | Cytoplasm - metabolism | Cytoplasm - pathology | Peptides - metabolism | Peptides - toxicity | Amyloid - biosynthesis | Disease Transmission, Infectious | Inclusion Bodies - metabolism | Huntington Disease - physiopathology | Cell Line | Neurodegenerative Diseases - pathology | Amyloidosis - pathology | Amyloidosis - physiopathology | Neurodegenerative Diseases - metabolism | Neurofibrils - pathology | Huntington Disease - metabolism | Endocytosis - physiology | Neurodegenerative Diseases - physiopathology | Proteasome Endopeptidase Complex - ultrastructure | Trinucleotide Repeat Expansion - genetics | Proteasome Endopeptidase Complex - metabolism | Amyloidosis - metabolism | Prion Diseases - metabolism | Neurofibrils - metabolism | Amyloid beta-protein | Physiological aspects | Nervous system | Genetic aspects | Degeneration | Research | Glutamine | Index Medicus | Huntington Disease | Neurodegenerative Diseases | Peptides | Neurofibrils | Cell Communication | Proteasome Endopeptidase Complex | Trinucleotide Repeat Expansion | Life Sciences | Prion Diseases | Endocytosis | Inclusion Bodies | Amyloid | Amyloidosis | Cytoplasm
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 512 - 516
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4(1). APOE4 is a major genetic risk factor for Alzheimer's disease(2,3) and is associated with... 
OXIDATIVE STRESS | DEMENTIA | PROTEIN | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | COGNITIVE IMPAIRMENT | NEURODEGENERATION | MICE | APOE | BLOOD-BRAIN-BARRIER | EXPRESSION | Neurons - pathology | Apolipoprotein E4 - genetics | Apolipoproteins E - deficiency | Cerebrovascular Circulation - physiology | Humans | Blood-Brain Barrier - physiopathology | NF-kappa B - metabolism | Apolipoproteins E - metabolism | Microcirculation | Matrix Metalloproteinase 9 - metabolism | Apolipoprotein E2 - deficiency | Apolipoprotein E4 - deficiency | Apolipoprotein E3 - deficiency | Blood-Brain Barrier - physiology | Neurons - metabolism | Cyclophilin A - metabolism | Apolipoprotein E4 - metabolism | Neurodegenerative Diseases - pathology | Apolipoprotein E2 - genetics | Pericytes - metabolism | Mice, Transgenic | Hippocampus - pathology | Neurodegenerative Diseases - metabolism | Apolipoprotein E3 - metabolism | Apolipoprotein E2 - metabolism | Blood-Brain Barrier - drug effects | Cyclophilin A - antagonists & inhibitors | Hippocampus - metabolism | Apolipoprotein E3 - genetics | Animals | Apolipoproteins E - genetics | Mice | Cyclophilin A - deficiency | Cyclophilin | Brain cells | Physiological aspects | Development and progression | Apolipoproteins | Properties | Alzheimer's disease | Proteins | Studies | Rodents | Index Medicus
Journal Article
Journal Article
Journal Article