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1. Full Text Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
by Liu-Chittenden, Yi and Huang, Bo and Shim, Joong Sup and Chen, Qian and Lee, Se-Jin and Anders, Robert A and Liu, Jun O and Pan, Duojia
Genes and Development, ISSN 0890-9369, 06/2012, Volume 26, Issue 12, pp. 1300 - 1305
The Drosophila TEAD ortholog Scalloped is required for Yki-mediated overgrowth but is largely dispensable for normal tissue growth, suggesting that its... 
Chemical biology | YAP | Hippo signaling | Oncogene | APOPTOSIS | GROWTH-CONTROL | ORGAN SIZE CONTROL | HIPPO SIGNALING PATHWAY | CELL-PROLIFERATION | DEVELOPMENTAL BIOLOGY | oncogene | CANCER | DROSOPHILA | CELL BIOLOGY | INHIBITION | chemical biology | GENETICS & HEREDITY | TUMORIGENESIS | MAMMALS | Hepatomegaly - pathology | Liver - pathology | Humans | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Liver - drug effects | Protein Binding - drug effects | HEK293 Cells | Neurofibromin 2 - metabolism | Liver - metabolism | Mice, Transgenic | Phosphoproteins - genetics | Porphyrins - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Phenotype | Animals | Adaptor Proteins, Signal Transducing - genetics | Hepatomegaly - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Genes, Dominant - genetics | Research Communication
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2. Full Text Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
by Basu-Roy, Upal and Bayin, N. Sumru and Rattanakorn, Kirk and Han, Eugenia and Placantonakis, Dimitris G and Mansukhani, Alka and Basilico, Claudio
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6411
The repressive Hippo pathway has a profound tumour suppressive role in cancer by restraining the growth-promoting function of the transcriptional coactivator,... 
INHIBITION | ORGAN SIZE CONTROL | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | GROWTH | TISSUE REGENERATION | YAP | OSTEOSARCOMA | PROLIFERATION | TAZ | Neurofibromin 2 - genetics | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - genetics | Phosphoproteins - metabolism | RNA, Messenger - metabolism | SOXB1 Transcription Factors - metabolism | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Glioblastoma - metabolism | Osteosarcoma - genetics | Adaptor Proteins, Signal Transducing - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Neurofibromin 2 - metabolism | Real-Time Polymerase Chain Reaction | Osteosarcoma - metabolism | Protein-Serine-Threonine Kinases - metabolism
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3. Full Text A molecular mechanotransduction pathway regulates collective migration of epithelial cells
by Das, Tamal and Safferling, Kai and Rausch, Sebastian and Grabe, Niels and Boehm, Heike and Spatz, Joachim P
Nature Cell Biology, ISSN 1465-7392, 03/2015, Volume 17, Issue 3, pp. 276 - 287
Collective movement of epithelial cells drives essential multicellular organization during various fundamental physiological processes encompassing embryonic... 
MERLIN | ACTIVATION | COMPLEX | NF2 TUMOR-SUPPRESSOR | RAC | KINASE | MOVEMENT | DYNAMICS | FORCES | CANCER | CELL BIOLOGY | Cell Line | Neurofibromin 2 - genetics | Actin Cytoskeleton - metabolism | Pseudopodia - ultrastructure | Rheology | Humans | Gene Expression Regulation | Intercellular Junctions - metabolism | Cell Communication | Actomyosin - metabolism | Cell Adhesion | Time-Lapse Imaging | Animals | Pseudopodia - metabolism | Keratinocytes - metabolism | Dogs | Madin Darby Canine Kidney Cells | Actin Cytoskeleton - ultrastructure | Keratinocytes - ultrastructure | Mechanotransduction, Cellular - genetics | Neurofibromin 2 - metabolism | rac1 GTP-Binding Protein - metabolism | Cell Movement | rac1 GTP-Binding Protein - genetics | Tumor suppressor genes | Cell research | Research | Properties | Cell migration
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4. Full Text Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
by Serrano, Isabel and McDonald, Paul C and Lock, Frances and Muller, William J and Dedhar, Shoukat
Nature Communications, ISSN 2041-1723, 12/2013, Volume 4, Issue 1, p. 2976
One of the hallmarks of cancers is the silencing of tumour suppressor genes and pathways. The Hippo tumour suppressor pathway is inactivated in many types of... 
PHOSPHATASE TARGET SUBUNIT | TISSUE-GROWTH | BREAST-CANCER CELLS | GROWTH-CONTROL | STEM-CELLS | PHOSPHORYLATION | SIGNALING-PATHWAY | MULTIDISCIPLINARY SCIENCES | CONTACT INHIBITION | UBIQUITIN LIGASE CRL4(DCAF1) | YAP PATHWAY | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Phosphorylation | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Male | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Glioma - metabolism | Neoplasm Metastasis | Gene Deletion | Myosin-Light-Chain Phosphatase - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Gene Silencing | Mice, Transgenic | Nuclear Proteins - metabolism | Disease Progression | Hepatocyte Growth Factor - metabolism | Transcription Factors - metabolism | Animals | Cell Line, Tumor | Mice | Apoptosis
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5. Full Text Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
by Mindos, Thomas and Dun, Xin-peng and North, Katherine and Doddrell, Robin D.S and Schulz, Alexander and Edwards, Philip and Russell, James and Gray, Bethany and Roberts, Sheridan L and Shivane, Aditya and Mortimer, Georgina and Pirie, Melissa and Zhang, Nailing and Pan, Duojia and Morrison, Helen and Parkinson, David B
Journal of Cell Biology, ISSN 0021-9525, 2017, Volume 216, Issue 2, pp. 495 - 510
Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play major roles in the control of cell proliferation and tumorigenesis. We... 
MYELIN | PERIPHERAL-NERVES | ORGAN SIZE CONTROL | SIGNALING PATHWAY | REGENERATION | TISSUE HOMEOSTASIS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | YAP | C-JUN | NEGATIVE REGULATOR | CELL BIOLOGY | Neurofibromin 2 - genetics | Sciatic Nerve - injuries | Cell Proliferation | Male | Sciatic Nerve - physiopathology | Crush Injuries - genetics | Nerve Growth Factors - metabolism | Motor Activity | Phosphoproteins - metabolism | Recovery of Function | Myelin Sheath - metabolism | Sciatic Nerve - metabolism | Sciatic Neuropathy - genetics | Time Factors | Neurofibromin 2 - deficiency | Female | Crush Injuries - pathology | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Signal Transduction | Sciatic Nerve - pathology | Axons - metabolism | Sciatic Neuropathy - pathology | Genotype | Schwann Cells - pathology | Schwann Cells - metabolism | Crush Injuries - physiopathology | Nerve Regeneration | Phosphoproteins - genetics | Mice, Knockout | Crush Injuries - metabolism | Phenotype | Animals | Neuronal Plasticity | Proto-Oncogene Proteins c-jun - metabolism | Adaptor Proteins, Signal Transducing - deficiency | Axons - pathology | Phosphoproteins - deficiency | Adaptor Proteins, Signal Transducing - genetics | Sciatic Neuropathy - physiopathology | Adaptor Proteins, Signal Transducing - metabolism | Sciatic Neuropathy - metabolism | Mitogen-Activated Protein Kinases - metabolism
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6. Full Text KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals
by Moleirinho, S and Chang, N and Sims, A.H and Tilston-Lünel, A.M and Angus, L and Steele, A and Boswell, V and Barnett, S.C and Ormandy, C and Faratian, D and Gunn-Moore, F.J and Reynolds, P.A
Oncogene, ISSN 0950-9232, 04/2013, Volume 32, Issue 14, pp. 1821 - 1830
The Salvador/Warts/Hippo (Hippo) signaling pathway defines a novel signaling cascade regulating cell contact inhibition, organ size control, cell growth,... 
KIBRA | Willin | breast cancer | Hippo pathway | Merlin | claudin-low | APOPTOSIS | PROTEIN | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | YAP | PROLIFERATION | DROSOPHILA | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER CELLS | ONCOGENE | ONCOLOGY | CYCLE EXIT | GENETICS & HEREDITY | RNA, Small Interfering - genetics | Neurofibromin 2 - genetics | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Cytoskeletal Proteins - genetics | Humans | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Immunoenzyme Techniques | Hepatocyte Growth Factor - antagonists & inhibitors | Biomarkers, Tumor - metabolism | Hepatocyte Growth Factor - genetics | Carcinoma, Ductal, Breast - pathology | Carcinoma, Ductal, Breast - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Breast - cytology | Membrane Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Hepatocyte Growth Factor - metabolism | Breast Neoplasms - genetics | Claudin-1 - genetics | Biomarkers, Tumor - genetics | Cell Movement | Carcinoma, Ductal, Breast - genetics | Phosphorylation | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Breast - metabolism | Breast Neoplasms - metabolism | Claudin-1 - metabolism | Epithelial-Mesenchymal Transition | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cytoskeletal Proteins - metabolism | Female | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Neurofibromin 2 - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Phosphoproteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Breast Neoplasms - pathology | Nuclear Proteins - antagonists & inhibitors | Apoptosis | Cellular proteins | Prognosis | Physiological aspects | Breast cancer | Genetic aspects | Cellular signal transduction | Research | Health aspects | Mammals | Gene expression
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7. Full Text The Hippo Pathway Member Nf2 Is Required for Inner Cell Mass Specification
by Cockburn, Katie and Biechele, Steffen and Garner, Jodi and Rossant, Janet
Current Biology, ISSN 0960-9822, 07/2013, Volume 23, Issue 13, pp. 1195 - 1201
During mammalian development, the first two lineages to be specified are the trophectoderm (TE) and the inner cell mass (ICM). The Hippo pathway kinases Lats 1... 
MERLIN | YAP1 | ACTS DOWNSTREAM | TROPHECTODERM | SUPPRESSOR GENE-PRODUCT | ALPHA-CATENIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TUMOR-SUPPRESSOR | NANOG | EXPRESSION | CELL BIOLOGY | Neurofibromin 2 - genetics | Phosphorylation | Tumor Suppressor Proteins - metabolism | Signal Transduction | Homeodomain Proteins - metabolism | Blastocyst - metabolism | Protein-Serine-Threonine Kinases - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Phosphoproteins - metabolism | Homeodomain Proteins - genetics | Mice, Inbred ICR | Transcription Factors - metabolism | Animals | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Polymerase Chain Reaction | Mice | Adaptor Proteins, Signal Transducing - metabolism | CDX2 Transcription Factor | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Molecular genetics | RNA | Phosphotransferases | Children's hospitals | Stem cells
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8. Full Text Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2
by Yin, Feng and Yu, Jianzhong and Zheng, Yonggang and Chen, Qian and Zhang, Nailing and Pan, Duojia
Cell, ISSN 0092-8674, 09/2013, Volume 154, Issue 6, pp. 1342 - 1355
Although Merlin/NF2 was discovered two decades ago as a tumor suppressor underlying Neurofibromatosis type II, its precise molecular mechanism remains poorly... 
TISSUE-GROWTH | F-ACTIN | PATHWAY | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESTRICTS | CELL-PROLIFERATION | NF2 GENE | CONJUNCTION | SALVADOR | CELL BIOLOGY | Amino Acid Sequence | Signal Transduction | Drosophila melanogaster - cytology | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Biological Evolution | Drosophila melanogaster - metabolism | Sequence Alignment | Animals | Cytoskeleton - metabolism | Cell Membrane - metabolism | Mice | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell membranes | Muscle proteins | Analysis | Tumors
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9. Full Text PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
by De Raedt, Thomas and De Raedt, Thomas and Beert, Eline and Beert, Eline and Pasmant, Eric and Pasmant, Eric and Luscan, Armelle and Luscan, Armelle and Brems, Hilde and Brems, Hilde and Ortonne, Nicolas and Ortonne, Nicolas and Helin, Kristian and Helin, Kristian and Hornick, Jason L and Hornick, Jason L and Mautner, Victor and Mautner, Victor and Kehrer-Sawatzki, Hildegard and Kehrer-Sawatzki, Hildegard and Clapp, Wade and Clapp, Wade and Bradner, James and Bradner, James and Vidaud, Michel and Vidaud, Michel and Upadhyaya, Meena and Upadhyaya, Meena and Legius, Eric and Legius, Eric and Cichowski, Karen and Cichowski, Karen
Nature, ISSN 0028-0836, 2014, Volume 514, Issue 7521, pp. 247 - 251
The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types(1). However, loss-of-function mutations in PRC2 components occur in a... 
SUPPRESSOR | GENE | MULTIDISCIPLINARY SCIENCES | MICE | NF1 MICRODELETION PATIENTS | MUTATIONS | BET BROMODOMAIN INHIBITION | CANCER | TUMORS | NEUROFIBROMATOSIS TYPE-1 | EZH2 | Chromatin - metabolism | Transcription, Genetic - drug effects | Polycomb Repressive Complex 2 - genetics | Humans | Transcription Factors - deficiency | ras Proteins - metabolism | Neurofibromin 1 - deficiency | Glioma - genetics | Neoplasms - genetics | Melanoma - genetics | Tumor Suppressor Proteins - deficiency | Glioma - pathology | Nerve Sheath Neoplasms - pathology | Nuclear Proteins - deficiency | Tumor Suppressor Proteins - genetics | Epigenesis, Genetic - drug effects | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Chromatin - drug effects | Nerve Sheath Neoplasms - drug therapy | Disease Models, Animal | Triazoles - therapeutic use | Nerve Sheath Neoplasms - genetics | Tumor Suppressor Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Melanoma - pathology | Transcription Factors - genetics | Azepines - therapeutic use | Neoplasms - drug therapy | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Polycomb Repressive Complex 2 - deficiency | Melanoma - drug therapy | Nuclear Proteins - antagonists & inhibitors | Mice | Neoplasms - pathology | Polycomb Repressive Complex 2 - metabolism | Chromatin - genetics | Neurofibromin 1 - genetics | Glioma - drug therapy | Epigenetic inheritance | Ras genes | Genetic transcription | Research | Gliomas | Studies | Mutation | Genes | Tumors | Defects
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10. Full Text A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
by Moroishi, Toshiro and Park, Hyun Woo and Qin, Baodong and Chen, Qian and Meng, Zhipeng and Plouffe, Steven W and Taniguchi, Koji and Yu, Fa-Xing and Karin, Michael and Pan, Duojia and Guan, Kun-Liang
Genes and Development, ISSN 0890-9369, 06/2015, Volume 29, Issue 12, pp. 1271 - 1284
YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are major downstream effectors of the Hippo pathway that influences... 
YAP | Negative feedback | Phosphorylation | Hippo pathway | TAZ | Cancer | MIGRATION | CELL-PROLIFERATION | ACTIN-BINDING | DEVELOPMENTAL BIOLOGY | negative feedback | CELL BIOLOGY | SIGNALING PATHWAY | GROWTH | GENETICS & HEREDITY | YAP ONCOPROTEIN | cancer | phosphorylation | ANGIOMOTIN | Humans | Male | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Female | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Cells, Cultured | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Homeostasis - physiology | Adaptor Proteins, Signal Transducing - genetics | Mice | Feedback, Physiological - physiology | Adaptor Proteins, Signal Transducing - metabolism | Enzyme Activation - physiology | Homeostasis - genetics | Cell Movement | Transcriptional coactivators | Research | Carcinogenesis | Research Paper
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11. Full Text An essential role for the tumor-suppressor merlin in regulating fatty acid synthesis
by Stepanova, Dina S and Semenova, Galina and Kuo, Yin-Ming and Andrews, Andrew J and Ammoun, Sylwia and Hanemann, C. Oliver and Chernoff, Jonathan
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 18, pp. 5026 - 5038
Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the development of multiple tumors in the central nervous system, most... 
Fatty Acid Synthase, Type I - genetics | Neurofibromin 2 - genetics | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes - genetics | Meningioma - genetics | Embryo, Mammalian - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Neurilemmoma - genetics | Biomarkers, Tumor - metabolism | Female | Lipogenesis | Fatty Acids - metabolism | Neurofibromin 2 - metabolism | Fibroblasts - metabolism | Meningeal Neoplasms - genetics | Meningioma - metabolism | Cells, Cultured | Rats | Survival Rate | Fatty Acid Synthase, Type I - metabolism | Neurilemmoma - pathology | Xenograft Model Antitumor Assays | Meningioma - pathology | Animals | Neurilemmoma - metabolism | Embryo, Mammalian - cytology | Mice, Nude | Biomarkers, Tumor - genetics | Fibroblasts - cytology | Meningeal Neoplasms - metabolism | Mice | Meningeal Neoplasms - pathology | Apoptosis | Deactivation | Central nervous system | Schwann cells | Neurofibromin 2 | Neurofibromatosis 2 | Metabolism | Palmitic acid | Inactivation | Fatty acids | Fatty-acid synthase | Hereditary diseases | Molecular modelling | Inhibitors | Neurofibromatosis | Tumor suppressor genes | Lipid metabolism | Mutation | Tumors | Cancer | small molecule inhibitors | metabolism | fatty acid synthesis | neurofibromatosis 2 | schwannoma
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12. Full Text Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types
by James, Marianne F and Stivison, Elizabeth and Beauchamp, Roberta and Han, Sangyeul and Li, Hua and Wallace, Margaret R and Gusella, James F and Stemmer-Rachamimov, Anat O and Ramesh, Vijaya
Molecular Cancer Research, ISSN 1541-7786, 05/2012, Volume 10, Issue 5, pp. 649 - 659
Inactivating mutations in the neurofibromatosis 2 (NF2) tumor suppressor gene results in the development of schwannomas and meningiomas. Using NF2-deficient... 
MERLIN | TSC1-TSC2 COMPLEX | ACTIVATION | VESTIBULAR SCHWANNOMA | GENE | ONCOLOGY | PATHWAY | GROWTH | TUMOR-SUPPRESSOR | TUBEROUS SCLEROSIS | NF2 | CELL BIOLOGY | Neurofibromin 2 - genetics | Humans | Multiprotein Complexes | Meningioma - genetics | Mechanistic Target of Rapamycin Complex 1 | Neurilemmoma - genetics | RNA Interference | Neurofibromin 2 - deficiency | Gene Expression Regulation, Neoplastic - drug effects | Oncogene Protein v-akt - metabolism | Neurofibromin 2 - metabolism | Gene Expression Regulation, Neoplastic - genetics | Meningeal Neoplasms - genetics | Meningioma - metabolism | Signal Transduction | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Sirolimus - pharmacology | Tuberous Sclerosis - genetics | Transcription Factors - metabolism | Proteins - metabolism | Neurilemmoma - metabolism | Tuberous Sclerosis - metabolism | Cell Line, Tumor | Meningeal Neoplasms - metabolism | TOR Serine-Threonine Kinases | Proteins - antagonists & inhibitors | Naphthyridines - pharmacology
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13. Full Text β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin
by Sabra, Hiba and Brunner, Molly and Mandati, Vinay and Wehrle-Haller, Bernhard and Lallemand, Dominique and Ribba, Anne-Sophie and Chevalier, Genevieve and Guardiola, Philippe and Block, Marc R and Bouvard, Daniel
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 47, pp. 19179 - 19197
Cell adhesion to the extracellular matrix or to surrounding cells plays a key role in cell proliferation and differentiation and is critical for proper tissue... 
Neurofibromin 2 - genetics | Cell Proliferation | Phosphoproteins - metabolism | Embryo, Mammalian - metabolism | Integrin beta1 - physiology | Tumor Suppressor Proteins - genetics | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Genes, Neurofibromatosis 2 - physiology | Tumor Suppressor Proteins - metabolism | p21-Activated Kinases - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Phosphoproteins - genetics | p21-Activated Kinases - metabolism | Cell Adhesion | Mice, Knockout | Animals | Embryo, Mammalian - cytology | Adaptor Proteins, Signal Transducing - genetics | Fibroblasts - cytology | Mice | Adaptor Proteins, Signal Transducing - metabolism | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Life Sciences | Biochemistry, Molecular Biology | adhesion | cell proliferation | yes-associated protein (YAP) | integrin | Rac (Rac GTPase) | Cell Biology
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14. Full Text ERM proteins and merlin: integrators at the cell cortex
by Edwards, Kevin and Fehon, Richard G and Bretscher, Anthony
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 08/2002, Volume 3, Issue 8, pp. 586 - 599
A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | CAMP-MEDIATED INHIBITION | AMINO-TERMINAL DOMAIN | RHO-ASSOCIATED KINASE | EXCHANGER REGULATORY FACTOR | MEMBRANE-MICROFILAMENT LINKER | TUMOR-SUPPRESSOR PROTEIN | ACTIN-BINDING-SITE | BORDER NA+/H+ EXCHANGER | TYROSINE KINASE SUBSTRATE | CELL BIOLOGY | Protein Structure, Tertiary | Cell Line | Cell Polarity | Multigene Family | Tumor Suppressor Proteins - metabolism | Humans | Phylogeny | Blood Proteins - metabolism | Phosphoproteins - metabolism | Animals | Models, Biological | Cytoskeleton - metabolism | Cytoskeletal Proteins - metabolism | Signal Transduction - physiology | Cell Membrane - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Neurofibromin 2 - metabolism
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