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1. Full Text Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling
by Wu, Jiao and Minikes, Alexander M and Gao, Minghui and Bian, Huijie and Li, Yong and Stockwell, Brent R and Chen, Zhi-Nan and Jiang, Xuejun
Nature (London), ISSN 0028-0836, 08/2019, Volume 572, Issue 7769, pp. 402 - 406
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Epithelial Cells - metabolism | Cadherins - metabolism | Mesothelioma - pathology | Signal Transduction | Cell Count | HCT116 Cells | Humans | Ferroptosis | Receptors, Transferrin - metabolism | Antigens, CD - metabolism | Coenzyme A Ligases - metabolism | Transcription Factors - metabolism | Animals | Mesothelioma - metabolism | Female | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell interaction | Cell death | Analysis | Cancer cells | Transcription | Mesenchyme | Epithelial cells | p53 Protein | Lipid peroxidation | Neurofibromin 2 | Mesothelioma | Intracellular signalling | Lipids | Iron | Kinases | Inactivation | E-cadherin | Modulators | Cell adhesion & migration | Metastases | Signal transduction | Fumarase | Peroxides | Peroxidase | Lipid metabolism | Glutathione | Peroxidation | Glutathione peroxidase | Deactivation | Byproducts | Substrate inhibition | Metabolism | Lymphoma | Suppressors | Yes-associated protein | Signaling | Depletion | Intracellular | Tumors | Cancer | Apoptosis | Index Medicus
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2. Full Text Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
by Mindos, Thomas and Dun, Xin-peng and North, Katherine and Doddrell, Robin D.S and Schulz, Alexander and Edwards, Philip and Russell, James and Gray, Bethany and Roberts, Sheridan L and Shivane, Aditya and Mortimer, Georgina and Pirie, Melissa and Zhang, Nailing and Pan, Duojia and Morrison, Helen and Parkinson, David B
The Journal of cell biology, ISSN 0021-9525, 2017, Volume 216, Issue 2, pp. 495 - 510
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neurofibromin 2 - genetics | Sciatic Nerve - injuries | Cell Proliferation | Male | Sciatic Nerve - physiopathology | Crush Injuries - genetics | Nerve Growth Factors - metabolism | Motor Activity | Phosphoproteins - metabolism | Recovery of Function | Myelin Sheath - metabolism | Sciatic Nerve - metabolism | Sciatic Neuropathy - genetics | Time Factors | Neurofibromin 2 - deficiency | Female | Crush Injuries - pathology | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Signal Transduction | Sciatic Nerve - pathology | Axons - metabolism | Sciatic Neuropathy - pathology | Genotype | Schwann Cells - pathology | Schwann Cells - metabolism | Crush Injuries - physiopathology | Nerve Regeneration | Phosphoproteins - genetics | Mice, Knockout | Crush Injuries - metabolism | Phenotype | Animals | Neuronal Plasticity | Proto-Oncogene Proteins c-jun - metabolism | Adaptor Proteins, Signal Transducing - deficiency | Axons - pathology | Phosphoproteins - deficiency | Adaptor Proteins, Signal Transducing - genetics | Sciatic Neuropathy - physiopathology | Adaptor Proteins, Signal Transducing - metabolism | Sciatic Neuropathy - metabolism | Cell Cycle Proteins | Mitogen-Activated Protein Kinases - metabolism | Proteins | Nervous system | Cell growth | Tumorigenesis | Cellular biology | Tumors | Index Medicus
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3. Full Text KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals
by Moleirinho, S and Chang, N and Sims, A.H and Tilston-LĂĽnel, A.M and Angus, L and Steele, A and Boswell, V and Barnett, S.C and Ormandy, C and Faratian, D and Gunn-Moore, F.J and Reynolds, P.A
Oncogene, ISSN 0950-9232, 04/2013, Volume 32, Issue 14, pp. 1821 - 1830
KIBRA | Willin | breast cancer | Hippo pathway | Merlin | claudin-low | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Neurofibromin 2 - genetics | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Cytoskeletal Proteins - genetics | Humans | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Immunoenzyme Techniques | Hepatocyte Growth Factor - antagonists & inhibitors | Biomarkers, Tumor - metabolism | Hepatocyte Growth Factor - genetics | Carcinoma, Ductal, Breast - pathology | Carcinoma, Ductal, Breast - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Breast - cytology | Membrane Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Hepatocyte Growth Factor - metabolism | Breast Neoplasms - genetics | Claudin-1 - genetics | Biomarkers, Tumor - genetics | Cell Movement | Carcinoma, Ductal, Breast - genetics | Phosphorylation | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Breast - metabolism | Breast Neoplasms - metabolism | Claudin-1 - metabolism | Epithelial-Mesenchymal Transition | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cytoskeletal Proteins - metabolism | Female | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Neurofibromin 2 - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Phosphoproteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Breast Neoplasms - pathology | Nuclear Proteins - antagonists & inhibitors | Apoptosis | Cellular proteins | Prognosis | Physiological aspects | Breast cancer | Genetic aspects | Cellular signal transduction | Research | Health aspects | Mammals | Gene expression | Index Medicus
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4. Full Text Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
by Basu-Roy, Upal and Bayin, N. Sumru and Rattanakorn, Kirk and Han, Eugenia and Placantonakis, Dimitris G and Mansukhani, Alka and Basilico, Claudio
Nature communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6411 - 6411
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neurofibromin 2 - genetics | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - genetics | Phosphoproteins - metabolism | RNA, Messenger - metabolism | SOXB1 Transcription Factors - metabolism | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Glioblastoma - metabolism | Osteosarcoma - genetics | Adaptor Proteins, Signal Transducing - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Neurofibromin 2 - metabolism | Real-Time Polymerase Chain Reaction | Osteosarcoma - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus
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5. Full Text An essential role for the tumor-suppressor merlin in regulating fatty acid synthesis
by Stepanova, Dina S and Semenova, Galina and Kuo, Yin-Ming and Andrews, Andrew J and Ammoun, Sylwia and Hanemann, C. Oliver and Chernoff, Jonathan
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2017, Volume 77, Issue 18, pp. 5026 - 5038
Fatty Acid Synthase, Type I - genetics | Neurofibromin 2 - genetics | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes - genetics | Meningioma - genetics | Embryo, Mammalian - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Neurilemmoma - genetics | Biomarkers, Tumor - metabolism | Female | Lipogenesis | Fatty Acids - metabolism | Neurofibromin 2 - metabolism | Fibroblasts - metabolism | Meningeal Neoplasms - genetics | Meningioma - metabolism | Cells, Cultured | Rats | Survival Rate | Fatty Acid Synthase, Type I - metabolism | Neurilemmoma - pathology | Xenograft Model Antitumor Assays | Meningioma - pathology | Animals | Neurilemmoma - metabolism | Embryo, Mammalian - cytology | Mice, Nude | Biomarkers, Tumor - genetics | Fibroblasts - cytology | Meningeal Neoplasms - metabolism | Mice | Meningeal Neoplasms - pathology | Apoptosis | Deactivation | Central nervous system | Schwann cells | Neurofibromin 2 | Neurofibromatosis 2 | Metabolism | Palmitic acid | Inactivation | Fatty acids | Fatty-acid synthase | Hereditary diseases | Molecular modelling | Inhibitors | Neurofibromatosis | Tumor suppressor genes | Lipid metabolism | Mutation | Tumors | Cancer | Index Medicus | small molecule inhibitors | metabolism | fatty acid synthesis | neurofibromatosis 2 | schwannoma
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6. Full Text YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells
by White, Shannon M and Avantaggiati, Maria Laura and Nemazanyy, Ivan and Di Poto, Cristina and Yang, Yang and Pende, Mario and Gibney, Geoffrey T and Ressom, Habtom W and Field, Jeffery and Atkins, Michael B and Yi, Chunling
Developmental cell, ISSN 1534-5807, 05/2019, Volume 49, Issue 3, pp. 425 - 443.e9
YAP | Hippo pathway | NF2 | TAZ | ROS | RAF-MEK-ERK pathway | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Kidney Neoplasms - genetics | Neurofibromin 2 - genetics | Humans | Carcinoma, Renal Cell - genetics | Kidney Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - metabolism | MAP Kinase Signaling System | Heterografts | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Neurofibromin 2 - deficiency | Neurofibromatosis 2 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Neurofibromin 2 - metabolism | Signal Transduction | Carcinoma, Renal Cell - pathology | Oxidative Phosphorylation | Transcription Factors - antagonists & inhibitors | Neurofibromatosis 2 - genetics | Transcription Factors - genetics | Mice, SCID | Neurofibromatosis 2 - pathology | Transcription Factors - metabolism | Carcinoma, Renal Cell - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Glycolysis | Kidney Neoplasms - pathology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Glucose metabolism | Medical colleges | Cell death | Analysis | Genes | Cyclic adenylic acid | Biosynthesis | Gene expression | Cancer | Index Medicus
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7. Full Text Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
by Serrano, Isabel and McDonald, Paul C and Lock, Frances and Muller, William J and Dedhar, Shoukat
Nature communications, ISSN 2041-1723, 12/2013, Volume 4, Issue 1, pp. 2976 - 2976
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Phosphorylation | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Male | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Glioma - metabolism | Neoplasm Metastasis | Gene Deletion | Myosin-Light-Chain Phosphatase - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Gene Silencing | Mice, Transgenic | Nuclear Proteins - metabolism | Disease Progression | Hepatocyte Growth Factor - metabolism | Transcription Factors - metabolism | Animals | Cell Line, Tumor | Mice | Apoptosis | Index Medicus
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8. Full Text Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
by Liu-Chittenden, Yi and Huang, Bo and Shim, Joong Sup and Chen, Qian and Lee, Se-Jin and Anders, Robert A and Liu, Jun O and Pan, Duojia
Genes & development, ISSN 0890-9369, 06/2012, Volume 26, Issue 12, pp. 1300 - 1305
Chemical biology | YAP | Hippo signaling | Oncogene | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Hepatomegaly - pathology | Liver - pathology | Humans | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Liver - drug effects | Protein Binding - drug effects | HEK293 Cells | Verteporfin | Neurofibromin 2 - metabolism | Liver - metabolism | Mice, Transgenic | Phosphoproteins - genetics | Porphyrins - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Phenotype | Animals | Adaptor Proteins, Signal Transducing - genetics | Hepatomegaly - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Genes, Dominant - genetics | Cell Cycle Proteins | Index Medicus | Research Communication | chemical biology | oncogene
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9. Full Text β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin
by Sabra, Hiba and Brunner, Molly and Mandati, Vinay and Wehrle-Haller, Bernhard and Lallemand, Dominique and Ribba, Anne-Sophie and Chevalier, Genevieve and Guardiola, Philippe and Block, Marc R and Bouvard, Daniel
The Journal of biological chemistry, ISSN 0021-9258, 11/2017, Volume 292, Issue 47, pp. 19179 - 19197
Neurofibromin 2 - genetics | Cell Proliferation | Phosphoproteins - metabolism | Embryo, Mammalian - metabolism | Integrin beta1 - physiology | Tumor Suppressor Proteins - genetics | Neurofibromin 2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Genes, Neurofibromatosis 2 - physiology | Tumor Suppressor Proteins - metabolism | p21-Activated Kinases - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Phosphoproteins - genetics | p21-Activated Kinases - metabolism | Cell Adhesion | Mice, Knockout | Animals | Embryo, Mammalian - cytology | Adaptor Proteins, Signal Transducing - genetics | Fibroblasts - cytology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle Proteins | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | adhesion | cell proliferation | yes-associated protein (YAP) | integrin | Rac (Rac GTPase) | Cell Biology
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