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Neuron, ISSN 0896-6273, 2009, Volume 62, Issue 4, pp. 479 - 493
Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of... 
STEMCELL | HUMDISEASE | MOLNEURO | SEROTONIN-1A RECEPTOR FUNCTION | MESSENGER-RNA | BETA-ARRESTINS | PROTEIN-COUPLED RECEPTORS | ANTIDEPRESSANT TREATMENT | CELL-PROLIFERATION | ADULT MICE | MAJOR DEPRESSION | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | NEUROSCIENCES | Depression - pathology | Microtubule-Associated Proteins - metabolism | Radiation | Arrestins - genetics | GTP-Binding Protein alpha Subunit, Gi2 - metabolism | Male | Hippocampus - drug effects | Antidepressive Agents, Second-Generation - therapeutic use | RNA, Messenger - metabolism | Arrestins - metabolism | Hypothalamus - radiation effects | Corticosterone - toxicity | Depression - drug therapy | GTP-Binding Protein alpha Subunit, Gi2 - genetics | Anxiety - diet therapy | Depression - chemically induced | Reaction Time - drug effects | Exploratory Behavior - drug effects | Neurogenesis - radiation effects | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Fluoxetine - therapeutic use | Hypothalamus - drug effects | Disease Models, Animal | Cell Survival - drug effects | Drug Administration Schedule | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Neuropeptides - metabolism | Hippocampus - pathology | Cell Survival - radiation effects | Anxiety - pathology | Feeding Behavior - drug effects | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Hypothalamus - metabolism | Analysis of Variance | beta-Arrestin 2 | beta-Arrestins | Hippocampus - radiation effects | Gene Expression Regulation - radiation effects | Anxiety - chemically induced | Cell Proliferation - drug effects | Mice | Arrestins - deficiency | Cell Proliferation - radiation effects | Neurosciences | Corticosterone | Neurons | Fluoxetine | Analysis | Depression, Mental | Models | Survival analysis | Genotype & phenotype | Brain research | Antidepressants | Anxieties | Rodents | Behavior | Feeds | Neurogenesis | Index Medicus
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2007, Volume 2, Issue 7, pp. e588 - e588
Background. The cellular basis of long term radiation damage in the brain is not fully understood. Methods and Findings. We administered a dose of 25Gy to... 
BIOLOGY | Interneurons - physiology | Myelin Sheath - radiation effects | Olfactory Bulb - radiation effects | Humans | Radiotherapy - adverse effects | Necrosis | Cerebral Ventricles - physiology | Corpus Callosum - radiation effects | Female | Oligodendroglia - radiation effects | Interneurons - radiation effects | Olfactory Bulb - pathology | Myelin Sheath - pathology | Stem Cells - radiation effects | Cell Division - radiation effects | Rats | Brain - radiation effects | Cerebral Ventricles - radiation effects | Corpus Callosum - anatomy & histology | Rats, Sprague-Dawley | Cerebral Cortex - radiation effects | S100 Calcium Binding Protein G - metabolism | Magnetic Resonance Imaging | Animals | Calbindin 2 | S100 Calcium Binding Protein G - radiation effects | Radiotherapy - methods | Brain | Brain damage | Brain research | Radiotherapy | Stem cells | Radiation | Neuroimaging | Neuropathology | Pathogenesis | DNA damage | Nervous system | Neurosurgery | Neurogenesis | Cancer therapies | Glial stem cells | Cell growth | Sheaths | Demyelination | Precursors | Rodents | Radiation injuries | Radiation shielding | Dosimetry | Capillaries | Background radiation | Post-radiation | Medical research | Preservation | Calretinin | Myelin | Radiation therapy | Substantia alba | Corpus callosum | Endothelium | Studies | Pathology | Hypotheses | Magnetic resonance imaging | Neural stem cells | Olfactory bulb | Brain injury | Radiation damage | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0128316 - e0128316
The response of the brain to irradiation is complex, involving a multitude of stress inducible pathways that regulate neurotransmission within a dynamic... 
COGNITIVE IMPAIRMENTS | IRRADIATION | RAT | CHEMOKINES | MULTIDISCIPLINARY SCIENCES | INJURY | PATHOLOGY | NEURAL PRECURSOR CELLS | EXPRESSION | BRAIN | CCR2 | Biomarkers - metabolism | Microglia - metabolism | Mice, Inbred C57BL | Microglia - radiation effects | Hippocampus - cytology | Cell Survival - radiation effects | Cerebral Cortex - metabolism | Mice, Knockout | Radiation Exposure | Cerebral Cortex - radiation effects | Cellular Microenvironment - radiation effects | Dentate Gyrus - cytology | Receptors, CCR2 - metabolism | Animals | Hippocampus - radiation effects | Inflammation Mediators - metabolism | Gene Expression Regulation - radiation effects | Neurogenesis - radiation effects | Receptors, CCR2 - deficiency | Dose-Response Relationship, Radiation | Cell Proliferation - radiation effects | Radiation, Ionizing | Gene expression | Ionizing radiation | Neuroprotection | CC chemokine receptors | Brain | Oxidative stress | Memory | Central nervous system | Oncology | Nervous system | Neurogenesis | Learning | CCR2 protein | Rodents | Cell cycle | Trends | Genotypes | Dosing | Radiation effects | Phenotypes | Cell survival | Neurons | Exposure | Inflammation | Radiation therapy | Metabolism | Progenitor cells | Radiation dosage | Microglia | Signaling | Irradiation | Mice | Laboratory animals | Alzheimers disease | Charged particles | Chemokines | Monocyte chemoattractant protein 1 | Neurotransmission | Hippocampus | Animal cognition | Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2017, Volume 98, Issue 1, pp. 63 - 74
Purpose To investigate long-term changes in behavioral functions of mice after exposure to low-dose prenatal radiation at an early organogenesis stage. Methods... 
Radiology | Hematology, Oncology and Palliative Medicine | GAMMA-IRRADIATION | IN-UTERO | ADULT BRAIN-FUNCTION | ONCOLOGY | EARLY FETAL STAGE | MEMORY IMPAIRMENT | RESPONSE RELATIONSHIP | POSTNATAL-DEVELOPMENT | IONIZING-RADIATION | INDUCED INHIBITION | X-IRRADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Immobility Response, Tonic - physiology | Prenatal Exposure Delayed Effects | Age Factors | Maze Learning - radiation effects | Male | Behavior, Animal - radiation effects | Exploratory Behavior - physiology | Immobility Response, Tonic - radiation effects | Exploratory Behavior - radiation effects | Cognition - physiology | Neurogenesis - radiation effects | Female | Cognition - radiation effects | Hippocampus - embryology | Memory, Long-Term - radiation effects | Motor Skills - physiology | Affect - physiology | Mice, Inbred C57BL | Affect - radiation effects | Behavior, Animal - physiology | Hippocampus - pathology | Radiation Dosage | Memory, Long-Term - physiology | Pregnancy | Locomotion - radiation effects | Animals | Body Weight - radiation effects | Neurogenesis - physiology | Motor Skills - radiation effects | Hippocampus - radiation effects | Sex Factors | Mice | Locomotion - physiology | Developmental biology | Pregnant women | Radiation | Neurons | Index Medicus | PRENATAL IRRADIATION | SEX | RADIOLOGY AND NUCLEAR MEDICINE | FEMALES | MICE | RADIOTHERAPY | AGE GROUPS | NERVE CELLS
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2017, Volume 7, Issue 1, pp. 46181 - 46181
Posterior fossa tumors are the most common childhood intracranial tumors, and radiotherapy is one of the most effective treatments. However, irradiation... 
MITOCHONDRIAL-DNA DAMAGE | LONG-TERM | NEUROVASCULAR NICHE | OXIDATIVE STRESS | HYPOXIA-ISCHEMIA | MULTIDISCIPLINARY SCIENCES | POSTERIOR-FOSSA TUMORS | YOUNG-MOUSE BRAIN | ADULT HIPPOCAMPAL NEUROGENESIS | IONIZING-RADIATION | X-IRRADIATION | Inflammation - pathology | Cell Death - radiation effects | Cerebellum - radiation effects | Rats, Wistar | Radiation | Stem Cells - radiation effects | Male | Microglia - radiation effects | Cerebellum - blood supply | Cerebellum - pathology | Mitochondrial Dynamics - radiation effects | Blood-Brain Barrier - pathology | Animals | Cerebrovascular Circulation - radiation effects | Blood-Brain Barrier - radiation effects | Microglia - pathology | Stem Cells - pathology | Oxidative Stress - radiation effects | Cell Proliferation - radiation effects | Cerebellum | Oxidative stress | Leukocyte migration | Brain cancer | Cognitive ability | Radiation therapy | Motor task performance | Blood flow | Microglia | Quality of life | Side effects | Cell activation | Blood-brain barrier | Cell death | Cerebral blood flow | Rodents | Children | Brain injury | Cell migration | Tumors | Apoptosis | Index Medicus | hypoxia-ischemia | mitochondrial-dna damage | ionizing-radiation | posterior-fossa tumors | neurogenesis | x-irradiation | young-mouse brain | adult hippocampal | Cancer and Oncology | neurovascular niche | oxidative stress | Cancer och onkologi | long-term
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 77, pp. 26 - 43
Journal Article
Journal Article