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The Journal of Cell Biology, ISSN 0021-9525, 12/2009, Volume 187, Issue 6, pp. 761 - 772
Selective degeneration and death of one or more classes of neurons is the defining feature of human neurodegenerative disease. Although traditionally viewed as... 
Motor neurons | Nervous system diseases | Reviews | Neurodegenerative diseases | Neurons | Astrocytes | Motor neuron disease | Huntington disease | Parkinson disease | Amyotrophic lateral sclerosis | Prion diseases | CU/ZN-SUPEROXIDE-DISMUTASE | GLUTAMATE TRANSPORTER EAAT2 | MOTOR-NEURON DEGENERATION | SLOW DISEASE PROGRESSION | MONOAMINE-OXIDASE-B | LINKED SOD1 MUTANTS | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | TRANSGENIC MOUSE MODEL | GENOME-WIDE ASSOCIATION | CELL BIOLOGY | Neurons - pathology | Axonal Transport | Superoxide Dismutase - genetics | Capillaries - pathology | T-Lymphocytes - enzymology | Humans | Astrocytes - pathology | Stress, Physiological | Nerve Degeneration - genetics | Astrocytes - enzymology | Endoplasmic Reticulum - pathology | Cell Death | Superoxides - metabolism | Microglia - pathology | Amyotrophic Lateral Sclerosis - enzymology | T-Lymphocytes - pathology | Superoxide Dismutase - metabolism | Endoplasmic Reticulum - enzymology | Nerve Degeneration - enzymology | Amyotrophic Lateral Sclerosis - genetics | Microglia - enzymology | Capillaries - enzymology | Nerve Degeneration - pathology | Amyotrophic Lateral Sclerosis - pathology | Animals | Neurons - enzymology | Glutamic Acid - metabolism | Mutation | Superoxide Dismutase-1 | Care and treatment | Physiological aspects | Superoxide dismutase | Genetic aspects | Disease susceptibility | Research | Health aspects | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2001, Volume 21, Issue 19, pp. 7691 - 7704
L-Serine is synthesized from glycolytic intermediate 3-phosphoglycerate and is an indispensable precursor for the synthesis of proteins, membrane lipids,... 
Immunohistochemistry | Brain | L-serine | Olfactory ensheathing glia | Mouse | Development | 3-Phosphoglycerate dehydrogenase | Astrocyte | In situ hybridization | development | 3-phosphoglycerate dehydrogenase | CEREBELLAR PURKINJE-CELLS | GLUCOSE DEPRIVATION | NEURON REGENERATION | brain | PRIMARY CULTURES | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | FETAL MONKEY NEOCORTEX | mouse | olfactory ensheathing glia | AMINO-ACIDS | immunohistochemistry | RAT-BRAIN | BASIC-PROTEIN | astrocyte | DEVELOPMENTAL EXPRESSION | in situ hybridization | Antibody Specificity | Brain - embryology | Brain - enzymology | Serine - biosynthesis | Dendrites - ultrastructure | Stem Cells - cytology | Astrocytes - enzymology | Olfactory Bulb - embryology | Microscopy, Immunoelectron | RNA, Messenger - biosynthesis | Neuroglia - cytology | In Situ Hybridization | Organelles - ultrastructure | Stem Cells - enzymology | Gene Expression Regulation, Developmental | Organelles - enzymology | Cell Differentiation - physiology | Carbohydrate Dehydrogenases - genetics | Olfactory Bulb - cytology | Olfactory Bulb - enzymology | Astrocytes - cytology | Brain - cytology | Mice, Inbred C57BL | Neuroglia - enzymology | Synapses - enzymology | Synapses - ultrastructure | Phosphoglycerate Dehydrogenase | Cell Lineage - physiology | Animals | Dendrites - enzymology | Mice | Aging - metabolism | Carbohydrate Dehydrogenases - metabolism
Journal Article
Journal of Histochemistry and Cytochemistry, ISSN 0022-1554, 02/2006, Volume 54, Issue 2, pp. 191 - 199
Journal Article
Neuron, ISSN 0896-6273, 2004, Volume 43, Issue 1, pp. 5 - 17
One cause of amyotrophic lateral sclerosis (ALS) is mutation in ubiquitously expressed copper/zinc superoxide dismutase (SOD1), but the mechanism of toxicity... 
COPPER CHAPERONE | DEAFNESS DYSTONIA SYNDROME | PROPOSED MECHANISM | CU,ZN-SUPEROXIDE DISMUTASE | MOTONEURON DEGENERATION | CU/ZN SUPEROXIDE-DISMUTASE | AMYOTROPHIC-LATERAL-SCLEROSIS | MOTOR-NEURON DISEASE | TRANSGENIC MOUSE MODEL | NEUROSCIENCES | MOLECULAR-WEIGHT COMPLEXES | Mitochondria - enzymology | Protein Binding - genetics | Superoxide Dismutase - genetics | Intracellular Membranes - enzymology | Molecular Chaperones - metabolism | Humans | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | Cytoplasm - metabolism | Intracellular Membranes - ultrastructure | Superoxide Dismutase - toxicity | Spinal Cord - chemistry | Protein Isoforms - metabolism | Mitochondria - genetics | Motor Neuron Disease - genetics | Mitochondrial Proteins - metabolism | Spinal Cord - pathology | Motor Neuron Disease - enzymology | Intracellular Membranes - pathology | Superoxide Dismutase - metabolism | Disease Models, Animal | Nerve Degeneration - enzymology | Spinal Cord - enzymology | Mice, Transgenic | Mitochondria - pathology | Microscopy, Electron | Mutation - genetics | Protein Folding | Protein Transport - genetics | Macromolecular Substances | Motor Neuron Disease - pathology | Animals | Mice | Superoxide Dismutase-1 | Aging - metabolism | Protein Isoforms - genetics | Medical research | Amyotrophic lateral sclerosis | Spinal cord | Mutation | Toxicity | Rodents | Protein Binding/genetics | Aging/metabolism | Mice; Transgenic | Protein Isoforms/genetics/metabolism | Mutation/genetics | Cytoplasm/metabolism | Nerve Degeneration/enzymology/genetics/physiopathology | Microscopy; Electron | Mitochondrial Proteins/metabolism | Spinal Cord/chemistry/enzymology/pathology | Mitochondria/enzymology/genetics/pathology | Motor Neuron Disease/enzymology/genetics/pathology | Protein Transport/genetics | Intracellular Membranes/enzymology/pathology/ultrastructure | Molecular Chaperones/metabolism | Disease Models; Animal | Superoxide Dismutase/genetics/metabolism/toxicity
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 9/2009, Volume 186, Issue 6, pp. 805 - 816
The dynamin-related guanosine triphosphatase Drp1 mediates the division of mitochondria and peroxisomes. To understand the in vivo function of Drp1, complete... 
Cerebellum | Mitochondria | Peroxisomes | Neurons | Antibodies | Cytochromes | Reports | Mice | Giant cells | Embryos | Apoptosis | OUTER-MEMBRANE | APOPTOSIS | DOMINANT OPTIC ATROPHY | FUSION | MITOCHONDRIAL FISSION MACHINERY | SYNAPSE FORMATION | CYTOCHROME-C RELEASE | PROTEIN DLP1 | DIVISION | CELL-DEATH | CELL BIOLOGY | Mitochondria - enzymology | Trophoblasts - ultrastructure | Fibroblasts - enzymology | Giant Cells - enzymology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Trophoblasts - enzymology | Cerebellum - enzymology | Fibroblasts - ultrastructure | Mitochondria - ultrastructure | Purkinje Cells - enzymology | Cerebellum - embryology | Myocytes, Cardiac - enzymology | Adenosine Triphosphate - metabolism | Ultrasonography | Microtubule-Associated Proteins - deficiency | Purkinje Cells - diagnostic imaging | Mice, Inbred C57BL | Cells, Cultured | Dynamins | Gestational Age | Mice, Knockout | Organogenesis | Animals | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | GTP Phosphohydrolases - deficiency | Peroxisomes - enzymology | Cerebellum - ultrastructure | Mitochondrial Size | Myocytes, Cardiac - ultrastructure | Organelle Shape | Peroxisomes - ultrastructure | Giant Cells - ultrastructure | Physiological aspects | Brain | Embryonic development | Research | Guanosine triphosphatase
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2006, Volume 103, Issue 39, pp. 14602 - 14607
Allopregnanolone (ALLO) and tetrahydrodeoxycorticosterone (THDOC) are potent positive allosteric modulators of GABA action at receptors. ALLO and THDOC are... 
Brain | Enzymes | Receptors | Messenger RNA | Neurons | Purkinje cells | Pyramidal cells | Neuroglia | Antibodies | Hippocampus | Glutamatergic neurons | 5α-reductase (type I) | GABAergic neurons | 3α-hydroxysteroid dehydrogenase | GABA(A) RECEPTOR FUNCTION | ALLOPREGNANOLONE SYNTHESIS | SOCIAL-ISOLATION | REELIN MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | IN-SITU HYBRIDIZATION | STEROID 5-ALPHA-REDUCTASE | glutamatergic neurons | 3 alpha-hydroxysteroid dehydrogenase | NEUROACTIVE STEROIDS | 5 alpha-reductase (type I) | GAMMA-AMINOBUTYRIC-ACID | RAT-BRAIN | 3-ALPHA-HYDROXYSTEROID DIHYDRODIOL DEHYDROGENASE | Brain - enzymology | Male | Neurons - cytology | Cerebellum - enzymology | RNA, Messenger - metabolism | Cerebral Cortex - cytology | Corpus Striatum - cytology | 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - genetics | Amygdala - enzymology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Hippocampus - enzymology | Corpus Striatum - enzymology | Olfactory Bulb - cytology | Olfactory Bulb - enzymology | Cerebral Cortex - enzymology | RNA, Messenger - genetics | Thalamus - enzymology | Rats | Amygdala - cytology | Hippocampus - cytology | Desoxycorticosterone - analogs & derivatives | Desoxycorticosterone - biosynthesis | Gene Expression Regulation, Enzymologic | Membrane Proteins | Animals | Pregnanolone - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - metabolism | Neurons - enzymology | Cerebellum - cytology | Thalamus - cytology | Mice | GABA | Research | Progesterone | Oxidoreductases | Structure | Steroids | Biological Sciences
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 2009, Volume 32, Issue 11, pp. 591 - 601
Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histones and other proteins and in regulating fundamental cellular... 
Neurology | SPINAL MUSCULAR-ATROPHY | DISEASE TRANSGENIC MICE | SUBEROYLANILIDE HYDROXAMIC ACID | PROTECTS DOPAMINERGIC-NEURONS | INCREASES SMN EXPRESSION | VALPROIC ACID | AMYOTROPHIC-LATERAL-SCLEROSIS | HISTONE DEACETYLASE INHIBITORS | BDNF GENE-TRANSCRIPTION | NEUROSCIENCES | HEAT-SHOCK-PROTEIN | Neuroprotective Agents - therapeutic use | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Muscular Atrophy, Spinal - enzymology | Parkinson Disease - drug therapy | Neurodegenerative Diseases - drug therapy | Stroke - physiopathology | Amyotrophic Lateral Sclerosis - drug therapy | Amyotrophic Lateral Sclerosis - enzymology | Acetylation | Huntington Disease - drug therapy | Huntington Disease - enzymology | Muscular Atrophy, Spinal - physiopathology | Huntington Disease - physiopathology | Disease Models, Animal | Alzheimer Disease - physiopathology | Neurodegenerative Diseases - pathology | Alzheimer Disease - drug therapy | Rats | Histone Deacetylases - metabolism | Stroke - drug therapy | Alzheimer Disease - enzymology | Parkinson Disease - physiopathology | Stroke - enzymology | Animals | Neurodegenerative Diseases - physiopathology | Neuroprotective Agents - classification | Parkinson Disease - enzymology | Muscular Atrophy, Spinal - drug therapy | Histone Deacetylase Inhibitors - therapeutic use | Histones - metabolism | Neurodegenerative Diseases - enzymology | Histones | Nervous system diseases | Analysis
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 2012, Volume 35, Issue 11, pp. 700 - 709
Caspase-3 has been identified as a key mediator of neuronal programmed cell death. This protease plays a central role in the developing nervous system and its... 
Neurology | synaptic plasticity | synaptic loss | Alzheimer's disease | long-term depression | neuronal differentiation | long-term potentiation | Neuronal differentiation | Synaptic loss | Long-term depression | Long-term potentiation | Synaptic plasticity | ALZHEIMERS-DISEASE | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | PROGRAMMED CELL-DEATH | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | PRECURSOR PROTEIN | HUNTINGTONS-DISEASE | PARKINSONS-DISEASE | Nerve Net - embryology | Mitochondria - enzymology | Caspase Inhibitors - pharmacology | Humans | Huntington Disease - pathology | Neurons - cytology | Nerve Net - enzymology | Molecular Targeted Therapy | Alzheimer Disease - pathology | Caspase 3 - physiology | Nervous System - growth & development | Nervous System - embryology | Huntington Disease - enzymology | Disease Models, Animal | Nerve Net - growth & development | Long-Term Synaptic Depression - physiology | Nerve Tissue Proteins - physiology | Nervous System - enzymology | Parkinson Disease - pathology | Embryonic Development - physiology | Neural Tube - physiology | Alzheimer Disease - enzymology | Receptors, N-Methyl-D-Aspartate - physiology | Mice, Knockout | Animals | Caspase Inhibitors - therapeutic use | Neurons - enzymology | Parkinson Disease - enzymology | Apoptosis Regulatory Proteins - physiology | Mice | Apoptosis - physiology | Enzyme Activation | Nervous system diseases | Neurosciences | Neural networks | Proteases | Neurons | Depression, Mental | Apoptosis | Neurodegenerative diseases | Proteinase | Central nervous system | Caspase-3 | Neurological diseases | Axons | Mitochondria | Neural tube | Plasticity (synaptic) | Reviews | Differentiation
Journal Article
Neuron, ISSN 0896-6273, 2002, Volume 36, Issue 1, pp. 57 - 68
Journal Article