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PloS one, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0170814 - e0170814
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a debilitating adverse effect of cancer treatment. Current understanding... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hyperalgesia - chemically induced | Neuralgia - genetics | Spleen - immunology | Chemokine CCL2 - immunology | Male | Spleen - drug effects | Activating Transcription Factor 3 - immunology | T-Lymphocytes, Regulatory - pathology | Hyperalgesia - pathology | T-Lymphocytes, Regulatory - immunology | Neurofilament Proteins - genetics | Neuralgia - immunology | Chemokine CCL3 - genetics | Microglia - pathology | Lymph Nodes - drug effects | Activating Transcription Factor 3 - genetics | Receptors, Purinergic P2Y12 - genetics | Gene Expression | Receptors, Purinergic P2Y12 - immunology | Mice, Transgenic | Lymph Nodes - immunology | Spinal Cord - immunology | Hyperalgesia - immunology | T-Lymphocytes, Regulatory - drug effects | Hyperalgesia - genetics | Ganglia, Spinal - pathology | Mice | CD8-Positive T-Lymphocytes - immunology | Ganglia, Spinal - drug effects | CD8-Positive T-Lymphocytes - pathology | Lymph Nodes - pathology | Spinal Cord - drug effects | Chemokine CCL3 - immunology | Sensory Receptor Cells - immunology | Neuralgia - pathology | Microglia - immunology | Antineoplastic Agents - adverse effects | Spinal Cord - pathology | Neuralgia - chemically induced | Neurofilament Proteins - immunology | Spleen - pathology | Ganglia, Spinal - immunology | Sensory Receptor Cells - pathology | Microglia - drug effects | Mice, Inbred C57BL | Paclitaxel - adverse effects | Chemokine CCL2 - genetics | Animals | Sensory Receptor Cells - drug effects | CD8-Positive T-Lymphocytes - drug effects | Organoplatinum Compounds - adverse effects | Usage | Chemotherapy | Care and treatment | Oxalic acid | Polyneuropathies | Research | Diagnosis | T cells | Cancer | Spinal cord | Neurosciences | CD8 antigen | Carbon tetrachloride | Interleukin | Central nervous system | Transgenic | Nervous system | Diabetic neuropathy | Lymphocytes T | Cerebrospinal fluid | Peripheral neuropathy | Macrophages | Lymph nodes | Proteins | Neurotoxicity | Interleukin 4 | Pain | Dorsal root ganglia | Lymphocytes | Rodents | Sensory neurons | Tumor necrosis factor-TNF | Horns | Dorsal horn | Peripheral nervous system | Pain sensitivity | Spleen | Pain perception | Immune response | Cytokines | Granulocyte-macrophage colony-stimulating factor | Hypersensitivity | CCL3 protein | Interleukin 12 | Inflammation | CCL4 protein | Microglia | CD4 antigen | Studies | White blood cells | TNF inhibitors | Infiltration | Chemokines | Monocyte chemoattractant protein 1 | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2016, Volume 113, Issue 1, pp. 212 - 217
Journal Article
PloS one, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e57208 - e57208
Background: Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to neuronal damage and behavioral impairment. Toll-like... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Nitric Oxide Synthase Type II - biosynthesis | I-kappa B Proteins - immunology | Cerebral Cortex - pathology | MAP Kinase Kinase 4 - immunology | NF-kappa B - metabolism | Brain Injuries - metabolism | Interleukin-1beta - genetics | Tyrosine - analogs & derivatives | Inflammation - metabolism | Tryptases - immunology | NF-KappaB Inhibitor alpha | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Brain Injuries - genetics | Poly(ADP-ribose) Polymerases - biosynthesis | Tyrosine - immunology | Mice, Knockout | Tyrosine - metabolism | Cerebral Cortex - immunology | Tryptases - biosynthesis | MAP Kinase Kinase 4 - genetics | Mice | Poly (ADP-Ribose) Polymerase-1 | Poly(ADP-ribose) Polymerases - immunology | Toll-Like Receptor 4 - biosynthesis | NF-kappa B - immunology | Brain Infarction - metabolism | Brain Infarction - pathology | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Cerebral Cortex - metabolism | Glial Fibrillary Acidic Protein | MAP Kinase Kinase 4 - metabolism | Brain Injuries - immunology | Nitric Oxide Synthase Type II - immunology | Nerve Tissue Proteins - biosynthesis | Interleukin-1beta - biosynthesis | Tryptases - genetics | Nerve Tissue Proteins - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Brain Infarction - immunology | Inflammation - genetics | Brain Infarction - genetics | Brain Injuries - pathology | Tyrosine - genetics | Brain | Brain damage | Brain research | Neurons | Injuries | Neuroprotection | Animal models | Traumatic brain injury | Bax protein | Bcl-2 protein | Control methods | Kinases | Proteins | Signal transduction | Receptors | Head injuries | Animal tissues | Toll-like receptors | Immune system | Translocation | NF-κB protein | Glial fibrillary acidic protein | Cortex | Poly(ADP-ribose) polymerase | JNK protein | Inflammation | TLR4 protein | IL-1β | Trauma | Nitric-oxide synthase | Chymase | Augmentation | Signaling | Injury prevention | Tryptase | Nitrotyrosine | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2009, Volume 284, Issue 6, pp. 3691 - 3699
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease, in which activated microglia overexpressing ALS-linked SOD1 mutants (mSOD1) are... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | ADAM17 Protein | Tumor Necrosis Factor-alpha - metabolism | Amyloid Precursor Protein Secretases - genetics | Amyloid Precursor Protein Secretases - immunology | ADAM Proteins - immunology | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Toll-Like Receptor 2 - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Amino Acid Substitution - immunology | Cell Death - immunology | Immunity, Innate - genetics | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Microglia - immunology | Reactive Oxygen Species - immunology | Tumor Necrosis Factor-alpha - immunology | NADPH Oxidases - genetics | Membrane Proteins - metabolism | Superoxide Dismutase - metabolism | Amyotrophic Lateral Sclerosis - immunology | Cell Line | Membrane Proteins - genetics | Amyotrophic Lateral Sclerosis - genetics | Neurons - immunology | ADAM10 Protein | Microglia - enzymology | Toll-Like Receptor 4 - genetics | Membrane Proteins - immunology | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Amyotrophic Lateral Sclerosis - ethnology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Superoxide Dismutase - immunology | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Neurons - enzymology | Inflammation - genetics | Toll-Like Receptor 2 - immunology | Mutation, Missense - immunology | Superoxide Dismutase-1 | ADAM Proteins - genetics | Inflammation - enzymology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 05/2014, Volume 111, Issue 22, pp. 8191 - 8196
Osteoprotegerin (OPG) is a soluble secreted protein and a decoy receptor, which inhibits a receptor activator of nuclear factor κB (NF-κB) ligand (RANKL)/the... 
Brain | Receptors | Messenger RNA | Cytokines | Neurons | Body temperature | Strokes | Brain edema | Inflammation | Microglia | Immune cells | Neuroprotection | Cerebral ischemia | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Microglia - metabolism | RANK Ligand - metabolism | Coculture Techniques | Cell Death - immunology | Brain Ischemia - metabolism | Brain Ischemia - immunology | RNA, Messenger - metabolism | Brain - metabolism | RANK Ligand - immunology | Signal Transduction - immunology | Microglia - immunology | Encephalitis - metabolism | Osteoprotegerin - genetics | Neurons - metabolism | Cell Death - drug effects | Receptor Activator of Nuclear Factor-kappa B - metabolism | Brain Edema - immunology | Macrophages - immunology | Cytokines - immunology | Brain Edema - metabolism | Cytokines - metabolism | Brain Edema - pathology | Mice, Inbred C57BL | Cells, Cultured | Neurons - immunology | Encephalitis - pathology | Osteoprotegerin - immunology | Encephalitis - immunology | Mice, Knockout | RANK Ligand - genetics | Macrophages - metabolism | Animals | Brain Ischemia - pathology | Lipopolysaccharides - pharmacology | Receptor Activator of Nuclear Factor-kappa B - genetics | Brain - pathology | Mice | Osteoprotegerin - metabolism | Receptor Activator of Nuclear Factor-kappa B - immunology | Brain - immunology | Medicine, Experimental | Medical research | Research | Ligands (Biochemistry) | Proteins | Stroke | Ischemia | Rodents | Index Medicus | Biological Sciences | immune cells | cerebral ischemia | neuroprotection
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 4/2012, Volume 109, Issue 16, pp. 6175 - 6180
Dendritic cells (DC) are antigen-presenting cells found in both lymphoid and nonlymphoid organs, including the brain (bDC) of Cd11c/eyfp transgenic C57BL/6... 
T lymphocytes | Antigens | Brain | Phenotypes | Dendritic cells | Memory interference | Neurons | Antigen presenting cells | Infections | Ova | Antigen presentation | Neuroinflammation | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Antigens, CD - immunology | Receptor, Macrophage Colony-Stimulating Factor - immunology | Encephalitis, Viral - genetics | Leukocyte Common Antigens - metabolism | Ovalbumin - immunology | Dendritic Cells - immunology | Brain - virology | Olfactory Bulb - metabolism | Olfactory Bulb - immunology | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Antigens, CD - metabolism | Brain - metabolism | Leukocyte Common Antigens - immunology | Flow Cytometry | T-Lymphocytes - metabolism | Integrin alpha Chains - immunology | Antigens, Ly - metabolism | Encephalitis, Viral - metabolism | Dendritic Cells - metabolism | Rhabdoviridae Infections - metabolism | CD11b Antigen - immunology | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Cells, Cultured | Mice, Transgenic | Integrin alpha Chains - metabolism | Receptors, Chemokine - immunology | Antigen Presentation - immunology | Microscopy, Confocal | Animals | Antigens, Ly - immunology | Rhabdoviridae Infections - immunology | Rhabdoviridae Infections - genetics | Luminescent Proteins - genetics | T-Lymphocytes - immunology | Mice | CD11b Antigen - metabolism | Brain - immunology | Encephalitis, Viral - immunology | Vesicular stomatitis Indiana virus - immunology | Luminescent Proteins - metabolism | Encephalitis | Neurology | Lymphocytes | Viral infections | Chemosensory perception | Index Medicus | antigen presentation | Biological Sciences | neuroinflammation
Journal Article