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Circulation research, ISSN 1524-4571, 2018, Volume 122, Issue 10, pp. 1369 - 1384
RATIONALE:Macrophages face a substantial amount of cholesterol following the ingestion of apoptotic cells and the lysosomal acid lipase (LIPA) has a major role... 
CLEARANCE | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | oxysterols | STORAGE DISEASE | mitochondria | MACROPHAGE FOAM CELLS | macrophage | NLRP3 INFLAMMASOME | AUTOPHAGY | inflammation | APOPTOTIC CELLS | CALCIUM | cholesterol | PERIPHERAL VASCULAR DISEASE | ACID LIPASE | HEMATOLOGY | CORONARY-ARTERY-DISEASE | Cholesterol Esters - metabolism | Inflammasomes - metabolism | Sterol Esterase - metabolism | Inflammation - metabolism | Lysosomes - metabolism | Biological Transport | Oxysterols - metabolism | Lymphocytes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Receptors, LDL - metabolism | Neuropeptides - metabolism | Liver X Receptors - metabolism | Mitochondria - metabolism | Splenomegaly - metabolism | Cholesterol - metabolism | Hydrolysis | Macrophages - metabolism | Animals | Erythrocytes - metabolism | Sterol Esterase - antagonists & inhibitors | Mice | Hypercholesterolemia - metabolism | rac1 GTP-Binding Protein - metabolism | Apoptosis | Usage | Lysosomes | Research | Macrophages | Health aspects | Cholesterol | Spleen | Splenomegaly | Oxidative stress | Liver diseases | Liver X receptors | Erythrocytes | Caspase | Esters | Rac1 protein | Inflammation | Botulinum toxin | Caspase-1 | Mitochondria | Pyrin protein | Hypercholesterolemia | Lymphocytes | LipA protein
Journal Article
Molecular cell, ISSN 1097-2765, 2006, Volume 21, Issue 4, pp. 521 - 531
Oxygen (O 2) deprivation, or hypoxia, has profound effects on cell metabolism and growth... 
RNA | CELLCYCLE | SIGNALING | MAMMALIAN TARGET | RAPAMYCIN | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | GAP | ELONGATION-FACTOR-2 | TSC2 | TUBEROUS-SCLEROSIS | MTOR | CELL BIOLOGY | Protein Kinases - metabolism | Protein Biosynthesis | eIF-2 Kinase - metabolism | Humans | Multienzyme Complexes - metabolism | Ras Homolog Enriched in Brain Protein | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Hypoxia-Inducible Factor 1 - metabolism | AMP-Activated Protein Kinases | Oxygen - metabolism | Peptide Elongation Factor 2 - antagonists & inhibitors | Tumor Suppressor Proteins - genetics | Eukaryotic Initiation Factor-2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Eukaryotic Initiation Factor-2 - antagonists & inhibitors | Cell Line | Tumor Suppressor Proteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Gene Expression Regulation | Neuropeptides - metabolism | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Energy Metabolism | Monomeric GTP-Binding Proteins - metabolism | Hypoxia | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Enzyme Activation | Peptide Elongation Factor 2 - metabolism | Messenger RNA | Growth | Energy conservation | Oncology, Experimental | Physiological aspects | Research | Cancer | eEF2 | Rheb | mTOR | AMPK | eIF2
Journal Article
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2006, Volume 116, Issue 7, pp. 1983 - 1993
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 36, pp. 13193 - 13198
Journal Article
Journal Article
Nature immunology, ISSN 1529-2916, 2011, Volume 12, Issue 4, pp. 295 - 303
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2010, Volume 141, Issue 2, pp. 290 - 303
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 11680
Journal Article