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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 11/2009, Volume 331, Issue 2, pp. 547 - 554
The α6 nicotinic acetylcholine receptor (nAChR) subunit is involved in nicotine-stimulated dopamine release in the striatum. It is expressed in brain regions... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2018, Volume 365, Issue 3, pp. 583 - 601
Neurosteroids are powerful modulators of γ-aminobutyric acid (GABA)-A receptors. Ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one, GX) and synthetic analogs... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2010, Volume 333, Issue 2, pp. 533 - 539
(−)- N -Propyl-norapomorphine (NPA) is a full dopamine D 2/3 receptor agonist, and [ 11 C]NPA is a suitable radiotracer to image D 2/3 receptors configured in... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2009, Volume 329, Issue 2, pp. 791 - 807
Nicotinic receptor activation is inextricably linked to desensitization. This duality affects our ability to develop useful therapeutics targeting nicotinic... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2011, Volume 336, Issue 1, pp. 145 - 154
GABA type A receptors (GABA A -Rs) are potential targets of ethanol. However, there are multiple subtypes of this receptor, and, thus far, individual subunits... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 03/2010, Volume 332, Issue 3, pp. 1127 - 1135
Differences in the mechanisms underlying tolerance and μ-opioid receptor desensitization resulting from exposure to opioid agonists of different efficacy have... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2011, Volume 338, Issue 1, pp. 214 - 219
Modulation of the extracellular levels of GABA via inhibition of the synaptic GABA transporter GAT1 by the clinically effective and selective GAT1 inhibitor... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2010, Volume 334, Issue 3, pp. 917 - 926
Neuronal nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of ligand-gated ion channels. nAChRs are involved in modulating... 
Neuropharmacology
Journal Article
The Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 4/2015, Volume 353, Issue 1, pp. 80 - 90
Previous studies have shown that the effect of ethanol on glycine receptors (GlyRs) containing the α 1 subunit is affected by interaction with heterotrimeric G... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2011, Volume 336, Issue 1, pp. 134 - 144
The mechanism by which the inhaled anesthetic isoflurane produces amnesia and immobility is not understood. Isoflurane modulates GABA A receptors (GABA A -Rs)... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2010, Volume 334, Issue 3, pp. 761 - 774
Allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs) is considered to be one of the most promising approaches for therapeutics. We have... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2010, Volume 332, Issue 2, pp. 588 - 598
The use of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea], a positive allosteric modulator of α7 nicotinic acetylcholine receptor... 
Neuropharmacology
Journal Article
The Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 4/2013, Volume 345, Issue 1, pp. 125 - 138
There are currently no registered drugs that slow the progression of neurodegenerative diseases, in part because translation from animal models to the clinic... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2009, Volume 329, Issue 1, pp. 306 - 313
ATPM [(-)-3-amino-thiazolo[5,4- b ]- N -cyclopropylmethylmorphinan hydrochloride] was found to have mixed κ- and μ-opioid activity and identified to act as a... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2009, Volume 331, Issue 1, pp. 35 - 44
Subtype diversity of heterotrimeric G proteins and G protein-coupled receptors enables a wide spectrum of signal transduction. However, the significance of... 
Neuropharmacology
Journal Article
The Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 4/2012, Volume 341, Issue 1, pp. 251 - 262
Several compounds have been identified that display low-efficacy, “partial substrate” activity. Here, we tested the hypothesis that the mechanism of this... 
Neuropharmacology
Journal Article
The Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 4/2012, Volume 341, Issue 1, pp. 115 - 125
Long-term use of opioids is hindered by respiratory depression and the possibility for fatal overdose in drug abusers. This is attributed to higher levels of... 
Neuropharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 1521-0103, 02/2012, Volume 340, Issue 2, pp. 445 - 456
Ionotropic GABA A receptors (GABA A Rs), which mediate inhibitory neurotransmission in the central nervous system, are implicated in the behavioral effects of... 
Neuropharmacology
Journal Article
The Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2011, Volume 339, Issue 1, pp. 125 - 131
Varenicline, a widely used and successful smoking cessation agent, acts as a partial agonist at nicotinic acetylcholine receptors. Here, we explore the effects... 
Neuropharmacology
Journal Article
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