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Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2010, Volume 53, Issue 13, pp. 4927 - 4937
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2010, Volume 132, Issue 31, pp. 10842 - 10846
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2015, Volume 58, Issue 13, pp. 5242 - 5255
Journal Article
ELIFE, ISSN 2050-084X, 04/2015, Volume 4, pp. e07314 - e07314
The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response... 
GUANINE-NUCLEOTIDE-EXCHANGE | UNFOLDED PROTEIN RESPONSE | 40S RIBOSOMAL-SUBUNIT | OPEN READING FRAMES | MESSENGER-RNA | BIOLOGY | TRANSLATION INITIATION | INITIATION-FACTOR EIF2B | VANISHING WHITE-MATTER | MAMMALIAN-CELLS | GENETIC INTERACTION MAPS | RNA, Small Interfering - genetics | Phosphorylation | Humans | Thapsigargin - antagonists & inhibitors | Acetamides - pharmacology | Structure-Activity Relationship | Protein Subunits - metabolism | Acetamides - chemical synthesis | Neuroprotective Agents - pharmacology | Cyclohexylamines - pharmacology | Eukaryotic Initiation Factor-2B - genetics | HEK293 Cells | Binding Sites | Genes, Reporter | Protein Subunits - genetics | Gene Expression | Neuroprotective Agents - chemistry | Cyclohexylamines - chemical synthesis | Endoplasmic Reticulum Stress - drug effects | Bacterial Proteins - genetics | Cyclohexylamines - chemistry | Nootropic Agents - chemical synthesis | Nootropic Agents - chemistry | Neuroprotective Agents - chemical synthesis | Acetamides - chemistry | High-Throughput Screening Assays | K562 Cells | Protein Binding | Thapsigargin - pharmacology | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Eukaryotic Initiation Factor-2B - metabolism | Protein Subunits - antagonists & inhibitors | HeLa Cells | Eukaryotic Initiation Factor-2B - antagonists & inhibitors | Nootropic Agents - pharmacology | Protein Multimerization - drug effects | Luminescent Proteins - metabolism | RNA, Small Interfering - metabolism | Cell culture | Transcription factors | Neurodegenerative diseases | Serine | Translation initiation | Cognitive ability | Kinases | Proteins | Protein synthesis | Stress response | Dimerization | Long-term depression | Binding sites | Index Medicus
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2016, Volume 24, Issue 18, pp. 4324 - 4338
A novel series of compounds obtained by fusing the acetylcholinesterase (AChE) inhibitor donepezil and the antioxidant melatonin were designed as... 
Melatonin | Biometal chelators | Alzheimer's disease | Antioxidant activity | Donepezil | Cholinesterase | AMYLOID-BETA AGGREGATION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | NEUROPROTECTIVE PROPERTIES | CHOLINESTERASE-INHIBITORS | BUTYRYLCHOLINESTERASE INHIBITORS | NEURODEGENERATIVE DISEASES | TACRINE-TROLOX HYBRIDS | MULTIFUNCTIONAL AGENTS | BIOLOGICAL EVALUATION | PHARMACOLOGICAL EVALUATION | Cholinesterase Inhibitors - toxicity | Humans | Protein Multimerization | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Zinc - chemistry | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Indoles - pharmacology | Piperidines - toxicity | Catalytic Domain | Iron - chemistry | Alzheimer Disease - drug therapy | Rats | Electrophorus | Indoles - toxicity | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Blood-Brain Barrier - metabolism | Antioxidants - toxicity | Melatonin - toxicity | Amyloid beta-Peptides - antagonists & inhibitors | Melatonin - analogs & derivatives | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Horses | Indans - toxicity | Indans - chemical synthesis | Melatonin - chemical synthesis | Molecular Docking Simulation | Kinetics | Chelating Agents - chemical synthesis | Melatonin - pharmacology | Acetylcholinesterase - metabolism | Indans - pharmacology | Drug therapy | Analysis | Oligomers | Enzyme inhibitors | Surface active agents | Cell death | Index Medicus
Journal Article
Nature Chemistry, ISSN 1755-4330, 04/2019, Volume 11, Issue 4, pp. 342 - 350
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 14, pp. 6791 - 6806
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2012, Volume 55, Issue 7, pp. 3076 - 3087
Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents... 
IN-VITRO | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | THERAPEUTIC AGENTS | MOUSE MODEL | NITRIC-OXIDE | BIOLOGICAL EVALUATION | NITRATE ESTER | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | PROTEASE INHIBITORS | Nitric Oxide Donors - chemistry | Peptidomimetics - chemical synthesis | Stereoisomerism | Crystallography, X-Ray | Neurons - cytology | Guanylate Cyclase - antagonists & inhibitors | Structure-Activity Relationship | Hippocampus - drug effects | Quinoxalines - pharmacology | Neuroprotective Agents - pharmacology | Long-Term Potentiation - drug effects | Oxadiazoles - pharmacology | Cysteine - metabolism | Nitric Oxide Donors - pharmacology | Neurons - drug effects | Oxadiazoles - chemistry | Synapses - drug effects | Peptidomimetics - pharmacology | Neuroprotective Agents - chemistry | Oxadiazoles - chemical synthesis | Signal Transduction | Amyloid beta-Peptides - toxicity | Synapses - physiology | Cells, Cultured | Rats | Nitric Oxide - physiology | Soluble Guanylyl Cyclase | Peptidomimetics - chemistry | Nootropic Agents - chemical synthesis | Nootropic Agents - chemistry | Neuroprotective Agents - chemical synthesis | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Nitric Oxide Donors - chemical synthesis | Hippocampus - physiology | In Vitro Techniques | Nootropic Agents - pharmacology | Index Medicus | OXYGEN | THIOLS | PEPTIDES | LEARNING | CELL CULTURES | GLUCOSE | INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY | THERAPEUTIC USES | MODULATION | Neuroprotection | Furoxan | Alzheimer's disease | Amyloid Beta | Nitric oxide | Synaptic plasticity
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9312 - 9330
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's... 
TAU EXON 10 | FUNCTIONAL-LINK | CHEMISTRY, MEDICINAL | DYRK1A OVEREXPRESSION | DOWN-SYNDROME | INTRACELLULAR TARGETS | NEUROFIBRILLARY DEGENERATION | DUAL-SPECIFICITY | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | AFFINITY-CHROMATOGRAPHY | GLYCOGEN-SYNTHASE KINASE | Stereoisomerism | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Dioxoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Neuroprotective Agents - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Dioxoles - pharmacology | Molecular Structure | Pyramidal Cells - drug effects | Cell Death - drug effects | Imidazoles - chemical synthesis | Porifera - chemistry | Pyramidal Cells - cytology | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Brain - cytology | Recombinant Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Glutamic Acid - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Imidazoles - pharmacology | Dioxoles - chemistry | Rats, Sprague-Dawley | Brain - drug effects | Neuroprotective Agents - chemical synthesis | Amyloid beta-Protein Precursor - genetics | Animals | Chromatography, Affinity | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | In Vitro Techniques | Alkaloids - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2019, Volume 174, pp. 216 - 225
The identification of a valid therapeutic treatment for Alzheimer's disease (AD) represents nowadays an urgent and still unmet medical need, since currently... 
Hybrids | Multi-target-directed ligands | Neuroprotective agents | Rivastigmine | Alzheimer's disease | CHOLINESTERASE | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | COMPLEXES | NEURODEGENERATIVE DISEASES | SERUM COPPER | ACID HYBRIDS | PHARMACOLOGICAL EVALUATION | DERIVATIVES | Free Radical Scavengers - pharmacology | Cholinesterase Inhibitors - toxicity | Cholinesterase Inhibitors - chemical synthesis | Rivastigmine - toxicity | Rivastigmine - analogs & derivatives | Copper - chemistry | Neuroprotective Agents - pharmacology | Rivastigmine - pharmacology | Butyrylcholinesterase - metabolism | Coordination Complexes - pharmacology | Free Radical Scavengers - chemical synthesis | Coordination Complexes - toxicity | Rivastigmine - chemical synthesis | Neuroprotective Agents - toxicity | Chelating Agents - pharmacology | Neuroprotective Agents - chemical synthesis | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Coordination Complexes - chemical synthesis | Mice | Free Radical Scavengers - toxicity | Chelating Agents - chemical synthesis | Acetylcholinesterase - metabolism | Cell Line, Transformed | Medical research | Nervous system diseases | Spectrum analysis | Pharmacy | Medicine, Experimental | Development and progression | Derivatives (Financial instruments) | Index Medicus
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 08/2013, Volume 21, Issue 15, pp. 4559 - 4569
Journal Article