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Current medicinal chemistry, ISSN 0929-8673, 03/2016, Volume 23, Issue 8, pp. 774 - 791
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of... 
Natural drug | Polyphenol | Morin | Anti-oxidant | Anti-diabetic | Anti-inflammatory | Flavonoid | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | anti-oxidant | polyphenol | PSIDIUM-GUAJAVA | ANTIOXIDANT ACTIVITY RELATIONSHIPS | P-GLYCOPROTEIN | IN-VITRO | INDUCED DIABETIC-RATS | anti-inflammatory | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | flavonoid | anti-diabetic | NATURALLY-OCCURRING FLAVONOIDS | HUMAN MAST-CELLS | natural drug | QUANTITATIVE STRUCTURE | Antihypertensive Agents - pharmacology | Antioxidants - chemistry | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Biological Products - pharmacology | Antihypertensive Agents - metabolism | Neuroprotective Agents - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Antineoplastic Agents - metabolism | Neuroprotective Agents - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Neuroprotective Agents - chemistry | Anti-Bacterial Agents - metabolism | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Antihypertensive Agents - chemistry | Biological Products - chemistry | Animals | Flavonoids - metabolism | Biological Products - metabolism | Anti-Bacterial Agents - pharmacology | Flavonoids - chemistry
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2016, Volume 21, Issue 8, p. 991
...) moiety attached to a beta-glucopyranose/beta-allopyranose via a glycosidic bond. The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research... 
Bioactivity | Pharmacokinetics | Novel structures | Phenylethanoid glycosides | CISTANCHE-SALSA EXTRACT | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | novel structures | TANDEM MASS-SPECTROMETRY | CHEMISTRY, MULTIDISCIPLINARY | PERFORMANCE LIQUID-CHROMATOGRAPHY | phenylethanoid glycosides | VITRO ANTIINFLAMMATORY ACTIVITY | IN-VITRO | bioactivity | FORSYTHIA-SUSPENSA | METABOLITE P-TYROSOL | LC-MS/MS METHOD | pharmacokinetics | RAT PLASMA | Neuroprotective Agents - therapeutic use | Antioxidants - chemistry | Antiviral Agents - pharmacokinetics | Immunologic Factors - isolation & purification | Anti-Bacterial Agents - therapeutic use | Immunologic Factors - pharmacokinetics | Neuroprotective Agents - pharmacokinetics | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Glycosides - isolation & purification | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - pharmacokinetics | Anti-Inflammatory Agents - isolation & purification | Drugs, Chinese Herbal - therapeutic use | Glycosides - chemistry | Immunologic Factors - chemistry | Plants, Medicinal - chemistry | Neuroprotective Agents - chemistry | Antiviral Agents - therapeutic use | Phenylethyl Alcohol - pharmacokinetics | Anti-Bacterial Agents - isolation & purification | Phenylethyl Alcohol - isolation & purification | Drugs, Chinese Herbal - pharmacokinetics | Antioxidants - therapeutic use | Anti-Inflammatory Agents - chemistry | Neuroprotective Agents - isolation & purification | Antioxidants - isolation & purification | Drugs, Chinese Herbal - chemistry | Anti-Bacterial Agents - pharmacokinetics | Glycosides - pharmacokinetics | Antioxidants - pharmacokinetics | Antiviral Agents - isolation & purification | Phenylethyl Alcohol - therapeutic use | Glycosides - therapeutic use | Immunologic Factors - therapeutic use | Phenylethyl Alcohol - chemistry
Journal Article
Trends in molecular medicine, ISSN 1471-4914, 2012, Volume 18, Issue 6, pp. 337 - 347
Glucosinolates and isothiocyanates have both been objects of research for more than half a century. Interest in these unique phytochemicals escalated following... 
Pathology | PHENETHYL ISOTHIOCYANATE | MEDICINE, RESEARCH & EXPERIMENTAL | MIGRATION INHIBITORY FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BENZYL ISOTHIOCYANATE | CRUCIFEROUS VEGETABLES | SULFORAPHANE RESTORES | CELL BIOLOGY | TRANSCRIPTION FACTOR NRF2 | TRAUMATIC BRAIN-INJURY | INTRACEREBRAL HEMORRHAGE | SPINAL-CORD-INJURY | BROCCOLI SPROUT BEVERAGES | Cardiovascular Diseases - drug therapy | Humans | Isothiocyanates - administration & dosage | Diabetic Nephropathies - drug therapy | Glucosinolates - chemistry | Neuroprotective Agents - pharmacology | Anticarcinogenic Agents - administration & dosage | Isothiocyanates - chemistry | Anti-Bacterial Agents - chemistry | Helicobacter Infections - drug therapy | Models, Animal | Neuroprotective Agents - administration & dosage | Anticarcinogenic Agents - pharmacology | Isothiocyanates - pharmacology | Neuroprotective Agents - chemistry | Cardiotonic Agents - chemistry | Cardiotonic Agents - pharmacology | Animals | Anticarcinogenic Agents - chemistry | Cardiotonic Agents - administration & dosage | Glucosinolates - pharmacology | Central Nervous System - drug effects | Anti-Bacterial Agents - pharmacology | Cell Transformation, Neoplastic - drug effects | Anti-Bacterial Agents - administration & dosage | Glucosinolates - administration & dosage | Skin - drug effects | Proteins | Analysis
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 2017, Volume 17, Issue 1, pp. 33 - 43
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 05/2017, Volume 17, Issue 8, pp. 693 - 720
Background: The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD). Objective:... 
Natural products | Neolignans | Piperaceae | Isolation | Extraction | Piper | Biological activity | CHEMISTRY, MEDICINAL | NATURAL-PRODUCTS | ANTIFUNGAL ACTIVITY | MACHILUS-THUNBERGII | isolation | extraction | TETRAHYDROFURAN LIGNANS | I FLOS-MAGNOLIAE | RECEPTOR ANTAGONIST | natural products | neolignans | NEGLECTED TROPICAL DISEASES | SAURURUS-CHINENSIS | PLATELET-ACTIVATING-FACTOR | DC. VAR. SOLMSIANUM | Plant Extracts - chemistry | Antioxidants - chemistry | Plant Extracts - pharmacology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Anti-Inflammatory Agents, Non-Steroidal - isolation & purification | Lignans - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neuroprotective Agents - pharmacology | Antineoplastic Agents - isolation & purification | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Neuroprotective Agents - chemistry | Lignans - chemistry | Plant Extracts - isolation & purification | Antiprotozoal Agents - chemistry | Anti-Bacterial Agents - isolation & purification | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Antiprotozoal Agents - pharmacology | Piper - chemistry | Antiprotozoal Agents - isolation & purification | Lignans - isolation & purification | Neuroprotective Agents - isolation & purification | Antioxidants - isolation & purification | Anti-Bacterial Agents - pharmacology
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 04/2008, Volume 8, Issue 4, pp. 399 - 420
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 2013, Volume 19, Issue 11, pp. 2011 - 2031
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 04/2012, Volume 55, Issue 7, pp. 3076 - 3087
Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents... 
IN-VITRO | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | THERAPEUTIC AGENTS | MOUSE MODEL | NITRIC-OXIDE | BIOLOGICAL EVALUATION | NITRATE ESTER | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | PROTEASE INHIBITORS | Nitric Oxide Donors - chemistry | Peptidomimetics - chemical synthesis | Stereoisomerism | Crystallography, X-Ray | Neurons - cytology | Guanylate Cyclase - antagonists & inhibitors | Structure-Activity Relationship | Hippocampus - drug effects | Quinoxalines - pharmacology | Neuroprotective Agents - pharmacology | Long-Term Potentiation - drug effects | Oxadiazoles - pharmacology | Cysteine - metabolism | Nitric Oxide Donors - pharmacology | Neurons - drug effects | Oxadiazoles - chemistry | Synapses - drug effects | Peptidomimetics - pharmacology | Neuroprotective Agents - chemistry | Oxadiazoles - chemical synthesis | Signal Transduction | Amyloid beta-Peptides - toxicity | Synapses - physiology | Cells, Cultured | Rats | Nitric Oxide - physiology | Soluble Guanylyl Cyclase | Peptidomimetics - chemistry | Nootropic Agents - chemical synthesis | Nootropic Agents - chemistry | Neuroprotective Agents - chemical synthesis | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Nitric Oxide Donors - chemical synthesis | Hippocampus - physiology | In Vitro Techniques | Nootropic Agents - pharmacology | OXYGEN | THIOLS | PEPTIDES | LEARNING | CELL CULTURES | GLUCOSE | INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY | THERAPEUTIC USES | MODULATION | Neuroprotection | Furoxan | Alzheimer's disease | Amyloid Beta | Nitric oxide | Synaptic plasticity
Journal Article
Journal Article
Journal of controlled release, ISSN 0168-3659, 2015, Volume 207, pp. 18 - 30
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are... 
Oxidative stress | Neuroinflammation | Parkinson's disease | Catalase | Exosomes | Blood–brain barrier | Blood-brain barrier | ALZHEIMERS-DISEASE | REPEATED INJECTIONS | MACROPHAGE DELIVERY | MEDIATED TRANSFER | BLOOD-BRAIN-BARRIER | BIOLOGICAL BARRIERS | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | SUPEROXIDE-DISMUTASE | Antioxidants - chemistry | Antioxidants - metabolism | Oxidopamine | Anti-Inflammatory Agents - metabolism | PC12 Cells | Neuroprotective Agents - metabolism | Drug Carriers | Brain - metabolism | Nanoparticles | Parkinsonian Disorders - metabolism | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Neurons - metabolism | Neuroprotective Agents - administration & dosage | Nanomedicine | Disease Models, Animal | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Solubility | Rats | Technology, Pharmaceutical - methods | Parkinsonian Disorders - chemically induced | Administration, Intranasal | Chemistry, Pharmaceutical | Brain - drug effects | Catalase - metabolism | Catalase - administration & dosage | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | RAW 264.7 Cells | Antiparkinson Agents - administration & dosage | Mice | Kinetics | Oxidative Stress - drug effects | Antiparkinson Agents - metabolism | Catalase - chemistry | Drugs | Drug delivery systems | Proteases | Analysis | Antiparkinsonian agents | Vehicles | blood-brain barrier | neuroinflammation | exosomes | catalase | oxidative stress | Parkinson’s disease
Journal Article
Nature chemistry, ISSN 1755-4349, 2019, Volume 11, Issue 4, pp. 342 - 350
Journal Article