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Journal of Controlled Release, ISSN 0168-3659, 06/2015, Volume 207, pp. 18 - 30
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are... 
Oxidative stress | Neuroinflammation | Parkinson's disease | Catalase | Exosomes | Blood–brain barrier | Blood-brain barrier | ALZHEIMERS-DISEASE | REPEATED INJECTIONS | MACROPHAGE DELIVERY | MEDIATED TRANSFER | BLOOD-BRAIN-BARRIER | BIOLOGICAL BARRIERS | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | SUPEROXIDE-DISMUTASE | Antioxidants - chemistry | Antioxidants - metabolism | Oxidopamine | Anti-Inflammatory Agents - metabolism | PC12 Cells | Neuroprotective Agents - metabolism | Drug Carriers | Brain - metabolism | Nanoparticles | Parkinsonian Disorders - metabolism | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Neurons - metabolism | Neuroprotective Agents - administration & dosage | Nanomedicine | Disease Models, Animal | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Solubility | Rats | Technology, Pharmaceutical - methods | Parkinsonian Disorders - chemically induced | Administration, Intranasal | Chemistry, Pharmaceutical | Brain - drug effects | Catalase - metabolism | Catalase - administration & dosage | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | RAW 264.7 Cells | Antiparkinson Agents - administration & dosage | Mice | Kinetics | Oxidative Stress - drug effects | Antiparkinson Agents - metabolism | Catalase - chemistry | Drugs | Drug delivery systems | Proteases | Analysis | Antiparkinsonian agents | Vehicles | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
APP TRANSGENIC MICE | NATURAL OLIGOMERS | HUMAN IGG1 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PASSIVE-IMMUNIZATION | SECRETED OLIGOMERS | P38 MAP KINASE | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged | Index Medicus
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 2010, Volume 78, Issue 3, pp. 466 - 477
Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by a progressive loss of dopamine (DA) neurons in the substantia... 
RESPONSES | IN-VITRO | MICROGLIAL ACTIVATION | PHOSPHORYLATION | GENE-EXPRESSION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | NECROSIS-FACTOR-ALPHA | NADPH OXIDASE ACTIVITY | PARKINSONS-DISEASE | DEGENERATION | Microglia - metabolism | Mesencephalon - cytology | Reactive Oxygen Species - metabolism | Embryo, Mammalian | Rats, Inbred F344 | NADPH Oxidases - metabolism | Lipopolysaccharides - antagonists & inhibitors | Anti-Inflammatory Agents - metabolism | Nerve Degeneration - metabolism | Neuroprotective Agents - metabolism | Microglia - physiology | Neuroprotective Agents - pharmacology | Stilbenes | Dopamine - physiology | Anti-Inflammatory Agents - therapeutic use | Polyphenols | Neurons - metabolism | Dopamine - metabolism | Phenols - pharmacology | Anti-Inflammatory Agents - pharmacology | NADPH Oxidases - antagonists & inhibitors | Rats | Reactive Oxygen Species - therapeutic use | Lipopolysaccharides - pharmacology | Mitogen-Activated Protein Kinases - pharmacology | Neurotoxicity Syndromes - metabolism | Mice | NADPH Oxidases - physiology | Neuroprotective Agents - therapeutic use | Mesencephalon - metabolism | Reactive Oxygen Species - pharmacology | Lipopolysaccharides - metabolism | Parkinson Disease - drug therapy | Substantia Nigra - metabolism | Flavonoids - therapeutic use | Neuroglia - drug effects | Nerve Degeneration - prevention & control | Neurons - physiology | Female | Flavonoids - pharmacology | Parkinson Disease - metabolism | Neurons - drug effects | Microglia - drug effects | Mice, Inbred C57BL | Dopamine - pharmacology | Phenols - metabolism | Pregnancy | Animals | Flavonoids - metabolism | Phenols - therapeutic use | Neuroglia - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 448 - 454
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are... 
LIFE-SPAN | CAENORHABDITIS-ELEGANS | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ANALYSIS | NEURONS | MILD COGNITIVE IMPAIRMENT | SEL-12 PRESENILIN | REPRESSOR | C. ELEGANS | Neurons - pathology | Up-Regulation | Humans | Oxidative Stress - physiology | Caenorhabditis elegans Proteins - metabolism | Phagosomes | Neurons - cytology | Cognition | Autophagy | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Brain - metabolism | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | Young Adult | Cell Nucleus - metabolism | Aging - genetics | Cell Death - genetics | Chromatin Immunoprecipitation | Repressor Proteins - deficiency | Aged, 80 and over | Neurons - metabolism | Repressor Proteins - metabolism | Wnt Signaling Pathway | Frontotemporal Dementia - pathology | Brain - cytology | Amyloid beta-Peptides - toxicity | Cognitive Dysfunction - metabolism | Down-Regulation | Gene Expression Regulation | Lewy Body Disease - pathology | Oxidative Stress - genetics | Repressor Proteins - genetics | Longevity | Aging - pathology | Lewy Body Disease - metabolism | Transcription Factors - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Alzheimer Disease - metabolism | Brain - pathology | Aged | Mice | Alzheimer Disease - genetics | Aging - metabolism | Oxidative stress | Control | Transcription factors | Neurons | Aging | Physiological aspects | Genetic aspects | Research | Alzheimer's disease | Studies | Pathology | Cognitive ability | Epigenetics | Kinases | Stress response | Gene expression | Alzheimers disease | Age | Apoptosis | Index Medicus
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2009, Volume 30, Issue 10, pp. 1523 - 1534
Abstract Hydrogen sulfide (H2 S) is an essential physiological product in brain. We investigated the expression of cystathionine-β-synthase (CBS) and... 
Neurology | Internal Medicine | Alzheimer disease | Parkinson disease | Aging | Neuroinflammation | NaSH | Cystathionine-β-synthase | Microglia | CELLS | ALZHEIMERS-DISEASE BRAIN | OXIDATIVE STRESS | MOUSE | H2S | CYSTATHIONINE BETA-SYNTHASE | NEUROMODULATOR | TOXICITY | NEUROSCIENCES | Cystathionine-beta-synthase | GERIATRICS & GERONTOLOGY | VASORELAXANT | Hydrogen Sulfide - metabolism | Tumor Necrosis Factor-alpha - metabolism | Glycine - analogs & derivatives | Microglia - metabolism | Cystathionine beta-Synthase - antagonists & inhibitors | Humans | Brain - enzymology | Nitrites - metabolism | Cystathionine gamma-Lyase - metabolism | Male | NF-kappa B - metabolism | Astrocytes - enzymology | Neuroprotective Agents - metabolism | Brain - metabolism | Microglia - immunology | Astrocytes - immunology | Aged, 80 and over | Alkynes - pharmacology | Female | Interleukin-6 - metabolism | Hydroxylamine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Microglia - enzymology | Cystathionine beta-Synthase - metabolism | Cystathionine gamma-Lyase - antagonists & inhibitors | Glycine - pharmacology | Cell Line, Tumor | Aged | Brain - immunology | Astrocytes - metabolism | Hydrogen sulfide | Enzymes | Nervous system diseases | Hydroxides | Parkinson's disease | Anti-inflammatory drugs | Nitrites | Physiological aspects | Alzheimer's disease | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7498, pp. 96 - 100
Journal Article
Endocrinology, ISSN 0013-7227, 09/2013, Volume 154, Issue 9, pp. 3294 - 3304
Gonadal steroids are potent regulators of adult neurogenesis. We previously reported that androgens, such as testosterone (T) and dihydrotestosterone (DHT),... 
SPINAL NUCLEUS | FEMALE RATS | TESTOSTERONE | ENDOCRINOLOGY & METABOLISM | PROMOTES SURVIVAL | CELL-PROLIFERATION | GRANULE CELLS | HIPPOCAMPAL NEUROGENESIS | NEWBORN NEURONS | BRAIN | INSENSITIVITY | Castration - adverse effects | Neuroprotective Agents - therapeutic use | Neurons - pathology | Microtubule-Associated Proteins - metabolism | Neuroprotective Agents - antagonists & inhibitors | Receptors, Androgen - metabolism | Testosterone Propionate - antagonists & inhibitors | Male | Neurons - cytology | Neural Stem Cells - cytology | Hormone Replacement Therapy | Neuroprotective Agents - metabolism | Neuroprotective Agents - pharmacology | Dentate Gyrus - drug effects | Androgens - therapeutic use | Receptors, Androgen - chemistry | Neurogenesis - drug effects | Neurons - metabolism | Neurons - drug effects | Androgen Antagonists - toxicity | Mutant Proteins - antagonists & inhibitors | Drug Resistance | Biomarkers - metabolism | Cell Survival - drug effects | Testosterone Propionate - pharmacology | Dentate Gyrus - metabolism | Androgen-Insensitivity Syndrome - drug therapy | Neural Stem Cells - drug effects | Rats | Mutant Proteins - metabolism | Neuropeptides - metabolism | Neural Stem Cells - pathology | Rats, Sprague-Dawley | Dentate Gyrus - cytology | Animals | Receptors, Androgen - genetics | Androgens - pharmacology | Signal Transduction - drug effects | Androgen-Insensitivity Syndrome - metabolism | Androgen-Insensitivity Syndrome - chemically induced | Androgens - chemistry | Androgens - metabolism | Dentate Gyrus - pathology | Neural Stem Cells - metabolism | Testosterone Propionate - therapeutic use | Mutant Proteins - agonists | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2003, Volume 112, Issue 6, pp. 892 - 901
Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of the nigrostriatal dopaminergic neurons accompanied by a deficit in... 
ELECTRON-TRANSPORT CHAIN | RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX-I | 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MOUSE MODEL | NITRIC-OXIDE | NEURODEGENERATION | DIETARY RESTRICTION | MPTP | DOPAMINERGIC NEUROTOXICITY | BRAIN
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2016, Volume 63, Issue 2, pp. 229 - 239
In response to apoptotic stimuli, mitochondria in mammalian cells release cytochrome and other apoptogenic proteins, leading to the subsequent activation of... 
INDUCED CHANNEL | DOMINANT OPTIC ATROPHY | COMPLEX-II | OPA1 | CRISTAE | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BAX | CYTOCHROME-C RELEASE | PROTEASE | CELL-DEATH | CELL BIOLOGY | Electron Transport | Antiparkinson Agents - pharmacology | Apoptosis - drug effects | Dopaminergic Neurons - pathology | Humans | Motor Activity - drug effects | Oxidopamine | Sulfones - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Neuroprotective Agents - metabolism | Dose-Response Relationship, Drug | Parkinsonian Disorders - metabolism | Neuroprotective Agents - pharmacology | Transfection | RNA Interference | Time Factors | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | Behavior, Animal - drug effects | Disease Models, Animal | Cytochromes c - metabolism | Parkinsonian Disorders - psychology | bcl-2-Associated X Protein - metabolism | Rats | Sulfones - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Succinate Dehydrogenase - genetics | Animals | Bcl-2-Like Protein 11 - metabolism | Parkinsonian Disorders - pathology | Signal Transduction - drug effects | Protein Binding | Pyridones - metabolism | Succinate Dehydrogenase - metabolism | Cell Proliferation - drug effects | Parkinsonian Disorders - prevention & control | HeLa Cells | Antiparkinson Agents - metabolism | Pyridones - pharmacology | Cytochrome c | Proteins | Electron transport | Analysis | Cells | Apoptosis | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 734 - 743
Background and purpose: Although CB1 receptor activation evokes neuroprotection in response to cannabinoids, some cannabinoids have been reported to be... 
Neuroprotection | Peroxisome proliferator-activated receptors (PPARs) | Cannabinoids | N-oleoylethanolamine | GAMMA | CELLS | FOCAL CEREBRAL-ISCHEMIA | ANANDAMIDE | ENDOCANNABINOID SYSTEM | NUCLEAR RECEPTOR | peroxisome proliferator-activated receptors (PPARs) | neuroprotection | cannabinoids | THERAPEUTIC TARGETS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | TRANSCRIPTION FACTOR | BRAIN | Luciferases - metabolism | Humans | Benzoxazines - metabolism | Male | Recombinant Fusion Proteins - metabolism | Cerebral Cortex - metabolism | Neuroprotective Agents - metabolism | Luciferases - genetics | Oleic Acids - metabolism | Arachidonic Acids - metabolism | Fenofibrate - pharmacology | Neuroprotective Agents - pharmacology | Transfection | I-kappa B Kinase - metabolism | Cerebral Cortex - drug effects | Oleic Acids - pharmacology | Dronabinol - pharmacology | Naphthalenes - metabolism | Cannabinoids - metabolism | Endocannabinoids | Fenofibrate - metabolism | Mice, Inbred C57BL | Morpholines - pharmacology | Fatty Acids, Unsaturated - pharmacology | Morpholines - metabolism | PPAR alpha - genetics | Polyunsaturated Alkamides - metabolism | Arachidonic Acids - pharmacology | Cannabinoids - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Animals | Benzoxazines - pharmacology | Cyclooxygenase 2 - metabolism | Polyunsaturated Alkamides - pharmacology | Protein Binding | Recombinant Fusion Proteins - genetics | Ligands | PPAR alpha - agonists | Mice | HeLa Cells | PPAR alpha - metabolism | Dronabinol - metabolism | Index Medicus | Research Papers
Journal Article