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Pediatrics, ISSN 0031-4005, 10/2012, Volume 130, Issue 4, pp. 683 - 691
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 02/2015, Volume 23, Issue 4, pp. 668 - 680
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of scutellarein carbamate derivatives were designed and synthesized... 
Neuroprotective effects | Scutellarein carbamate derivatives | Metal-chelating agents | Alzheimer's disease | Cholinesterase inhibitors | Antioxidant activity | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBAMATE DERIVATIVES | CHEMISTRY, ORGANIC | CHOLINESTERASE-INHIBITORS | ACETYLCHOLINESTERASE | METALS | HYDROGEN-PEROXIDE | AGENTS | BRAIN | Neuroprotective Agents - therapeutic use | Cholinesterase Inhibitors - pharmacokinetics | Antioxidants - chemistry | Apigenin - therapeutic use | Humans | Cholinesterase Inhibitors - chemistry | Carbamates - pharmacokinetics | Carbamates - chemistry | Apigenin - chemistry | Chelating Agents - pharmacokinetics | Neuroprotective Agents - pharmacokinetics | Butyrylcholinesterase - metabolism | Glucuronates - therapeutic use | Glucuronates - chemistry | Chelating Agents - therapeutic use | Cell Line | Neuroprotective Agents - chemistry | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Rats | Apigenin - pharmacokinetics | Cognition - drug effects | Blood-Brain Barrier - metabolism | Glucuronates - pharmacokinetics | Antioxidants - therapeutic use | Animals | Alzheimer Disease - metabolism | Mice | Molecular Docking Simulation | Antioxidants - pharmacokinetics | Carbamates - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Antioxidants | Drug therapy | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 18, pp. 8326 - 8344
Journal Article
Journal Article
Journal of Neurotrauma, ISSN 0897-7151, 05/2011, Volume 28, Issue 5, pp. 787 - 796
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 93, pp. 42 - 50
Combining tacrine with trolox in a single molecule, novel multifunctional hybrids have been designed and synthesized. All these hybrids showed ChE inhibitory... 
Antioxidant | Trolox | Alzheimer's disease | Hepatotoxicity | Tacrine | Cholinesterase | NO DONOR | TARGET-DIRECTED LIGANDS | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | RAT HEPATOCYTES | NEURODEGENERATIVE DISEASES | IN-VITRO | AMYLOID-BETA | ACETYLCHOLINESTERASE INHIBITORS | DERIVATIVES | Cholinesterase Inhibitors - pharmacokinetics | Male | Cholinesterase Inhibitors - chemical synthesis | PC12 Cells | Tacrine - adverse effects | Tacrine - pharmacology | Neuroprotective Agents - pharmacology | Tacrine - pharmacokinetics | Chromans - pharmacokinetics | Chromans - pharmacology | Neuroprotective Agents - pharmacokinetics | Swine | Picrates - chemistry | Drug Design | Molecular Structure | Biphenyl Compounds - chemistry | Neuroprotective Agents - adverse effects | Chromans - chemistry | Tacrine - chemistry | Cell Survival - drug effects | Chemical and Drug Induced Liver Injury - prevention & control | Alzheimer Disease - drug therapy | Rats | Alzheimer Disease - enzymology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Blood-Brain Barrier - metabolism | Chromans - adverse effects | Neuroprotective Agents - chemical synthesis | Animals | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Cholinesterase Inhibitors - adverse effects | Antioxidants - adverse effects | Molecular Docking Simulation | Kinetics | Antioxidants - pharmacokinetics | In Vitro Techniques | Antioxidants | Enzyme inhibitors | Drug therapy | Analysis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1243 - 1248
The creation of effective bioscavengers as a pretreatment for exposure to nerve agents is a challenging medical objective. We report a recombinant method using... 
Enzymes | Organic chemistry | Toxicity | Nerves | Plasma stability | Poisoning | Biochemistry | Pharmacokinetics | Dosage | Blood plasma | organophosphate | POLYSIALIC ACIDS | pesticide | MULTIDISCIPLINARY SCIENCES | CIRCULATORY STABILITY | HYDROLYSIS | TOXICITY | EQUINE SERUM BUTYRYLCHOLINESTERASE | IMMUNOGENICITY | PEPTIDES | ACETYLCHOLINESTERASE | PHARMACOKINETICS | Russian VX | mass spectrometry | SARIN | N-acetylneuraminic acid | Butyrylcholinesterase - genetics | Cricetulus | Humans | Molecular Sequence Data | Male | Recombinant Proteins - pharmacokinetics | Organothiophosphorus Compounds - antagonists & inhibitors | Sialic Acids - chemistry | Butyrylcholinesterase - chemistry | Organothiophosphorus Compounds - toxicity | Neuroprotective Agents - pharmacokinetics | Neuroprotective Agents - administration & dosage | CHO Cells | Amino Acid Sequence | Cricetinae | Neuroprotective Agents - chemistry | Butyrylcholinesterase - pharmacokinetics | Models, Molecular | Recombinant Proteins - chemistry | Butyrylcholinesterase - administration & dosage | Recombinant Proteins - genetics | Lethal Dose 50 | Recombinant Proteins - administration & dosage | Animals | Mice | Mice, Inbred BALB C | Chemical Warfare Agents - toxicity | Nerve gas | Peptides | Cholinesterases | Physiological aspects | Chemical reactions | Research | Mass spectrometry | Health aspects | Methods | Organic chemicals | Genetic recombination | Gene expression | Rodents | Index Medicus | Biological Sciences
Journal Article
FASEB Journal, ISSN 0892-6638, 02/2013, Volume 27, Issue 2, pp. 769 - 781
Epidemiological and preclinical studies indicate that polyphenol intake from moderate consumption of red wines may lower the relative risk for developing... 
Neuroplasticity | Cognitive deterioration | Polyphenol bioavailability | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | cognitive deterioration | SYNAPTIC PLASTICITY | CELL BIOLOGY | LIQUID-CHROMATOGRAPHY | MOUSE MODEL | IN-VIVO | BIOLOGY | VARIETAL DIFFERENCES | LONG-TERM POTENTIATION | RED WINE | polyphenol bioavailability | VITIS-VINIFERA | neuroplasticity | TRANSGENIC MICE | Humans | Neuronal Plasticity - drug effects | Biological Availability | Male | Anthocyanins - administration & dosage | Polyphenols - metabolism | Brain - metabolism | Alzheimer Disease - diet therapy | Quercetin - pharmacokinetics | Neuroprotective Agents - pharmacokinetics | Amyloid beta-Peptides - metabolism | Quercetin - administration & dosage | Neurons - metabolism | Neurons - drug effects | Neuroprotective Agents - administration & dosage | Anthocyanins - pharmacokinetics | Disease Models, Animal | Glucosides | Quercetin - analogs & derivatives | Administration, Oral | Cells, Cultured | Rats | Mice, Transgenic | Rats, Sprague-Dawley | Wine - analysis | Brain - drug effects | Animals | Polyphenols - pharmacokinetics | Signal Transduction - drug effects | Alzheimer Disease - metabolism | Mice | Dietary Supplements | Polyphenols - administration & dosage | Protein Multimerization - drug effects | Index Medicus | Research Communications
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 9/2017, Volume 37, Issue 9, pp. 3110 - 3123
Journal Article