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Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2016, Volume 24, Issue 18, pp. 4324 - 4338
A novel series of compounds obtained by fusing the acetylcholinesterase (AChE) inhibitor donepezil and the antioxidant melatonin were designed as... 
Melatonin | Biometal chelators | Alzheimer's disease | Antioxidant activity | Donepezil | Cholinesterase | AMYLOID-BETA AGGREGATION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | NEUROPROTECTIVE PROPERTIES | CHOLINESTERASE-INHIBITORS | BUTYRYLCHOLINESTERASE INHIBITORS | NEURODEGENERATIVE DISEASES | TACRINE-TROLOX HYBRIDS | MULTIFUNCTIONAL AGENTS | BIOLOGICAL EVALUATION | PHARMACOLOGICAL EVALUATION | Cholinesterase Inhibitors - toxicity | Humans | Protein Multimerization | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Zinc - chemistry | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Indoles - pharmacology | Piperidines - toxicity | Catalytic Domain | Iron - chemistry | Alzheimer Disease - drug therapy | Rats | Electrophorus | Indoles - toxicity | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Blood-Brain Barrier - metabolism | Antioxidants - toxicity | Melatonin - toxicity | Amyloid beta-Peptides - antagonists & inhibitors | Melatonin - analogs & derivatives | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Horses | Indans - toxicity | Indans - chemical synthesis | Melatonin - chemical synthesis | Molecular Docking Simulation | Kinetics | Chelating Agents - chemical synthesis | Melatonin - pharmacology | Acetylcholinesterase - metabolism | Indans - pharmacology | Drug therapy | Analysis | Oligomers | Enzyme inhibitors | Surface active agents | Cell death | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 15, pp. 6528 - 6547
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 2011, Volume 77, Issue 1, pp. 43 - 55
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1377 - 1392
Journal Article
Glia, ISSN 0894-1491, 03/2011, Volume 59, Issue 3, pp. 435 - 451
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2016, Volume 122, pp. 326 - 338
Journal Article
Neuroscience, ISSN 0306-4522, 2014, Volume 274, pp. 308 - 317
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1243 - 1248
The creation of effective bioscavengers as a pretreatment for exposure to nerve agents is a challenging medical objective. We report a recombinant method using... 
Enzymes | Organic chemistry | Toxicity | Nerves | Plasma stability | Poisoning | Biochemistry | Pharmacokinetics | Dosage | Blood plasma | organophosphate | POLYSIALIC ACIDS | pesticide | MULTIDISCIPLINARY SCIENCES | CIRCULATORY STABILITY | HYDROLYSIS | TOXICITY | EQUINE SERUM BUTYRYLCHOLINESTERASE | IMMUNOGENICITY | PEPTIDES | ACETYLCHOLINESTERASE | PHARMACOKINETICS | Russian VX | mass spectrometry | SARIN | N-acetylneuraminic acid | Butyrylcholinesterase - genetics | Cricetulus | Humans | Molecular Sequence Data | Male | Recombinant Proteins - pharmacokinetics | Organothiophosphorus Compounds - antagonists & inhibitors | Sialic Acids - chemistry | Butyrylcholinesterase - chemistry | Organothiophosphorus Compounds - toxicity | Neuroprotective Agents - pharmacokinetics | Neuroprotective Agents - administration & dosage | CHO Cells | Amino Acid Sequence | Cricetinae | Neuroprotective Agents - chemistry | Butyrylcholinesterase - pharmacokinetics | Models, Molecular | Recombinant Proteins - chemistry | Butyrylcholinesterase - administration & dosage | Recombinant Proteins - genetics | Lethal Dose 50 | Recombinant Proteins - administration & dosage | Animals | Mice | Mice, Inbred BALB C | Chemical Warfare Agents - toxicity | Nerve gas | Peptides | Cholinesterases | Physiological aspects | Chemical reactions | Research | Mass spectrometry | Health aspects | Methods | Organic chemicals | Genetic recombination | Gene expression | Rodents | Index Medicus | Biological Sciences
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 12/2016, Volume 7, Issue 12, pp. 1658 - 1670
Parkinson's disease (PD) is the most widespread form of dementia where there is an age related degeneration of dopaminergic neurons in the substantia nigra... 
blood-brain barrier | piperine | lipid based nanoparticles | Parkinson's disease | α-synuclein | curcumin | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | COMBINATION THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | alpha-synuclein | MAGNETIC NANOPARTICLES | NEUROSCIENCES | CANCER-THERAPY | RAT MODEL | IN-VITRO | POLYMERIC NANOPARTICLES | MITOCHONDRIAL DYSFUNCTION | ORAL DELIVERY | Capillary Permeability - physiology | Alkaloids - pharmacokinetics | Male | Antiparkinson Agents - toxicity | Polyunsaturated Alkamides - toxicity | Benzodioxoles - administration & dosage | Curcumin - administration & dosage | PC12 Cells | Drug Delivery Systems | alpha-Synuclein - drug effects | Nanoparticles | Benzodioxoles - toxicity | Neuroprotective Agents - pharmacokinetics | Benzodioxoles - pharmacokinetics | Parkinsonian Disorders - drug therapy | Piperidines - pharmacokinetics | Drug Therapy, Combination | Neuroprotective Agents - administration & dosage | Surface-Active Agents | Piperidines - toxicity | Alkaloids - toxicity | Piperidines - administration & dosage | Mice, Inbred C57BL | Curcumin - pharmacokinetics | Rats | Neuroprotective Agents - toxicity | Random Allocation | Protein Aggregation, Pathological - drug therapy | Blood-Brain Barrier - metabolism | Rotenone | Antiparkinson Agents - pharmacokinetics | Polyunsaturated Alkamides - administration & dosage | Animals | Curcumin - toxicity | Alkaloids - administration & dosage | Antiparkinson Agents - administration & dosage | Mice, Inbred BALB C | Polyunsaturated Alkamides - pharmacokinetics | Liposomes | alpha-Synuclein - metabolism | Protein Aggregation, Pathological - metabolism | Index Medicus
Journal Article
Journal Article
Pharmaceutical Biology, ISSN 1388-0209, 01/2017, Volume 55, Issue 1, pp. 1423 - 1435
Context: Alzheimer's disease (AD) is believed to develop due to deposition of β-amyloid (Aβ) peptide. Hence, efforts are being made to develop potent drug that... 
toxicity | AChE | BuChE | β-secretase | apoptosis | Alzheimer's disease | oxidative stress | monoamine oxidase | caspase-3 | Oxidative stress | Monoamine oxidase | Alzheimer’s disease | Toxicity | Caspase-3 | Apoptosis | NATURAL-PRODUCTS | INVOLVEMENT | RATS | IDENTIFICATION | PLANT SCIENCES | INHIBITION | ACETYLCHOLINESTERASE | beta-secretase | MOUSE MODEL | PHARMACOLOGY & PHARMACY | DYSFUNCTION | MEDICAL LABORATORY TECHNOLOGY | EXTRACT | Memory - drug effects | Peptide Fragments | Apoptosis - drug effects | Caspase 3 - metabolism | Brain - enzymology | Memory Disorders - metabolism | Male | Protein Carbonylation - drug effects | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Alzheimer Disease - prevention & control | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides | Lipid Peroxidation - drug effects | Escape Reaction - drug effects | Behavior, Animal - drug effects | Alzheimer Disease - chemically induced | Alzheimer Disease - psychology | Disease Models, Animal | Memory Disorders - psychology | Brain - physiopathology | Nootropic Agents - isolation & purification | bcl-2-Associated X Protein - metabolism | Neuroprotective Agents - toxicity | Maze Learning - drug effects | GPI-Linked Proteins - metabolism | Brain - drug effects | Nootropic Agents - toxicity | Amyloid Precursor Protein Secretases - metabolism | Memory Disorders - prevention & control | Animals | Neuroprotective Agents - isolation & purification | Alzheimer Disease - metabolism | Brain - pathology | Mice | Oxidative Stress - drug effects | Seaweed - chemistry | Acetylcholinesterase - metabolism | Nootropic Agents - pharmacology | Indans - pharmacology | Memory Disorders - chemically induced | Monoamine Oxidase - metabolism | Proteins | Hydrocarbons | Peptides | Albinism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 47, pp. 20251 - 20256
The concept of using cholinesterase bioscavengers for prophylaxis against organophosphorous nerve agents and pesticides has progressed from the bench to... 
Oximes | Enzymes | Pain | Toxicity | Humans | Drug interactions | Nerves | Poisoning | Mice | Dosage | Nonconventional warfare agents | Countermeasures | Protein engineering | Transgenic plants | Organophosphorous pesticides | CHOLINESTERASE | transgenic plants | CIRCULATORY LONGEVITY | HUMAN PLASMA | organophosphorous pesticides | MULTIDISCIPLINARY SCIENCES | countermeasures | RECOMBINANT HUMAN ACETYLCHOLINESTERASE | TOXICITY | ANHYDRIDE HYDROLASE ACTIVITY | protein engineering | nonconventional warfare agents | MICE | POLYETHYLENE-GLYCOL | EXPRESSION | BIOSCAVENGERS | Polyethylene Glycols - metabolism | Guinea Pigs | Butyrylcholinesterase - pharmacokinetics | Tobacco - metabolism | Immunoblotting | Butyrylcholinesterase - pharmacology | Chromatography, High Pressure Liquid | Chemical Warfare Agents - metabolism | Organophosphorus Compounds - metabolism | Neuroprotective Agents - metabolism | Animals | Neuroprotective Agents - pharmacology | Neuroprotective Agents - pharmacokinetics | Butyrylcholinesterase - metabolism | Pesticides - toxicity | Protein Engineering | Chemical Warfare Agents - toxicity | Kinetics | Organophosphorus Compounds - toxicity | Pesticides - metabolism | Nerve gas | Genetically modified plants | Research | Health aspects | Pesticides | Proteins | Polyethylene glycol | Rodents | Phosphorus | Flowers & plants | Disease control | Index Medicus | organophosphorus acid anhydride | Mortality | Prophylaxis | Clinical trials | nerve agents | Plants | Acetylcholinesterase | Cholinesterase | Morbidity | hydrolase | Pharmacokinetics | rodents | Biological Sciences
Journal Article