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Current medicinal chemistry, ISSN 0929-8673, 03/2016, Volume 23, Issue 8, pp. 774 - 791
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of... 
Natural drug | Polyphenol | Morin | Anti-oxidant | Anti-diabetic | Anti-inflammatory | Flavonoid | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | anti-oxidant | polyphenol | PSIDIUM-GUAJAVA | ANTIOXIDANT ACTIVITY RELATIONSHIPS | P-GLYCOPROTEIN | IN-VITRO | INDUCED DIABETIC-RATS | anti-inflammatory | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | flavonoid | anti-diabetic | NATURALLY-OCCURRING FLAVONOIDS | HUMAN MAST-CELLS | natural drug | QUANTITATIVE STRUCTURE | Antihypertensive Agents - pharmacology | Antioxidants - chemistry | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Biological Products - pharmacology | Antihypertensive Agents - metabolism | Neuroprotective Agents - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Antineoplastic Agents - metabolism | Neuroprotective Agents - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Neuroprotective Agents - chemistry | Anti-Bacterial Agents - metabolism | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Antihypertensive Agents - chemistry | Biological Products - chemistry | Animals | Flavonoids - metabolism | Biological Products - metabolism | Anti-Bacterial Agents - pharmacology | Flavonoids - chemistry
Journal Article
Life sciences (1973), ISSN 0024-3205, 2005, Volume 78, Issue 5, pp. 442 - 453
.... Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads... 
Indole alkaloids | Bioactive marine natural products | New drug leads | MISCELLANEOUS MECHANISMS | MEDICINE, RESEARCH & EXPERIMENTAL | indole alkaloids | BETA-CARBOLINES | BIS-INDOLE | NERVOUS SYSTEMS | ANTIVIRAL ACTIVITIES | new drug leads | SPONGE | TUNICATE | EUDISTOMINS | PHARMACOLOGY & PHARMACY | ANTIFUNGAL | DEEP-WATER | bioactive marine natural products | Anti-Infective Agents - isolation & purification | Serotonin Agents - isolation & purification | Anti-Infective Agents - pharmacology | Humans | Parasitic Diseases - drug therapy | Neoplasms - prevention & control | Neuroprotective Agents - pharmacology | Antineoplastic Agents - isolation & purification | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Antiparasitic Agents - isolation & purification | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Enzyme Inhibitors - pharmacology | Nervous System Diseases - drug therapy | Antineoplastic Agents - chemistry | Enzyme Inhibitors - isolation & purification | Neoplasms - drug therapy | Biological Products - chemistry | Nervous System Diseases - prevention & control | Animals | Serotonin Agents - chemistry | Serotonin Agents - pharmacology | Neuroprotective Agents - isolation & purification | Antiparasitic Agents - pharmacology | Alkaloids - therapeutic use | Indoles - therapeutic use | Indoles - chemistry | Alkaloids - chemistry | Antiparasitic Agents - chemistry | Antimitotic agents | Alkaloids | Care and treatment | Antineoplastic agents | Cancer
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2016, Volume 21, Issue 3, p. 264
Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease,... 
Lung diseases | Liver disorders | ROS | Curcumin | Bioavailability | Natural compound | Antioxidant | Cardiovascular diseases | Anti-inflammatory | Cancer | lung diseases | antioxidant | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | natural compound | CHEMOPREVENTIVE AGENT CURCUMIN | cardiovascular diseases | ALLERGIC AIRWAY INFLAMMATION | INDUCED LIPID-PEROXIDATION | I CLINICAL-TRIAL | CHEMISTRY, MULTIDISCIPLINARY | HUMAN COLORECTAL-CANCER | TUMOR-NECROSIS-FACTOR | bioavailability | liver disorders | INDUCED PULMONARY-FIBROSIS | anti-inflammatory | cancer | GLUTATHIONE-S-TRANSFERASE | NF-KAPPA-B | curcumin | Neuroprotective Agents - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Biological Availability | Curcumin - chemical synthesis | Neurodegenerative Diseases - drug therapy | Cardiotonic Agents - therapeutic use | Cardiotonic Agents - chemical synthesis | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - isolation & purification | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - chemical synthesis | Curcumin - therapeutic use | Curcumin - isolation & purification | Inflammation | Antioxidants - chemical synthesis | Neoplasms - drug therapy | Antioxidants - therapeutic use | Neuroprotective Agents - chemical synthesis | Animals | Cardiotonic Agents - isolation & purification | Neuroprotective Agents - isolation & purification | Antioxidants - isolation & purification | Anti-Inflammatory Agents - chemical synthesis | Plants, Medicinal | Antineoplastic Agents, Phytogenic - isolation & purification | Curcuma - chemistry
Journal Article
Trends in molecular medicine, ISSN 1471-4914, 2012, Volume 18, Issue 6, pp. 337 - 347
Glucosinolates and isothiocyanates have both been objects of research for more than half a century. Interest in these unique phytochemicals escalated following... 
Pathology | PHENETHYL ISOTHIOCYANATE | MEDICINE, RESEARCH & EXPERIMENTAL | MIGRATION INHIBITORY FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BENZYL ISOTHIOCYANATE | CRUCIFEROUS VEGETABLES | SULFORAPHANE RESTORES | CELL BIOLOGY | TRANSCRIPTION FACTOR NRF2 | TRAUMATIC BRAIN-INJURY | INTRACEREBRAL HEMORRHAGE | SPINAL-CORD-INJURY | BROCCOLI SPROUT BEVERAGES | Cardiovascular Diseases - drug therapy | Humans | Isothiocyanates - administration & dosage | Diabetic Nephropathies - drug therapy | Glucosinolates - chemistry | Neuroprotective Agents - pharmacology | Anticarcinogenic Agents - administration & dosage | Isothiocyanates - chemistry | Anti-Bacterial Agents - chemistry | Helicobacter Infections - drug therapy | Models, Animal | Neuroprotective Agents - administration & dosage | Anticarcinogenic Agents - pharmacology | Isothiocyanates - pharmacology | Neuroprotective Agents - chemistry | Cardiotonic Agents - chemistry | Cardiotonic Agents - pharmacology | Animals | Anticarcinogenic Agents - chemistry | Cardiotonic Agents - administration & dosage | Glucosinolates - pharmacology | Central Nervous System - drug effects | Anti-Bacterial Agents - pharmacology | Cell Transformation, Neoplastic - drug effects | Anti-Bacterial Agents - administration & dosage | Glucosinolates - administration & dosage | Skin - drug effects | Proteins | Analysis
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2016, Volume 21, Issue 8, p. 991
Phenylethanoid glycosides (PhGs) are widely distributed in traditional Chinese medicines as well as in other medicinal plants, and they were characterized by a... 
Bioactivity | Pharmacokinetics | Novel structures | Phenylethanoid glycosides | CISTANCHE-SALSA EXTRACT | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | novel structures | TANDEM MASS-SPECTROMETRY | CHEMISTRY, MULTIDISCIPLINARY | PERFORMANCE LIQUID-CHROMATOGRAPHY | phenylethanoid glycosides | VITRO ANTIINFLAMMATORY ACTIVITY | IN-VITRO | bioactivity | FORSYTHIA-SUSPENSA | METABOLITE P-TYROSOL | LC-MS/MS METHOD | pharmacokinetics | RAT PLASMA | Neuroprotective Agents - therapeutic use | Antioxidants - chemistry | Antiviral Agents - pharmacokinetics | Immunologic Factors - isolation & purification | Anti-Bacterial Agents - therapeutic use | Immunologic Factors - pharmacokinetics | Neuroprotective Agents - pharmacokinetics | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Glycosides - isolation & purification | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - pharmacokinetics | Anti-Inflammatory Agents - isolation & purification | Drugs, Chinese Herbal - therapeutic use | Glycosides - chemistry | Immunologic Factors - chemistry | Plants, Medicinal - chemistry | Neuroprotective Agents - chemistry | Antiviral Agents - therapeutic use | Phenylethyl Alcohol - pharmacokinetics | Anti-Bacterial Agents - isolation & purification | Phenylethyl Alcohol - isolation & purification | Drugs, Chinese Herbal - pharmacokinetics | Antioxidants - therapeutic use | Anti-Inflammatory Agents - chemistry | Neuroprotective Agents - isolation & purification | Antioxidants - isolation & purification | Drugs, Chinese Herbal - chemistry | Anti-Bacterial Agents - pharmacokinetics | Glycosides - pharmacokinetics | Antioxidants - pharmacokinetics | Antiviral Agents - isolation & purification | Phenylethyl Alcohol - therapeutic use | Glycosides - therapeutic use | Immunologic Factors - therapeutic use | Phenylethyl Alcohol - chemistry
Journal Article
Journal of controlled release, ISSN 0168-3659, 2015, Volume 207, pp. 18 - 30
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are... 
Oxidative stress | Neuroinflammation | Parkinson's disease | Catalase | Exosomes | Blood–brain barrier | Blood-brain barrier | ALZHEIMERS-DISEASE | REPEATED INJECTIONS | MACROPHAGE DELIVERY | MEDIATED TRANSFER | BLOOD-BRAIN-BARRIER | BIOLOGICAL BARRIERS | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | SUPEROXIDE-DISMUTASE | Antioxidants - chemistry | Antioxidants - metabolism | Oxidopamine | Anti-Inflammatory Agents - metabolism | PC12 Cells | Neuroprotective Agents - metabolism | Drug Carriers | Brain - metabolism | Nanoparticles | Parkinsonian Disorders - metabolism | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Neurons - metabolism | Neuroprotective Agents - administration & dosage | Nanomedicine | Disease Models, Animal | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Solubility | Rats | Technology, Pharmaceutical - methods | Parkinsonian Disorders - chemically induced | Administration, Intranasal | Chemistry, Pharmaceutical | Brain - drug effects | Catalase - metabolism | Catalase - administration & dosage | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | RAW 264.7 Cells | Antiparkinson Agents - administration & dosage | Mice | Kinetics | Oxidative Stress - drug effects | Antiparkinson Agents - metabolism | Catalase - chemistry | Drugs | Drug delivery systems | Proteases | Analysis | Antiparkinsonian agents | Vehicles | blood-brain barrier | neuroinflammation | exosomes | catalase | oxidative stress | Parkinson’s disease
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 08/2015, Volume 22, Issue 24, pp. 2819 - 2857
Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory,... 
Antichagasic agents | Heterocyclic N-oxides | Bioisosteres | Factor xa inhibitors | Antimalarials | Hypoxia | Nitric oxide mimics | Coagulation cascade direct thrombin inhibitors | hypoxia | TRANSITION-METAL CATALYSIS | BETA-AMINOESTER CLASS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | antichagasic agents | K-ATP CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | antimalarials | HUMAN-LEUKOCYTE ELASTASE | coagulation cascade direct thrombin inhibitors | CARBON BOND FORMATION | 1,3-DIOXIDE CORE SCAFFOLDS | HIV-1 ENTRY INHIBITORS | PHARMACOLOGY & PHARMACY | bioisosteres | factor Xa inhibitors | LONG-TERM POTENTIATION | FACTOR XA INHIBITOR | nitric oxide mimics | Anti-HIV Agents - pharmacology | Neuroprotective Agents - therapeutic use | Antihypertensive Agents - pharmacology | Humans | Antineoplastic Agents - therapeutic use | Herbicides - pharmacology | Antihypertensive Agents - therapeutic use | Anti-Bacterial Agents - therapeutic use | Fibrinolytic Agents - pharmacology | Cyclic N-Oxides - therapeutic use | Animals | Neuroprotective Agents - pharmacology | Cyclic N-Oxides - pharmacology | Protein Kinase Inhibitors - therapeutic use | Fibrinolytic Agents - therapeutic use | Anti-HIV Agents - therapeutic use | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 2017, Volume 17, Issue 1, pp. 33 - 43
Journal Article
Acta pharmacologica Sinica, ISSN 1671-4083, 05/2018, Volume 39, Issue 5, pp. 787 - 801
Arctigenin (AR) and its glycoside, arctiin, are two major active ingredients of Arctium lappa L (A lappa), a popular medicinal herb and health supplement... 
arctigenin | arctiin | Fructus Arctii | Arctium lappa L | pharmacokinetics | anti-inflammatory agents | clinical efficacy | CANCER-CELLS | NITRIC-OXIDE SYNTHASE | STRUCTURAL TRANSFORMATION | KAPPA-B | CHEMISTRY, MULTIDISCIPLINARY | PHENYLPROPANOID DIBENZYLBUTYROLACTONE LIGNAN | PLANT LIGNAN | SESQUITERPENE LACTONES | HUMAN INTESTINAL BACTERIUM | IN-VITRO | TRADITIONAL CHINESE MEDICINE | PHARMACOLOGY & PHARMACY | Anti-Infective Agents - pharmacology | Furans - pharmacology | Humans | Diabetic Nephropathies - drug therapy | Glucosides - pharmacokinetics | Antineoplastic Agents - administration & dosage | Lignans - pharmacology | Furans - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lignans - therapeutic use | Pancreatic Neoplasms - drug therapy | Furans - pharmacokinetics | Neuroprotective Agents - pharmacology | Neuroprotective Agents - pharmacokinetics | Arctium | Glucosides - therapeutic use | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Neuroprotective Agents - administration & dosage | Glucosides - pharmacology | Lignans - administration & dosage | Lignans - pharmacokinetics | Animals | Anti-Infective Agents - administration & dosage | Glucosides - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Anti-Infective Agents - pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Cell Line, Tumor | Furans - administration & dosage | Medicinal plants | Effectiveness | Cytokines | Liver | Oral administration | Pharmacology | Inflammation | Chemical compounds | Biological activity | Nitric-oxide synthase | Herbal medicine | Intestine | Nitric oxide | Pharmacokinetics | Review
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 2013, Volume 19, Issue 11, pp. 2011 - 2031
Journal Article
Clinical immunology (Orlando, Fla.), ISSN 1521-6616, 2012, Volume 142, Issue 1, pp. 57 - 67
Abstract Chronic inflammation and neurodegeneration are the main pathological traits of multiple sclerosis that coexist in all stages of the disease course,... 
Allergy and Immunology | Experimental autoimmune encephalomyelitis | Neuroprotection | Cannabinoids | Multiple sclerosis | Immune modulation | MURINE MACROPHAGES | ENDOCANNABINOID SYSTEM | IMMUNOLOGY | CB2 RECEPTORS | ACID-AMIDE-HYDROLASE | MULTIPLE-SCLEROSIS | DIRECT SUPPRESSION | VANILLOID RECEPTORS | DOUBLE-BLIND |