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Journal Article
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, pp. e0209363 - e0209363
One of the pathological site effects in excitotoxic activation is Zn2+ overload to postsynaptic neurons. Such an effect is considered to be equivalent to the... 
ACETYL-COA | INHIBITION | NEURONAL DEATH | MULTIDISCIPLINARY SCIENCES | ZN2+ TOXICITY | ISOCITRATE DEHYDROGENASE | NITRIC-OXIDE | CA2+ CHANNEL | GLUCOSE DEPRIVATION | NEUROTOXICITY | ACETYLCHOLINE METABOLISM | Cell Survival - drug effects | Nifedipine - pharmacology | Calcium - metabolism | Cholinergic Neurons - metabolism | Zinc - metabolism | Mitochondria - metabolism | Cholinergic Neurons - drug effects | Calcium Channel Blockers - pharmacology | Calcium Channels, N-Type - metabolism | Animals | Cations, Divalent - metabolism | Cell Line, Tumor | Neurotoxins - metabolism | Mice | Calcium Channels, L-Type - metabolism | Energy Metabolism - drug effects | Neuroblastoma - pathology | Antimitotic agents | Calcium channels | Physiological aspects | Genetic aspects | Research | Neuroblastoma | Drug therapy | Antineoplastic agents | Tricarboxylic acid cycle | Oxidative stress | Calcium antagonists | Cell culture | Dehydrogenases | Calcium | Laboratories | Toxicity | Homeostasis | Pyruvic acid | Antagonists | Dehydrogenase | Depolarization | Neurotoxicity | Mitochondria | Energy | Neurodegeneration | NADP-isocitrate dehydrogenase | Oxidation | NADP | Isocitrate dehydrogenase | Calcium homeostasis | Glutathione | Enzymes | Neurons | Shortages | Calcium channels (voltage-gated) | Pyruvate dehydrogenase (lipoamide) | Gene expression | Zinc | Malondialdehyde | Nifedipine | Medicine | Calcium ion channel blockers | Excitotoxicity | Calcium channels (L-type) | Axonal transport | ATP | Index Medicus
Journal Article
Biochemistry, ISSN 0006-2960, 07/2007, Volume 46, Issue 30, pp. 8717 - 8724
We have purified a novel paralytic peptide with 32 AA and a single disulfide bond from the venom of Conus parius, a fish-hunting species. The peptide has the... 
HAIR-CELLS | VENOM | PEPTIDES | NEUROTOXINS | CHANNEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXINS | CONUS-GEOGRAPHUS | A-CONOTOXINS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2000, Volume 97, Issue 23, pp. 12885 - 12890
Journal Article
Biochemistry, ISSN 0006-2960, 06/2014, Volume 53, Issue 23, pp. 3758 - 3766
We isolated a novel, atypical long-chain three-finger toxin (TFT), alpha-elapitoxin-Dpp2d (alpha-EPTX-Dpp2d), from black mamba (Dendroaspis polylepis... 
KAPPA-BUNGAROTOXIN | ALPHA-NEUROTOXINS | SNAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | NICOTINIC RECEPTOR PROBE | CRYSTAL-STRUCTURES | 3-FINGERED TOXINS | PROTEINS | BINDING | ACETYLCHOLINE-RECEPTOR | Reptilian Proteins - chemistry | Humans | alpha7 Nicotinic Acetylcholine Receptor - antagonists & inhibitors | Nicotinic Antagonists - pharmacology | Nicotinic Agonists - chemistry | Reptilian Proteins - pharmacology | Receptors, Nicotinic - chemistry | Neurons - metabolism | Amino Acid Sequence | Nicotinic Antagonists - isolation & purification | Receptors, Nicotinic - metabolism | Nerve Tissue Proteins - agonists | Carrier Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | alpha7 Nicotinic Acetylcholine Receptor - genetics | Reptilian Proteins - isolation & purification | Elapid Venoms - pharmacology | Nicotinic Antagonists - chemistry | Calcium Signaling - drug effects | Neurotoxins - metabolism | Protein Conformation | Protein Processing, Post-Translational | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Reptilian Proteins - metabolism | Elapid Venoms - chemistry | Nicotinic Antagonists - metabolism | Molecular Sequence Data | Neurotoxins - isolation & purification | Carrier Proteins - chemistry | Protein Stability | Elapid Venoms - isolation & purification | Neurons - drug effects | Nicotinic Agonists - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Neurotoxins - chemistry | alpha7 Nicotinic Acetylcholine Receptor - agonists | Recombinant Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Neurotoxins - pharmacology | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Elapidae - metabolism | Elapid Venoms - metabolism | Receptors, Nicotinic - genetics | Venom | Chemical properties | Research | Index Medicus
Journal Article
Journal Article
Journal Article
Archives of Toxicology, ISSN 0340-5761, 1/2017, Volume 91, Issue 1, pp. 231 - 246
Astrocytes, the largest cell population in the human brain, are powerful inflammatory effectors. Several studies have examined the interaction of activated... 
Biomedicine, general | p38 kinase | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Neuroinflammation | Astrocyte | Neuropharmacology | Pharmacology/Toxicology | LUHMES | SYSTEM | CELLS | BRAIN-INJURY | DOPAMINERGIC-NEURONS | DISEASE | NITRIC-OXIDE | IMMUNE ACTIVATION | REACTIVE ASTROCYTES | TOXICOLOGY | INDUCED NEUROTOXICITY | GLIA | Tumor Necrosis Factor-alpha - metabolism | Dexamethasone - antagonists & inhibitors | Coculture Techniques | Humans | Neuronal Plasticity - drug effects | Neurons - cytology | Interleukin-1beta - agonists | Tumor Necrosis Factor-alpha - agonists | Dexamethasone - pharmacology | Neuroprotective Agents - pharmacology | Astrocytes - immunology | Interleukin-1beta - metabolism | Neurogenesis - drug effects | Neurons - metabolism | Neurons - drug effects | Interleukin-1beta - antagonists & inhibitors | Astrocytes - cytology | Astrocytes - drug effects | Cell Survival - drug effects | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Cytokines - agonists | Neurons - immunology | Neurotoxins - toxicity | Hormone Antagonists - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | MAP Kinase Signaling System - drug effects | Cell Communication - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Cytokines - antagonists & inhibitors | Mifepristone - pharmacology | Neurotoxins - antagonists & inhibitors | Cell Line, Transformed | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Astrocytes - metabolism | Control systems | Corticosteroids | Cytokines | Neurons | Analysis | Resveratrol | Brain | Neurodegeneration | Cells | Index Medicus
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 12/2015, Volume 10, Issue 12, pp. 2805 - 2815
Snake venom alpha-neurotoxins from the three-finger toxin (3FTx) family are competitive antagonists with nanomolar affinity and high selectivity for nicotinic... 
3-FINGER TOXINS | HANNAH KING COBRA | MAXIMUM-LIKELIHOOD | BLACK MAMBA VENOM | ALPHA-NEUROTOXINS | DIRECTED MUTAGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OPHIOPHAGUS-HANNAH | BIOLOGICAL-ACTIVITY | PURIFICATION | NONNEURONAL CHOLINERGIC SYSTEM
Journal Article
Nature, ISSN 0028-0836, 01/1991, Volume 349, Issue 6308, pp. 414 - 418
Journal Article