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Biochemical journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 303 - 310
To identify high-affinity interactions between long-chain α-neurotoxins and nicotinic receptors, we determined the crystal structure of the complex between... 
Molecular recognition | Neurotoxin | Nicotinic acetylcholine receptor | Crystal structure | Reptilian Proteins - chemistry | Nicotinic Agonists - metabolism | Cobra Neurotoxin Proteins - metabolism | Pyridines - chemistry | Humans | Recombinant Fusion Proteins - metabolism | Nicotinic Agonists - chemistry | Receptors, Nicotinic - chemistry | Carrier Proteins - chemistry | Protein Interaction Domains and Motifs | Binding Sites | Peptide Fragments - genetics | Bridged Bicyclo Compounds, Heterocyclic - metabolism | Bungarotoxins - metabolism | Neurotoxins - chemistry | Peptide Fragments - metabolism | Receptors, Nicotinic - metabolism | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Bungarotoxins - chemistry | Lymnaea | Models, Molecular | Mutant Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Cobra Neurotoxin Proteins - chemistry | Bungarus | Carrier Proteins - genetics | Peptide Fragments - chemistry | Animals | Carrier Proteins - metabolism | Pyridines - metabolism | Mutant Proteins - chemistry | Ligands | Neurotoxins - metabolism | Protein Conformation | Receptors, Nicotinic - genetics | Amino Acid Substitution | Reptilian Proteins - metabolism | alpha7 Nicotinic Acetylcholine Receptor | Index Medicus | BASIC BIOLOGICAL SCIENCES | crystal structure | neurotoxin | molecular recognition | nicotinic acetylcholine receptor
Journal Article
Journal of Mathematical Biology, ISSN 0303-6812, 8/2009, Volume 59, Issue 2, pp. 193 - 231
Journal Article
The FEBS journal, ISSN 1742-464X, 2012, Volume 279, Issue 7, pp. 1156 - 1166
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2006, Volume 63, Issue 24, pp. 3030 - 3041
Journal Article
PLoS biology, ISSN 1544-9173, 05/2012, Volume 10, Issue 5, p. e1001335
Amyloidogenic neurodegenerative diseases are incurable conditions with high social impact that are typically caused by specific, largely disordered proteins.... 
OXIDATIVE STRESS | NMR | PROTEIN | AMYLOID FORMATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYGLUTAMINE DISEASES | BIOLOGY | ALPHA-SYNUCLEIN | MOLECULE FORCE SPECTROSCOPY | BETA | CONFORMATIONS | Protein Engineering - methods | Protein Unfolding | Saccharomyces cerevisiae - genetics | Humans | Molecular Sequence Data | Neurotoxins - genetics | Amyloidogenic Proteins - chemistry | Vesicle-Associated Membrane Protein 2 - genetics | Thermodynamics | Vesicle-Associated Membrane Protein 2 - chemistry | Cloning, Molecular | Plasmids - genetics | Carrier Proteins - chemistry | alpha-Synuclein - genetics | Protein Stability | Amino Acid Sequence | Nephelometry and Turbidimetry | Neurotoxins - chemistry | Neurodegenerative Diseases - pathology | Peptide Termination Factors - genetics | Protein Structure, Secondary | Polyproteins - chemistry | Rats | Neurodegenerative Diseases - genetics | Saccharomyces cerevisiae Proteins - genetics | Saccharomyces cerevisiae - chemistry | alpha-Synuclein - chemistry | Carrier Proteins - genetics | Biomechanical Phenomena | Animals | Spectrum Analysis - methods | Plasmids - chemistry | Peptide Termination Factors - chemistry | Nanotechnology | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Health aspects | Genetic polymorphisms | Neurotoxicity | Nuclear magnetic resonance--NMR | Disease | Aggregates | Microscopy | Neurodegeneration | Spectrum analysis | Cytotoxicity | Experiments | Nuclear magnetic resonance
Journal Article
PloS one, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e109846 - e109846
Two subtypes of phospholipases A2 (PLA2s) with the ability to induce myonecrosis, 'Asp49' and 'Lys49' myotoxins, often coexist in viperid snake venoms. Since... 
Reptilian Proteins - chemistry | Bothrops - metabolism | Molecular Sequence Data | Isoenzymes - chemistry | Structure-Activity Relationship | Muscle Fibers, Skeletal - drug effects | Crotalid Venoms - isolation & purification | Neurotoxins - isolation & purification | Isoenzymes - isolation & purification | Isoenzymes - toxicity | Enzyme Inhibitors - chemistry | Muscle, Skeletal - drug effects | Cell Death - drug effects | Crotalid Venoms - antagonists & inhibitors | Crotalid Venoms - toxicity | Phospholipases A2 - chemistry | Amino Acid Sequence | Cell Line | Neurotoxins - chemistry | Muscle, Skeletal - enzymology | Creatine Kinase - blood | Neurotoxins - toxicity | Phospholipases A2 - toxicity | Reptilian Proteins - isolation & purification | Drug Synergism | Animals | Acetophenones - chemistry | Muscle Fibers, Skeletal - pathology | Crotalid Venoms - chemistry | Mice | Reptilian Proteins - toxicity | Aspartic Acid - chemistry | Muscle, Skeletal - pathology | Reptilian Proteins - antagonists & inhibitors | Lysine - chemistry | Neurotoxins - antagonists & inhibitors | Phospholipases A2 - isolation & purification | Isoenzymes - antagonists & inhibitors | Peptides | Venom toxins | Toxicity | Cytotoxicity | Myotoxins | Catalytic activity | Synergism | Snakes | Calcium influx | Proteins | Reaction products | Phylogenetics | Biocompatibility | Catalysis | Enzymes | Myotubes | Phospholipase A2 | Electrostatic properties | Musculoskeletal system | Phospholipase | Hydrologic data | Cell death | Venom | Lysis | Toxins | Myonecrosis | Evolution & development | Calcium ions | Index Medicus
Journal Article
Journal Article