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1. Full Text Of Mice and Men: NAD.sup.+ Boosting with Niacin Provides Hope for Mitochondrial Myopathy Patients
by Chini, Eduardo Nunes
Cell metabolism, ISSN 1550-4131, 06/2020, Volume 31, Issue 6, p. 1041
Niacin
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2. Full Text Ex vivo supplementation with nicotinic acid enhances cellular polyation and improves cell viability in human peripheral blood mononuclear cells
by Weidele, Kathrin and Kunzmann, Andrea and Schmitz, Maike and Beneke, Sascha and Burkle, Alexander
Biochemical pharmacology, ISSN 0006-2952, 10/2010, Volume 80, Issue 7, p. 1103
Niacin
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3. Full Text Vitamin B3, a competitive inhibitor of mushroom tyrosinase (MT)
by Ahmadi, Abolfazl and Gheibi, Nematolah and Sabet, Majid Sirati and Kamaleddin, Haghbeen
Clinical biochemistry, ISSN 0009-9120, 09/2011, Volume 44, Issue 13, pp. S251 - S251
Niacin
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4. Full Text Stereoselective hetero-Diels-Alder reaction of 3-chromones with enol ethers. Novel synthesis of 2-R.sup.F-containing nicotinic acid derivatives
by Sosnovskikh, Vyacheslav Ya and Khalymbadzha, Igor A and Irgashev, Roman A and Slepukhin, Pavel A
Tetrahedron, ISSN 0040-4020, 10/2008, Volume 64, Issue 44, p. 10172
Niacin
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5. Full Text ACMSD: A Novel Target for Modulating NAD.sup.+ Homeostasis
by Yoshino, Jun
Trends in endocrinology and metabolism, ISSN 1043-2760, 04/2019, Volume 30, Issue 4, p. 229
Tryptophan | Niacin
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6. Full Text HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: Trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
by Haynes, Richard and Jiang, Lixin and Hopewell, Jemma C and Li, Jing and Chen, Fang and Parish, Sarah and Landray, Martin J and Collins, Rory and Armitage, Jane and Baigent, C and Chen, Z and Chen, Y and Pedersen, T and Bowman, L and Chen, F and Hill, M and Knott, C and Rahimi, K and Tobert, J and Sleight, P and Simpson, D and Baxter, A and Lay, M and Bray, C and Wincott, E and Leijenhorst, G and Skattebol, A and Moen, G and Mitchel, Y and Kuznetsova, O and MacMahon, S and Kjekshus, J and Hill, C and Lam, T.H and Sandercock, P and Peto, R and HPS2-THRIVE Collaborative Grp and HPS2-THRIVE Collaborative Group
European heart journal, ISSN 0195-668X, 05/2013, Volume 34, Issue 17, pp. 1279 - 1291
cardiovascular disease | LDL-cholesterol | ER niacin/laropiprant | secondary prevention | HDL-cholesterol | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Hypolipidemic Agents - adverse effects | Stroke - prevention & control | Simvastatin - administration & dosage | Humans | Middle Aged | Myocardial Reperfusion - statistics & numerical data | Death, Sudden, Cardiac - prevention & control | Male | Indoles - administration & dosage | Niacin - administration & dosage | Indoles - adverse effects | Arterial Occlusive Diseases - drug therapy | Hypolipidemic Agents - administration & dosage | Niacin - adverse effects | Female | Myocardial Infarction - prevention & control | Muscular Diseases - chemically induced | Drug Therapy, Combination | Delayed-Action Preparations | Chemical and Drug Induced Liver Injury - etiology | Index Medicus | ER niacin | laropiprant | Fasttrack Clinical
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7. Full Text Fighting glioblastoma with vitamin B3
by Crunkhorn, Sarah
Nature reviews. Drug discovery, ISSN 1474-1776, 05/2020, Volume 19, Issue 5, pp. 310 - 310
Glioblastoma multiforme | Niacin
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8. Full Text Structure of the human P2Y12 receptor in complex with an antithrombotic drug
by Zhang, Kaihua and Zhang, Jin and Gao, Zhan-Guo and Zhang, Dandan and Zhu, Lan and Han, Gye Won and Moss, Steven M and Paoletta, Silvia and Kiselev, Evgeny and Lu, Weizhen and Fenalti, Gustavo and Zhang, Wenru and Müller, Christa E and Yang, Huaiyu and Jiang, Hualiang and Cherezov, Vadim and Katritch, Vsevolod and Jacobson, Kenneth A and Stevens, Raymond C and Wu, Beili and Zhao, Qiang
Nature (London), ISSN 0028-0836, 2014, Volume 508, Issue 7498, pp. 115 - 118
Disulfides - metabolism | Fibrinolytic Agents - chemistry | Sulfonamides - chemistry | Humans | Models, Molecular | Crystallography, X-Ray | Niacin - chemistry | Niacin - metabolism | Niacin - analogs & derivatives | Purinergic P2Y Receptor Antagonists - metabolism | Receptors, Purinergic P2Y12 - chemistry | Purinergic P2Y Receptor Antagonists - chemistry | Sulfonamides - metabolism | Ligands | Protein Conformation | Molecular Docking Simulation | Receptors, Purinergic P2Y12 - metabolism | Binding Sites | Index Medicus
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9. Full Text Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients
by Landray, Martin J and Haynes, Richard and Hopewell, Jemma C and Parish, Sarah and Aung, Theingi and Tomson, Joseph and Wallendszus, Karl and Craig, Martin and Jiang, Lixin and Collins, Rory and Armitage, Jane and The HPS2-THRIVE Collaborative Group and HPS2-THRIVE Collaborative Grp and HPS2-THRIVE Collaborative Group
The New England journal of medicine, ISSN 0028-4793, 07/2014, Volume 371, Issue 3, pp. 203 - 212
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Follow-Up Studies | Humans | Middle Aged | Male | Hypercholesterolemia - drug therapy | Indoles - administration & dosage | Infection - chemically induced | Niacin - administration & dosage | Treatment Failure | Musculoskeletal Diseases - chemically induced | Niacin - adverse effects | Cholesterol, LDL - blood | Female | Hypolipidemic Agents - adverse effects | Atherosclerosis - drug therapy | Double-Blind Method | Risk Factors | Indoles - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Hypolipidemic Agents - administration & dosage | Diabetes Mellitus - chemically induced | Aged | Hemorrhage - chemically induced | Delayed-Action Preparations | Drug Combinations | Dose-response relationship (Biochemistry) | Laropiprant | Blood circulation disorders | Care and treatment | Dosage and administration | Niacin | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Stroke | Heart attacks | Risk groups | Diabetes mellitus | Cardiovascular disease | Low density lipoprotein | Cholesterol | Musculoskeletal system | Vascular diseases | Arteriosclerosis | Vitamin B | Skin | Lipoproteins (high density) | Drug dosages | Statins | Index Medicus | Abridged Index Medicus | Medicin och hälsovetenskap
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10. Full Text Two dinuclear Gd.sup.III clusters based on isobutyric acid and nicotinic acid with large magnetocaloric effects
by Zhou, Min and Wu, Lin-Hui and Wu, Xin-Yu and Yao, Shu-Li and Zheng, Teng-Fei and Xie, Xin and Liu, Sui-Jun
Journal of molecular structure, ISSN 0022-2860, 03/2021, Volume 1227
Ferromagnetism | Niacin | Magnetic properties
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11. Full Text Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
by Boden, William E and Probstfield, Jeffrey L and Anderson, Todd and Chaitman, Bernard R and Desvignes-Nickens, Patrice and Koprowicz, Kent and McBride, Ruth and Teo, Koon and Weintraub, William and The AIM-HIGH Investigators and AIM-HIGH Investigators
The New England journal of medicine, ISSN 0028-4793, 12/2011, Volume 365, Issue 24, pp. 2255 - 2267
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Metabolic diseases | General aspects | Medical sciences | Disorders of blood lipids. Hyperlipoproteinemia | Simvastatin - therapeutic use | Humans | Middle Aged | Male | Niacin - therapeutic use | Treatment Failure | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Niacin - adverse effects | Cholesterol, LDL - blood | Female | Brain Ischemia - chemically induced | Muscular Diseases - chemically induced | Drug Therapy, Combination | Brain Ischemia - epidemiology | Hypolipidemic Agents - adverse effects | Atherosclerosis - drug therapy | Kaplan-Meier Estimate | Proportional Hazards Models | Atherosclerosis - blood | Medication Adherence | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Triglycerides - blood | Cholesterol, HDL - blood | Aged | Hypolipidemic Agents - therapeutic use | Drugs | Dose-response relationship (Biochemistry) | Control | Dosage and administration | Product/Service Evaluations | Drug therapy | Niacin | Cholesterol | Statins | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Stroke | Simvastatin | Cardiovascular disease | Triglycerides | Coronary artery disease | Ischemia | Diet | Arteriosclerosis | Atherosclerosis | Cardiovascular diseases | Lipoproteins (high density) | Heart diseases | Index Medicus | Abridged Index Medicus
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12. Full Text 6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins
by Panda, Atulya K and Das, Umashankar and Umemura, Naoki and Sakagami, Hiroshi and Kawase, Masami and Balzarini, Jan and De Clercq, Erik and Dimmock, Stephen G and Roayapalley, Praveen K and Dimmock, Jonathan R
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 04/2017, Volume 27, Issue 7, pp. 1611 - 1615
Tumour-selective toxicity | Cytotoxins | Structure-activity relationships | QSAR | Niacin | Conjugated unsaturated ketones | Antineoplastic Agents - chemical synthesis | Humans | Niacin - chemical synthesis | Antineoplastic Agents - administration & dosage | Niacin - pharmacology | Antineoplastic Agents - toxicity | Niacin - administration & dosage | Antineoplastic Agents - pharmacology | Benzylidene Compounds - toxicity | Melphalan - pharmacology | Niacin - toxicity | Cyclohexanones - chemical synthesis | Quantitative Structure-Activity Relationship | Cyclohexanones - toxicity | Rats | Benzylidene Compounds - chemical synthesis | Cyclohexanones - administration & dosage | Cyclohexanones - pharmacology | Hydrolysis | Niacin - analogs & derivatives | Animals | Benzylidene Compounds - pharmacology | Benzylidene Compounds - administration & dosage | Cell Line, Tumor | Poly (ADP-Ribose) Polymerase-1 - chemistry | Mice | G1 Phase Cell Cycle Checkpoints - drug effects | Drug Screening Assays, Antitumor | Tumors | Index Medicus
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13. Full Text Agonist-bound structure of the human P2Y12 receptor
by Zhang, Jin and Zhang, Kaihua and Gao, Zhan-Guo and Paoletta, Silvia and Zhang, Dandan and Han, Gye Won and Li, Tingting and Ma, Limin and Zhang, Wenru and Müller, Christa E and Yang, Huaiyu and Jiang, Hualiang and Cherezov, Vadim and Katritch, Vsevolod and Jacobson, Kenneth A and Stevens, Raymond C and Wu, Beili and Zhao, Qiang
Nature (London), ISSN 0028-0836, 2014, Volume 508, Issue 7498, pp. 119 - 122
Humans | Substrate Specificity | Crystallography, X-Ray | Adenosine Diphosphate - chemistry | Purinergic P2Y Receptor Antagonists - metabolism | Thionucleotides - chemistry | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2Y12 - metabolism | Binding Sites | Sulfonamides - chemistry | Models, Molecular | Purinergic P2Y Receptor Agonists - chemistry | Adenosine Triphosphate - analogs & derivatives | Niacin - chemistry | Niacin - metabolism | Niacin - analogs & derivatives | Receptors, Purinergic P2Y12 - chemistry | Thionucleotides - metabolism | Purinergic P2Y Receptor Antagonists - chemistry | Sulfonamides - metabolism | Ligands | Protein Conformation | Adenosine Diphosphate - metabolism | Adenosine Triphosphate - chemistry | Adenosine Diphosphate - analogs & derivatives | Purinergic P2Y Receptor Agonists - metabolism | Index Medicus
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14. Full Text Optimization of P2Y 12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties
by Kong, Deyu and Xue, Tao and Guo, Bin and Cheng, Jianjun and Liu, Shunyin and Wei, Jianhai and Lu, Zhengyu and Liu, Haoran and Gong, Guoqing and Lan, Tian and Hu, Wenhao and Yang, Yushe
Journal of medicinal chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 6, pp. 3088 - 3106
Purinergic P2Y Receptor Antagonists - pharmacology | Rats, Wistar | Sulfonamides - chemistry | Humans | Purinergic P2Y Receptor Antagonists - pharmacokinetics | Receptors, Purinergic P2Y12 - drug effects | Rats | Male | Structure-Activity Relationship | Sulfonamides - pharmacology | Drug Discovery | Niacin - pharmacology | Rats, Sprague-Dawley | Niacin - chemistry | Sulfonamides - pharmacokinetics | Niacin - analogs & derivatives | Animals | Purinergic P2Y Receptor Antagonists - chemistry | Platelet Aggregation Inhibitors - chemistry | Niacin - pharmacokinetics | Platelet Aggregation Inhibitors - pharmacology | Platelet Aggregation Inhibitors - pharmacokinetics
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15. Full Text Mechanism of Action of Niacin
by Kamanna, Vaijinath S., PhD and Kashyap, Moti L., MD
The American journal of cardiology, ISSN 0002-9149, 2008, Volume 101, Issue 8, pp. S20 - S26
Cardiovascular | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Dyslipidemias - drug therapy | Humans | Endothelium, Vascular - drug effects | Apolipoproteins - drug effects | Cholesterol, VLDL - blood | Niacin - pharmacology | Anticholesteremic Agents - adverse effects | Anticholesteremic Agents - therapeutic use | Niacin - therapeutic use | Triglycerides - blood | Cholesterol, HDL - blood | Niacin - adverse effects | Cholesterol, LDL - blood | Flushing - chemically induced | Anticholesteremic Agents - pharmacology | Proteins | Low density lipoproteins | Atherosclerosis | Physiological aspects | Blood lipids | Niacin | Lipoprotein A | Lipids | Nutrition | Cardiology | Low density lipoprotein | Vitamin B | Cholesterol | Index Medicus | Abridged Index Medicus
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