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European Journal of Cancer, ISSN 0959-8049, 2014, Volume 50, Issue 17, pp. 3021 - 3028
Journal Article
Cancer Letters, ISSN 0304-3835, 2012, Volume 320, Issue 1, pp. 104 - 110
Abstract Molecularly targeted therapies have emerged as the leading theme in cancer therapeutics. Multi-cytotoxic drug regimens have been highly successful,... 
Hematology, Oncology and Palliative Medicine | Combination index | Dasatinib | Molecular targeted therapy | Rapamycin | ACTIVATION | SRC | BCR-ABL | TUMOR | MECHANISMS | SIMULATION | CHEMOTHERAPY | ONCOLOGY | RESISTANCE | SYSTEMS | KINASES | Niacinamide - analogs & derivatives | Paclitaxel - pharmacology | Nitriles - pharmacology | Humans | Epothilones - pharmacology | Thiazoles - administration & dosage | Chromones - administration & dosage | Phenylurea Compounds | Benzenesulfonates - administration & dosage | Tamoxifen - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Nitriles - administration & dosage | Benzenesulfonates - pharmacology | Female | Chromones - pharmacology | Paclitaxel - administration & dosage | Butadienes - pharmacology | Pyridines - administration & dosage | Pyrimidines - administration & dosage | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Pyrimidines - pharmacology | Breast Neoplasms - drug therapy | Sirolimus - pharmacology | Drug Synergism | Sirolimus - administration & dosage | Signal Transduction - drug effects | Butadienes - administration & dosage | Epothilones - administration & dosage | Tamoxifen - pharmacology | Cell Line, Tumor | Pyridines - pharmacology | Thiazoles - pharmacology | Care and treatment | Oncology, Experimental | Genes | Breast cancer | Research | Tamoxifen | Cancer | Index Medicus
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 328 - 338
Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to... 
Early onset of fibrosis | Precision-cut liver slices | Antifibrotic drugs | Liver fibrosis | Ex vivo model | ROSMARINIC ACID | ANGIOTENSIN-II | ANTI-FIBROTIC DRUGS | IN-VITRO | INHIBITS ACTIVATION | HEPATIC STELLATE CELLS | ENDOPLASMIC-RETICULUM | DERMAL FIBROBLASTS | GROWTH-FACTOR | IMATINIB MESYLATE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Niacinamide - analogs & derivatives | Rats, Wistar | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Male | Valproic Acid - pharmacology | Depsides - pharmacology | Perindopril - pharmacology | Collagen Type I - genetics | Liver - drug effects | Benzamides - pharmacology | Benzylisoquinolines - pharmacology | Organ Culture Techniques | Liver Cirrhosis - drug therapy | Gene Expression | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Down-Regulation | Liver - metabolism | Rats | Becaplermin | Transforming Growth Factor beta1 - genetics | Pyrimidines - pharmacology | Cinnamates - pharmacology | HSP47 Heat-Shock Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Animals | Models, Biological | Sorafenib | HSP47 Heat-Shock Proteins - metabolism | Connective Tissue Growth Factor - genetics | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Connective Tissue Growth Factor - metabolism | Pyridones - pharmacology | Proto-Oncogene Proteins c-sis - antagonists & inhibitors | Drugs | Liver diseases | Analysis | Liver | Fibrosis | Gene expression | Growth factors | Index Medicus | FIBROSIS | DRUGS | GENES | LIVER | RATS | 60 APPLIED LIFE SCIENCES | ATP
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2013, Volume 66, pp. 170 - 178
The medial prefrontal cortex (mPFC) serves executive cognitive functions such as decision-making that are impaired in neuropsychiatric disorders and pain. We... 
Positive allosteric modulator | CB1 | Prefrontal cortex | Synaptic transmission | mGluR5 | PAM | CONDITIONED TASTE-AVERSION | SYNAPTIC-TRANSMISSION | ENDOCANNABINOID SYSTEM | METABOTROPIC GLUTAMATE RECEPTORS | AMYGDALA NEURONS | NEUROSCIENCES | FEAR EXTINCTION | COGNITIVE INFLEXIBILITY | NEOCORTICAL INTERNEURONS | POSITIVE ALLOSTERIC MODULATORS | PHARMACOLOGY & PHARMACY | DIFFERENTIAL ROLES | Niacinamide - analogs & derivatives | Glycine - analogs & derivatives | Niacinamide - antagonists & inhibitors | Synaptic Transmission - physiology | Receptors, Metabotropic Glutamate - physiology | Male | Cannabinoid Receptor Agonists - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Receptor, Cannabinoid, CB1 - physiology | Excitatory Postsynaptic Potentials - physiology | Neural Inhibition - physiology | Prefrontal Cortex - drug effects | Pyramidal Cells - physiology | Cannabinoid Receptor Antagonists - pharmacology | Receptor, Metabotropic Glutamate 5 | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Pyrazoles - pharmacology | Inhibitory Postsynaptic Potentials - physiology | Morpholines - pharmacology | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Rats, Sprague-Dawley | Arachidonic Acids - pharmacology | Animals | Glycine - pharmacology | Pyridines - pharmacology | Thiazoles - pharmacology | Niacinamide - pharmacology | Receptors, Metabotropic Glutamate - agonists | Neural Inhibition - drug effects | Prefrontal Cortex - physiology | Inhibitory Postsynaptic Potentials - drug effects | Phenylacetates - pharmacology | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Nervous system diseases | Neurosciences | Glutamate | Neurons | Cognitive ability
Journal Article
Neoplasia, ISSN 1476-5586, 2015, Volume 17, Issue 7, pp. 564 - 573
Journal Article
Investigational New Drugs, ISSN 0167-6997, 8/2013, Volume 31, Issue 4, pp. 833 - 844
The HGF/MET signaling pathway regulates a wide variety of normal cellular functions that can be subverted to support neoplasia, including cell proliferation,... 
Medicine & Public Health | MET inhibitor | Oncology | MST1R | Pharmacology/Toxicology | LY2801653 | ROS1 | MKNK | ACTIVATION | GEFITINIB | TYROSINE KINASE | COEXPRESSION | AMPLIFICATION | ONCOLOGY | AXL | C-MET | RESISTANCE | PHARMACOLOGY & PHARMACY | GROWTH-FACTOR | MUTATIONS | Niacinamide - analogs & derivatives | Proto-Oncogene Proteins c-met - metabolism | Tetrazoles - pharmacology | Blood Vessels - pathology | Humans | Biological Availability | Antineoplastic Agents - administration & dosage | Indazoles - administration & dosage | Protein Kinase Inhibitors - chemistry | Tetrazoles - chemistry | Niacinamide - chemistry | Tetrazoles - administration & dosage | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Indazoles - chemistry | Administration, Oral | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Antineoplastic Agents - chemistry | Mutation - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Niacinamide - administration & dosage | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Blood Vessels - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Niacinamide - pharmacology | Complications and side effects | Enzyme inhibitors | Physiological aspects | Genetic aspects | Cellular signal transduction | Dosage and administration | Research | Drug therapy | Cancer | Studies | Pharmaceutical sciences | Tumors | Preclinical Studies
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 03/2006, Volume 6, Issue 3, pp. 496 - 504
Journal Article
PloS one, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35429
A range of novel carboxamide fungicides, inhibitors of the succinate dehydrogenase enzyme (SDH, EC 1.3.5.1) is currently being introduced to the crop... 
UBIQUINONE-BINDING SITE | BOSCALID RESISTANCE | OXIDATIVE STRESS | CARBOXIN RESISTANCE | ELECTRON-TRANSFER | COMPLEX-II SUCCINATE | BOTRYTIS-CINEREA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | OXIDOREDUCTASE | IRON-SULFUR SUBUNIT | Niacinamide - analogs & derivatives | Oxidative Stress | Molecular Sequence Data | Plant Diseases - microbiology | Ascomycota - drug effects | Fungal Proteins - antagonists & inhibitors | Norbornanes - pharmacology | Ascomycota - growth & development | Fungicides, Industrial - pharmacology | Biphenyl Compounds - pharmacology | Computer Simulation | Ascomycota - genetics | Conserved Sequence | Inhibitory Concentration 50 | Benzamides - pharmacology | Binding Sites | Triticum - microbiology | Pyrazoles - pharmacology | Amino Acid Sequence | Succinate Dehydrogenase - antagonists & inhibitors | Models, Molecular | Ascomycota - enzymology | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Succinate Dehydrogenase - genetics | Mutagenesis | Protein Binding | Pyridines - pharmacology | Niacinamide - pharmacology | Carboxin - pharmacology | Drug resistance in microorganisms | Fungicides | Wheat | Analysis | Reactive oxygen species | Succinate dehydrogenase | Yeast | Dehydrogenases | Enzyme activity | Laboratories | Genes | Amino acids | Homology | Dehydrogenase | Proteins | Ubiquinone | E coli | Enzymatic activity | Docking | Physiology | Pharmaceutical sciences | Binding | Enzymes | Pathogens | Oxygen | Cell survival | Cloning | Pesticides | Pharmacology | Plant protection | Bacteriology | Chemistry | Inhibitors | Neural networks | In vivo methods and tests | Recombinants | Mutation | Binding sites | Fitness
Journal Article
Journal of investigative dermatology, ISSN 0022-202X, 2008, Volume 128, Issue 8, pp. 2013 - 2023
The RAS–RAF–MEK–ERK and PI3K–AKT–mTOR signaling pathways are activated through multiple mechanisms and appear to play a major role in melanoma progression.... 
MAMMALIAN TARGET | RAPAMYCIN | PATHWAYS | APOPTOSIS | HUMAN-LEUKEMIA-CELLS | CUTANEOUS MELANOMA | DOWN-REGULATION | AKT | BCL-2 FAMILY-MEMBERS | UP-REGULATION | DERMATOLOGY | Niacinamide - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - genetics | Skin Neoplasms - drug therapy | Nitriles - pharmacology | Apoptosis - drug effects | Humans | Multiprotein Complexes | Phenylurea Compounds | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - drug effects | Proteins | Proto-Oncogene Proteins c-bcl-2 - metabolism | Benzenesulfonates - pharmacology | Flavonoids - pharmacology | Chromones - pharmacology | Skin Neoplasms - pathology | Butadienes - pharmacology | Neoplasm Invasiveness | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Melanoma - pathology | Transcription Factors - genetics | Down-Regulation - drug effects | Sirolimus - pharmacology | Androstadienes - pharmacology | Signal Transduction - drug effects | Melanoma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein | Mitogen-Activated Protein Kinase Kinases - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | TOR Serine-Threonine Kinases | Proto-Oncogene Proteins c-bcl-2 - genetics
Journal Article