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Anti-Cancer Drugs, ISSN 0959-4973, 03/2013, Volume 24, Issue 3, pp. 251 - 259
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2012, Volume 21, Issue 1, pp. 66 - 81
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 5/2013, Volume 71, Issue 5, pp. 1297 - 1307
To evaluate first-generation rapamycin analogs (everolimus, temsirolimus, and rapamycin) and second-generation drugs inhibiting mTOR kinase (AZD-8055), PI3K... 
Resistance | Angiogenesis | Medicine & Public Health | VEGFr tyrosine kinase inhibitor | Kidney cancer | mTOR inhibitor | Oncology | Cancer Research | Pharmacology/Toxicology | MAMMALIAN TARGET | RAPAMYCIN | EVEROLIMUS | GUIDELINES | NVP-BEZ235 | CANCER | TRIAL | INTERFERON-ALPHA | ONCOLOGY | TEMSIROLIMUS | mTOR inhibitor Resistance | PHARMACOLOGY & PHARMACY | PHASE-I | Niacinamide - analogs & derivatives | Humans | Imidazoles - administration & dosage | Drug Resistance, Neoplasm | Antineoplastic Agents - administration & dosage | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - administration & dosage | Quinolines - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Sunitinib | Carcinoma, Hepatocellular - drug therapy | Indoles - pharmacology | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Carcinoma, Renal Cell - drug therapy | Everolimus | Aminopyridines - administration & dosage | Sirolimus - analogs & derivatives | Carcinoma, Renal Cell - pathology | Pyrimidines - administration & dosage | Morpholines - administration & dosage | Liver Neoplasms - drug therapy | Morpholines - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Imidazoles - pharmacology | Pyrimidines - pharmacology | Sirolimus - pharmacology | Sirolimus - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Pyrroles - pharmacology | Signal Transduction - drug effects | Aminopyridines - pharmacology | Sorafenib | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Kidney Neoplasms - pathology | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Kidney Neoplasms - drug therapy | Antimitotic agents | Benchmarks | Carcinoma, Renal cell | Antineoplastic agents | Vascular endothelial growth factor | Analysis | Index Medicus
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2014, Volume 50, Issue 17, pp. 3021 - 3028
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0148242 - e0148242
Annual losses of honey bee colonies remain high and pesticide exposure is one possible cause. Dangerous combinations of pesticides, plant-produced compounds... 
MALPIGHIAN TUBULES | DRUG INTERACTIONS | APIS-MELLIFERA | GLYCOPROTEIN-MEDIATED TRANSPORT | MULTIDISCIPLINARY SCIENCES | INSECTICIDE TOXICITY | IVERMECTIN | ABC TRANSPORTERS | EXPRESSION | P-GLYCOPROTEIN | TRANSEPITHELIAL TRANSPORT | Niacinamide - analogs & derivatives | Drug Resistance, Multiple | Cyclohexanes - pharmacology | Neonicotinoids | Rhodamines - metabolism | Ivermectin - metabolism | Biphenyl Compounds - pharmacology | Membrane Transport Proteins - metabolism | Biological Transport - drug effects | Carbamates - pharmacology | Pyrazoles - pharmacology | Insecticides - pharmacology | Risk Assessment | Fatty Acids, Unsaturated - pharmacology | Ivermectin - pharmacology | Verapamil - pharmacology | Environmental Exposure - adverse effects | Animals | Quercetin - pharmacology | ATP-Binding Cassette Transporters - drug effects | Bees - drug effects | Pyridines - pharmacology | Niacinamide - pharmacology | Sesquiterpenes - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Honeybee | Research | Drug resistance | Health aspects | Ivermectin | Rhodamine | Laboratories | Fluorescence | Insecticides | Biochemistry | Parasites | Tissues | Bees | Proteins | Toxicology | Insecticide resistance | Agrochemicals | Metabolites | Risk assessment | Physiology | Agriculture | Enzymes | Colonies | Multidrug resistance | Pesticides | Hemolymph | Substrate inhibition | Metabolism | Chemicals | Honey | Sensitivity | Antibiotics | Insects | Animal behavior | Quercetin | Strategy | Chemical interactions | Verapamil | In vivo methods and tests | Molecular biology | Transporter | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 14, pp. 2984 - 2992
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2013, Volume 66, pp. 170 - 178
The medial prefrontal cortex (mPFC) serves executive cognitive functions such as decision-making that are impaired in neuropsychiatric disorders and pain. We... 
Positive allosteric modulator | CB1 | Prefrontal cortex | Synaptic transmission | mGluR5 | PAM | CONDITIONED TASTE-AVERSION | SYNAPTIC-TRANSMISSION | ENDOCANNABINOID SYSTEM | METABOTROPIC GLUTAMATE RECEPTORS | AMYGDALA NEURONS | NEUROSCIENCES | FEAR EXTINCTION | COGNITIVE INFLEXIBILITY | NEOCORTICAL INTERNEURONS | POSITIVE ALLOSTERIC MODULATORS | PHARMACOLOGY & PHARMACY | DIFFERENTIAL ROLES | Niacinamide - analogs & derivatives | Glycine - analogs & derivatives | Niacinamide - antagonists & inhibitors | Synaptic Transmission - physiology | Receptors, Metabotropic Glutamate - physiology | Male | Cannabinoid Receptor Agonists - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Receptor, Cannabinoid, CB1 - physiology | Excitatory Postsynaptic Potentials - physiology | Neural Inhibition - physiology | Prefrontal Cortex - drug effects | Pyramidal Cells - physiology | Cannabinoid Receptor Antagonists - pharmacology | Receptor, Metabotropic Glutamate 5 | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Pyrazoles - pharmacology | Inhibitory Postsynaptic Potentials - physiology | Morpholines - pharmacology | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Rats, Sprague-Dawley | Arachidonic Acids - pharmacology | Animals | Glycine - pharmacology | Pyridines - pharmacology | Thiazoles - pharmacology | Niacinamide - pharmacology | Receptors, Metabotropic Glutamate - agonists | Neural Inhibition - drug effects | Prefrontal Cortex - physiology | Inhibitory Postsynaptic Potentials - drug effects | Phenylacetates - pharmacology | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Nervous system diseases | Neurosciences | Glutamate | Neurons | Index Medicus | Cognitive ability
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 328 - 338
Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to... 
Early onset of fibrosis | Precision-cut liver slices | Antifibrotic drugs | Liver fibrosis | Ex vivo model | ROSMARINIC ACID | ANGIOTENSIN-II | ANTI-FIBROTIC DRUGS | IN-VITRO | INHIBITS ACTIVATION | HEPATIC STELLATE CELLS | PHARMACOLOGY & PHARMACY | ENDOPLASMIC-RETICULUM | DERMAL FIBROBLASTS | TOXICOLOGY | GROWTH-FACTOR | IMATINIB MESYLATE | Niacinamide - analogs & derivatives | Rats, Wistar | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Male | Valproic Acid - pharmacology | Depsides - pharmacology | Perindopril - pharmacology | Collagen Type I - genetics | Liver - drug effects | Benzamides - pharmacology | Benzylisoquinolines - pharmacology | Organ Culture Techniques | Liver Cirrhosis - drug therapy | Gene Expression | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Down-Regulation | Liver - metabolism | Rats | Transforming Growth Factor beta1 - genetics | Pyrimidines - pharmacology | Cinnamates - pharmacology | HSP47 Heat-Shock Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Animals | Models, Biological | HSP47 Heat-Shock Proteins - metabolism | Connective Tissue Growth Factor - genetics | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Connective Tissue Growth Factor - metabolism | Pyridones - pharmacology | Proto-Oncogene Proteins c-sis - antagonists & inhibitors | Drugs | Liver diseases | Analysis | Liver | Fibrosis | Gene expression | Growth factors | Index Medicus | FIBROSIS | DRUGS | GENES | LIVER | RATS | 60 APPLIED LIFE SCIENCES | ATP
Journal Article
British Journal of Cancer, ISSN 0007-0920, 2017, Volume 117, Issue 12, pp. 1777 - 1786
Background: Although chemotherapy is the cornerstone treatment for patients with metastatic colorectal cancer (mCRC), acquired chemoresistance is common and... 
Nuclear internalisation | Acquired resistance | IGF-1R | Colorectal cancer | BRAF mutation | colorectal cancer | I RECEPTOR | TUMOR-CELLS | COMBINATION | acquired resistance | INSULIN | nuclear internalisation | MUTATION STATUS | ONCOLOGY | POOR-PROGNOSIS | KRAS | INHIBITOR | TRANSCRIPTION FACTOR | EXPRESSION | Leucovorin - administration & dosage | Receptor, IGF Type 1 - metabolism | Molecular Chaperones - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Panitumumab | Drug Resistance, Neoplasm | Male | Protein Inhibitors of Activated STAT - metabolism | Protein Transport - drug effects | Cell Nucleus - metabolism | Colorectal Neoplasms - drug therapy | Protein Inhibitors of Activated STAT - genetics | Camptothecin - administration & dosage | Camptothecin - analogs & derivatives | Cell Survival - drug effects | Bevacizumab - administration & dosage | Antibodies, Monoclonal - pharmacology | HCT116 Cells | Curcumin - pharmacology | Molecular Chaperones - genetics | Pyrimidines - pharmacology | Dasatinib - pharmacology | Signal Transduction - drug effects | Sorafenib | Fluorouracil - pharmacology | Niacinamide - analogs & derivatives | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Molecular Targeted Therapy | Organoplatinum Compounds - pharmacology | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Oxaliplatin | Female | Antineoplastic Agents - pharmacology | Gene Silencing | Fatty Acids, Unsaturated - pharmacology | HT29 Cells | Pyrroles - pharmacology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cetuximab - administration & dosage | Aged | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Colorectal Neoplasms - pathology | Immunohistochemistry | Medical research | Cell survival | Insulin-like growth factor I | RNA-mediated interference | Colorectal carcinoma | Chemoresistance | Clinical trials | Insulin-like growth factors | Metastasis | Insulin | Patients | Survival | Metastases | Proteins | SUMO protein | Chemotherapy | Cell lines | Monoclonal antibodies | Tumors | Cancer | Index Medicus | Translational Therapeutics
Journal Article