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Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 166 - 170
The gamma-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important... 
PRESENILIN | COMPLEX | PARTICLE ELECTRON CRYOMICROSCOPY | TRANSMEMBRANE DOMAIN-4 | MEMBRANE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NICASTRIN | CRYO-EM | FAMILY INTRAMEMBRANE PROTEASE | BINDING | Cryoelectron Microscopy | Protein Structure, Tertiary | Models, Molecular | Crystallography, X-Ray | Amyloid Precursor Protein Secretases - chemistry | Humans
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 3/2016, Volume 136, Issue 6, pp. 1246 - 1258
The γ-secretase complex is composed of at least four components: presenilin (PS1 or PS2), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin... 
nicastrin | APP | Alzheimer’s disease | Aph-1 | gamma-secretase
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 02/2014, Volume 5
A body of evidence suggests that aberrant metabolism of amyloid-beta peptide (A beta) underlies the aetiology of Alzheimer disease (AD). Recently, a... 
PRESENILIN | APP | TRANSPORT | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | NICASTRIN | AMYLOID PRECURSOR PROTEIN | INHIBITOR | CLEAVAGE | PLASMA-MEMBRANE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2009, Volume 284, Issue 21, pp. 13975 - 13979
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 01/2019, Volume 139, Issue 1, pp. 124 - 134
Nicastrin ( ) mutations are associated with familial acne inversa (AI), and emerging evidence suggests that microRNAs (miRNAs) are involved in various skin... 
GROWTH-FACTOR RECEPTOR | NCSTN | HOMEOSTASIS | INFLAMMATION | NOTCH | PROLIFERATION | GAMMA-SECRETASE | HIDRADENITIS SUPPURATIVA | EXPRESSION | NICASTRIN MUTATIONS | DERMATOLOGY
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 10/2017, Volume 177, Issue 4, pp. 895 - 896
Linked Article: Frew et al. Br J Dermatol 2017; 177:987–998. 
GENE-MUTATIONS | PRESENILIN/GAMMA-SECRETASE | NICASTRIN | ASSOCIATION | ACNE INVERSA | DERMATOLOGY | Hidradenitis Suppurativa | Humans
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 11/2019, Volume 58, Issue 44, pp. 4398 - 4407
gamma-Secretase is a membrane-embedded aspartyl protease complex with presenilin as the catalytic component that cleaves within the transmembrane domain (TMD)... 
PRESENILIN | SITE | APH-1 INTERACTS | INTRAMEMBRANE PROTEOLYSIS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-APP | NICASTRIN | TRANSMEMBRANE DOMAIN | AMYLOID PRECURSOR PROTEIN | CLEAVAGE
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2019, Volume 28, Issue 7, pp. 1173 - 1182
Abstract Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin disorder characterized clinically with acne-like lesions in apocrine... 
PSENEN | ADALIMUMAB | ALZHEIMERS-DISEASE | FAMILIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | DOUBLE-BLIND | NOTCH | NCSTN GENE | ACNE INVERSA | NICASTRIN MUTATIONS | PRESENILIN GENE
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2006, Volume 8, Issue 8, pp. 894 - 896
γ-secretase and signal peptide peptidase (SPP) are unusual GxGD aspartyl proteases, which mediate intramembrane proteolysis. In addition to SPP, a family of... 
ENZYME | SIGNAL PEPTIDE PEPTIDASE | SUBSTRATE | NICASTRIN | NOTCH-1 | PROTEOLYSIS | IDENTIFICATION | CELL BIOLOGY
Journal Article
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 8, pp. 5576 - 5584
gamma-Secretase is an intramembrane-cleaving aspartyl protease that plays an essential role in the processing of a variety of integral membrane proteins. Its... 
PRESENILIN | MARTINI FORCE-FIELD | COMPLEX | ACTIVE-SITE | ALZHEIMERS-DISEASE | AMYLOID-BETA | NICASTRIN FUNCTIONS | TRANSMEMBRANE DOMAIN | ASPARTIC PROTEASES | SIMULATIONS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical science, ISSN 2041-6520, 08/2017, Volume 8, Issue 8, pp. 5576 - 5584
γ-Secretase is an intramembrane-cleaving aspartyl protease that plays an essential role in the processing of a variety of integral membrane proteins. Its role... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2016, Volume 113, Issue 5, pp. E509 - E518
Journal Article