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nicorandil (65) 65
animals (48) 48
index medicus (43) 43
male (43) 43
humans (29) 29
nicorandil - pharmacology (29) 29
pharmacology & pharmacy (27) 27
rats (25) 25
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heart (10) 10
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vasodilator agents - adverse effects (10) 10
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aged, 80 and over (9) 9
toxicology (9) 9
apoptosis (8) 8
glyburide - pharmacology (8) 8
niacinamide - analogs & derivatives (8) 8
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angina pectoris - drug therapy (7) 7
dermatology (7) 7
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glibenclamide (7) 7
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potassium channels - drug effects (7) 7
rats, sprague-dawley (7) 7
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article (6) 6
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pinacidil (6) 6
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rabbits (6) 6
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amlodipine (5) 5
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angina pectoris (5) 5
antihypertensive agents - pharmacology (5) 5
arrhythmias, cardiac - chemically induced (5) 5
cardiology (5) 5
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disease models, animal (5) 5
heart - drug effects (5) 5
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acetylcholinesterase (4) 4
arrhythmias (4) 4
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Circulation, ISSN 0009-7322, 04/2013, Volume 127, Issue 16, pp. 1677 - 1691
Background-Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths.... 
arrhythmias, cardiac | stem cells | induced pluripotent stem cells | LONG-QT | INDUCED ARRHYTHMIAS | POLYMORPHIC VENTRICULAR-TACHYCARDIA | CARDIAC & CARDIOVASCULAR SYSTEMS | SUDDEN-DEATH | QT INTERVAL PROLONGATION | DISCOVERY | CHANNEL | MODELS | TORSADE-DE-POINTES | PERIPHERAL VASCULAR DISEASE | MOLECULAR-BASIS | Cardiomyopathy, Dilated - pathology | Embryonic Stem Cells - cytology | Kidney - embryology | Cardiomyopathy, Hypertrophic, Familial - genetics | Humans | Ion Channels - genetics | Verapamil - toxicity | Gene Expression Profiling | HEK293 Cells - drug effects | Cell Line - drug effects | Nicorandil - toxicity | Cell Line - physiology | Myofibrils - ultrastructure | Drug-Related Side Effects and Adverse Reactions - genetics | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Action Potentials - drug effects | Cardiomyopathy, Dilated - genetics | Drug Evaluation, Preclinical - methods | Genetic Predisposition to Disease | Ion Channels - biosynthesis | Cardiomyopathy, Hypertrophic, Familial - pathology | Cell Size | Kidney - cytology | Long QT Syndrome - pathology | Embryonic Stem Cells - physiology | Embryoid Bodies - drug effects | Patch-Clamp Techniques | Myocytes, Cardiac - drug effects | Quinazolines - toxicity | HEK293 Cells - physiology | Myocytes, Cardiac - physiology | Long QT Syndrome - genetics | Cisapride - toxicity | In Vitro Techniques | Drugs | Usage | Analysis | Heart cells | Stem cells | Product/Service Evaluations | Research | Health aspects | Methods | cardiotoxicity | Induced pluripotent stem cells | arrhythmia
Journal Article
Life Sciences, ISSN 0024-3205, 02/2019, Volume 218, pp. 284 - 291
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease which poses a need to explore effective yet safe pharmacotherapeutic options.... 
NF-κB | TLR-4-MyD88-TRAF6 axis | Nicorandil | Rheumatoid arthritis | MAP kinases | Diclofenac | RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | MUSCLE | EXERCISE | FIBROBLAST-LIKE SYNOVIOCYTES | NF-kappa B | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | CHANNELS | EXPRESSION | MODULATION | Arthritis, Experimental - drug therapy | Freund's Adjuvant - toxicity | Vasodilator Agents - pharmacology | Rats, Wistar | Myeloid Differentiation Factor 88 - genetics | Rats | Toll-Like Receptor 4 - genetics | Male | Adjuvants, Immunologic - toxicity | Toll-Like Receptor 4 - metabolism | Arthritis, Experimental - metabolism | Gene Expression Regulation - drug effects | Nicorandil - pharmacology | Animals | Signal Transduction - drug effects | Arthritis, Experimental - chemically induced | TNF Receptor-Associated Factor 6 - metabolism | TNF Receptor-Associated Factor 6 - genetics | Pain Measurement | Myeloid Differentiation Factor 88 - metabolism | Rheumatoid factor | Arthritis | Interleukins | Gene expression | Knee | Transcription factors | Body weight | Interleukin | Kinases | Inflammatory diseases | Interleukin 6 | Signal transduction | Pain | Toll-like receptors | Tumor necrosis factor-TNF | NF-κB protein | TRAF6 protein | Cytokines | Extracellular signal-regulated kinase | c-Jun protein | JNK protein | Knee (anatomy) | Pharmacology | TLR4 protein | Tumor necrosis factor-α | IL-1β | Serum levels | Signaling | Freund's adjuvant | MyD88 protein | Biomarkers
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33367
Background: An antianginal K-ATP channel opener nicorandil has various beneficial effects on cardiovascular systems; however, its effects on pulmonary... 
SURVIVAL | ACTIVATION | INHIBITION | POTASSIUM CHANNELS | K-ATP CHANNELS | BIOLOGY | INJURY | RATS | CELL-PROLIFERATION | CARDIAC PROTECTION | Antihypertensive Agents - pharmacology | Human Umbilical Vein Endothelial Cells - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Endothelium, Vascular - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | NG-Nitroarginine Methyl Ester - administration & dosage | Hypertension, Pulmonary - chemically induced | Hypertension, Pulmonary - prevention & control | Enzyme Inhibitors - administration & dosage | Nicorandil - pharmacology | Glyburide - pharmacology | Glyburide - administration & dosage | Drug Therapy, Combination | Proto-Oncogene Proteins c-akt - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Cells, Cultured | Enzyme Inhibitors - pharmacology | Injections, Intraperitoneal | Ventricular Pressure - drug effects | Rats | Familial Primary Pulmonary Hypertension | Monocrotaline - toxicity | Nicorandil - administration & dosage | Random Allocation | Rats, Sprague-Dawley | Blotting, Western | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Endothelium, Vascular - pathology | Arginine | Glibenclamide | Nitric oxide | Pulmonary hypertension | Endothelium | Heart | Systolic pressure | Bcl-2 protein | Monocrotaline | AKT protein | Kinases | Caspase-3 | Serum-free medium | Signal transduction | Rodents | Attenuation | Blood pressure | Adenosine triphosphate | Hypertension | Cell survival | Extracellular signal-regulated kinase | Caspase | Injection | Nitric-oxide synthase | Endothelial cells | 1-Phosphatidylinositol 3-kinase | NG-Nitroarginine methyl ester | Signaling | Lungs | Ventricle | Circulatory system | Mercury | Umbilical vein | Potassium | Apoptosis
Journal Article
Medecine Buccale Chirurgie Buccale, ISSN 1273-2761, 04/2016, Volume 22, Issue 2, pp. 123 - 129
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e18922
Background: Transgenic (TG) mice with overexpression of an arg120gly (R120G) missense mutation in HSPB5 display desmin-related cardiomyopathy, which is... 
MULTIDISCIPLINARY SCIENCES | CARDIOMYOPATHY | BCL-2 FAMILY PROTEINS | INJURY | ISCHEMIA | REPERFUSION | RELEASE | DESMIN | EXPRESSION | CELL-DEATH | alpha-Crystallin B Chain - genetics | Mutation, Missense - genetics | Nicorandil - pharmacology | Nicorandil - toxicity | Adenoviridae - genetics | Cell Death - drug effects | Animals, Newborn | Cell Survival - drug effects | Cytochromes c - secretion | Rats | Mice, Transgenic | Mitochondria - metabolism | Cardiotonic Agents - pharmacology | Mitochondria - drug effects | Genetic Vectors - genetics | Apoptosis Regulatory Proteins - metabolism | KATP Channels - metabolism | Myocytes, Cardiac - pathology | Animals | Mitochondria - secretion | Myocytes, Cardiac - drug effects | Survival Analysis | Myocytes, Cardiac - metabolism | Mice | Adenoviridae - drug effects | Ion Channel Gating - drug effects | Cytochrome c | Potassium channels | Apoptosis | Cytochrome | Heart | Neonates | Oxidative stress | Bax protein | Aggresomes | Disease | Cardiomyopathy | Childrens health | Activation | Myocytes | Caspase-3 | Proteins | Mitochondria | Reduction | Missense mutation | Ischemia | Rodents | Life sciences | Drug therapy | Cell survival | Abnormalities | Mortality | Transgenic mice | Caspase | Cardiomyocytes | Pharmacology | Angina pectoris | Survival | Desmin | Cell death | Pharmacy | ATP | Potassium | Viability
Journal Article