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The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 36, pp. 25938 - 25949
NAD(+) is mainly synthesized in human cells via the "salvage" pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The... 
NAMPT INHIBITION | IN-VITRO | CYCLIC-ADP-RIBOSE | CHS 828 | ENZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | CD38 | FK866 | LYMPHOCYTES | 5'-Nucleotidase - genetics | Gene Expression Regulation, Enzymologic - drug effects | Humans | Membrane Glycoproteins - biosynthesis | GPI-Linked Proteins - biosynthesis | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Neoplasms - genetics | Nicotinamide Phosphoribosyltransferase - metabolism | Piperidines - pharmacology | NAD - biosynthesis | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Acrylamides - pharmacology | Cytokines - genetics | Gene Expression Regulation, Neoplastic - genetics | 5'-Nucleotidase - biosynthesis | NAD - genetics | ADP-ribosyl Cyclase 1 - genetics | Cytokines - metabolism | Gene Silencing | Neoplasms - enzymology | Down-Regulation - drug effects | Down-Regulation - genetics | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Nicotinamide Phosphoribosyltransferase - genetics | Gene Expression Regulation, Enzymologic - genetics | ADP-ribosyl Cyclase 1 - biosynthesis | Cell Line, Tumor | Cytokines - antagonists & inhibitors | Nicotinamide Mononucleotide - biosynthesis | Nicotinamide Mononucleotide - genetics | GPI-Linked Proteins - genetics | NAD | Cancer Therapy | CD73 | Nicotinamide Riboside | NAD Biosynthesis | Signal Transduction | Cell Death | Nicotinamide Mononucleotide | Nicotinamide
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 6, p. e98972
Nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme for nicotinamide adenine dinucleotide (NAD(+)) synthesis, and Sirt1, an... 
DEACETYLATION | METABOLISM | POSSIBLE INVOLVEMENT | MULTIDISCIPLINARY SCIENCES | CALORIC RESTRICTION | DISEASE | AMPK | AUTOPHAGY | CELL-SURVIVAL | SIRT1 | ISCHEMIA/REPERFUSION | Heart - physiopathology | Sirtuin 1 - metabolism | Caloric Restriction | Cardiotonic Agents - metabolism | Nicotinamide Mononucleotide - metabolism | Ischemic Preconditioning | Male | Cardiotonic Agents - pharmacology | Nicotinamide Phosphoribosyltransferase - deficiency | Up-Regulation - drug effects | Animals | Reperfusion Injury - prevention & control | Nicotinamide Phosphoribosyltransferase - metabolism | Myocardial Ischemia - complications | NAD - biosynthesis | Heart - drug effects | Nicotinamide Mononucleotide - pharmacology | Mice | Myocardial Infarction - prevention & control | Reperfusion Injury - complications | Reperfusion Injury - metabolism | Heart | Oxidative stress | Histone deacetylase | Biosynthesis | Biology | Autophagy | Medical schools | Mimicry | Proteins | Dietary restrictions | Reperfusion | Synthesis | Salvage | Ischemia | FOXO1 protein | Rodents | Aging | Phosphoribosyltransferase | Trends | Acetylation | Heart diseases | Adenosine triphosphate | Enzymes | Adenine | Cardiomyocytes | Metabolism | SIRT1 protein | Calories | NAD | Medicine | Injury prevention | Nicotinamide phosphoribosyltransferase | Nicotinamide adenine dinucleotide | Hypoxia | Nicotinamide | Preconditioning | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 32, pp. 15957 - 15966
Nicotinamide adenine dinucleotide (NAD) provides an important link between metabolism and signal transduction and has emerged as central hub between... 
LIFE-SPAN | nicotinamide phosphoribosyltransferase (NamPT) | MITOCHONDRIAL | MULTIDISCIPLINARY SCIENCES | MODEL | MONONUCLEOTIDE | CELL-SURVIVAL | CANCER | NAD pathway dynamics and evolution | METABOLISM | nicotinamide N-methyltransferase (NNMT) | mathematical modeling | ADP-RIBOSYLATION | NICOTINAMIDE N-METHYLTRANSFERASE | NAD-dependent signaling and biosynthesis | EXPRESSION | Amino Acid Sequence | Signal Transduction | Humans | Nicotinamide Phosphoribosyltransferase - chemistry | Substrate Specificity | Biosynthetic Pathways | Phylogeny | Biological Evolution | Animals | Nicotinamide Phosphoribosyltransferase - metabolism | HeLa Cells | Kinetics | Nicotinamide N-Methyltransferase | Vertebrates - metabolism | NAD - metabolism | Automobile drivers | Niacinamide | Analysis | Transferases | Physiological aspects | Cellular signal transduction | Sugars | Adenosine triphosphatase | Monosaccharides | Sirtuins | Methyltransferase | Biosynthesis | Signal transduction | Bioenergetics | Ribose | N-Methyltransferase | Phosphoribosyltransferase | Mathematical models | Supplementation | Adenosine | Medical treatment | Adenine | Adenosine diphosphate | Metabolism | Coevolution | NAD | Signaling | Vertebrates | Nicotinamide phosphoribosyltransferase | Nicotinamide adenine dinucleotide | Transduction | Nicotinamide | Nicotinamide N-methyltransferase | Molecular biology: 473 | VDP | Basale biofag: 470 | Mathematics and natural science: 400 | Matematikk og Naturvitenskap: 400 | Basic biosciences: 470 | Molekylærbiologi: 473 | Biological Sciences | PNAS Plus
Journal Article
Cell metabolism, ISSN 1550-4131, 2007, Volume 6, Issue 5, pp. 363 - 375
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 42, pp. 10654 - 10659
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Cell metabolism, ISSN 1550-4131, 2016, Volume 24, Issue 6, pp. 795 - 806
NAD+ availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance... 
NAD | NAD+ precursor | insulin sensitivity | eye function | anti-aging | mitochondria | aging | nicotinamide mononucleotide | glucose metabolism | NMN | energy metabolism | precursor | LIFE-SPAN | STEM-CELLS | ACTIVATION | MITOCHONDRIAL | NAD BIOSYNTHESIS | INSULIN-SECRETION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RIBOSIDE | SIRT1 | ADIPOSE-TISSUE | CELL BIOLOGY | Darkness | Aging - drug effects | Male | Muscle, Skeletal - metabolism | Nicotinamide Mononucleotide - administration & dosage | Aging - genetics | Time Factors | Lipids - blood | Muscle, Skeletal - drug effects | Cell Respiration - drug effects | Myeloid Cells - drug effects | Weight Gain - drug effects | NAD - metabolism | Physical Conditioning, Animal | Food | Lymphocytes - metabolism | Insulin - pharmacology | Administration, Oral | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Eating - drug effects | Bone Density - drug effects | Animals | Aging - physiology | Lymphocytes - drug effects | Myeloid Cells - metabolism | Nicotinamide Mononucleotide - pharmacology | Drinking - drug effects | Nicotinamide Mononucleotide - blood | Energy Metabolism - drug effects | Niacinamide | Medical colleges | Exercise | Pharmacy | Genes | Body weight | Physiological aspects | Muscles | Mice | Ophthalmology | Gene expression
Journal Article