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Gastroenterology, ISSN 0016-5085, 2014, Volume 147, Issue 5, pp. 1119 - 1133.e4
Background & Aims Although smoking is a leading risk factor for pancreatic ductal adenocarcinoma (PDAC), little is known about the mechanisms by which smoking... 
Gastroenterology and Hepatology | Metastasis | Pancreas | Progenitor Cells | Mouse Model | METFORMIN | STEM-CELLS | DUCTAL ADENOCARCINOMA | PROLIFERATION | EPITHELIAL-MESENCHYMAL TRANSITION | ADULT-MOUSE PANCREAS | ACETYLCHOLINE-RECEPTORS | K-RAS | GROWTH | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | Pancreatic Neoplasms - metabolism | Neoplastic Stem Cells - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Epithelial-Mesenchymal Transition - drug effects | Mice, 129 Strain | Carcinoma, Pancreatic Ductal - genetics | Neoplastic Stem Cells - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | Neoplastic Stem Cells - pathology | Pancreatic Neoplasms - chemically induced | Liver Neoplasms - secondary | Nicotinic Agonists - toxicity | Proto-Oncogene Proteins c-akt - metabolism | Neoplastic Cells, Circulating - drug effects | GATA6 Transcription Factor - deficiency | Liver Neoplasms - genetics | Pancreatic Neoplasms - pathology | Pancreas - pathology | alpha7 Nicotinic Acetylcholine Receptor - genetics | Pancreas - metabolism | Mice, Knockout | Acinar Cells - pathology | Signal Transduction - drug effects | Mice, Nude | Liver Neoplasms - metabolism | Cell Line, Tumor | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Mutation | Carcinoma, Pancreatic Ductal - secondary | Carcinoma, Pancreatic Ductal - chemically induced | Neoplastic Cells, Circulating - pathology | Neoplastic Cells, Circulating - metabolism | Cell Transformation, Neoplastic - chemically induced | Extracellular Signal-Regulated MAP Kinases - metabolism | Carcinoma, Pancreatic Ductal - prevention & control | Tumor Suppressor Protein p53 - genetics | Transfection | Proto-Oncogene Proteins p21(ras) - deficiency | Gene Expression Regulation, Neoplastic - drug effects | Pancreatic Neoplasms - prevention & control | Tumor Cells, Cultured | Proto-Oncogene Proteins p21(ras) - metabolism | Acinar Cells - metabolism | Cell Dedifferentiation - drug effects | Metformin - pharmacology | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Pancreas - drug effects | Pancreatic Neoplasms - genetics | Nicotine - toxicity | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | GATA6 Transcription Factor - metabolism | Animals | Acinar Cells - drug effects | GATA6 Transcription Factor - genetics | Cell Transformation, Neoplastic - pathology | Pancreatic cancer | Stem cells | Nicotine
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e108789 - e108789
Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of... 
SECONDARY METABOLISM | COPTIS-JAPONICA | MEDICAGO-TRUNCATULA | CATHARANTHUS-ROSEUS | MULTIDISCIPLINARY SCIENCES | PLANT-CELLS | ARABIDOPSIS | BINDING CASSETTE PROTEIN | MEMBRANE-TRANSPORT | ALKALOID METABOLISM | TOBACCO | Plant Cells - microbiology | Saccharomyces cerevisiae - drug effects | Gene Expression Profiling | Phylogeny | RNA, Messenger - metabolism | Nicotine - pharmacology | Saccharomyces cerevisiae - metabolism | Plant Proteins - classification | Alkaloids - metabolism | Cell Membrane - metabolism | Plant Proteins - metabolism | Plant Roots - metabolism | Tobacco - metabolism | Cyclopentanes - pharmacology | Up-Regulation - drug effects | Plant Proteins - genetics | Anabasine - metabolism | Nicotine - metabolism | Pyridines - metabolism | Plant Leaves - metabolism | Flavonoids - metabolism | Oxylipins - pharmacology | Plant Cells - drug effects | Vacuoles - metabolism | Acetates - pharmacology | Flavonoids | Flavones | RNA | Bioflavonoids | Analysis | Physiological aspects | Fluorescence | Nicotine | Yeast | Xylem | Laboratories | Amino acids | Biochemistry | Plants (organisms) | Biosynthesis | Tissues | Proteins | Alkaloids | Leaves | Metabolites | Cell cycle | Jasmonic acid | Pharmaceutical sciences | Translocation | Cloning | Dentistry | Metabolism | Gene expression | Methyl jasmonate | Tobacco | Extrusion | Herbivores | Transport | Transporter | Vacuoles | Index Medicus
Journal Article
BMC Cardiovascular Disorders, ISSN 1471-2261, 03/2013, Volume 13, Issue 1, pp. 13 - 13
Background: Arterial media calcification (AMC) is highly prevalent and is a major cause of morbidity, mortality, stroke and amputation in patients with... 
Calcification | Oxidative stress | Advanced glycation end products | Diabetes mellitus | Vascular smooth muscle cells | SUPEROXIDE | CARDIAC & CARDIOVASCULAR SYSTEMS | HORMONE-RELATED PEPTIDE | INCREASES | MECHANISMS | MODEL | DIABETES-MELLITUS | CORONARY-ARTERY CALCIFICATION | SMOOTH-MUSCLE-CELLS | COMPLICATIONS | Muscle, Smooth, Vascular - metabolism | Oxidative Stress | Rats, Wistar | Streptozocin | Alkaline Phosphatase - metabolism | Male | Insulin - blood | Aortic Diseases - chemically induced | Aortic Diseases - metabolism | Diabetes Mellitus, Experimental - blood | Vascular Calcification - metabolism | Vascular Calcification - etiology | Lipids - blood | Superoxides - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Experimental - metabolism | NADH, NADPH Oxidoreductases - metabolism | Myocytes, Smooth Muscle - metabolism | Receptor for Advanced Glycation End Products | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Signal Transduction | Cholecalciferol | Cells, Cultured | Aorta, Thoracic - metabolism | Rats | Biomarkers - blood | Serum Albumin, Bovine - metabolism | Rats, Sprague-Dawley | NADPH Oxidase 1 | Animals | Glycation End Products, Advanced - metabolism | Vascular Calcification - chemically induced | Glycation End Products, Advanced - blood | Blood Glucose - metabolism | Aortic Diseases - etiology | Receptors, Immunologic - metabolism | Nicotine | Phosphatases | Health aspects | Proteins | Carbohydrates | Cell culture | Hospitals | Rodents | Mortality | Cell cycle | Smooth muscle | Diabetes | Cholesterol
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 06/2011, Volume 14, Issue 11, pp. 257 - 2070
Activation of nicotinic acetylcholine receptor alpha7 subunit (α7nAChR) by nicotine leads to the improved survival rate in experimental model of sepsis.... 
Original Research Communications | VAGUS NERVE | SYSTEMIC INFLAMMATION | CELLS | OXIDATIVE STRESS | IN-VITRO | PATHWAY | HO-1 EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | CIGARETTE-SMOKE | MICE | KAPPA-B | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Endotoxemia - genetics | Humans | NADPH Oxidases - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | Nicotine - pharmacology | Heme Oxygenase-1 - genetics | Protein Kinase C - metabolism | Sepsis - metabolism | HMGB1 Protein - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Nicotinic Agonists - pharmacology | Cell Line | Receptors, Nicotinic - metabolism | Lipopolysaccharides - toxicity | Anti-Inflammatory Agents - pharmacology | Kaplan-Meier Estimate | Heme Oxygenase-1 - antagonists & inhibitors | Sepsis - genetics | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Calcium Signaling - drug effects | NF-E2-Related Factor 2 - metabolism | Macrophages - drug effects | Inflammation - prevention & control | Mice | Mice, Inbred BALB C | Endotoxemia - metabolism | Nitric Oxide Synthase Type II - metabolism | alpha7 Nicotinic Acetylcholine Receptor | Receptors | Physiological aspects | Inflammation | Acetylcholine | Research | Health aspects | Risk factors | Lipopolysaccharides | Nicotine
Journal Article
Neuropharmacology, ISSN 0028-3908, 09/2012, Volume 63, Issue 4, pp. 538 - 546
Drug development for nicotinic acetylcholine receptors (nAChR) is challenged by subtype diversity arising from variations in subunit composition. On-target... 
Smoking cessation | Partial agonists | Drug screening | Ganglionic receptors | Acetylcholine - agonists | Ganglia - metabolism | Humans | Nicotinic Antagonists - pharmacology | Quinolizines - metabolism | Azocines - metabolism | Receptors, Nicotinic - chemistry | Oocytes - drug effects | Mutant Proteins - antagonists & inhibitors | Protein Subunits - genetics | Receptors, Nicotinic - metabolism | Drug Partial Agonism | Oocytes - metabolism | Nerve Tissue Proteins - agonists | Protein Subunits - agonists | Rats | Quinoxalines - metabolism | Benzazepines - pharmacology | Nicotine - antagonists & inhibitors | Nicotine - agonists | Evoked Potentials - drug effects | Ligands | Protein Subunits - antagonists & inhibitors | Benzazepines - metabolism | Mutant Proteins - agonists | Nicotinic Agonists - metabolism | Species Specificity | Nicotinic Antagonists - metabolism | Varenicline | Acetylcholine - metabolism | Recombinant Fusion Proteins - metabolism | Protein Subunits - metabolism | Quinoxalines - pharmacology | Recombinant Fusion Proteins - antagonists & inhibitors | Recombinant Fusion Proteins - agonists | Alkaloids - metabolism | Nicotinic Agonists - pharmacology | Nerve Tissue Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Mutagenesis, Site-Directed | Xenopus laevis | Mutant Proteins - genetics | Mutant Proteins - metabolism | Quinolizines - pharmacology | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Nicotine - metabolism | Azocines - pharmacology | Acetylcholine - antagonists & inhibitors | Receptors, Nicotinic - genetics
Journal Article
Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, 2006, Volume 30, Issue 2, pp. 215 - 238
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 14, pp. 5891 - 5896
Journal Article