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Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 43, pp. 15148 - 15157
Journal Article
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2015, Volume 55, Issue 12, pp. 2532 - 2540
.... Acute niacin treatment inhibits nonesterified fatty acid release from adipocytes and stimulates prostaglandin release from skin Langerhans cells, but the acute effects diminish upon prolonged... 
Polyunsaturated fatty acid | Fatty acid/biosynthesis | Adipocytes | Cytochrome P450 | Drug therapy/hypolipidemic drugs | Omega-3 fatty acids | NICOTINIC-ACID INFUSION | drug therapy | ESTER TRANSFER PROTEIN | OMEGA-3-FATTY-ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | fatty acid | ATHEROSCLEROSIS | omega-3 fatty acids | FATTY-ACIDS | cytochrome P450 | hypolipidemic drugs | SOLUBLE EPOXIDE HYDROLASE | AVAILABILITY | DOCOSAHEXAENOIC ACID | INSULIN-RESISTANCE | biosynthesis | adipocytes | polyunsaturated fatty acid | EXTENDED-RELEASE NIACIN | Oxylipins - blood | Arachidonic Acid - metabolism | Hyperlipidemias - blood | Arachidonic Acid - blood | Gene Expression Profiling | Intra-Abdominal Fat - secretion | Niacin - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Liver - immunology | Niacin - therapeutic use | Liver - drug effects | Time Factors | Cholesterol Ester Transfer Proteins - genetics | Female | Intra-Abdominal Fat - drug effects | Hyperlipidemias - immunology | Arachidonic Acid - secretion | Biomarkers - metabolism | Intra-Abdominal Fat - immunology | Fatty Acids, Unsaturated - secretion | Fatty Acids, Omega-3 - metabolism | Hydroxylation | Hyperlipidemias - metabolism | Hyperlipidemias - drug therapy | Liver - metabolism | Mice, Transgenic | Biomarkers - blood | Fatty Acids, Unsaturated - metabolism | Apolipoprotein E3 - metabolism | Hypolipidemic Agents - pharmacology | Intra-Abdominal Fat - metabolism | Diet, Western - adverse effects | Gene Expression Regulation - drug effects | Docosahexaenoic Acids - secretion | Fatty Acids, Unsaturated - blood | Oxylipins - metabolism | Apolipoprotein E3 - genetics | Algorithms | Animals | Docosahexaenoic Acids - blood | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Fatty Acids, Omega-3 - blood | Fatty Acids, Omega-3 - secretion | Hypolipidemic Agents - therapeutic use | Cholesterol Ester Transfer Proteins - metabolism | Docosahexaenoic Acids - metabolism
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 24, pp. 9988 - 10001
...)2 nAChR, is an important and promising drug target. In this report we used site-directed mutagenesis to substitute specific amino acid residues and computational analyses to elucidate... 
NONCANONICAL SUBUNIT INTERFACES | NERVOUS-SYSTEM | AGONIST BINDING-SITE | SUBTYPES | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-2 SUBUNIT | SENSITIVITY | THERAPEUTIC TARGETS | MODULATOR | NS9283 | Hydrocarbons, Brominated - metabolism | Nicotinic Agonists - metabolism | Pyridines - chemistry | Humans | Hydrocarbons, Brominated - pharmacology | Nicotinic Agonists - chemistry | Nerve Tissue Proteins - chemistry | Pyrazoles - chemistry | Receptors, Nicotinic - chemistry | Oxadiazoles - pharmacology | Oocytes - drug effects | Hydrocarbons, Brominated - chemistry | Protein Interaction Domains and Motifs | Indole Alkaloids - chemistry | Oxadiazoles - chemistry | Nicotinic Agonists - pharmacology | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Receptors, Nicotinic - metabolism | Oocytes - metabolism | Isoxazoles - metabolism | Nerve Tissue Proteins - agonists | Xenopus laevis | Models, Molecular | Recombinant Proteins - chemistry | Isoxazoles - chemistry | Pyrazoles - metabolism | Nerve Tissue Proteins - genetics | Isoxazoles - pharmacology | Nerve Tissue Proteins - metabolism | Point Mutation | Patch-Clamp Techniques | Animals | Pyridines - metabolism | Indole Alkaloids - pharmacology | Ligands | Protein Conformation | Molecular Docking Simulation | Pyridines - pharmacology | Structural Homology, Protein | Indole Alkaloids - metabolism | Receptors, Nicotinic - genetics | Amino Acid Substitution | Oxadiazoles - metabolism | Index Medicus | nicotinic acetylcholine receptors (nAChR) | electrophysiology | Positive allosteric modulators | drug design | ion channel | Neurobiology | drug development | pentameric ligand-gated ion channel | CMPI | dFBr
Journal Article
Nature Neuroscience, ISSN 1097-6256, 11/2011, Volume 14, Issue 11, pp. 1439 - 1446
Maternal exposure to cocaine may perturb fetal development and affect synaptic maturation in the offspring. However, the molecular mechanism underlying such... 
MATERNAL TOXICITY | AMPA RECEPTORS | NMDA RECEPTORS | DOPAMINE-TRANSPORTER | LONG-TERM DEPRESSION | TRANSPORTER KNOCKOUT MICE | SUBUNIT COMPOSITION | NEUROSCIENCES | PRENATAL COCAINE | VENTRAL TEGMENTAL AREA | WORKING-MEMORY | Receptors, Glutamate - metabolism | Electric Stimulation | Calcium - metabolism | Male | Nicotinic Antagonists - pharmacology | Anesthetics, Local - pharmacology | Time Factors | Dopamine Agents - pharmacology | Estrenes - pharmacology | Excitatory Amino Acid Agents - pharmacology | Synaptic Transmission - drug effects | Dopamine - metabolism | Animals, Newborn | Synapses - drug effects | Ventral Tegmental Area - drug effects | Gene Expression Regulation, Developmental - drug effects | Mice, Transgenic | Chelating Agents - pharmacology | Dopamine Plasma Membrane Transport Proteins - genetics | Mice | Synaptic Transmission - physiology | Age Factors | Receptors, Metabotropic Glutamate - physiology | Ventral Tegmental Area - cytology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Ventral Tegmental Area - growth & development | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Receptors, Metabotropic Glutamate - genetics | Pyrrolidinones - pharmacology | Egtazic Acid - analogs & derivatives | Neurons - physiology | Female | Neurons - drug effects | Synapses - physiology | Mice, Inbred C57BL | Dopamine - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Biophysics | Prenatal Exposure Delayed Effects - physiopathology | Calcium Channel Blockers - pharmacology | Pregnancy | Cocaine - pharmacology | Polyamines - pharmacology | Animals | Egtazic Acid - pharmacology | Glutamic Acid - metabolism | In Vitro Techniques | Physiological aspects | Neural transmission | Fetus | Neural receptors | Research | Growth
Journal Article
International Journal of Food Sciences and Nutrition, ISSN 1465-3478, 2014, Volume 65, Issue 8, pp. 925 - 936
Journal Article
European journal of pharmacology, ISSN 0014-2999, 07/2018, Volume 831, pp. 52 - 59
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1312 - 1321
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2014, Volume 124, Issue 5, pp. 2188 - 2192
...; however, it is unclear how DMF mediates a protective effect. DMF and, more so, its active metabolite, monomethyl fumarate, are known agonists of the hydroxyearboxylic acid receptor 2 (HCA(2... 
NICOTINIC-ACID | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | PLACEBO-CONTROLLED PHASE-3 | ESTERS | GPR109A | CENTRAL-NERVOUS-SYSTEM | MICE | ORAL BG-12 | PSORIASIS | Physiological aspects | Esters | Care and treatment | Cell receptors | Encephalomyelitis | Health aspects | Studies | Spinal cord | Acids | Rodents | Migration | Gene expression | Experiments | Apoptosis | Brief Report
Journal Article