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1. Full Text Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost–benefit decision making tasks in rats
by Mendez, Ian A and Gilbert, Ryan J and Bizon, Jennifer L and Setlow, Barry
Psychopharmacology, ISSN 0033-3158, 12/2012, Volume 224, Issue 4, pp. 489 - 499
Nicotinic | Neurosciences | Impulsivity | Perseveration | Biomedicine | Muscarinic | Risk | Delay discounting | Pharmacology/Toxicology | Psychiatry | Cholinergic | Probability discounting | Pharmacology & Pharmacy | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Choice Behavior - drug effects | Nicotine - administration & dosage | Rats, Long-Evans | Decision Making - drug effects | Probability | Rats | Atropine - pharmacology | Male | Nicotine - pharmacology | Dose-Response Relationship, Drug | Muscarinic Antagonists - administration & dosage | Nicotinic Agonists - administration & dosage | Scopolamine Hydrobromide - pharmacology | Animals | Muscarinic Antagonists - pharmacology | Cost-Benefit Analysis | Scopolamine Hydrobromide - administration & dosage | Atropine - administration & dosage | Reward | Nicotinic Agonists - pharmacology | Decision-making | Economic aspects | Schizophrenia | Cost benefit analysis | Attention-deficit hyperactivity disorder | Drug addiction | Behavioral decision theory | Psychopharmacology | Benefit cost analysis | Index Medicus | Scopolamine | Acetylcholine receptors (muscarinic) | Mental disorders | Decision making | Therapeutic applications | Attention deficit hyperactivity disorder | Data processing | Antagonists | mecamylamine | oxotremorine | Addiction | Etiology | Acetylcholine receptors | Atropine | Reinforcement | Acetylcholine receptors (nicotinic) | Cholinergic transmission | Nicotine
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2. Full Text α7-Nicotinic Acetylcholine Receptor Agonists for Cognitive Enhancement in Schizophrenia
by Freedman, Robert
Annual review of medicine, ISSN 0066-4219, 1/2014, Volume 65, Issue 1, pp. 245 - 261
olanzapine | chromosome human pair 15 | clozapine | CHRNA7 | autism | smoking | Autism | Olanzapine | Chromosome human pair 15 | Clozapine | Smoking | Memory - drug effects | Sensory Gating - drug effects | Humans | Fetal Development | alpha7 Nicotinic Acetylcholine Receptor - genetics | alpha7 Nicotinic Acetylcholine Receptor - agonists | Eye Movements - drug effects | Cognition - drug effects | Nicotinic Agonists - therapeutic use | Nicotine - pharmacology | Animals | Benzylidene Compounds - pharmacology | Schizophrenia - genetics | Benzylidene Compounds - therapeutic use | Attention - drug effects | Pyridines - pharmacology | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Schizophrenia - drug therapy | Nicotinic Agonists - pharmacology | Pyridines - therapeutic use | Schizophrenia | Physiological aspects | Acetylcholine | Dosage and administration | Cognition | Drug therapy | Health aspects | Index Medicus
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3. Full Text Repeated administration of 7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases 7 nAChR levels in the brain
by Christensen, Ditte Z and Mikkelsen, Jens D and Hansen, Henrik H and Thomsen, Morten S
Journal of neurochemistry, ISSN 0022-3042, 08/2010, Volume 114, Issue 4, pp. 1205 - 1216
alpha 7 nicotinic receptor | c-fos | Arc | desensitization | tolerance | Erk | Schizophrenia | Alzheimer's disease | Messenger RNA | Neurotransmitters | Biochemistry | Alzheimers disease | Binding sites
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4. Full Text Normalizing effects of EVP-6124, an alpha-7 nicotinic partial agonist, on event-related potentials and cognition: A proof of concept, randomized trial in patients with schizophrenia
by Preskorn, Sheldon H and Gawryl, Maria and Dgetluck, Nancy and Palfreyman, Michael and Bauer, Lance O and Hilt, Dana C
Journal of psychiatric practice, ISSN 1527-4160, 01/2014, Volume 20, Issue 1, pp. 12 - 24
evoked response potentials | proof of concept study | computerized cognitive testing | antipsychotics | cognitive impairment | schizophrenia | alpha-7 nicotinic receptor partial agonist | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Thiophenes - adverse effects | Humans | Middle Aged | Male | Schizophrenia - complications | Cognition | Thiophenes - administration & dosage | Quinuclidines - administration & dosage | Young Adult | Schizophrenia - physiopathology | Cognition Disorders - etiology | Adult | Female | Drug Therapy, Combination | Quinuclidines - adverse effects | Cognition Disorders - physiopathology | Double-Blind Method | Quinuclidines - pharmacology | Thiophenes - pharmacology | Treatment Outcome | alpha7 Nicotinic Acetylcholine Receptor - agonists | Cognition Disorders - drug therapy | Antipsychotic Agents - administration & dosage | Evoked Potentials - drug effects | Adolescent | Schizophrenia - drug therapy | Index Medicus
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5. Full Text Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo
by Tai, Leon M and Koster, Kevin P and Luo, Jia and Lee, Sue H and Wang, Yue-Ting and Collins, Nicole C and Aissa, Manel Ben and Thatcher, Gregory R. J and LaDu, Mary Jo
The Journal of biological chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 44, pp. 30538 - 30555
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Disks Large Homolog 4 Protein | Liver - pathology | Nicotinic Acids - pharmacokinetics | Humans | Male | Tetrahydronaphthalenes - adverse effects | ATP Binding Cassette Transporter 1 - metabolism | Liver - drug effects | Tetrahydronaphthalenes - administration & dosage | Amyloid beta-Peptides - metabolism | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Membrane Proteins - metabolism | Nicotinic Acids - administration & dosage | Drug Evaluation, Preclinical | Nicotinic Acids - adverse effects | Retinoid X Receptors - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Bexarotene | Peptide Fragments - metabolism | Administration, Oral | Mice, Inbred C57BL | Solubility | Alzheimer Disease - drug therapy | Tetrahydronaphthalenes - pharmacokinetics | Genotype | Mice, Transgenic | Organ Size - drug effects | Animals | Retinoid X Receptors - agonists | Apolipoproteins E - genetics | Guanylate Kinases - metabolism | Index Medicus | ABCA1 | Molecular Bases of Disease | Oligomeric Aβ | Alzheimer Disease | Drug Delivery | Aβ Complex | Apolipoprotein E (ApoE) | Amyloid-β (AB) | RXR Agonists | Hepatomegaly | ABCG1 Lipid Transporters | Drug Action | ApoE
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6. Full Text Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)
by Ghiron, Chiara and Haydar, Simon N and Aschmies, Suzan and Bothmann, Hendrick and Castaldo, Cristiana and Cocconcelli, Giuseppe and Comery, Thomas A and Di, Li and Dunlop, John and Lock, Tim and Kramer, Angela and Kowal, Dianne and Jow, Flora and Grauer, Steve and Harrison, Boyd and La Rosa, Salvatore and Maccari, Laura and Marquis, Karen L and Micco, Iolanda and Nencini, Arianna and Quinn, Joanna and Robichaud, Albert J and Roncarati, Renza and Scali, Carla and Terstappen, Georg C and Turlizzi, Elisa and Valacchi, Michela and Varrone, Maurizio and Zanaletti, Riccardo and Zanelli, Ugo
Journal of medicinal chemistry, ISSN 0022-2623, 06/2010, Volume 53, Issue 11, pp. 4379 - 4389
Urea - pharmacokinetics | Humans | Pyridines - pharmacokinetics | Substrate Specificity | Male | Structure-Activity Relationship | Urea - chemical synthesis | Receptors, Nicotinic - chemistry | Urea - analogs & derivatives | Inhibitory Concentration 50 | Nicotinic Agonists - pharmacology | Urea - administration & dosage | Receptors, Nicotinic - metabolism | Pyridines - administration & dosage | Administration, Oral | Pyridines - chemical synthesis | Models, Molecular | Rats | Nicotinic Agonists - administration & dosage | Animals | Nicotinic Agonists - chemical synthesis | Protein Conformation | Pyridines - pharmacology | Nicotinic Agonists - pharmacokinetics | Urea - pharmacology | alpha7 Nicotinic Acetylcholine Receptor | Index Medicus
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7. Full Text Nicotine receptor partial agonists for smoking cessation
by Cahill, Kate and Lindson‐Hawley, Nicola and Thomas, Kyla H and Fanshawe, Thomas R and Lancaster, Tim and Lindson‐Hawley, Nicola
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 05/2016, Volume 2016, Issue 5, pp. CD006103 - CD006103
Interventions to help smokers and other tobacco users to quit | Lungs & airways | Pharmacological interventions | Varenicline | Substance Withdrawal Syndrome | Azepines | Randomized Controlled Trials as Topic | Heterocyclic Compounds, 4 or More Rings | Alkaloids | Quinolizines | Tobacco, drugs & alcohol | By treatment type | Tobacco | Azocines | Bupropion | Benzazepines | Nicotinic Agonists | Counseling | Medications | Medicine General & Introductory Medical Sciences | Nicotine | Smoking | Smoking Cessation | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Quinolizines - therapeutic use | Azepines - adverse effects | Azocines - therapeutic use | Azocines - adverse effects | Substance Withdrawal Syndrome - prevention & control | Alkaloids - adverse effects | Benzazepines - adverse effects | Humans | Smoking - drug therapy | Heterocyclic Compounds, 4 or More Rings - adverse effects | Nicotinic Agonists - therapeutic use | Nicotine - antagonists & inhibitors | Smoking Cessation - methods | Azepines - therapeutic use | Nicotine - adverse effects | Nicotinic Agonists - adverse effects | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Benzazepines - therapeutic use | Counseling - methods | Alkaloids - therapeutic use | Quinolizines - adverse effects | Varenicline - therapeutic use | Bupropion - therapeutic use | Index Medicus
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