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European Journal of Pharmacology, ISSN 0014-2999, 01/2015, Volume 746, pp. 308 - 316
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 09/2012, Volume 63, Issue 4, pp. 538 - 546
Drug development for nicotinic acetylcholine receptors (nAChR) is challenged by subtype diversity arising from variations in subunit composition. On-target... 
Smoking cessation | Partial agonists | Drug screening | Ganglionic receptors | Acetylcholine - agonists | Ganglia - metabolism | Humans | Nicotinic Antagonists - pharmacology | Quinolizines - metabolism | Azocines - metabolism | Receptors, Nicotinic - chemistry | Oocytes - drug effects | Mutant Proteins - antagonists & inhibitors | Protein Subunits - genetics | Receptors, Nicotinic - metabolism | Drug Partial Agonism | Oocytes - metabolism | Nerve Tissue Proteins - agonists | Protein Subunits - agonists | Rats | Quinoxalines - metabolism | Benzazepines - pharmacology | Nicotine - antagonists & inhibitors | Nicotine - agonists | Evoked Potentials - drug effects | Ligands | Protein Subunits - antagonists & inhibitors | Benzazepines - metabolism | Mutant Proteins - agonists | Nicotinic Agonists - metabolism | Species Specificity | Nicotinic Antagonists - metabolism | Varenicline | Acetylcholine - metabolism | Recombinant Fusion Proteins - metabolism | Protein Subunits - metabolism | Quinoxalines - pharmacology | Recombinant Fusion Proteins - antagonists & inhibitors | Recombinant Fusion Proteins - agonists | Alkaloids - metabolism | Nicotinic Agonists - pharmacology | Nerve Tissue Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Mutagenesis, Site-Directed | Xenopus laevis | Mutant Proteins - genetics | Mutant Proteins - metabolism | Quinolizines - pharmacology | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Nicotine - metabolism | Azocines - pharmacology | Acetylcholine - antagonists & inhibitors | Receptors, Nicotinic - genetics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 13, pp. 6076 - 6081
Spirolide and gymnodimine macrocyclic imine phycotoxins belong to an emerging class of chemical agents associated with marine algal blooms and shelfish... 
Receptors | Imines | Shellfish | Ligands | Agonists | Toxins | Pharmacology | Nicotinic receptors | Nitrogen | Oocytes | Pharmacological and structural analyses | Seafood poisoning | Acetylcholine binding protein | Nicotinic acetylcholine receptor | Marine phycotoxins | PLANKTON | acetylcholine binding protein | seafood poisoning | DINOFLAGELLATE ALEXANDRIUM-OSTENFELDII | SHELLFISH TOXINS | SPIROLIDE-C | PROTEIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | marine phycotoxins | AGONISTS | ACETYLCHOLINE-RECEPTOR | GYMNODIMINE | pharmacological and structural analyses | nicotinic acetylcholine receptor | REVEALS | Heterocyclic Compounds, 3-Ring - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Nicotinic Antagonists - metabolism | Humans | Aplysia - metabolism | Crystallography, X-Ray | Acetylcholine - metabolism | Nicotinic Antagonists - pharmacology | Hydrocarbons, Cyclic - pharmacology | Imines - chemistry | Oocytes - drug effects | Carrier Proteins - chemistry | Female | Molecular Structure | Spiro Compounds - chemistry | Receptors, Nicotinic - metabolism | Marine Toxins - metabolism | Oocytes - metabolism | Imines - metabolism | Models, Molecular | Electric Organ - metabolism | Marine Toxins - pharmacology | Imines - pharmacology | Macromolecular Substances | Animals | Carrier Proteins - metabolism | Xenopus - metabolism | Marine Toxins - chemistry | Nicotinic Antagonists - chemistry | Heterocyclic Compounds, 3-Ring - chemistry | Torpedo - metabolism | Kinetics | In Vitro Techniques | Hydrocarbons, Cyclic - chemistry | Spiro Compounds - pharmacology | Hydrocarbons, Cyclic - metabolism | Spiro Compounds - metabolism | Marine toxins | Crystals | Physiological aspects | Acetylcholine | Structure | Properties | Protein binding | Index Medicus | Life Sciences | Neurons and Cognition | Biological Sciences
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 11/2011, Volume 24, Issue 11, pp. 1817 - 1829
In recent years, there has been an increase in the production of shellfish and in global demand for seafood as nutritious and healthy food. Unfortunately, a... 
1ST EVIDENCE | SPIROLIDE-B | CHEMISTRY, MEDICINAL | PTERIATOXIN-A | DINOFLAGELLATE | (-)-GYMNODIMINE | CHEMISTRY, MULTIDISCIPLINARY | SHELLFISH POISON | GYMNODIMINE | RELATIVE STEREOCHEMISTRY | MARINE TOXIN | PINNATOXIN-A | TOXICOLOGY | Heterocyclic Compounds, 3-Ring - metabolism | Marine Toxins - toxicity | Food Contamination | Nicotinic Antagonists - metabolism | Humans | Pyrans - toxicity | Receptors, Muscarinic - metabolism | Shellfish Poisoning - metabolism | Structure-Activity Relationship | Pyrans - chemistry | Pyrans - metabolism | Heterocyclic Compounds, 3-Ring - toxicity | Imines - chemistry | Biological Assay | Binding Sites | Microalgae - chemistry | Nicotinic Antagonists - toxicity | Spiro Compounds - chemistry | Muscarinic Antagonists - metabolism | Cell Survival - drug effects | Muscarinic Antagonists - toxicity | Receptors, Nicotinic - metabolism | Shellfish - toxicity | Marine Toxins - metabolism | Hydrocarbons, Cyclic - toxicity | Imines - metabolism | Injections, Intraperitoneal | Imines - toxicity | Muscarinic Antagonists - chemistry | Animals | Spiro Compounds - toxicity | Marine Toxins - chemistry | Nicotinic Antagonists - chemistry | Heterocyclic Compounds, 3-Ring - chemistry | Protein Binding | Mice | Hydrocarbons, Cyclic - chemistry | Shellfish Poisoning - physiopathology | Hydrocarbons, Cyclic - metabolism | Spiro Compounds - metabolism | Index Medicus
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 06/2014, Volume 53, Issue 23, pp. 3758 - 3766
We isolated a novel, atypical long-chain three-finger toxin (TFT), α-elapitoxin-Dpp2d (α-EPTX-Dpp2d), from black mamba (Dendroaspis polylepis polylepis) venom.... 
KAPPA-BUNGAROTOXIN | ALPHA-NEUROTOXINS | SNAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | NICOTINIC RECEPTOR PROBE | CRYSTAL-STRUCTURES | 3-FINGERED TOXINS | PROTEINS | BINDING | ACETYLCHOLINE-RECEPTOR | Reptilian Proteins - chemistry | Humans | alpha7 Nicotinic Acetylcholine Receptor - antagonists & inhibitors | Nicotinic Antagonists - pharmacology | Nicotinic Agonists - chemistry | Reptilian Proteins - pharmacology | Receptors, Nicotinic - chemistry | Neurons - metabolism | Amino Acid Sequence | Nicotinic Antagonists - isolation & purification | Receptors, Nicotinic - metabolism | Nerve Tissue Proteins - agonists | Carrier Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | alpha7 Nicotinic Acetylcholine Receptor - genetics | Reptilian Proteins - isolation & purification | Elapid Venoms - pharmacology | Nicotinic Antagonists - chemistry | Calcium Signaling - drug effects | Neurotoxins - metabolism | Protein Conformation | Protein Processing, Post-Translational | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Reptilian Proteins - metabolism | Elapid Venoms - chemistry | Nicotinic Antagonists - metabolism | Molecular Sequence Data | Neurotoxins - isolation & purification | Carrier Proteins - chemistry | Protein Stability | Elapid Venoms - isolation & purification | Neurons - drug effects | Nicotinic Agonists - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Neurotoxins - chemistry | alpha7 Nicotinic Acetylcholine Receptor - agonists | Recombinant Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Neurotoxins - pharmacology | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Elapidae - metabolism | Elapid Venoms - metabolism | Receptors, Nicotinic - genetics | Venom | Chemical properties | Research
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 02/2009, Volume 29, Issue 3, pp. 529 - 538
We tested the hypothesis that fluctuations in the levels of kynurenic acid (KYNA), an endogenous antagonist of the α7 nicotinic acetylcholine (ACh) receptor,... 
amphetamine | schizophrenia | microdialysis | glia | prefrontal cortex | Schizophrenia | Amphetamine | Microdialysis | Prefrontal cortex | Glia | GLUTAMATERGIC MODULATION | ALPHA-7 NICOTINIC AGONIST | FRONTAL-CORTEX | PRESYNAPTIC ALPHA-7 | RAT PREFRONTAL CORTEX | NEUROSCIENCES | NUCLEUS-ACCUMBENS | RECEPTORS MODULATE | AMINOTRANSFERASE-II | BRAIN | Schizophrenia - metabolism | Central Nervous System Stimulants - pharmacology | Synaptic Transmission - physiology | Rats, Wistar | Nicotinic Antagonists - metabolism | Transaminases - antagonists & inhibitors | Male | Acetylcholine - metabolism | Nicotinic Antagonists - pharmacology | Kynurenic Acid - metabolism | Cerebral Cortex - metabolism | Prefrontal Cortex - drug effects | Schizophrenia - physiopathology | Up-Regulation - physiology | Transaminases - metabolism | Synaptic Transmission - drug effects | Cerebral Cortex - drug effects | Astrocytes - drug effects | Receptors, Nicotinic - drug effects | Receptors, Nicotinic - metabolism | Presynaptic Terminals - drug effects | Amphetamine - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Acetylcholine - secretion | Up-Regulation - drug effects | Animals | Prefrontal Cortex - metabolism | Presynaptic Terminals - metabolism | Presynaptic Terminals - secretion | Schizophrenia - drug therapy | Kynurenic Acid - antagonists & inhibitors | Astrocytes - metabolism | Astrocytes - secretion | alpha7 Nicotinic Acetylcholine Receptor | Enzymes | Neurosciences | Questions and answers | Acetylcholine | Dextroamphetamine | Universities and colleges | Organic acids
Journal Article