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Tetrahedron Letters, ISSN 0040-4039, 07/2017, Volume 58, Issue 30, pp. 2959 - 2963
A number of A-ring analogues of the lantibiotic nisin, containing replacements for the Dha residue at position 5, have been successfully prepared by... 
Nisin | Thioamide | Dehydroalanine | Microwave-enhanced solid-phase peptide synthesis | Lantibiotics | LANTHIONINE | ACID | BIOSYNTHESIS | MODE | CHEMISTRY, ORGANIC | LACTICIN 3147 | DISCOVERY | Peptides | Phenylalanine | Glycine
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2018, Volume 62, Issue 12
Mutacin 1140, a member of the epidermin family of type AI lantibiotics, has a broad spectrum of activity against Gram-positive bacteria. It blocks cell wall... 
Mutacin | Lantibiotics | MRSA | NISIN | BIOSYNTHESIS | lantibiotics | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | LYSOSTAPHIN | MODEL | mutacin
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2018, Volume 140, Issue 38, pp. 11884 - 11888
Most native producers of ribosomally synthesized and post-translationally modified peptides (RiPPs) utilize N-terminal leader peptides to avoid potential... 
NISIN | MUTAGENESIS | PROTEIN | VARIANTS | BIOSYNTHESIS | HALODURACIN | NUKACIN ISK-1 | LANTIBIOTICS | GENERATION | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | BASIC BIOLOGICAL SCIENCES
Journal Article
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 09/2017, Volume 139, Issue 37, pp. 13063 - 13075
Spider venom toxins, such as Protoxin-II (ProTx-II), have recently received much attention as selective Na(v)1.7 channel blockers, with potential to be... 
POTENT | ACTIVATION | LANTHIONINES | ALPHA-CONOTOXIN | BRIDGES | SOLID-PHASE | BPTI | BINDING | CHEMISTRY, MULTIDISCIPLINARY | CHEMICAL-SYNTHESES | PEPTIDE
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 07/2017, Volume 83, Issue 14
Mutacin 1140 belongs to the epidermin group of lantibiotics. Epidermin class lantibiotics are ribosomally synthesized and posttranslationally modified... 
Nisin | Cysteine | Analogue | Gram-positive bacteria | Antimicrobial agents | Drug resistance | Lantibiotics | Biological activity | Methicillin | Synthesis | Tuberculosis | Antibiotics | Decarboxylation | Fluorescein | Carboxyl group | Bacteria | Organic chemicals | Binding sites
Journal Article
Journal Article
Peptides, ISSN 0196-9781, 05/2017, Volume 91, pp. 33 - 39
Journal Article
Organic Letters, ISSN 1523-7060, 02/2007, Volume 9, Issue 4, pp. 699 - 702
Chemical synthesis of lantibiotic analogues wherein monosulfide bridges are replaced with other groups can shed light on structure-activity relationships and... 
NISIN | DEHYDRATASE | MECHANISM | SOLID-PHASE SYNTHESIS | LANTHIONINES | ACIDS | BIOSYNTHESIS | MODE | CHEMISTRY, ORGANIC | Anti-Bacterial Agents - chemical synthesis | Alkenes - chemistry | Amino Acid Sequence | Cyclization | Models, Molecular | Molecular Sequence Data | Structure-Activity Relationship | Bacteriocins - chemical synthesis
Journal Article
Organic Letters, ISSN 1523-7060, 08/2011, Volume 13, Issue 16, pp. 4216 - 4219
A methodology for the solid-phase synthesis of the overlapping lanthionine bridges found in many lantibiotics has been developed. A novel Teoc/TMSE-protected... 
CHEMISTRY, ORGANIC | RESIN | STEREOSELECTIVE-SYNTHESIS | ANTIBIOTIC NISIN | CYCLIZATION | PROTECTED LANTHIONINES | Alanine - analogs & derivatives | Amino Acid Sequence | Alanine - chemistry | Peptides - chemistry | Nisin - analogs & derivatives | Sulfides - chemistry
Journal Article
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