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1. Full Text Nitric oxide release: Part I. Macromolecular scaffolds
by Riccio, Daniel A and Schoenfisch, Mark H
Chemical Society Reviews, ISSN 0306-0012, 4/2012, Volume 41, Issue 1, pp. 3731 - 3741
The roles of nitric oxide (NO) in physiology and pathophysiology merit the use of NO as a therapeutic for certain biomedical applications. Unfortunately,... 
GOLD NANOPARTICLES | METAL-ORGANIC FRAMEWORKS | S-NITROSOTHIOL | DRUG-DELIVERY | SERUM-ALBUMIN | MESOPOROUS SILICA NANOPARTICLES | BIOMEDICAL APPLICATIONS | SOL-GELS | VASCULAR BIOLOGY | BACTERIAL ADHESION | CHEMISTRY, MULTIDISCIPLINARY | Animals | Nitric Oxide Donors - chemistry | Humans | Metal Nanoparticles - chemistry | Silicon Dioxide - chemistry | Coated Materials, Biocompatible - chemistry | Delayed-Action Preparations - chemistry | Polymers - chemistry | Proteins - chemistry | Nitric Oxide - administration & dosage | Zeolites - chemistry
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2. Full Text Photoactive ruthenium nitrosyls as NO donors: How to sensitize them toward visible light
by Fry, Nicole L and Mascharak, Pradip K
Accounts of Chemical Research, ISSN 0001-4842, 04/2011, Volume 44, Issue 4, pp. 289 - 298
Nitric oxide (NO) can induce apoptosis (programmed cell death) at micromolar or higher doses. Although cell death via NO-induced apoptosis has been studied... 
METAL NITROSYLS | LIGANDS | BIOLOGICAL-ACTIVITY | NITRIC-OXIDE | NITROGEN | RELEASE | PHOTOLABILE RUTHENIUM | CANCER | CHEMISTRY, MULTIDISCIPLINARY | AQUEOUS-SOLUTION | DELIVERY | Nitric Oxide Donors - chemistry | Nitric Oxide - chemistry | Humans | Light | Nitric Oxide Donors - radiation effects | Ligands | Ruthenium - chemistry | Coloring Agents - chemistry | Ruthenium - radiation effects | Usage | Ruthenium | Nitric oxide | Analysis | Cancer cells | Causes of | Physiological aspects | Density functionals | Oxidation-reduction reaction | Chemical properties | Organic dyes | Apoptosis
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3. S-Nitrosothiols as nitric oxide-donors: Chemistry, biology and possible future therapeutic applications
by Al Sa'doni, H.H and Ferro, Albert
Current Medicinal Chemistry, ISSN 0929-8673, 10/2004, Volume 11, Issue 20, pp. 2679 - 2690
In recent years, the gaseous molecule nitric oxide (NO) has been shown to be involved in many important biological events. S-Nitrosothiols are biological... 
Nitric oxide donors | S-Nitrosothiols | Nitric oxide | Therapeutics | RAT FEMORAL ARTERIES | nitric oxide | therapeutics | INHIBITS PLATELET ACTIVATION | CHEMISTRY, MEDICINAL | TARGET-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELAXING FACTOR | VASCULAR SMOOTH-MUSCLE | TUMOR-NECROSIS-FACTOR | CYTOTOXICITY IN-VITRO | L-ARGININE | PHARMACOLOGY & PHARMACY | S-nitrosothiols | nitric oxide donors | BEARING MICE | NITROSYL COMPLEX-FORMATION | Animals | Nitric Oxide Donors - chemistry | S-Nitrosothiols - chemistry | Humans | Nitric Oxide Donors - metabolism | Nitric Oxide Donors - therapeutic use | S-Nitrosothiols - therapeutic use | S-Nitrosothiols - metabolism | Forecasting
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4. Full Text Nitric Oxide Donor-Based Cancer Therapy: Advances and Prospects
by Huang, Zhangjian and Fu, Junjie and Zhang, Yihua
Journal of Medicinal Chemistry, ISSN 0022-2623, 2017, Volume 60, Issue 18, pp. 7617 - 7635
The increasing understanding of the role of nitric oxide (NO) in cancer biology has generated significant progress in the use of NO donor-based therapy to... 
Neoplasms - metabolism | Nitric Oxide Donors - chemistry | Humans | Nitro Compounds - chemistry | Antineoplastic Agents - therapeutic use | Azetidines - pharmacology | Antineoplastic Agents - chemistry | Azetidines - chemistry | Neoplasms - drug therapy | Animals | Nitro Compounds - therapeutic use | Azetidines - therapeutic use | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Nitric Oxide Donors - therapeutic use | Nitric Oxide Synthase - metabolism | Nitric Oxide Donors - pharmacology | Nitric Oxide - metabolism | Index Medicus
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5. Full Text Recent developments in nitric oxide donor drugs
by Miller, M R and Megson, I L
British Journal of Pharmacology, ISSN 0007-1188, 06/2007, Volume 151, Issue 3, pp. 305 - 321
During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial signalling molecule, with wide‐ranging functions in the cardiovascular,... 
nitric oxide | nitric oxide donor drugs | furoxan | NONOate | organic nitrate | diazeniumdiolate | nitroaspirin | nitrosothiol | Nitroaspirin | Diazeniumdiolate | Nitric oxide | Organic nitrate | Nitric oxide donor drugs | S-nitrosothiol | Furoxan | Animals | Nitric Oxide Donors - chemistry | Models, Biological | Humans | Cardiovascular Physiological Phenomena - drug effects | Endothelium, Vascular - drug effects | Nitric Oxide - physiology | Molecular Structure | Nitric Oxide Donors - pharmacology | Endothelium, Vascular - physiology | Review
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6. Full Text Nitric oxide donors: Chemical activities and biological applications
by Wang, Peng George and Xian, Ming and Tang, Xiaoping and Wu, Xuejun and Wen, Zhong and Cai, Tingwei and Janczuk, Adam J
Chemical Reviews, ISSN 0009-2665, 04/2002, Volume 102, Issue 4, pp. 1091 - 1134
SICKLE-CELL HEMOGLOBIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ORGANIC NITRATE ESTERS | LOW-DENSITY-LIPOPROTEIN | UNSYMMETRICALLY SUBSTITUTED FUROXANS | GLUTATHIONE-S-TRANSFERASE | SOLUBLE GUANYLATE-CYCLASE | HYDROXY-L-ARGININE | CHEMISTRY, MULTIDISCIPLINARY | VASCULAR SMOOTH-MUSCLE | METAL NITROSYL COMPLEXES | Nitric Oxide Donors - chemistry | Nitric Oxide - chemistry | Nitric Oxide - pharmacology | Humans | Nitroso Compounds - chemistry | Nitroso Compounds - pharmacology | Animals | Nitroso Compounds - metabolism | Drug Design | Organometallic Compounds - chemistry | Nitric Oxide - classification | Nitric Oxide Donors - classification | Nitric Oxide Donors - pharmacology | Organometallic Compounds - pharmacology | Enzymes | Analysis | Nitric oxide | Nitroglycerin | Chemical research | Physiological aspects | Coordination compounds
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7. Full Text Tacrine-ferulic acid-nitric oxide (no) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors
by Chen, Yao and Sun, Jianfei and Fang, Lei and Liu, Mei and Peng, Sixun and Liao, Hong and Lehmann, Jochen and Zhang, Yihua
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 9, pp. 4309 - 4321
In search of multifunctional cholinesterase inhibitors as potential anti-Alzheimer drug candidates, tacrine-ferulic acid-NO donor trihybrids were synthesized... 
ACETYLCHOLINESTERASE ACTIVITY | DESIGN STRATEGY | TORPEDO-CALIFORNICA | CHEMISTRY, MEDICINAL | AMYLOID-BETA | ACTIVE-SITE GORGE | DISEASE | BIOLOGICAL EVALUATION | ALZHEIMER DRUG CANDIDATES | BINDING | HYBRIDS | Liver - pathology | Nitric Oxide Donors - chemistry | Coumaric Acids - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Male | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Tacrine - pharmacology | Spectrometry, Mass, Electrospray Ionization | Butyrylcholinesterase - metabolism | Picrates - chemistry | Binding Sites - physiology | Inhibitory Concentration 50 | Behavior, Animal - drug effects | Biphenyl Compounds - chemistry | Nitric Oxide Donors - pharmacology | Tacrine - analogs & derivatives | Tacrine - chemistry | Magnetic Resonance Spectroscopy | Liver - metabolism | Alzheimer Disease - drug therapy | Models, Molecular | Coumaric Acids - chemical synthesis | Mice, Inbred ICR | Animals | Cholinesterase Inhibitors - pharmacology | Mice | Kinetics | Nitric Oxide Donors - chemical synthesis | Vasodilation - drug effects | Nitric Oxide - metabolism | Coumaric Acids - pharmacology | Index Medicus
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8. Full Text Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms
by Barraud, Nicolas and Kardak, Bharat G and Yepuri, Nageshwar R and Howlin, Robert P and Webb, Jeremy S and Faust, Saul N and Kjelleberg, Staffan and Rice, Scott A and Kelso, Michael J
Angewandte Chemie - International Edition, ISSN 1433-7851, 09/2012, Volume 51, Issue 36, pp. 9057 - 9060
Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached... 
nitric oxide | prodrugs | antibiotics | biofilms | cephalosporins | INFECTIONS | PSEUDOMONAS-AERUGINOSA | HYDROLYSIS | NITRIC-OXIDE DONORS | AGENTS | CHEMISTRY, MULTIDISCIPLINARY | Biofilms - drug effects | Nitric Oxide Donors - chemistry | Cephalosporins - chemistry | Anti-Bacterial Agents - pharmacology | Prodrugs - chemistry | Pseudomonas aeruginosa - physiology | Nitric Oxide Donors - pharmacology | beta-Lactamases - metabolism | Prodrugs - pharmacology | Drugs | Activated | Biofilms | Disperse | Antibiotics | Dispersing | Bacteria | Chemical compounds
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9. Full Text PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
by Ramandeep Singh and Ujjini Manjunatha and Helena I. M. Boshoff and Young Hwan Ha and Pornwaratt Niyomrattanakit and Richard Ledwidge and Cynthia S. Dowd and Ill Young Lee and Pilho Kim and Liang Zhang and Sunhee Kang and Thomas H. Keller and Jan Jiricek and Clifton E. Barry
Science, ISSN 0036-8075, 11/2008, Volume 322, Issue 5906, pp. 1392 - 1395
Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for... 
Anaerobiosis | Protons | Enzymes | Tuberculosis | Mycobacterium tuberculosis | Bacteria | Hypoxia | Oxides | Reports | Nitrogen | Research universities | METABOLISM | BOVIS BCG | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | RESISTANCE | IDENTIFICATION | COENZYME F-420 | Nitric Oxide Donors - chemistry | Nitroimidazoles - pharmacology | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Stereoisomerism | Nitric Oxide Donors - metabolism | Antitubercular Agents - pharmacology | Mycobacterium tuberculosis - immunology | Immunity, Innate | Mycobacterium tuberculosis - drug effects | Prodrugs - metabolism | Riboflavin - analogs & derivatives | Nitroimidazoles - metabolism | Nitroreductases - metabolism | Riboflavin - metabolism | Glucosephosphate Dehydrogenase - metabolism | Nitric Oxide Donors - pharmacology | Antitubercular Agents - metabolism | Nitric Oxide - metabolism | Nitroimidazoles - chemistry | Mycobacterium tuberculosis - metabolism | Prodrugs - pharmacology | Mycobacterium tuberculosis - growth & development | Drug therapy | Health aspects | Nitric oxide | Cellular biology | Immune system
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10. Full Text Near-Infrared Photoactivatable Nitric Oxide Donors with Integrated Photoacoustic Monitoring
by Zhou, Effie Y and Knox, Hailey J and Reinhardt, Christopher J and Partipilo, Gina and Nilges, Mark J and Chan, Jefferson
Journal of the American Chemical Society, ISSN 0002-7863, 09/2018, Volume 140, Issue 37, pp. 11686 - 11697
Photoacoustic (PA) tomography is a non-invasive technology that utilizes near-infrared (NIR) excitation and ultrasonic detection to image biological tissue at... 
LIGHT-TRIGGERED RELEASE | 2-PHOTON EXCITATION | IN-VITRO | CANCER COMBINATION THERAPY | NITROBENZENE DERIVATIVES | UP-CONVERSION NANOPARTICLES | NIR-LIGHT | DRUG-RELEASE | TUMOR-CELLS | NF-KAPPA-B | CHEMISTRY, MULTIDISCIPLINARY | Nitric Oxide Donors - chemistry | Nitric Oxide - analysis | Photoacoustic Techniques | Tissue Distribution | Xenograft Model Antitumor Assays | Nitric Oxide Donors - administration & dosage | Mammary Neoplasms, Animal - pathology | Animals | Infrared Rays | Injections, Subcutaneous | Cell Line, Tumor | Female | Cell Proliferation - drug effects | Mammary Neoplasms, Animal - drug therapy | Mice | Mice, Inbred BALB C | Molecular Structure | Nitric Oxide Donors - pharmacology
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11. Full Text Novel quantum dots-carboxymethyl chitosan nanocomposite nitric oxide donors capable of detecting release of nitric oxide in situ
by Tan, L and Wan, A and Li, H and Lu, Q
Acta Biomaterialia, ISSN 1742-7061, 10/2012, Volume 8, Issue 10, pp. 3744 - 3753
Nitric oxide (NO) donor compounds are primarily monofunctional in that they release NO under the requisite conditions. To detect the amount and duration of NO... 
Nitric oxide donors | Nanocomposite | Carboxymethyl chitosan | Quantum dots | Fluorescence detection | VITRO | COMPLEX | MATERIALS SCIENCE, BIOMATERIALS | PHOTOLUMINESCENCE | VIVO | ENGINEERING, BIOMEDICAL | IONS | FUNCTIONAL-GROUP | CDSE | CDTE NANOCRYSTALS | PROBES | CHEMISTRY | Nitric Oxide Donors - chemistry | Nanocomposites - chemistry | Spectroscopy, Fourier Transform Infrared | Nitric Oxide - analysis | Water - chemistry | Nanocomposites - ultrastructure | Cell Death - drug effects | Nitric Oxide Donors - pharmacology | Chitosan - analogs & derivatives | Chitosan - chemical synthesis | Cell Survival - drug effects | Photoelectron Spectroscopy | Cadmium Compounds - chemistry | Endothelial Cells - metabolism | Tellurium - chemistry | Spectrophotometry, Ultraviolet | Particle Size | Animals | Chitosan - chemistry | Cadmium Compounds - chemical synthesis | Quantum Dots | Endothelial Cells - cytology | Nitric Oxide Donors - chemical synthesis | Sus scrofa | Microscopy, Fluorescence | Endothelial Cells - drug effects | Fluorescence | Questions and answers | Nitric oxide | Nanotechnology
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12. Full Text A Nonmetal‐Containing Nitric Oxide Donor Activated with Single‐Photon Green Light
by Blangetti, Marco and Fraix, Aurore and Lazzarato, Loretta and Marini, Elisabetta and Rolando, Barbara and Sodano, Federica and Fruttero, Roberta and Gasco, Alberto and Sortino, Salvatore
Chemistry – A European Journal, ISSN 0947-6539, 07/2017, Volume 23, Issue 38, pp. 9026 - 9029
Using a facile synthetic route, an organic NO release agent based on a BODIPY light‐harvesting antenna was devised. This compound is stable in the dark and... 
vasodilatation | BODIPY | controlled release | nitric oxide | photoactivation | RELEASE | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | Boron Compounds - chemistry | Spectrometry, Fluorescence - methods | Chromatography, High Pressure Liquid - methods | Nitric Oxide Donors - chemistry | Nitric Oxide - chemistry | Spectrometry, Mass, Electrospray Ionization - methods | Humans | Light | Drug Liberation | Photons | Vasodilation - drug effects | Nitric oxide | Antennas (Electronics) | Aorta | Vasodilation | Antennas | Photoexcitation
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13. Full Text Design, synthesis, and evaluation of fimbrolide-nitric oxide donor hybrids as antimicrobial agents
by Kutty, Samuel K and Barraud, Nicolas and Pham, Amy and Iskander, George and Rice, Scott A and Black, David Stc and Kumar, Naresh
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2013, Volume 56, Issue 23, pp. 9517 - 9529
Fimbrolides from marine algae have shown promising activity against quorum sensing (QS), a chief regulatory and communication system in bacteria controlling... 
Biofilms - drug effects | Nitric Oxide Donors - chemistry | Quorum Sensing - drug effects | Anti-Infective Agents - pharmacology | 4-Butyrolactone - pharmacology | Biofilms - growth & development | 4-Butyrolactone - chemical synthesis | Pseudomonas aeruginosa - drug effects | Anti-Infective Agents - chemical synthesis | Lactones - pharmacology | Lactones - chemical synthesis | Anti-Infective Agents - chemistry | 4-Butyrolactone - chemistry | 4-Butyrolactone - analogs & derivatives | Nitric Oxide Donors - chemical synthesis | Nitric Oxide Donors - pharmacology | Lactones - chemistry | Virulence Factors - biosynthesis
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14. Full Text Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor
by Duan, Wenwen and Li, Jin and Inks, Elizabeth S and Chou, C. James and Jia, Yuping and Chu, Xiaojing and Li, Xiaoyang and Xu, Wenfang and Zhang, Yingjie
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2015, Volume 58, Issue 10, pp. 4325 - 4338
On the basis of the strategy of creating multifunctional drugs, a novel series of phenylsulfonylfuroxan-based hydroxamates with histone deacetylase (HDAC)... 
TARGET | S-NITROSYLATION | CHEMISTRY, MEDICINAL | ACID | ENDOTHELIAL-CELLS | DRUGS | BIOLOGICAL EVALUATION | ANTIHEPATOCELLULAR CARCINOMA ACTIVITY | DERIVATIVES | CANCER | DISCOVERY | Chemistry Techniques, Synthetic | Nitric Oxide Donors - chemistry | Administration, Oral | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Male | Cell Line, Tumor - drug effects | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | HeLa Cells - drug effects | Dose-Response Relationship, Drug | Xenograft Model Antitumor Assays | Histone Deacetylase Inhibitors - chemical synthesis | Animals | Cell Cycle Checkpoints - drug effects | Drug Design | Histone Deacetylase Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice, Inbred BALB C | Nitric Oxide Donors - chemical synthesis | Nitric Oxide Donors - pharmacology | Drug Screening Assays, Antitumor
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15. Full Text Molecular Hybridization Tools in the Development of Furoxan‐Based NO‐Donor Prodrugs
by Fershtat, Leonid L and Makhova, Nina N
ChemMedChem, ISSN 1860-7179, 05/2017, Volume 12, Issue 9, pp. 622 - 638
The molecular hybridization of different compounds with known pharmacological activity is a particularly prominent approach for the design of potential drugs... 
nitric oxide | molecular diversity | prodrugs | drug design | furoxans | nitrogen heterocycles | CHEMISTRY, MEDICINAL | TRYPANOSOMA-CRUZI | NUCLEOPHILIC-SUBSTITUTION | HYBRID BIOISOSTER DERIVATIVES | NITRIC-OXIDE DONOR | ANTITUMOR AGENTS | IN-VIVO | UNSYMMETRICALLY SUBSTITUTED FUROXANS | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | DONATING DERIVATIVES | CEREBRAL MALARIA | Nitric Oxide Donors - pharmacokinetics | Prodrugs - chemistry | Nitric Oxide Donors - chemistry | Nitric Oxide Donors - pharmacology | Oxadiazoles - chemistry | Prodrugs - pharmacology | Nitric oxide | Drugs | Synergistic effects | Hybrids | Prodrugs | Oxides | Hybridization | Metabolism | Drug development | Cofactors
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