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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43665 - 43673
Myocardial constitutive No production depends on the activity of both endothelial and neuronal NOS (eNOS and nNOS, respectively). Stimulation of myocardial... 
ACTIVATION | XANTHINE OXIDOREDUCTASE | PHOSPHORYLATION | SUPEROXIDE GENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCULAR-DYSTROPHY | BETA-ADRENOCEPTOR | DEFICIENT SKELETAL-MUSCLE | VENTRICULAR MYOCYTES | UP-REGULATION | HUMAN HEART | Phosphorylation - physiology | Xanthine Dehydrogenase - metabolism | Heart Ventricles - cytology | Citrulline - analogs & derivatives | Membrane Glycoproteins - metabolism | Calcium Signaling - physiology | Arginase - metabolism | NADPH Oxidases - metabolism | Xanthine Dehydrogenase - genetics | Receptors, Adrenergic, beta-3 - immunology | Thiourea - pharmacology | Myocytes, Cardiac - enzymology | Isoenzymes - metabolism | Heart Ventricles - enzymology | Nitric Oxide Synthase Type I - antagonists & inhibitors | Receptors, Adrenergic, beta-3 - genetics | Muscle Proteins - metabolism | Superoxides - metabolism | NADPH Oxidases - genetics | Muscle Proteins - antagonists & inhibitors | Nitric Oxide Synthase Type III - metabolism | Phosphorylation - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Myocytes, Cardiac - cytology | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Arginase - genetics | NADPH Oxidase 2 | Nitric Oxide Synthase Type III - genetics | Membrane Glycoproteins - genetics | Mice, Knockout | Myocardium - cytology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Muscle Proteins - genetics | Myocardium - enzymology | Animals | Citrulline - pharmacology | Calcium Signaling - drug effects | Nitric Oxide Synthase Type I - metabolism | Mice | Nitric Oxide Synthase Type I - genetics | Isoenzymes - antagonists & inhibitors | Thiourea - analogs & derivatives | Signal Transduction | Oxidative Stress | Adrenergic Receptor | Nitric-oxide Synthase | Myocardium | Glutathionylation | Nitric Oxide
Journal Article
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 04/2017, Volume 2017, Issue 4, pp. CD000398 - CD000398
Journal Article
Circulation Research, ISSN 0009-7330, 10/2008, Volume 103, Issue 9, pp. 957 - 964
...) and attenuated by the XOR inhibitor allopurinol (100 μmol/L) in acidic and hypoxic conditions only. Whereas endothelial nitric oxide synthase (eNOS... 
Blood vessels | Hypoxia | Cardiovascular research | Nitric oxide | HEMOGLOBIN | hypoxia | nitric oxide | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | blood vessels | INDUCED VASODILATION | cardiovascular research | ISCHEMIA-REPERFUSION INJURY | IN-VIVO | S-NITROSOTHIOLS | MEDIATED DECOMPOSITION | PERIPHERAL VASCULAR DISEASE | RED-BLOOD-CELLS | REDUCES NITRITE | HEMATOLOGY | Xanthine Dehydrogenase - metabolism | Rats, Wistar | Xanthine Dehydrogenase - antagonists & inhibitors | Humans | Nitrites - metabolism | Male | omega-N-Methylarginine - pharmacology | Fluorometry | Cell Hypoxia | Nitrite Reductases - antagonists & inhibitors | Nitrites - blood | Erythrocytes - enzymology | Nitric Oxide Synthase Type III - metabolism | Aorta - enzymology | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - blood | Oxidation-Reduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Xanthine Dehydrogenase - blood | Erythrocytes - drug effects | Nitric Oxide Synthase Type III - antagonists & inhibitors | Xanthine - metabolism | Nitric Oxide Synthase Type III - blood | Animals | Allopurinol - pharmacology | Nitric Oxide - metabolism | Endothelial Cells - enzymology | Arginine - metabolism | Endothelial Cells - drug effects | Hydrogen-Ion Concentration | Nitric Oxide Synthase Type II - metabolism | Nitrite Reductases - metabolism
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 135, Issue 3, pp. 729 - 736.e5
Background Clinical observations suggest that anaphylaxis is more common in adult women compared with adult men, although the mechanistic basis for this sex... 
Allergy and Immunology | estrogen | Anaphylaxis | nitric oxide synthase | vascular permeability | mast cells | ACTIVATION | IDIOPATHIC ANAPHYLAXIS | SEX-HORMONES | CARDIOVASCULAR-SYSTEM | SENSITIVITY | BODY-TEMPERATURE | RELEASE | IMMUNOLOGY | SHOCK | ALLERGY | NO SYNTHASE | UP-REGULATION | Protein Aggregates | Capillary Permeability | Humans | Receptors, IgG - chemistry | Male | omega-N-Methylarginine - pharmacology | Histamine - immunology | Receptors, IgG - antagonists & inhibitors | Lung - enzymology | Receptors, Estrogen - immunology | Receptors, IgE - chemistry | Estrogen Receptor Antagonists - pharmacology | Anaphylaxis - physiopathology | Anaphylaxis - immunology | Female | Receptors, IgE - immunology | Estradiol - pharmacology | Disease Models, Animal | Estradiol - metabolism | Mast Cells - immunology | Nitric Oxide - biosynthesis | Nitric Oxide Synthase Type III - immunology | Gene Expression | Histamine - pharmacology | Ovariectomy | Receptors, Estrogen - antagonists & inhibitors | Receptors, IgE - antagonists & inhibitors | Lung - physiopathology | Receptors, IgG - immunology | Body Temperature | Anaphylaxis - enzymology | Mast Cells - drug effects | Nitric Oxide Synthase Type III - genetics | Mice, Knockout | Nitric Oxide Synthase Type III - antagonists & inhibitors | Anaphylaxis - genetics | Animals | Receptors, Estrogen - chemistry | Lung - drug effects | Mast Cells - pathology | Mice | Lung - immunology | Sex discrimination | Nitric oxide | Estrogen | Endothelium | Gender differences | Rodents | Allergies
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2017, Volume 37, Issue 9, pp. 1646 - 1656
... (endothelial nitric oxide synthase) at its positive regulatory site S1117 (p-eNOS) and NO generation. Maneuvers that restore glucose transport and glycolysis... 
cell physiological phenomena | endothelial cells | nitric oxide | autophagy | reactive oxygen species | ACTIVATION | KINASE-C | PROTEIN PHOSPHATASE 2A | VASCULAR ENDOTHELIUM | BLOOD-PRESSURE | DISTURBED FLOW | IN-VIVO | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | HEMATOLOGY | NF-KAPPA-B | Phosphorylation | Reactive Oxygen Species - metabolism | Mechanotransduction, Cellular - drug effects | Humans | Serine | Stress, Mechanical | Glucose Transporter Type 1 - metabolism | Receptors, Purinergic P2Y1 - drug effects | Glycolysis - drug effects | Autophagy - drug effects | Receptors, Purinergic P2Y1 - genetics | Transfection | RNA Interference | Cattle | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2Y1 - metabolism | Protein Kinase C-delta - antagonists & inhibitors | Nitric Oxide Synthase Type III - metabolism | Autophagy-Related Proteins - genetics | Purinergic P2Y Receptor Antagonists - pharmacology | Autophagy-Related Proteins - deficiency | Mice, Inbred C57BL | Cells, Cultured | Ubiquitin-Conjugating Enzymes - genetics | Mice, Knockout | Protein Kinase C-delta - metabolism | Animals | Glucose Transporter Type 1 - genetics | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - pathology | Nitric Oxide - metabolism | Endothelial Cells - enzymology | Protein Kinase C-delta - genetics | Endothelial Cells - drug effects | Ubiquitin-Conjugating Enzymes - deficiency
Journal Article
Hypertension, ISSN 0194-911X, 09/2009, Volume 54, Issue 3, pp. 652 - 658
Drugs and antibodies that interrupt vascular endothelial growth factor (VEGF) signaling pathways improve outcomes in patients with a variety of cancers by... 
Hypertension | Angiogenesis | Vascular endothelial growth factor | Cancer | TYROSINE KINASE-1 | BEVACIZUMAB | angiogenesis | vascular endothelial growth factor | VEGF | MOUSE | PERIPHERAL VASCULAR DISEASE | cancer | MONOCLONAL-ANTIBODY | MICE | hypertension | MOLECULAR-MECHANISMS | Gene Expression - drug effects | Kidney - enzymology | Antibodies, Monoclonal - adverse effects | Sodium Chloride, Dietary - administration & dosage | Male | Vascular Endothelial Growth Factor Receptor-2 - immunology | RNA, Messenger - metabolism | Aldosterone - urine | Hypertension - etiology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Renin - genetics | Prostaglandins - urine | Nitric Oxide Synthase Type I - antagonists & inhibitors | Blood Pressure - drug effects | Blood Pressure - physiology | Vascular Endothelial Growth Factor Receptor-2 - physiology | Nitric Oxide Synthase Type III - metabolism | Manometry | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Kidney - drug effects | Antibodies, Monoclonal - pharmacology | RNA, Messenger - genetics | Sodium Chloride, Dietary - adverse effects | Enzyme Inhibitors - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Nitric Oxide Synthase Type III - genetics | Hypertension - physiopathology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Nitric Oxide Synthase Type I - metabolism | Hybridomas | Mice | Nitric Oxide Synthase Type I - genetics | Vascular Endothelial Growth Factor A - physiology | Index Medicus | nitric oxide
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 40, pp. 28668 - 28686
Journal Article
Chemical Society reviews, ISSN 0306-0012, 2014, Volume 43, Issue 19, pp. 6814 - 6838
...Chem Soc Rev REVIEW ARTICLE Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain Cite this: Chem. Soc. Rev., 2014, 43,6 8... 
Journal Article
Molecular Pain, ISSN 1744-8069, 3/2010, Volume 6, Issue 1, pp. 13 - 13
Background: Although it has been largely demonstrated that nitric oxide synthase (NOS... 
PROINFLAMMATORY CYTOKINE | NEUROPATHIC PAIN | MECHANICAL ALLODYNIA | SPINAL-CORD | NECROSIS-FACTOR-ALPHA | INFLAMMATORY PAIN | PRIMARY SENSORY NEURONS | PHARMACOLOGICAL INHIBITION | PATHOLOGICAL PAIN | NEUROSCIENCES | NERVE GROWTH-FACTOR | Interleukin-1beta - drug effects | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Freund's Adjuvant - pharmacology | Tumor Necrosis Factor-alpha - genetics | Nitric Oxide Synthase - antagonists & inhibitors | Male | Interleukin-1beta - genetics | Nitric Oxide Synthase - genetics | RNA, Messenger - metabolism | Inflammation Mediators - pharmacology | Interleukin-1beta - metabolism | Isoenzymes - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Interleukin-10 - metabolism | Nitric Oxide Synthase Type III - metabolism | Cytokines - genetics | Disease Models, Animal | RNA, Messenger - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Cytokines - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III - genetics | Hyperalgesia - physiopathology | Mice, Knockout | Nitric Oxide Synthase Type III - antagonists & inhibitors | Hyperalgesia - immunology | Animals | Sensory Receptor Cells - drug effects | Tumor Necrosis Factor-alpha - drug effects | Cytokines - drug effects | Nitric Oxide Synthase Type II - genetics | Interleukin-10 - genetics | Nitric Oxide Synthase Type I - metabolism | Mice | Nitric Oxide Synthase - metabolism | Nitric Oxide Synthase Type I - genetics | Hyperalgesia - enzymology | Nociceptors - drug effects | Nitric Oxide Synthase Type II - metabolism | Physiological aspects | Rats | Research | Cytokines | Nitric oxide | Rattus
Journal Article