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The Journal of biological chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 40, pp. 28668 - 28686
Journal Article
Molecular Pain, ISSN 1744-8069, 3/2010, Volume 6, Issue 1, pp. 13 - 13
Background: Although it has been largely demonstrated that nitric oxide synthase (NOS... 
PROINFLAMMATORY CYTOKINE | NEUROPATHIC PAIN | MECHANICAL ALLODYNIA | SPINAL-CORD | NECROSIS-FACTOR-ALPHA | INFLAMMATORY PAIN | PRIMARY SENSORY NEURONS | PHARMACOLOGICAL INHIBITION | PATHOLOGICAL PAIN | NEUROSCIENCES | NERVE GROWTH-FACTOR | Interleukin-1beta - drug effects | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Freund's Adjuvant - pharmacology | Tumor Necrosis Factor-alpha - genetics | Nitric Oxide Synthase - antagonists & inhibitors | Male | Interleukin-1beta - genetics | Nitric Oxide Synthase - genetics | RNA, Messenger - metabolism | Inflammation Mediators - pharmacology | Interleukin-1beta - metabolism | Isoenzymes - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Interleukin-10 - metabolism | Nitric Oxide Synthase Type III - metabolism | Cytokines - genetics | Disease Models, Animal | RNA, Messenger - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Cytokines - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III - genetics | Hyperalgesia - physiopathology | Mice, Knockout | Nitric Oxide Synthase Type III - antagonists & inhibitors | Hyperalgesia - immunology | Animals | Sensory Receptor Cells - drug effects | Tumor Necrosis Factor-alpha - drug effects | Cytokines - drug effects | Nitric Oxide Synthase Type II - genetics | Interleukin-10 - genetics | Nitric Oxide Synthase Type I - metabolism | Mice | Nitric Oxide Synthase - metabolism | Nitric Oxide Synthase Type I - genetics | Hyperalgesia - enzymology | Nociceptors - drug effects | Nitric Oxide Synthase Type II - metabolism | Physiological aspects | Rats | Research | Cytokines | Nitric oxide | Rattus
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 568, Issue 7752, pp. 351 - 356
.... Here we report that concomitant metabolic and hypertensive stress in mice-elicited by a combination of high-fat diet and inhibition of constitutive nitric oxide synthase using N-omega-nitro-larginine methyl ester (L-NAME... 
S-NITROSYLATION | INHIBITION | DYSFUNCTION | MODEL | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | Humans | Heart Failure - physiopathology | Diet, High-Fat - adverse effects | Male | Heart Failure - prevention & control | Myocytes, Cardiac - enzymology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Endoribonucleases - metabolism | Signal Transduction | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Heart Failure - metabolism | Nitrosative Stress | Stroke Volume | Myocytes, Cardiac - pathology | Phenotype | Animals | Nitric Oxide Synthase Type II - genetics | X-Box Binding Protein 1 - metabolism | Myocytes, Cardiac - metabolism | Mice | X-Box Binding Protein 1 - genetics | Nitric Oxide Synthase Type II - metabolism | Heart failure | Care and treatment | Diagnosis | Health aspects | Nitric oxide | Heart | Genetic suppression | Kinases | High fat diet | Proteins | Arginine | Protein folding | Heart diseases | Hypertension | Obesity | Phenotypes | Inositol | Splicing | Cardiomyocytes | Pharmacology | Inflammation | Metabolism | Morbidity | Nitric-oxide synthase | NG-Nitroarginine methyl ester | Musculoskeletal system | Diet | Myocardium | Endonuclease | Ejection fraction
Journal Article
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 357, Issue 6351, pp. 570 - 575
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, p. e76538
Background: Simvastatin exerts pleiotropic effects on cardiovascular system. However, its effect on non-alcoholic fatty liver disease, especially the liver... 
PATHOGENESIS | ISSUES | HEPATIC STELLATE CELLS | MANAGEMENT | STEATOSIS | MULTIDISCIPLINARY SCIENCES | DISEASE | FATTY LIVER | STATINS | EXPRESSION | Liver - pathology | Liver - enzymology | Gene Expression - drug effects | Rats, Wistar | Fatty Liver - pathology | Humans | Actins - metabolism | Diet, High-Fat - adverse effects | Male | Liver Cirrhosis - enzymology | Simvastatin - pharmacology | Actins - genetics | Collagen Type I - genetics | Liver - drug effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Fatty Liver - enzymology | Non-alcoholic Fatty Liver Disease | Nitric Oxide Synthase Type III - metabolism | Hepatic Stellate Cells - pathology | Transforming Growth Factor beta1 - pharmacology | Hepatic Stellate Cells - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Liver Cirrhosis - etiology | Collagen Type I - metabolism | Liver Cirrhosis - prevention & control | Collagen Type I - antagonists & inhibitors | Cells, Cultured | Enzyme Inhibitors - pharmacology | Hepatic Stellate Cells - enzymology | Rats | Hypolipidemic Agents - pharmacology | Nitric Oxide Synthase Type III - genetics | Fatty Liver - drug therapy | Actins - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | Liver Cirrhosis - pathology | Fatty Liver - etiology | Nitric Oxide Synthase Type II - metabolism | Complications and side effects | Simvastatin | Fibrosis | Genetic aspects | Dosage and administration | Research | Drug therapy | Animal models | RNA-directed DNA polymerase | Liver | Collagens | Smooth muscle | Cardiovascular disease | Activation | Arthritis | High fat diet | Proteins | Fatty liver | Arginine | Ischemia | Actin | Rodents | Hepatology | Gastroenterology | Inhibition | Growth factors | Cardiovascular system | Medical research | Phenotypes | Liver diseases | Muscles | Nitric-oxide synthase | NG-Nitroarginine methyl ester | Polymerase chain reaction | Infectious diseases | Hospitals | Nitric oxide | MicroRNAs | Collagen | In vivo methods and tests | In vitro methods and tests
Journal Article
Blood, ISSN 1528-0020, 2006, Volume 109, Issue 1, pp. 228 - 234
.... We found that Stat5 phosphorylation in T cells is suppressed in the presence of MSCs and that nitric oxide... 
SYNTHASE | RESPONSES | ENGRAFTMENT | ACTIVATION | PATHWAY | IMMUNOSUPPRESSION | GROWTH | HEMATOLOGY | MARROW STROMAL CELLS | INHIBIT | TRANSPLANTATION | CD8-Positive T-Lymphocytes - cytology | Dinoprostone - physiology | Humans | B-Lymphocyte Subsets - cytology | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Phosphorylation - drug effects | Macrophages - physiology | B-Lymphocyte Subsets - drug effects | Nitric Oxide - biosynthesis | Signal Transduction | CD4-Positive T-Lymphocytes - metabolism | Cell Division - drug effects | Receptors, Antigen, T-Cell - physiology | Mice, Knockout | B-Lymphocyte Subsets - metabolism | Mice | Tryptophan - pharmacology | HeLa Cells | Interleukin-2 - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology | Nitric Oxide Synthase Type II - metabolism | Tetradecanoylphorbol Acetate - pharmacology | T-Lymphocyte Subsets - cytology | Concanavalin A - pharmacology | Nitric Oxide - pharmacology | STAT5 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Tryptophan - analogs & derivatives | Enzyme Induction - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Mesenchymal Stromal Cells - physiology | NG-Nitroarginine Methyl Ester - pharmacology | Transforming Growth Factor beta - immunology | Cell Line | Antigens, CD19 - analysis | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide - physiology | Cyclooxygenase Inhibitors - pharmacology | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Ionomycin - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interferon-gamma - biosynthesis | Prostaglandin-Endoperoxide Synthases - physiology
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 08/2014, Volume 73, pp. 51 - 59
... and its underlying mechanism during LPS-induced microglial activation are not known. Here we have used immuno-spin trapping and RNA interference to investigate the role of inducible nitric oxide synthase (iNOS... 
Peroxynitrite | Free radicals | Protein radical | Inducible nitric oxide synthase | Lipopolysaccharide | Nitrone adducts | Parkinson disease | Microglia | NADPH OXIDASE | OXIDATIVE STRESS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | KAPPA-B | LIPOPOLYSACCHARIDE-ACTIVATED MICROGLIA | REACTIVE OXYGEN | ENDOCRINOLOGY & METABOLISM | GENERATION | TYROSINE NITRATION | PARKINSONS-DISEASE | Microglia - metabolism | Metalloporphyrins - pharmacology | Lipopolysaccharides | Thiocarbamates - pharmacology | RNA Interference | Nitric Oxide Synthase Type II - antagonists & inhibitors | Spin Trapping | Acetophenones - pharmacology | Free Radicals - metabolism | Proline - pharmacology | Microglia - cytology | NG-Nitroarginine Methyl Ester - pharmacology | NF-kappa B - antagonists & inhibitors | Proline - analogs & derivatives | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antioxidants - pharmacology | Neurodegenerative Diseases - metabolism | Coumarins - pharmacology | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Peroxynitrous Acid - metabolism | Amidines - pharmacology | Mice | Pyridines - pharmacology | RNA, Small Interfering | Benzylamines - pharmacology | Cell Line, Transformed | Boronic Acids - pharmacology | Nitric Oxide Synthase Type II - metabolism | Nitration | Nervous system diseases | Multiple sclerosis | Analysis | Nitric oxide | Environmental health | Physiological aspects | Alzheimer's disease | Index Medicus | Inducible nitric | oxide synthase | LPS | Parkinson’s disease
Journal Article
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6676
Journal Article
Neurogastroenterology & Motility, ISSN 1350-1925, 07/2011, Volume 23, Issue 7, pp. 666 - e278
Background  Nitric oxide (NO) is implicated in the pathogenesis of irritable bowel syndrome (IBS... 
colonic distension | visceral hyperalgesia | nitric oxide synthase | irritable bowel syndrome | distal colon | neonatal maternal separation | Nitric oxide synthase | Distal colon | Colonic distension | Neonatal maternal separation | Irritable bowel syndrome | Visceral hyperalgesia | EARLY-LIFE STRESS | SENSITIVITY | SYMPTOMS | MODEL | NEUROSCIENCES | CLINICAL NEUROLOGY | IMPACT | VISCERAL HYPERSENSITIVITY | PAIN | DISEASE | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | IRRITABLE-BOWEL-SYNDROME | Colonic Diseases - physiopathology | Gastrointestinal Motility - physiology | Male | Nitric Oxide Synthase Type II - physiology | Animals, Newborn - physiology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Colon - physiopathology | Nitric Oxide Synthase Type III - physiology | Electromyography | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide Synthase Type II - drug effects | Rats | Maternal Behavior - physiology | Irritable Bowel Syndrome - physiopathology | Rats, Sprague-Dawley | Hyperalgesia - physiopathology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Indazoles - pharmacology | Animals | Nitric Oxide Synthase Type I - physiology | Oxidative Stress - drug effects | Nitric Oxide Synthase Type I - drug effects | Nitric Oxide Synthase Type III - drug effects | Stress, Psychological - physiopathology | Messenger RNA | Neurons | Nitric oxide | Endothelium | Neonates | Pain perception | Reactive oxygen species | Salts | Hypersensitivity | Gene expression | Pressure | Malondialdehyde | Nitric-oxide synthase | Distension | NG-Nitroarginine methyl ester | Polymerase chain reaction | Colon | EMG
Journal Article