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Circulation, ISSN 0009-7322, 03/2013, Volume 127, Issue 10, pp. 1116 - 1127
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5052 - 5060
Children conceived by assisted reproductive technologies (ART) display a level of vascular dysfunction similar to that seen in children of mothers with... 
PATERNAL METHYLATION | PULMONARY | MEDICINE, RESEARCH & EXPERIMENTAL | EPIGENETIC INHERITANCE | DNA METHYLATION | NITRIC-OXIDE SYNTHASE | INSULIN-RESISTANCE | MOUSE | DISEASE | IMPRINTED GENE | ASSISTED REPRODUCTIVE TECHNOLOGIES | Butyrates - pharmacology | Nitric Oxide Synthase Type III - biosynthesis | Male | Vascular Resistance - physiology | Hypertension - etiology | DNA Methylation | Cardiovascular Abnormalities - etiology | Gene Expression Regulation, Developmental | Butyrates - therapeutic use | Fertilization in Vitro - methods | Female | Nitric Oxide Synthase Type III - physiology | Vasodilation - physiology | Aorta - enzymology | Ovulation Induction - adverse effects | Endothelium, Vascular - embryology | Fertilization in Vitro - adverse effects | Promoter Regions, Genetic | Disease Susceptibility | Down-Regulation | Endothelium, Vascular - physiopathology | Cardiovascular Abnormalities - embryology | Longevity | Nitric Oxide Synthase Type III - genetics | Hypertension - physiopathology | Gene Expression Regulation, Enzymologic | Diet, Atherogenic | Animals | Hypertension - embryology | Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylase Inhibitors - therapeutic use | Mice | Nitric Oxide - metabolism | Infants (Newborn) | Blood circulation disorders | Research | Risk factors | Reproductive technology | Diseases | Studies | Blood pressure | Rodents | Metabolic disorders
Journal Article
Journal Article
Journal Article
Journal Article
Cell Biology International, ISSN 1065-6995, 07/2017, Volume 41, Issue 7, pp. 798 - 808
Under normal conditions, the activity of platelets is stringently and precisely balanced between activation and quiescent state. This guarantees rapid... 
platelet | endothelium‐derived inhibitory mechanisms | xenotransplantation | porcine aortic endothelial cells | endothelium-derived inhibitory mechanisms | OXIDATIVE STRESS | ACTIVATION | BABOONS | NITRIC-OXIDE SYNTHASE | PLATELET-FUNCTION | RECEPTOR | GENE-KNOCKOUT PIGS | MICE LACKING | CELL BIOLOGY | HUMAN-BLOOD | INFLAMMATORY RESPONSE | Intramolecular Oxidoreductases - biosynthesis | Prostaglandin-Endoperoxide Synthases - biosynthesis | Epoprostenol - metabolism | Endothelial Cells - metabolism | Humans | Nitric Oxide Synthase Type III - biosynthesis | Cytochrome P-450 Enzyme System - metabolism | Transplantation, Heterologous | Aorta - metabolism | Aorta - pathology | Animals | Blood Platelets - metabolism | Platelet Activation | Swine | Thromboxane-A Synthase - biosynthesis | Adenosine - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Serum | Nitric Oxide Synthase Type III - metabolism | Endothelial Cells - pathology | Intramolecular Oxidoreductases - metabolism | Nitric Oxide - metabolism | Cell culture | Animal models | Xenotransplantation | Activation | Prostacyclin | Arteries | Control | Blood platelets | Hemostasis | Xenografts | Aorta | CD73 antigen | Hemostatics | Thrombotic microangiopathy | Adenosine | Exposure | Gene expression | Thrombosis | Endothelial cells | Endothelium | Prostacyclin PGI2 | Nitric oxide | Regulatory mechanisms (biology) | Prostacyclin synthase | Platelets | Index Medicus
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 05/2009, Volume 119, Issue 19, pp. 2568 - 2577
Background-Some studies have shown that metformin activates AMP-activated protein kinase (AMPK) and has a potent cardioprotective effect against... 
Heart failure | Metformin | AMP-activated protein kinase | Nitric oxide | heart failure | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL NO SYNTHASE | BLOOD-GLUCOSE | metformin | ENDOPLASMIC-RETICULUM STRESS | DILATED CARDIOMYOPATHY | CONSCIOUS DOGS | NITRIC-OXIDE PRODUCTION | MYOCARDIAL FATTY-ACID | IN-VIVO | PERIPHERAL VASCULAR DISEASE | INDUCED CARDIAC-HYPERTROPHY | GLUCOSE-UPTAKE | HEMATOLOGY | Metformin - therapeutic use | Rats, Wistar | Apoptosis - drug effects | Heart Failure - enzymology | Nitric Oxide Synthase Type III - biosynthesis | Natriuretic Peptides - biosynthesis | Aminoimidazole Carboxamide - pharmacology | Cardiotonic Agents - therapeutic use | Myocytes, Cardiac - enzymology | Ribonucleotides - pharmacology | Protein Processing, Post-Translational - drug effects | Ventricular Dysfunction, Left - genetics | Ultrasonography | Ventricular Dysfunction, Left - enzymology | Heart Failure - diagnostic imaging | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Transforming Growth Factor beta1 - biosynthesis | Natriuretic Peptides - genetics | Pyrazoles - pharmacology | Nitric Oxide - biosynthesis | Cells, Cultured - drug effects | AMP-Activated Protein Kinases - antagonists & inhibitors | Insulin Resistance | Rats | Transforming Growth Factor beta1 - genetics | Pyrimidines - pharmacology | Nitric Oxide Synthase Type III - genetics | Cells, Cultured - enzymology | Disease Progression | Ventricular Dysfunction, Left - diagnostic imaging | Heart Failure - drug therapy | Gene Expression Regulation - drug effects | AMP-Activated Protein Kinases - physiology | Animals | Myocytes, Cardiac - drug effects | Ventricular Dysfunction, Left - drug therapy | Aminoimidazole Carboxamide - analogs & derivatives | Dogs | Fibrosis | Oxidative Stress - drug effects | Prevention | Oxidative stress | Usage | Demographic aspects | Animal models in research | Physiological aspects | Dosage and administration | Cyclic adenylic acid | Research | Protein kinases
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2014, Volume 34, Issue 9, pp. 2078 - 2085
OBJECTIVE—In a phase III clinical trial (PLATelet inhibition and patient Outcomes, PLATO), ticagrelor provided better clinical outcomes than clopidogrel in... 
adenosine | aspirin | cyclooxygenase | platelet aggregation inhibitors | ISCHEMIA/REPERFUSION INJURY | ACUTE CORONARY SYNDROMES | PLATO | COMBINATION | ATORVASTATIN | ISCHEMIA-REPERFUSION INJURY | CLOPIDOGREL | PLATELET INHIBITION | PERIPHERAL VASCULAR DISEASE | CARDIOPROTECTION | HEMATOLOGY | Receptor, Adenosine A1 - physiology | Ticlopidine - therapeutic use | Nitric Oxide Synthase Type III - biosynthesis | Adenosine A1 Receptor Antagonists - pharmacology | Male | Receptor, Adenosine A2A - physiology | Cardiotonic Agents - therapeutic use | Cyclooxygenase 2 - biosynthesis | Myocardial Reperfusion Injury - pathology | Cyclooxygenase 2 - genetics | Adenosine - therapeutic use | Myocardial Infarction - pathology | Enzyme Induction - drug effects | Nitric Oxide Synthase Type III - physiology | Aspirin - pharmacology | Myocardial Reperfusion Injury - drug therapy | Drug Evaluation, Preclinical | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Rats | Cyclooxygenase 2 - physiology | Adenosine - pharmacology | Cardiotonic Agents - pharmacology | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Ticlopidine - analogs & derivatives | Triazoles - pharmacology | Up-Regulation - drug effects | Adenosine A2 Receptor Antagonists - pharmacology | Animals | Myocardial Infarction - drug therapy | Adenosine - analogs & derivatives | Adenosine - physiology | 6-Ketoprostaglandin F1 alpha - metabolism | Quinazolines - pharmacology | Lipoxins - metabolism | Myocardial Reperfusion Injury - prevention & control
Journal Article