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1980, ISBN 3540096213, Volume 14., 162
Book
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 02/2018, Volume 148, pp. 684 - 692
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 41, pp. 42422 - 42430
Sphingosine 1-phosphate (S1P) is a lipid agonist that regulates smooth muscle cell (SMC) and endothelial cell functions by activating several members of the... 
MIGRATION | LYSOPHOSPHATIDIC ACID | PROTEIN-COUPLED RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-ACTIN EXPRESSION | ENDOTHELIAL-CELLS | SPHINGOSINE-1-PHOSPHATE | GENE-EXPRESSION | RHO-KINASE | VASCULAR MATURATION | CARG ELEMENTS | Lysophospholipids - metabolism | NIH 3T3 Cells | Up-Regulation | Phosphorylation | Transcription Factors - chemistry | Nitriles - pharmacology | rhoA GTP-Binding Protein - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Transfection | Genes, Dominant | Time Factors | Cell Division | Polymerase Chain Reaction | Cell Differentiation | Sphingosine - metabolism | Myocytes, Smooth Muscle - cytology | Genes, Reporter | Fibroblasts - metabolism | Amides - pharmacology | Proto-Oncogene Proteins - metabolism | Butadienes - pharmacology | Transcription Factors - physiology | ets-Domain Protein Elk-1 | Signal Transduction | Endothelial Cells - metabolism | Serum Response Factor - metabolism | Electrophoresis, Polyacrylamide Gel | Cells, Cultured | Enzyme Inhibitors - pharmacology | Glutathione Transferase - metabolism | Rats | Nuclear Proteins - metabolism | Muscle, Smooth - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Transcription Factors - metabolism | Sphingosine - analogs & derivatives | Animals | Trans-Activators - metabolism | Mice | Pyridines - pharmacology | Mitogen-Activated Protein Kinases - metabolism
Journal Article
The Plant Journal, ISSN 0960-7412, 10/2011, Volume 68, Issue 2, pp. 273 - 286
Cyanogenic glucosides are amino acid‐derived defence compounds found in a large number of vascular plants. Their hydrolysis by specific β‐glucosidases... 
Sorghum bicolor | cytochrome P450 | Lotus japonicus | Manihot esculenta | gene clustering | cyanogenic glucosides | CONVERGENT EVOLUTION | SECONDARY METABOLISM | DIVERSIFICATION | CYTOCHROMES P450 | SORGHUM-BICOLOR | PLANT SCIENCES | SUBSTRATE-SPECIFICITY | HYDROXYNITRILE GLUCOSIDES | PLANTS | ARABIDOPSIS | EXPRESSION | Sorghum - enzymology | Multigene Family | DNA, Complementary - genetics | Cytochrome P-450 Enzyme System - metabolism | Manihot - enzymology | Phylogeny | Glucosyltransferases - metabolism | Glucosides - genetics | Gene Expression Regulation, Plant | Glucosides - chemistry | Molecular Structure | Plant Proteins - metabolism | Sorghum - genetics | Plant Leaves - enzymology | Glycosides - chemistry | Glucosyltransferases - genetics | Manihot - metabolism | Nitriles - metabolism | Genome, Plant - genetics | Tobacco - metabolism | Loteae - metabolism | Manihot - genetics | Sorghum - metabolism | RNA, Plant - genetics | Glucosides - metabolism | Biological Evolution | Gene Expression Regulation, Enzymologic | Hydrogen Cyanide - metabolism | Plant Proteins - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Glycosides - metabolism | Tobacco - genetics | Nitriles - chemistry | Cytochrome P-450 Enzyme System - genetics | Loteae - enzymology | Glucosides - biosynthesis | Mutation | Loteae - genetics | Hydrolysis | Legumes | Enzymes | Beans | Genes | Genetic research | Physiological aspects | Nitriles | Mimosaceae | Plant biology | Biosynthesis | Genomics | Plant resistance
Journal Article
Development, ISSN 0950-1991, 06/2004, Volume 131, Issue 11, pp. 2749 - 2762
The receptor tyrosine kinase FLK1 and the transcription factor SCL play crucial roles in the establishment of hematopoietic and endothelial cell lineages in... 
BMP4 | TGFβ1 | Hematopoiesis | VEGF | Vasculogenesis | FLK1 | SCL | vasculogenesis | YOLK-SAC HEMATOPOIESIS | TGF beta 1 | DEVELOPMENTAL BIOLOGY | MOUSE EMBRYO | hematopoiesis | IN-VITRO | GENE | GROWTH-FACTOR VEGF | MICE | BONE MORPHOGENETIC PROTEIN-4 | DIFFERENTIATION | MESODERM INDUCTION | Endothelium, Vascular - cytology | Humans | Vascular Endothelial Growth Factor A - metabolism | MAP Kinase Kinase 1 | Vascular Endothelial Growth Factor Receptor-2 - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Bone Morphogenetic Proteins - metabolism | Bone Morphogenetic Proteins - pharmacology | Vascular Endothelial Growth Factor A - pharmacology | Basic Helix-Loop-Helix Transcription Factors | CD4 Antigens - genetics | Butadienes - pharmacology | Transforming Growth Factor beta1 | Smad6 Protein | Enzyme Inhibitors - pharmacology | Transforming Growth Factor beta - pharmacology | Endothelium, Vascular - metabolism | Hematopoietic Stem Cells - cytology | Nonmuscle Myosin Type IIB | Mice | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphoproteins - drug effects | Nitriles - pharmacology | Trans-Activators - drug effects | Culture Media, Serum-Free | Mitogen-Activated Protein Kinase 1 - drug effects | Stem Cells - cytology | Phosphoproteins - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Bone Morphogenetic Proteins - genetics | Extracellular Matrix Proteins - metabolism | T-Cell Acute Lymphocytic Leukemia Protein 1 | Proto-Oncogene Proteins - metabolism | Bone Morphogenetic Protein 4 | Cells, Cultured | DNA-Binding Proteins - drug effects | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Proto-Oncogene Proteins - genetics | Hematopoietic Stem Cells - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Extracellular Matrix Proteins - drug effects | Smad5 Protein | Transcription Factors - metabolism | Animals | Smad1 Protein | Smad Proteins | Myosin Heavy Chains | Stem Cells - drug effects | Trans-Activators - metabolism | Mitogen-Activated Protein Kinase 3 | CD4 Antigens - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35545
Plants have evolved a variety of mechanisms for dealing with insect herbivory among which chemical defense through secondary metabolites plays a prominent... 
PIERIS-RAPAE | CHEMICAL DEFENSE | ARABIDOPSIS-THALIANA | GENETIC-BASIS | EVOLUTION | BENZYLGLUCOSINOLATE | MULTIDISCIPLINARY SCIENCES | CYANOGENIC GLYCOSIDES | NITRILE FORMATION | PLANTS | MYROSINASE SYSTEM | Microsomes - metabolism | Thiocyanates - metabolism | Thioglucosides - metabolism | Nasturtium - genetics | Glucosinolates - metabolism | Aminohydrolases - genetics | Butterflies - metabolism | Nasturtium - metabolism | Larva - enzymology | Tropaeolum - genetics | Insect Proteins - isolation & purification | Nitriles - metabolism | Hydroxylation | Larva - metabolism | Microsomes - enzymology | Herbivory | Arabidopsis - metabolism | Arabidopsis - genetics | Animals | Feces - chemistry | Plant Leaves - genetics | Plant Leaves - metabolism | Insect Proteins - chemistry | Tropaeolum - metabolism | Aminohydrolases - metabolism | Arabidopsis thaliana | Enzymes | Evolutionary biology | Analysis | Physiological aspects | Amino acids | Evolution | Cyanides | Genetic engineering | Plants | Butterflies | Plant metabolites | Adaptations | Larvae | Cyanide | L-3-Cyanoalanine synthase | Fumigation | Seeds | Chemical defense | Genes | Glucosinolates | Biosynthesis | Biology | Transgenic plants | Proteins | Ecological effects | Secondary metabolites | Metabolites | Physiology | Species | Historical metallurgy | Plants (botany) | Acids | Ecological niches | Insects | Rhodanese | Butterflies & moths | Mustard | Herbivores | Plant metabolism | Pharmaceuticals
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2017, Volume 61, Issue 12
Journal Article
Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 787 - 790
Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive form of the disease called... 
COS cells | Androgens | Cell lines | Agonists | Oncology | Reports | Androgen antagonists | Prostate cancer | Heterologous transplantation | Tumors | Vehicles | NONSTEROIDAL ANTIANDROGENS | STRUCTURAL BASIS | AFFINITY | MULTIDISCIPLINARY SCIENCES | ANDROGEN-RECEPTOR | RESISTANCE | ANTAGONISM | LIGAND | MODEL | BICALUTAMIDE | Transcription, Genetic - drug effects | Nitriles - pharmacology | Phenylthiohydantoin - therapeutic use | Humans | Receptors, Androgen - metabolism | Biological Availability | Male | Antineoplastic Agents - therapeutic use | Tosyl Compounds - pharmacology | Antineoplastic Agents - metabolism | Cell Nucleus - metabolism | Receptors, Androgen - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Prostatic Neoplasms - drug therapy | Androgen Antagonists - pharmacokinetics | Phenylthiohydantoin - pharmacology | Nitriles - metabolism | Prostatic Neoplasms - pathology | Androgen Antagonists - metabolism | Androgen Antagonists - pharmacology | Anilides - metabolism | DNA - metabolism | Phenylthiohydantoin - analogs & derivatives | Xenograft Model Antitumor Assays | Animals | Receptors, Androgen - genetics | Anilides - pharmacology | Tosyl Compounds - metabolism | Androgen Antagonists - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Phenylthiohydantoin - metabolism | Drug Screening Assays, Antitumor | Phenylthiohydantoin - pharmacokinetics | Care and treatment | Antiandrogens | Dosage and administration | Drug therapy | Methods | Cancer | Chemotherapy | Pharmacology | Binding sites
Journal Article
Oncogene, ISSN 0950-9232, 01/2014, Volume 33, Issue 5, pp. 567 - 577
Tumor cells require increased adenosine triphosphate (ATP) to support anabolism and proliferation. The precise mechanisms regulating this process in tumor... 
pancreatic cancer | HMGB1 | RAGE | inflammation | ATP | mitochondria | MIGRATION | SIGNAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | AUTOPHAGY | RELEASE | CANCER | GROUP BOX-1 PROTEIN | CELL BIOLOGY | IMMUNE | ONCOLOGY | ADVANCED GLYCATION ENDPRODUCTS | GENETICS & HEREDITY | RNA, Small Interfering - genetics | Cell Proliferation | Extracellular Signal-Regulated MAP Kinases - drug effects | Pancreatic Neoplasms - metabolism | Toll-Like Receptor 2 - genetics | Uncoupling Agents | Nitriles - pharmacology | Humans | Tumor Microenvironment | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Adenosine Triphosphate - biosynthesis | Electron Transport Complex I - metabolism | Inflammation - metabolism | RNA Interference | Adenosine Triphosphate - metabolism | HMGB1 Protein - metabolism | Protein Binding - drug effects | Rotenone - pharmacology | CD24 Antigen - genetics | Phosphorylation - drug effects | Protein Synthesis Inhibitors - pharmacology | Receptor for Advanced Glycation End Products - genetics | MAP Kinase Kinase 2 - genetics | Butadienes - pharmacology | Electron Transport Complex I - antagonists & inhibitors | Signal Transduction | Pancreatic Neoplasms - pathology | Receptor for Advanced Glycation End Products - metabolism | Enzyme Inhibitors - pharmacology | Toll-Like Receptor 4 - genetics | HMGB1 Protein - drug effects | MAP Kinase Kinase 2 - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Cycloheximide - pharmacology | Animals | Energy Metabolism | Cell Line, Tumor | Mice | Cell Movement | NF-kappa B - drug effects | Growth | Oncology, Experimental | Development and progression | Inflammation | Research | Muscle proteins | Necrosis | Mitochondria | Pancreatic cancer | Cancer cells | Physiological aspects | Adenosine triphosphate | Cancer | Studies | Angiogenesis | Adenosine triphosphatase
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2013, Volume 191, Issue 8, pp. 4308 - 4316
Monocytes and macrophages are important innate immune cells equipped with danger-sensing receptors, including complement and Toll-like receptors. Complement... 
SIGNAL-TRANSDUCTION | ACTIVATION | CYTOKINE PRODUCTION | PATHWAY | KINASE | C5L2 | MOUSE | CSF | TOLL-LIKE RECEPTORS | IMMUNOLOGY | IDENTIFICATION | Inflammation - chemically induced | Nitriles - pharmacology | Humans | Complement C5a - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Monocytes - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System - immunology | Lipopolysaccharides | Receptors, Complement - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Anaphylatoxin C5a | Interleukin-10 - secretion | Interleukin-6 - metabolism | Pertussis Toxin - pharmacology | Butadienes - pharmacology | Salmonella typhimurium - immunology | Macrophage Colony-Stimulating Factor | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Tumor Necrosis Factors - metabolism | Toll-Like Receptor 4 - metabolism | Proto-Oncogene Proteins c-raf - metabolism | Macrophages - metabolism | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Interleukin-10 - biosynthesis | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor | Poly I-C | Aminoquinolines
Journal Article
Diabetes, ISSN 0012-1797, 02/2014, Volume 63, Issue 2, pp. 514 - 525
The number and activity of brown adipocytes are linked to the ability of mammals to resist body fat accumulation. In some conditions, certain white adipose... 
OBESITY | GENE | ENDOCRINOLOGY & METABOLISM | MUSCLE | RECEPTOR | PROLIFERATION | DIFFERENTIATION | EXPRESSION | FAT-CELL | EXERCISE | ADIPOSE-TISSUE | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins
Journal Article
Stem Cells and Development, ISSN 1547-3287, 09/2013, Volume 22, Issue 17, pp. 2384 - 2393
Mesenchymal stem cells (MSCs) are able to home and migrate into damaged tissues and are thus, considered an optimal therapeutic strategy for clinical use. We... 
Original Research Reports | MEDICINE, RESEARCH & EXPERIMENTAL | BONE-MARROW | TISSUE-REPAIR | CXCR4 | MIF | CELL & TISSUE ENGINEERING | TRANSPLANTATION | IN-VITRO | EPITHELIAL-CELLS | ENDOTHELIAL-CELLS | CHEMOKINE RECEPTORS | STROMAL CELLS | HEMATOLOGY | BLOOD | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Stress, Mechanical | JNK Mitogen-Activated Protein Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Cell Movement - physiology | MAP Kinase Signaling System | p38 Mitogen-Activated Protein Kinases - metabolism | Imidazoles - metabolism | Nitriles - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Receptors, CXCR4 - antagonists & inhibitors | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Heterocyclic Compounds - metabolism | Cell- and Tissue-Based Therapy | Receptors, CXCR4 - metabolism | Chemokine CXCL12 - metabolism | Pyridines - metabolism | Receptors, CXCR4 - biosynthesis | Butadienes - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Anthracenes - metabolism | Chemokine CXCL12 - biosynthesis | Wound Healing - physiology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Research | Analysis | Stem cells | Index Medicus
Journal Article