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Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 41, pp. 42422 - 42430
Sphingosine 1-phosphate (S1P) is a lipid agonist that regulates smooth muscle cell (SMC) and endothelial cell functions by activating several members of the... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Lysophospholipids - metabolism | NIH 3T3 Cells | Up-Regulation | Phosphorylation | Transcription Factors - chemistry | Nitriles - pharmacology | rhoA GTP-Binding Protein - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Transfection | Genes, Dominant | Time Factors | Cell Division | Polymerase Chain Reaction | Cell Differentiation | Sphingosine - metabolism | Myocytes, Smooth Muscle - cytology | Genes, Reporter | Fibroblasts - metabolism | Amides - pharmacology | Proto-Oncogene Proteins - metabolism | Butadienes - pharmacology | Transcription Factors - physiology | ets-Domain Protein Elk-1 | Signal Transduction | Endothelial Cells - metabolism | Serum Response Factor - metabolism | Electrophoresis, Polyacrylamide Gel | Cells, Cultured | Enzyme Inhibitors - pharmacology | Glutathione Transferase - metabolism | Rats | Nuclear Proteins - metabolism | Muscle, Smooth - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Transcription Factors - metabolism | Sphingosine - analogs & derivatives | Animals | Trans-Activators - metabolism | Mice | Pyridines - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Development, ISSN 0950-1991, 06/2004, Volume 131, Issue 11, pp. 2749 - 2762
The receptor tyrosine kinase FLK1 and the transcription factor SCL play crucial roles in the establishment of hematopoietic and endothelial cell lineages in... 
BMP4 | TGFβ1 | Hematopoiesis | VEGF | Vasculogenesis | FLK1 | SCL | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Endothelium, Vascular - cytology | Humans | Vascular Endothelial Growth Factor A - metabolism | MAP Kinase Kinase 1 | Vascular Endothelial Growth Factor Receptor-2 - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Bone Morphogenetic Proteins - metabolism | Bone Morphogenetic Proteins - pharmacology | Vascular Endothelial Growth Factor A - pharmacology | Basic Helix-Loop-Helix Transcription Factors | CD4 Antigens - genetics | Butadienes - pharmacology | Transforming Growth Factor beta1 | Smad6 Protein | Enzyme Inhibitors - pharmacology | Transforming Growth Factor beta - pharmacology | Endothelium, Vascular - metabolism | Hematopoietic Stem Cells - cytology | Nonmuscle Myosin Type IIB | Mice | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphoproteins - drug effects | Nitriles - pharmacology | Trans-Activators - drug effects | Culture Media, Serum-Free | Mitogen-Activated Protein Kinase 1 - drug effects | Stem Cells - cytology | Phosphoproteins - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Bone Morphogenetic Proteins - genetics | Extracellular Matrix Proteins - metabolism | T-Cell Acute Lymphocytic Leukemia Protein 1 | Proto-Oncogene Proteins - metabolism | Bone Morphogenetic Protein 4 | Cells, Cultured | DNA-Binding Proteins - drug effects | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Proto-Oncogene Proteins - genetics | Hematopoietic Stem Cells - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Extracellular Matrix Proteins - drug effects | Smad5 Protein | Transcription Factors - metabolism | Animals | Smad1 Protein | Smad Proteins | Myosin Heavy Chains | Stem Cells - drug effects | Trans-Activators - metabolism | Mitogen-Activated Protein Kinase 3 | CD4 Antigens - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Nature communications, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1897 - 1897
The cellular decision regarding whether to undergo proliferation or death is made at the restriction (R)-point, which is disrupted in nearly all tumors. The... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromatin - metabolism | RNA, Small Interfering - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | TOR Serine-Threonine Kinases - metabolism | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Polycomb-Group Proteins - metabolism | TOR Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Chromatin - chemistry | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Signal Transduction | Epithelial Cells - pathology | MAP Kinase Kinase 1 - metabolism | Imidazoles - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Cell Cycle Checkpoints - drug effects | Polycomb-Group Proteins - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA, Small Interfering - metabolism | ras Proteins - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Epithelial Cells - metabolism | Nitriles - pharmacology | Cyclin-Dependent Kinase 4 - genetics | Epithelial Cells - drug effects | ras Proteins - metabolism | Drosophila melanogaster - genetics | Chromatin Assembly and Disassembly - drug effects | Drosophila melanogaster - metabolism | MAP Kinase Kinase 1 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | HEK293 Cells | MAP Kinase Kinase 4 - antagonists & inhibitors | Chromatin - drug effects | Histone-Lysine N-Methyltransferase - genetics | Drosophila melanogaster - cytology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Sirolimus - pharmacology | Animals | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Core Binding Factor Alpha 3 Subunit - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Polycomb group proteins | Regulators | Molecular modelling | S phase | Genes | Cell cycle | Loci | Runx3 protein | Recruitment | Tumors | Chromatin remodeling | Index Medicus
Journal Article
The Plant journal : for cell and molecular biology, ISSN 0960-7412, 10/2011, Volume 68, Issue 2, pp. 273 - 286
Summary Cyanogenic glucosides are amino acid‐derived defence compounds found in a large number of vascular plants. Their hydrolysis by specific β‐glucosidases... 
Sorghum bicolor | cytochrome P450 | Lotus japonicus | Manihot esculenta | gene clustering | cyanogenic glucosides | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Sorghum - enzymology | Multigene Family | DNA, Complementary - genetics | Cytochrome P-450 Enzyme System - metabolism | Manihot - enzymology | Phylogeny | Glucosyltransferases - metabolism | Glucosides - genetics | Gene Expression Regulation, Plant | Glucosides - chemistry | Molecular Structure | Plant Proteins - metabolism | Sorghum - genetics | Plant Leaves - enzymology | Glycosides - chemistry | Glucosyltransferases - genetics | Manihot - metabolism | Nitriles - metabolism | Genome, Plant - genetics | Tobacco - metabolism | Loteae - metabolism | Manihot - genetics | Sorghum - metabolism | RNA, Plant - genetics | Glucosides - metabolism | Biological Evolution | Gene Expression Regulation, Enzymologic | Hydrogen Cyanide - metabolism | Plant Proteins - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Glycosides - metabolism | Tobacco - genetics | Nitriles - chemistry | Cytochrome P-450 Enzyme System - genetics | Loteae - enzymology | Glucosides - biosynthesis | Mutation | Loteae - genetics | Hydrolysis | Legumes | Enzymes | Beans | Genes | Genetic research | Physiological aspects | Nitriles | Mimosaceae | Plant biology | Biosynthesis | Genomics | Plant resistance | Index Medicus
Journal Article
Oncogene, ISSN 1476-5594, 01/2013, Volume 33, Issue 5, pp. 567 - 577
... through the HMGB1/RAGE pathway would enhance pancreatic ductal tumor cell survival and protect them from cytotoxic insult through linkage to altered cellular metabolism... 
pancreatic cancer | HMGB1 | RAGE | inflammation | ATP | mitochondria | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Cell Proliferation | Extracellular Signal-Regulated MAP Kinases - drug effects | Pancreatic Neoplasms - metabolism | Toll-Like Receptor 2 - genetics | Uncoupling Agents | Nitriles - pharmacology | Humans | Tumor Microenvironment | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Adenosine Triphosphate - biosynthesis | Electron Transport Complex I - metabolism | Inflammation - metabolism | RNA Interference | Adenosine Triphosphate - metabolism | HMGB1 Protein - metabolism | Protein Binding - drug effects | Rotenone - pharmacology | CD24 Antigen - genetics | Phosphorylation - drug effects | Protein Synthesis Inhibitors - pharmacology | Receptor for Advanced Glycation End Products - genetics | MAP Kinase Kinase 2 - genetics | Butadienes - pharmacology | Electron Transport Complex I - antagonists & inhibitors | Signal Transduction | Pancreatic Neoplasms - pathology | Receptor for Advanced Glycation End Products - metabolism | Enzyme Inhibitors - pharmacology | Toll-Like Receptor 4 - genetics | HMGB1 Protein - drug effects | MAP Kinase Kinase 2 - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Cycloheximide - pharmacology | Animals | Energy Metabolism | Cell Line, Tumor | Mice | Cell Movement | NF-kappa B - drug effects | Growth | Oncology, Experimental | Development and progression | Inflammation | Research | Muscle proteins | Necrosis | Mitochondria | Pancreatic cancer | Cancer cells | Physiological aspects | Adenosine triphosphate | Cancer | Studies | Angiogenesis | Adenosine triphosphatase | Index Medicus
Journal Article
Journal Article
Molecular neurobiology, ISSN 1559-1182, 01/2017, Volume 55, Issue 2, pp. 1082 - 1096
Multi-protein complexes, termed “inflammasomes,” are known to contribute to neuronal cell death and brain injury following ischemic stroke. Ischemic stroke... 
Neurology | Neurosciences | Stroke | Biomedicine | Neuronal cell death | Neurobiology | NLRP | Inflammasome | Cell Biology | Nuclear factor kappa B | Mitogen-activated protein kinases | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Inflammasomes - metabolism | Nitriles - pharmacology | Brain Ischemia - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Sulfones - pharmacology | Brain - metabolism | Inflammasomes - drug effects | Neurons - metabolism | Neurons - drug effects | Butadienes - pharmacology | NF-kappa B - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Imidazoles - pharmacology | Anthracenes - pharmacology | Apoptosis Regulatory Proteins - metabolism | Brain - drug effects | Stroke - metabolism | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Pyridines - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Brain | NF-κB protein | Immunoglobulins | Intravenous administration | Oligomerization | Bcl-2 protein | Therapeutic applications | Neurons | MAP kinase | Interleukin 18 | Proteins | Signal transduction | Pyrin protein | Bcl-x protein | Ischemia | Cell death | Brain injury | Apoptosis | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 06/2013, Volume 288, Issue 24, pp. 17713 - 17724
Journal Article
Journal Article