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Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2013, Volume 57, Issue 2, pp. 751 - 757
Journal Article
Nature Neuroscience, ISSN 1097-6256, 07/2004, Volume 7, Issue 7, pp. 711 - 718
Voltage-dependent Kv2.1 K+ channels, which mediate delayed rectifier Kv currents (I-K), are expressed in large clusters on the somata and dendrites of... 
ALPHA-SUBUNITS | RAT HIPPOCAMPAL-NEURONS | MAMMALIAN BRAIN | ACTIVATION | GATED POTASSIUM CHANNELS | RECEPTOR | NEOCORTICAL PYRAMIDAL NEURONS | IDENTIFICATION | KV2.1 K+ CHANNEL | BINDING | NEUROSCIENCES | Potassium - metabolism | Okadaic Acid - pharmacology | Potassium Channels, Voltage-Gated | Pyramidal Cells - metabolism | Cyclosporine - pharmacology | Cell Count | Neuronal Plasticity - drug effects | Pyrethrins - pharmacology | Translocation, Genetic - drug effects | Patch-Clamp Techniques - methods | Seizures - chemically induced | Dose-Response Relationship, Drug | Potassium Channels - metabolism | Phosphoprotein Phosphatases - pharmacology | Seizures - physiopathology | Drug Interactions | Neuronal Plasticity - physiology | Time Factors | Dendrites - physiology | Potassium Chloride - pharmacology | Nitriles | Pyramidal Cells - drug effects | Phosphorylation - drug effects | Cadmium Chloride - pharmacology | Ionophores - pharmacology | Potassium Channel Blockers - pharmacology | Disease Models, Animal | Animals, Newborn | Membrane Potentials - drug effects | Dendrites - drug effects | Translocation, Genetic - physiology | Glutamic Acid - pharmacology | Kainic Acid - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Nitrendipine - pharmacology | Calcium Channel Blockers - pharmacology | Delayed Rectifier Potassium Channels | Hippocampus - cytology | Membrane Potentials - physiology | Shab Potassium Channels | Calcimycin - pharmacology | Blotting, Western | Animals | Ion Channel Gating - drug effects | Physiological aspects | Phosphorylation | Ion channels | Research | Neurons | Index Medicus
Journal Article
Psychopharmacology, ISSN 0033-3158, 12/2008, Volume 201, Issue 3, pp. 443 - 458
Fluoxetine has relatively high affinity for Gq/11 protein-coupled 5-HT2 receptors. Part of these receptors in brain are on astrocytes, where fluoxetine causes... 
Neurosciences | Biomedicine | Serotonin | Astrocytes | Fluoxetine | EGFR transactivation | fosB | c-fos | Pharmacology/Toxicology | Psychiatry | ERK | 5-HT 2B receptor | receptor | C-fos | FosB | 5-HT | SIGNALING PATHWAYS | PSYCHIATRY | TYROSINE KINASE | PHARMACOLOGICAL CHARACTERIZATION | CELL-PROLIFERATION | 5-HT2B receptor | NEUROSCIENCES | SEROTONIN REUPTAKE INHIBITORS | MESSENGER-RNA | TISSUE DISTRIBUTION | MECHANICAL-STRESS | CULTURED ASTROCYTES | PHARMACOLOGY & PHARMACY | R-FLUOXETINE | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Phosphorylation | Transcriptional Activation - genetics | Nitriles - pharmacology | Calcium - metabolism | Maleimides - pharmacology | Substrate Specificity | Extracellular Signal-Regulated MAP Kinases - metabolism | Quinazolines | Calcium - chemistry | Receptor, Serotonin, 5-HT2B - physiology | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Receptor, Epidermal Growth Factor - metabolism | Piperidines - pharmacology | Receptor, Serotonin, 5-HT2B - drug effects | Urea - analogs & derivatives | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Astrocytes - drug effects | Fluoxetine - pharmacology | Butadienes - pharmacology | Gene Expression | Signal Transduction | Dipeptides - pharmacology | RNA, Messenger - genetics | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Antidepressive Agents, Second-Generation - pharmacology | Protein Kinase C - antagonists & inhibitors | Tyrphostins - pharmacology | Chelating Agents - pharmacology | Antidepressive Agents, Second-Generation - antagonists & inhibitors | Fluoxetine - antagonists & inhibitors | Astrocytes - physiology | Animals | Egtazic Acid - pharmacology | Aminopyridines - pharmacology | Proto-Oncogene Proteins c-fos - genetics | Mice | Urea - pharmacology | Brain | Neurotransmitters | Antidepressants | Psychopharmacology | Cells | Index Medicus
Journal Article
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 05/2014, Volume 110, Issue 10, pp. 2479 - 2488
Background: Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with those of... 
ACTIVATION | GROWTH-FACTOR-RECEPTOR | FACTOR SCATTER FACTOR | MALIGNANT PLEURAL MESOTHELIOMA | PHASE-II | tyrosine kinases | ANTITUMOR-ACTIVITY | MET RECEPTOR | PI3K/AKT/MDM2 | PI3K/AKT/mTOR | INHIBITION | ONCOLOGY | C-MET | mesothelioma | Mesothelioma - pathology | Nitriles - pharmacology | Humans | Neoplasm Proteins - physiology | Receptor Protein-Tyrosine Kinases - physiology | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | MAP Kinase Signaling System | TOR Serine-Threonine Kinases - antagonists & inhibitors | raf Kinases - physiology | RNA Interference | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Chromones - pharmacology | Everolimus | Butadienes - pharmacology | Sirolimus - analogs & derivatives | RNA, Small Interfering - pharmacology | Morpholines - pharmacology | Imidazoles - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Sirolimus - pharmacology | Indazoles - pharmacology | Signal Transduction - drug effects | Mesothelioma - enzymology | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Drug Screening Assays, Antitumor | Index Medicus | Translational Therapeutics | PI3K | mTOR | MDM2 | AKT
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2005, Volume 315, Issue 3, pp. 1346 - 1353
Journal Article
The Journal of Sexual Medicine, ISSN 1743-6095, 12/2012, Volume 9, Issue 12, pp. 3028 - 3040
The efficacy of phosphodiesterase type 5 inhibitors (PDE5i) in treating lower urinary tract symptoms is supported by the extremely high expression and activity... 
Bladder | PDE5 | Vardenafil | PHOSPHODIESTERASE-5 INHIBITORS | FUNCTIONAL-ACTIVITY | NITRIC-OXIDE SYNTHASE | DETRUSOR SMOOTH-MUSCLE | CGMP-BINDING | LOWER URINARY-TRACT | BENIGN PROSTATIC HYPERPLASIA | IN-VITRO | UROLOGY & NEPHROLOGY | SEXUAL DYSFUNCTION | EXPRESSION | Estradiol - blood | Estrogens - pharmacology | Nitriles - pharmacology | Aromatase Inhibitors - pharmacology | Male | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Sulfones - pharmacology | Testosterone - pharmacology | Muscle, Smooth - drug effects | Female | Nitric Oxide Donors - pharmacology | Testosterone - blood | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Progesterone - pharmacology | Estradiol - pharmacology | Gene Expression | Triazines - pharmacology | Ovariectomy | Urinary Bladder - metabolism | Progestins - pharmacology | Rats | Imidazoles - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Triazoles - pharmacology | Animals | Androgens - pharmacology | Sex Factors | Vardenafil Dihydrochloride | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Urinary Bladder - drug effects | Muscle Relaxation - drug effects | Testosterone | Enzymes | Genes | Phenols | Sodium nitroferricyanide | Cyanides | Estradiol | Cyclic guanylic acid | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2018, Volume 128, pp. 324 - 339
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 8, pp. 656 - 663
Journal Article
Journal Article