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Molecular Neurobiology, ISSN 0893-7648, 11/2016, Volume 53, Issue 9, pp. 6459 - 6475
...Oxidative Stress, Disrupted Energy Metabolism, and Altered Signaling Pathways in Glutaryl-CoA Dehydrogenase Knockout Mice: Potential Implications of Quinolinic... 
Signaling pathways | Neurology | Neurosciences | Energy metabolism | Biomedicine | Glutaric acidemia | Redox homeostasis | Neurobiology | Inflammatory response | Quinolinic acid | Cell Biology | PLASMA-MEMBRANES | 3-HYDROXYGLUTARIC ACID | NMDA RECEPTORS | NITRIC-OXIDE SYNTHASE | FACTOR-KAPPA-B | GLUTAMATE UPTAKE | NEUROSCIENCES | CEREBRAL-CORTEX | PRIMARY NEURONAL CULTURES | ANTIOXIDANT RESPONSE ELEMENT | CREATINE-KINASE | Brain Diseases, Metabolic - pathology | Glutaryl-CoA Dehydrogenase - metabolism | Glutathione - metabolism | Antioxidants - metabolism | Fluoresceins - metabolism | Nitrites - metabolism | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Electron Transport Complex IV - metabolism | Amino Acid Metabolism, Inborn Errors - metabolism | Sulfhydryl Compounds - metabolism | Neostriatum - drug effects | Lipid Peroxidation - drug effects | Neostriatum - metabolism | Quinolinic Acid - administration & dosage | Quinolinic Acid - toxicity | Amino Acid Metabolism, Inborn Errors - pathology | Brain Diseases, Metabolic - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Glutathione Peroxidase - metabolism | Neostriatum - pathology | Oxidation-Reduction | Brain Diseases, Metabolic - metabolism | Mice, Knockout | Nitrates - metabolism | Animals | Lactates - metabolism | Diet | Signal Transduction - drug effects | Models, Biological | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Amino Acid Metabolism, Inborn Errors - enzymology | Energy Metabolism - drug effects | Glutaryl-CoA Dehydrogenase - deficiency | Antioxidants | Lysine | Creatine kinase | Glutathione transferase | Physiological aspects | Superoxide | Inflammation | Creatine | Homeostasis | Signal transduction | Oxidative stress | Bioenergetics | Index Medicus
Journal Article
The FASEB Journal, ISSN 0892-6638, 11/2005, Volume 19, Issue 13, pp. 1890 - 1892
ABSTRACTWe investigated a possible beneficial role for bilirubin, one of the products of heme degradation by the cytoprotective enzyme heme oxygenase‐1 in... 
nitric oxide | oxygen free radicals | OXIDATIVE STRESS | SUPEROXIDE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | BILIVERDIN | CELL BIOLOGY | SYNTHASE EXPRESSION | ANTIOXIDANT | IN-VIVO | BIOLOGY | HEME OXYGENASE-1 | SERUM BILIRUBIN | Nitric Oxide Synthase Type II - biosynthesis | Bilirubin - metabolism | Antioxidants - metabolism | Kidney - enzymology | Malondialdehyde - chemistry | NADPH Oxidases - metabolism | Male | Aorta - metabolism | Kidney - metabolism | Time Factors | Myocardium - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Glutathione Peroxidase - metabolism | Free Radicals | Down-Regulation | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Blotting, Western | Nitrates - metabolism | Macrophages - metabolism | Rats, Gunn | Models, Biological | Lipopolysaccharides - chemistry | Mice | Nitric Oxide Synthase - metabolism | Blood Pressure | Jaundice - pathology | Tumor Necrosis Factor-alpha - metabolism | Nitric Oxide Synthase Type II - chemistry | Nitrites - metabolism | Shock, Septic - prevention & control | Oxygen - metabolism | Shock, Septic - metabolism | Heme - chemistry | Escherichia coli - metabolism | Shock, Septic - drug therapy | Interleukin-10 - metabolism | Aorta - enzymology | Superoxide Dismutase - metabolism | Cell Line | Bilirubin - chemistry | Models, Statistical | Homozygote | Myocardium - enzymology | Animals | Nitric Oxide - metabolism
Journal Article
Journal Article
Antioxidants & redox signaling, ISSN 1523-0864, 12/2011, Volume 15, Issue 11, pp. 2837 - 2854
Hepatic energy depletion has been described in severe sepsis, and lipopolysaccharide (LPS) has been shown to cause mitochondrial DNA (mtDNA) damage. To clarify... 
Original Research Communications | OXIDATIVE STRESS | LIVER-INJURY | PEROXYNITRITE | MANGANESE SUPEROXIDE-DISMUTASE | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | ETHANOL | MICE | TRANSCRIPTION-FACTOR | RESPIRATORY FACTOR-I | EXPRESSION | Aconitate Hydratase - metabolism | Electron Transport Complex III - metabolism | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Humans | Tumor Necrosis Factor-alpha - blood | Alanine Transaminase - blood | Electron Transport Complex I - metabolism | Tyrosine - analogs & derivatives | Electron Transport Complex IV - metabolism | DNA-Binding Proteins - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Sepsis - metabolism | Adenosine Triphosphate - metabolism | ATP Synthetase Complexes - metabolism | Nitrites - blood | Transcription, Genetic | Superoxide Dismutase - metabolism | Iron - blood | Nitrates - blood | DNA, Mitochondrial - metabolism | High Mobility Group Proteins - metabolism | Liver - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Thiobarbituric Acid Reactive Substances - metabolism | Iron - metabolism | Toll-Like Receptor 4 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Tyrosine - metabolism | Animals | Interferon-beta - pharmacology | Nitric Oxide Synthase Type II - genetics | Lipopolysaccharides - pharmacology | Interferon-beta - blood | Mice | Nitric Oxide Synthase Type II - metabolism | DNA damage | Physiological aspects | Septic shock | Mitochondrial DNA | Genetic aspects | Research | Health aspects | Risk factors | Lipopolysaccharides
Journal Article
Plant, Cell & Environment, ISSN 0140-7791, 11/2011, Volume 34, Issue 11, pp. 1803 - 1818
.... Whereas the metabolism of reactive oxygen species (ROS) is well established under HT, less is known about the metabolism of reactive nitrogen species (RNS). In sunflower (Helianthus annuus L... 
heat stress | nitric oxide | peroxynitrite | reactive nitrogen species | nitrotyrosine | S‐nitrosoglutathione | nitroproteome | protein tyrosine nitration | Peroxynitrite | Protein tyrosine nitration | Nitric oxide | Reactive nitrogen species | Nitrotyrosine | Heat stress | S-nitrosoglutathione | Nitroproteome | OXIDE SYNTHASE ACTIVITY | PLANT SCIENCES | PROGRAMMED CELL-DEATH | HEAT-STRESS | REACTIVE NITROGEN | PEA-PLANTS | NITROSOGLUTATHIONE REDUCTASE | NITRIC-OXIDE | GENE-EXPRESSION | PROTEIN NITRATION | SUPEROXIDE-DISMUTASE | Ferredoxin-NADP Reductase - metabolism | Stress, Physiological | Nitrites - metabolism | Lipid Peroxides - metabolism | S-Nitrosothiols - metabolism | Ferredoxin-NADP Reductase - antagonists & inhibitors | Tyrosine - analogs & derivatives | Gene Expression Regulation, Plant | Superoxides - metabolism | Hypocotyl - metabolism | Nitrate Reductase | Helianthus - metabolism | Hypocotyl - cytology | Helianthus - cytology | Aldehyde Oxidoreductases - genetics | Hot Temperature | Nitrosation | S-Nitrosoglutathione - metabolism | Aldehyde Oxidoreductases - metabolism | Nitrates - metabolism | Tyrosine - metabolism | Peroxynitrous Acid - metabolism | Proteomics | Helianthus - enzymology | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism | Photosynthesis | Arginine - metabolism | Helianthus - genetics | Proteins | Tyrosine | Nitration | Analysis | Phytochemistry | Physiological aspects | Phenols | Liquid chromatography | Stress (Physiology) | Mass spectrometry
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0178525
Mastitis is the most prevalent disease in dairy cattle worldwide and not only causes huge economic losses in the dairy industry but also threatens public... 
LIPOPOLYSACCHARIDE-INDUCED MASTITIS | DIAGNOSIS | OXIDATIVE STRESS | ACTIVATION | ACUTE-PHASE PROTEINS | PEROXYNITRITE | CHEMOKINES | MULTIDISCIPLINARY SCIENCES | AMNIOTIC-FLUID | EXPRESSION | NITRATION | Tumor Necrosis Factor-alpha - metabolism | Heme Oxygenase-1 - metabolism | Epithelial Cells - metabolism | Mammary Glands, Animal | Membrane Glycoproteins - metabolism | Epithelial Cells - drug effects | Colony-Stimulating Factors - metabolism | Lipopolysaccharide Receptors - metabolism | C-Reactive Protein - metabolism | Cattle Diseases - metabolism | Mastitis - metabolism | Mastitis - drug therapy | Cattle | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Female | Cattle Diseases - drug therapy | Interleukin-6 - metabolism | Acute-Phase Proteins - metabolism | Anti-Inflammatory Agents - pharmacology | Antioxidants - pharmacology | Toll-Like Receptor 4 - metabolism | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Melatonin - pharmacology | Mammary glands | Melatonin | Research | Health aspects | Lipopolysaccharides | Cell culture | Oxidative stress | C-reactive protein | Zoology | Glands | Cerebrospinal fluid | Cell surface | Antioxidants | Interleukin 6 | Proteins | Microorganisms | Metabolites | Amniotic fluid | Rodents | Interleukin 1 | Biosphere | Bacteria | Tumor necrosis factor-TNF | Amyloid | Gram-negative bacteria | Mammary gland | Astrocytoma | Public health | Mastitis | Advanced glycosylation end products | Antiinflammatory agents | Cytokines | Animal sciences | Inflammation | Epithelium | Gene expression | Pregnancy | Monocytes | Acute phase substances | Cell death | Ligands | Chemokines | Cancer | Apoptosis
Journal Article
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2010, Volume 30, Issue 4, pp. 749 - 757
OBJECTIVE—Animal and clinical studies have suggested that polyphenols in fruits, red wine, and tea may delay the development of atherosclerosis through their... 
Endothelial dysfunction | Soluble P-selectin | Oxidative stress | Polyphenol | Inflammation | Endothelin-1 | DEFICIENT MICE | polyphenol | endothelial dysfunction | GREEN TEA | QUERCETIN | soluble P-selectin | inflammation | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | BLACK TEA CONSUMPTION | HEME OXYGENASE-1 | RED WINE | endothelin-1 | HEMATOLOGY | NF-KAPPA-B | oxidative stress | Inflammation - pathology | Heme Oxygenase-1 - metabolism | Apolipoproteins E - deficiency | Cholesterol - blood | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | F2-Isoprostanes - metabolism | Lignans - pharmacology | Aortic Diseases - metabolism | Inflammation - metabolism | Leukotriene B4 - metabolism | Aortic Diseases - prevention & control | Dioxoles - pharmacology | Polyphenols | Anti-Inflammatory Agents - administration & dosage | Disease Models, Animal | Phenols - pharmacology | Biomarkers - metabolism | Atherosclerosis - pathology | Anti-Inflammatory Agents - pharmacology | Atherosclerosis - physiopathology | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Diet | Endothelium, Vascular - metabolism | Inflammation - prevention & control | Mice | Oxidative Stress - drug effects | Biflavonoids - pharmacology | Chlorogenic Acid - pharmacology | Nitrates - urine | Superoxides - metabolism | Flavonoids - administration & dosage | Flavonoids - pharmacology | Membrane Proteins - metabolism | Aorta - physiopathology | Nitric Oxide Synthase Type III - metabolism | Catechin - pharmacology | Fatty Acids - metabolism | Nitrites - urine | Aorta - drug effects | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Aortic Diseases - physiopathology | Animals | Quercetin - pharmacology | Apolipoproteins E - genetics | Endothelin-1 - urine | P-Selectin - blood | Phenols - administration & dosage | Nitric Oxide - metabolism | Atherosclerosis - prevention & control | Inflammation - physiopathology
Journal Article
Biotechnology and bioengineering, ISSN 1097-0290, 2003, Volume 84, Issue 2, pp. 170 - 178
Simultaneous nitrification and denitrification (SND) via the nitrite pathway and anaerobic–anoxic‐enhanced biological phosphorus removal (EBPR) are two... 
simultaneous nitrification | nitrous oxide (N2O) | nitrite pathway | denitrification and phosphorus removal (SNDPR) | titration and off‐gas analysis (TOGA) | denitrifying glycogen‐accumulating organisms (DGAOs) | Nitrite pathway | Nitrous oxide (N | Simultaneous nitrification | Titration and off-gas analysis (TOGA) | Denitrification and phosphorus removal (SNDPR) | Denitrifying glycogen-accumulating organisms (DGAOs) | STOICHIOMETRY | SND | GLYCOGEN-ACCUMULATING ORGANISMS | RELEASE | NITROGEN REMOVAL | denitrifying glycogen-accumulating organisms (DGAOs) | ACTIVATED-SLUDGE SYSTEMS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | WASTE-WATER | METABOLIC MODEL | titration and off-gas analysis (TOGA) | NITRITE | Anaerobiosis | Oxygen - pharmacology | Phosphates - chemistry | Nitrites - metabolism | Chromatography, Gas | Quaternary Ammonium Compounds - chemistry | Nitric Oxide - analysis | Oxygen - metabolism | Bacteria, Aerobic - growth & development | Nitrates - chemistry | Glycogen - metabolism | Mass Spectrometry | Nitrous Oxide - analysis | Oxygen - chemistry | Hydroxybutyrates - analysis | Bacteria, Anaerobic - metabolism | Ammonia - chemistry | Bacteria, Aerobic - metabolism | Acetic Acid - metabolism | Bacteria, Anaerobic - drug effects | Glycogen - analysis | Biodegradation, Environmental | Phosphorus - analysis | Nitrogen - metabolism | Aerobiosis | Ammonia - metabolism | Nitrogen - analysis | Valerates - metabolism | Nitrites - chemistry | Nitrous Oxide - metabolism | Valerates - analysis | Nitrates - metabolism | Phosphates - metabolism | Algorithms | Waste Disposal, Fluid - methods | Phosphorus - metabolism | Bioreactors - microbiology | Quaternary Ammonium Compounds - metabolism | Bacteria, Aerobic - drug effects | Acetic Acid - analysis | Hydroxybutyrates - metabolism | Nitric Oxide - metabolism | Bacteria, Anaerobic - growth & development
Journal Article
The Plant cell, ISSN 1532-298X, 2014, Volume 26, Issue 4, pp. 1410 - 1435
.... In the presence of acetate, respiratory metabolism is prioritized over photosynthesis; consequently, the N-sparing response targets proteins, pigments, and RNAs involved in photosynthesis and chloroplast function over those involved in respiration... 
Datasets | Enzymes | Messenger RNA | Genes | Ribosomes | Proteomics | Amino acids | LARGE-SCALE BIOLOGY ARTICLE | Proteomes | Plants | Plant cells | ARABIDOPSIS-THALIANA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NITRATE ASSIMILATION | IRON-DEFICIENCY | TANDEM MASS-SPECTROMETRY | PLANT SCIENCES | CELL BIOLOGY | HIGHER-PLANTS | RNA-SEQ | CHLAMYDORNONAS-REINHARDTII | TRIACYLGLYCEROL ACCUMULATION | REGULATORY GENE NIT2 | NITRITE REDUCTASE | Physiological aspects | Botanical research | Nitrogen | Health aspects | Chlamydomonas | Large-Scale Biology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2005, Volume 280, Issue 46, pp. 38247 - 38258
Activation of macrophages is important in chronic inflammatory disease states such as atherosclerosis. Proinflammatory cytokines such as interferon-γ... 
KRUPPEL-LIKE FACTORS | GROWTH-FACTOR-BETA | TGF-BETA | CREB-BINDING PROTEIN | INTERFERON-GAMMA | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR INTEGRATION | COACTIVATORS CBP/P300 | TRANSPLANTED MOUSE HEARTS |