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Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7550, pp. 74 - 76
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2008, Volume 105, Issue 21, pp. 7606 - 7611
Acetylcholine-binding proteins (AChBPs) from mollusks are suitable structural and functional surrogates of the nicotinic acetylcholine receptors when combined... 
Molecules | Hydrogen bonds | Atomic interactions | Drug interactions | Ligands | Agonists | Kinetics | Nicotinic receptors | Binding sites | Crystal structure | Acetylcholine-binding protein | Imidacloprid | Nicotinic receptor | Thiacloprid | SITE | DOMAIN | MULTIDISCIPLINARY SCIENCES | COMPLEXES | thiacloprid | MODEL | imidacloprid | ACETYLCHOLINE-BINDING-PROTEIN | CONFORMATIONAL-CHANGES | crystal structure | nicotinic receptor | acetylcholine-binding protein | SELECTIVITY | REVEALS | Imidazolines - metabolism | Pyridines - chemistry | Imidazoles - chemistry | Nitro Compounds - chemistry | Neonicotinoids | Crystallography, X-Ray | Nicotinic Agonists - chemistry | Nicotine - pharmacology | Aplysia | Receptors, Nicotinic - chemistry | Nitro Compounds - pharmacology | Thiazines - pharmacology | Nicotinic Agonists - pharmacology | Receptors, Nicotinic - drug effects | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Imidazolines - pharmacology | Imidazoles - pharmacology | Thiazines - chemistry | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Imidazolines - chemistry | Animals | Pyridines - metabolism | Nicotine - chemistry | Protein Conformation | Pyridines - pharmacology | Evaluation | Cell receptors | Pharmacology, Experimental | Crystals | Electronegativity | Binding proteins | Properties | Structure | Proteins | Molecular structure | Toxicity | Insecticides | Pharmacology | Mollusks | Index Medicus | TRYPTOPHAN | SPECIFICITY | ACETYLCHOLINE | RESOLUTION | CRYSTAL STRUCTURE | TOXICITY | INTERACTIONS | 60 APPLIED LIFE SCIENCES | FLUORESCENCE | LIGANDS | QUENCHING | AMINO ACIDS | KINETICS | ORIENTATION | EQUILIBRIUM | INTERFACES | INSECTS | AROMATICS | POSITIONING | PROTEINS | RECEPTORS | INSECTICIDES | FUNCTIONALS | Biological Sciences | Physical Sciences
Journal Article
Neurotoxicology and Teratology, ISSN 0892-0362, 2011, Volume 33, Issue 5, pp. 538 - 547
Abstract Kynurenic acid (KYNA) is an endogenous metabolite of the kynurenine pathway for tryptophan degradation and an antagonist of both N-methyl- d... 
Medical Education | Emergency | Lipid peroxidation | Oxidative stress | Kynurenic acid | Iron sulfate | Antioxidant defense | ROS formation | MITOCHONDRIAL TOXIN | 3-NITROPROPIONIC ACID | STRIATAL VULNERABILITY | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | HYDROXYL RADICALS | QUINOLINIC ACID | ACETYLCHOLINE-RECEPTORS | IN-VIVO | HYDROGEN-PEROXIDE | TOXICOLOGY | INDUCED NEUROTOXICITY | Free Radical Scavengers - pharmacology | Propionates - pharmacology | Reactive Oxygen Species - metabolism | Rats, Wistar | Cerebellum - drug effects | Male | Corpus Striatum - metabolism | Propionates - antagonists & inhibitors | Prosencephalon - drug effects | Dose-Response Relationship, Drug | Hydroxides - metabolism | Ferrous Compounds - pharmacology | Lipid Peroxidation - drug effects | Nitro Compounds - pharmacology | Kynurenic Acid - pharmacology | Prosencephalon - metabolism | Ferrous Compounds - antagonists & inhibitors | Microinjections | Oocytes - metabolism | Cerebellum - metabolism | Xenopus laevis | Cells, Cultured | Rats | Antioxidants - pharmacology | Animals | Antioxidants - administration & dosage | Corpus Striatum - drug effects | Oxidative Stress - drug effects | Kynurenic Acid - administration & dosage | Nitro Compounds - antagonists & inhibitors | Antioxidants | Tryptophan | Evaluation | Methyl aspartate | Analysis | Index Medicus | Free radicals | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Degradation | Controlled conditions | Anions | Metabolites | Hydroxyl radicals | superoxide anions
Journal Article
Nature, ISSN 0028-0836, 01/2013, Volume 493, Issue 7432, pp. 411 - 415
Autism spectrum disorders (ASDs) are an early onset, heterogeneous group of heritable neuropsychiatric disorders with symptoms that include deficits in social... 
DENDRITIC SPINES | MUTANT MICE | INHIBITION | MEMORY | DYSFUNCTIONS | MULTIDISCIPLINARY SCIENCES | LONG-TERM DEPRESSION | FRAGILE-X-SYNDROME | MODEL | PROTEIN-SYNTHESIS | TUBEROUS-SCLEROSIS | Dendrites - pathology | Autistic Disorder - pathology | Autistic Disorder - physiopathology | Eukaryotic Initiation Factor-4E - metabolism | Male | Thiazoles - administration & dosage | Eukaryotic Initiation Factor-4G - metabolism | Synapses - pathology | Thiazoles - therapeutic use | RNA Caps - metabolism | Nitro Compounds - administration & dosage | Nitro Compounds - therapeutic use | Synapses - metabolism | Nitro Compounds - pharmacology | Behavior, Animal - drug effects | Female | Neostriatum - metabolism | Protein Biosynthesis - genetics | Eukaryotic Initiation Factor-4E - genetics | Autistic Disorder - genetics | Dendrites - metabolism | Hydrazones | Mice, Transgenic | Hippocampus - metabolism | Animals | Neuronal Plasticity | Prefrontal Cortex - metabolism | Protein Biosynthesis - drug effects | Mice | Thiazoles - pharmacology | Infusions, Intraventricular | Autistic Disorder - drug therapy | Autism | Protein biosynthesis | Research | Brain | Experiments | Proteins | Studies | Transgenic animals | Protein synthesis | Social interaction | Rodents | Information storage | Behavior | Laboratory animals | Animal cognition | Index Medicus
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 12/2014, Volume 53, Issue 52, pp. 14605 - 14609
Journal Article