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Pharmacological Reports, ISSN 1734-1140, 10/2018, Volume 70, Issue 5, pp. 863 - 874
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 01/2013, Volume 304, Issue 1, pp. R23 - R32
The interaction between adenosine and soluble epoxide hydrolase (sEH) in vascular response is not known. Therefore, we hypothesized that lack of sEH in mice... 
Relaxation | CYP2J5-epoxgenase;ω-hydroxylase | receptor | Soluble epoxide hydrolase | Contraction | Adenosine A | Epoxide Hydrolases - physiology | Adenosine-5'-(N-ethylcarboxamide) - pharmacology | Butyrates - pharmacology | Male | Receptor, Adenosine A2A - physiology | Lauric Acids - pharmacology | Vasodilation - genetics | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Adenosine A2 Receptor Agonists - pharmacology | Urea - analogs & derivatives | Female | Benzamides - pharmacology | Oxygenases - physiology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | Adamantane - analogs & derivatives | NG-Nitroarginine Methyl Ester - pharmacology | Adamantane - pharmacology | Triazines - pharmacology | Phenethylamines - pharmacology | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Gene Silencing | Adenosine - pharmacology | Pyrimidines - pharmacology | Epoxide Hydrolases - genetics | Triazoles - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | PPAR gamma - physiology | Animals | Adenosine - analogs & derivatives | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Vasodilation - drug effects | Urea - pharmacology | adenosine A2a receptor | CYP2J5-epoxgenase | ω-hydroxylase | relaxation | contraction | Cardiovascular and Renal Integration | soluble epoxide hydrolase | adenosine A1 receptor
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure . However, the influence and mechanism of action of the prominent endocannabinoid,... 
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | VIRODHAMINE | VASORELAXATION | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | VESSELS | VASCULATURE | RESISTANCE | PHARMACOLOGY & PHARMACY | CHANNELS | HYPERTENSION | ABNORMAL-CANNABIDIOL | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 11, pp. 2862 - 2870
Neuronal activity evokes localized changes in blood flow. Although this response, termed neurovascular coupling, is widely used to monitor human brain function... 
Arachidonic acid metabolites | Retina | Calcium | Glia | ATP | Blood flow | arachidonic acid metabolites | NEURONAL-ACTIVITY | 20-HETE | calcium | RAT | ASTROCYTE-MEDIATED CONTROL | CALCIUM WAVES | ARACHIDONIC-ACID | glia | NEUROSCIENCES | HEMODYNAMIC-RESPONSE | retina | NITRIC-OXIDE | blood flow | MULLER CELLS | BRAIN | Arterioles - physiology | Cytochrome P-450 Enzyme Inhibitors | Rats, Long-Evans | Arterioles - enzymology | Nitric Oxide Synthase - physiology | Male | Vasodilation - radiation effects | Retinal Vessels - enzymology | Retinal Vessels - physiology | Hydroxyeicosatetraenoic Acids - biosynthesis | Vasoconstriction - radiation effects | Photolysis | Cyclic N-Oxides - pharmacology | Inositol 1,4,5-Trisphosphate - analogs & derivatives | Eye Proteins - antagonists & inhibitors | Purinergic Antagonists | Signal Transduction - radiation effects | Cytochrome P-450 Enzyme System - physiology | Hydrazines - pharmacology | Rats | Imidazoles - pharmacology | Retinal Vessels - drug effects | Arterioles - drug effects | Vasoconstriction - drug effects | Cytochrome P-450 CYP4A - physiology | Signal Transduction - drug effects | Miconazole - pharmacology | Eye Proteins - physiology | Retinal Vessels - radiation effects | Vasodilation - drug effects | Arterioles - radiation effects | Nitric Oxide - pharmacology | Caproates - pharmacology | Vasomotor System - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Inositol 1,4,5-Trisphosphate - pharmacology | Adenosine Triphosphate - pharmacology | Vasoconstriction - physiology | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Proadifen - pharmacology | Nitric Oxide Donors - pharmacology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Calcium Signaling - radiation effects | Cytochrome P-450 CYP4A - antagonists & inhibitors | Neuroglia - physiology | Nitric Oxide - physiology | Vasomotor System - radiation effects | Animals | Vasomotor System - physiology | Amidines - pharmacology | In Vitro Techniques
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2002, Volume 137, Issue 7, pp. 1021 - 1030
The mechanism(s) by which vascular endothelial growth factor (VEGF) induces endothelial nitric oxide synthase (eNOS) activation remain(s) unclear up to a... 
eNOS | PAF | PI3K | VEGF | PLC | PLA2 | PKC | NO | PLA | PROTEIN-KINASE-C | ANGIOGENESIS | PERMEABILITY | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | CALMODULIN | CALCIUM | PAF SYNTHESIS | PHARMACOLOGY & PHARMACY | PLATELET-ACTIVATING-FACTOR | GROWTH-FACTOR | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factors | Platelet Activating Factor - pharmacology | Protein-Serine-Threonine Kinases | Type C Phospholipases - metabolism | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Cell Surface - antagonists & inhibitors | Lactones - pharmacology | Platelet Membrane Glycoproteins - antagonists & inhibitors | Calcium - antagonists & inhibitors | Time Factors | Cattle | Protein Kinase C - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Receptors, G-Protein-Coupled | Chelating Agents - pharmacology | Serine - metabolism | 1-Methyl-3-isobutylxanthine - pharmacology | Ginkgolides | Platelet Activating Factor - metabolism | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Nitric Oxide Synthase - metabolism | Vascular Endothelial Growth Factor A | Maleimides - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Lymphokines - pharmacology | Nitric Oxide Donors - pharmacology | Ionophores - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Morpholines - pharmacology | Protein Kinase C - antagonists & inhibitors | Calcimycin - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Egtazic Acid - pharmacology | Androstadienes - pharmacology | Diterpenes | Signal Transduction - physiology | Nitric Oxide - metabolism | Papers
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2014, Volume 73, pp. 51 - 59
Microglia are the resident immune cells in the brain. Microglial activation is characteristic of several inflammatory and neurodegenerative diseases including... 
Peroxynitrite | Free radicals | Protein radical | Inducible nitric oxide synthase | Lipopolysaccharide | Nitrone adducts | Parkinson disease | Microglia | NADPH OXIDASE | OXIDATIVE STRESS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | KAPPA-B | LIPOPOLYSACCHARIDE-ACTIVATED MICROGLIA | REACTIVE OXYGEN | ENDOCRINOLOGY & METABOLISM | GENERATION | TYROSINE NITRATION | PARKINSONS-DISEASE | Microglia - metabolism | Metalloporphyrins - pharmacology | Lipopolysaccharides | Thiocarbamates - pharmacology | RNA Interference | Nitric Oxide Synthase Type II - antagonists & inhibitors | Spin Trapping | Acetophenones - pharmacology | Free Radicals - metabolism | Proline - pharmacology | Microglia - cytology | NG-Nitroarginine Methyl Ester - pharmacology | NF-kappa B - antagonists & inhibitors | Proline - analogs & derivatives | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antioxidants - pharmacology | Neurodegenerative Diseases - metabolism | Coumarins - pharmacology | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Peroxynitrous Acid - metabolism | Amidines - pharmacology | Mice | Pyridines - pharmacology | RNA, Small Interfering | Benzylamines - pharmacology | Cell Line, Transformed | Boronic Acids - pharmacology | Nitric Oxide Synthase Type II - metabolism | Nitration | Nervous system diseases | Multiple sclerosis | Analysis | Nitric oxide | Environmental health | Physiological aspects | Alzheimer's disease | Index Medicus | Inducible nitric | oxide synthase | LPS | Parkinson’s disease
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 03/2007, Volume 34, Issue 3, pp. 223 - 229
SUMMARY • The important role of the cannabinoid system in the modulation of anxiety like behaviours in clinical and experimental studies has been proposed.... 
interaction | anxiety | cannabinoids | nitric oxide | plus-maze test | rat | plus‐maze test | Cannabinoids | Anxiety | Plus-maze test | Rat | Interaction | Nitric oxide | PHYSIOLOGY | ANTAGONIST | ACETYLCHOLINE-RELEASE | SR 141716A | PHARMACOLOGICAL BLOCKADE | CORTICOTROPIN-RELEASING-FACTOR | AGONIST CP-55,940 | GABA RELEASE | IN-VIVO | PHARMACOLOGY & PHARMACY | MICE | MODULATION | NG-Nitroarginine Methyl Ester - pharmacology | Analgesics - pharmacology | Microinjections | Rats, Wistar | Cannabinoids - administration & dosage | Anxiety - psychology | Enzyme Inhibitors - pharmacology | Receptors, Cannabinoid - physiology | Anxiety - physiopathology | Morpholines - pharmacology | Rats | Male | Nitric Oxide - physiology | Benzoxazines | Cannabinoids - pharmacology | Naphthalenes - pharmacology | Stereotaxic Techniques | Animals | Piperidines - pharmacology | Arginine - pharmacology | Nitric Oxide Synthase Type I - antagonists & inhibitors | Hippocampus - physiology | Pyrazoles - pharmacology | Receptors, Cannabinoid, physiology | NG-Nitroarginine Methyl Ester, pharmacology | Anxiety, physiopathology | Arginine, pharmacology | Cannabinoids, pharmacology | Cannabinoids, administration and dosage | Nitric Oxide Synthase Type I, antagonists and inhibitors | Enzyme Inhibitors, pharmacology | Anxiety, psychology | Naphthalenes, pharmacology | Hippocampus, physiology | Piperidines, pharmacology | Pyrazoles, pharmacology | Analgesics, pharmacology | Morpholines, pharmacology | Nitric Oxide, physiology | Physiological aspects
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 09/2007, Volume 34, Issue 9, pp. 938 - 945
SUMMARY • In the present review, we addressed studies in humans and rats to determine the role that oxidative stress may play in mediating cardiovascular... 
kidney | aopcynin | F2-isoprostanes | superoxide | tempol | molsidomine | F2‐isoprostanes | Tempol | Aopcynin | Superoxide | Molsidomine | Kidney | PHYSIOLOGY | DIMORPHISM | QUANTIFICATION | PROSTAGLANDIN-F2-ALPHA METABOLITE | F-2-ISOPROSTANES | THERAPY | IN-VIVO | PHARMACOLOGY & PHARMACY | VASODILATOR | HYPERTENSIVE-RATS | PROGRESSION | Cardiovascular Diseases - prevention & control | Humans | Kidney - enzymology | NADPH Oxidases - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Hypertension - drug therapy | Male | Spin Labels | Kidney - metabolism | Cyclic N-Oxides - pharmacology | Acetophenones - pharmacology | Female | Blood Pressure - drug effects | Nitric Oxide Donors - pharmacology | Superoxide Dismutase - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Rats, Inbred SHR | Cardiovascular Diseases - etiology | Glutathione Peroxidase - metabolism | Cardiovascular Diseases - physiopathology | Kidney - drug effects | Cardiovascular Diseases - metabolism | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Antioxidants - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Catalase - metabolism | Antioxidants - therapeutic use | Animals | Ascorbic Acid - pharmacology | Molsidomine - pharmacology | Sex Factors | Hypertension - complications | Nitric Oxide Synthase - metabolism | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Vitamin E - pharmacology | Kidney, drug effects | NG-Nitroarginine Methyl Ester, pharmacology | Nitric Oxide Synthase, antagonists and inhibitors | Oxidative Stress, drug effects | Ascorbic Acid, pharmacology | Hypertension, drug therapy | Cardiovascular Diseases, etiology | Cardiovascular Diseases, prevention and control | Cyclic N-Oxides, pharmacology | Enzyme Inhibitors, pharmacology | Superoxide Dismutase, metabolism | Nitric Oxide Synthase, metabolism | Hypertension, physiopathology | Antioxidants, pharmacology | Kidney, metabolism | NADPH Oxidase, antagonists and inhibitors | Blood Pressure, drug effects | Catalase, metabolism | Cardiovascular Diseases, metabolism | Hypertension, metabolism | Acetophenones, pharmacology | Vitamin E, pharmacology | Antioxidants, therapeutic use | Kidney, enzymology | Nitric Oxide, metabolism | Molsidomine, pharmacology | NADPH Oxidase, metabolism | Hypertension, complications | Nitric Oxide Donors, pharmacology | Glutathione Peroxidase, metabolism | Cardiovascular Diseases, physiopathology | Hypertension | Oxidative stress | Blood pressure
Journal Article
Planta, ISSN 0032-0935, 3/2009, Volume 229, Issue 4, pp. 757 - 765
The effects of chitosan (β-1,4 linked glucosamine, a fungal elicitor), on the patterns of stomatal movement and signaling components were studied. cPTIO (NO... 
Pathogens | Reactive oxygen species | Calcium | Sodium | Fluorescence | Guard cells | Oxides | Stomata | Plants | Tungstates | Life Sciences | Signal transduction | Nitric oxide | Forestry | ROS | Ecology | Agriculture | Chitosan | Plant Sciences | Pea | ARABIDOPSIS-THALIANA | FREE CALCIUM | CULTURED-CELLS | PROTEIN-KINASES | BLUE-LIGHT | PLANT SCIENCES | SIGNAL-TRANSDUCTION | STRESS RESPONSES | HYDROGEN-PEROXIDE | ABSCISIC-ACID | DISEASE RESISTANCE | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Tungsten Compounds - pharmacology | Peas - cytology | Plant Epidermis - metabolism | Dose-Response Relationship, Drug | Time Factors | Cyclic N-Oxides - pharmacology | Egtazic Acid - analogs & derivatives | Chitosan - pharmacology | Plant Epidermis - cytology | Plant Stomata - drug effects | Peas - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Peas - drug effects | Imidazoles - pharmacology | Chelating Agents - pharmacology | Onium Compounds - pharmacology | Plant Epidermis - drug effects | Abscisic Acid - pharmacology | Microscopy, Confocal | Egtazic Acid - pharmacology | Kinetics | Nitric Oxide - metabolism | Plant Growth Regulators - pharmacology | Plant Stomata - physiology | Oxidases | Legumes | Beans | Mimosaceae | Tungsten compounds | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2017, Volume 794, pp. 209 - 215
N-arachidonoyl glycine (NAGLY), is the endogenous lipid that activates the G protein-couple receptor 18 (GPR18) with vasodilatory activity in resistance... 
Na+/Ca2+ exchanger | Vasorelaxation | Nitric oxide | N-arachidonoyl glycine | Hypotensive | Ca | exchanger | ANANDAMIDE-INDUCED VASORELAXATION | RAT | IDENTIFICATION | VASCULAR ENDOTHELIUM | CORONARY-ARTERIES | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | ABNORMAL-CANNABIDIOL | GPR18 | Glycine - analogs & derivatives | Kidney - blood supply | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Endothelium, Vascular - drug effects | Male | Thiourea - pharmacology | Quinoxalines - pharmacology | Phenylephrine - pharmacology | Regional Blood Flow - drug effects | Piperidines - pharmacology | Oxadiazoles - pharmacology | Blood Pressure - drug effects | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Kidney - drug effects | Rats | Capsaicin - analogs & derivatives | Arachidonic Acids - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Carbachol - pharmacology | Animals | Cyclic GMP - metabolism | Glycine - pharmacology | Endothelium, Vascular - metabolism | Anilides - pharmacology | Endothelium, Vascular - pathology | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Nitric Oxide - metabolism | Thiourea - analogs & derivatives | Medical colleges | Dilatation | Vasodilators | Blood vessels | Indomethacin | Glycine | Endothelium
Journal Article
Pharmacological Research, ISSN 1043-6618, 12/2014, Volume 90, pp. 25 - 35
Journal Article
Gastroenterology, ISSN 0016-5085, 2000, Volume 118, Issue 6, pp. 1149 - 1156
Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor factor, are frequently increased in chronic liver diseases. In these conditions,... 
FAT-STORING CELLS | RAT-LIVER | GLOMERULAR MESANGIAL CELLS | DEPENDENT CONTRACTILITY | NITRIC-OXIDE | GROWTH-FACTOR | ITO CELLS | GASTROENTEROLOGY & HEPATOLOGY | SMOOTH-MUSCLE CELLS | PORTAL-HYPERTENSION | ALDOSTERONE SYSTEM | Receptor, Angiotensin, Type 1 | Receptors