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Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2014, Volume 22, Issue 21, pp. 5935 - 5949
Drugs that target DNA topoisomerase II isoforms and alkylate DNA represent two mechanistically distinct and clinically important classes of anticancer drugs.... 
Etoposide | Hybrid | Topoisomerase II | K562 cells | Structure-based design | DNA | Molecular modeling | Nitrogen mustard | COMPARE | Docking | Anticancer | Alkylator | Epipodophyllotoxin | LEUKEMIA K562 CELLS | CANCER-THERAPY | STRAND BREAKS | DRUGS | PODOPHYLLOTOXIN | DERIVATIVES | DEXRAZOXANE ICRF-187 | CHEMISTRY, MEDICINAL | ANTICANCER AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ANTITUMOR AGENTS | INHIBITORS | Podophyllotoxin - pharmacology | Leukemia - pathology | Mustard Compounds - pharmacology | Humans | Mustard Compounds - chemistry | DNA Breaks, Double-Stranded - drug effects | Neoplasms - genetics | Topoisomerase II Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Leukemia - genetics | DNA Topoisomerases, Type II - metabolism | Etoposide - analogs & derivatives | Leukemia - enzymology | Etoposide - pharmacology | Leukemia - drug therapy | Neoplasms - enzymology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | DNA - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Docking Simulation | Neoplasms - pathology | Podophyllotoxin - analogs & derivatives | Chemical properties | epipodophyllotoxin | alkylator | nitrogen mustard | structure-based design | anticancer | docking | topoisomerase II | hybrid | molecular modeling | etoposide
Journal Article
Journal Article
癌症:英文版, ISSN 1000-467X, 2014, Volume 33, Issue 2, pp. 80 - 86
Journal Article